Clinical trials: Achalasia
Achalasia
Botox or Botox With Esophageal Dilation in Patients With Achalasia
Achalasia is a rare esophageal motility disorder. Treatment of achalasia is aimed toward palliation of symptoms. These include botox injections to the lower esophageal sphincter (LES), pneumatic dilation, surgical myotomy, and…
- Trial name
- NCT03654066
- Testing
- Botulinum toxin type A, Endoscope balloon dilator, Patient reported outcomes
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Vanderbilt University Medical Center
Achalasia, Esophageal
Metabolic Changes Associated With Weight Gain After Treatment of Achalasia
This goal of the study is to assess the effect of weight gain in patients with achalasia after they are treated. The main question to be answered is if weight gain after achalasia treatment is associated with worsening metabolic…
- Trial name
- NCT07334639
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Assaf-Harofeh Medical Center
Esophagus Disorder, Esophageal Achalasia
Impact of Antibiotic Prophylaxis in Per-oral Endoscopic Myotomy for Esophageal Motor Disorders
No recommendation regarding antibiotic prophylaxis and preparation modalities are available for patients with esophageal motor disorders who benefit from Per-Oral Endoscopic Myotomy (POEM).
- Trial name
- NCT03944863
- Testing
- Antibiotics
- Volunteers
- 252 people
- Sponsor
- Société Française d'Endoscopie Digestive
Esophageal Achalasia
Peroral Endoscopic Remyotomy for Failed Heller Myotomy
Achalasia is a rare esophageal motility disorder, which is characterized clinically by symptoms of dysphagia, regurgitation, weight loss and chest pain.
- Trial name
- NCT01637311
- Testing
- POEM
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
Achalasia, Alacrima
Genetic Evaluation of AAAS Gene in Early-Onset Achalasia and Alacrima Patients
The AAAS gene has been known to cause achalasia, alacrima, adrenal abnormalities and a progressive neurological syndrome. A considerable proportion of achalasia patients have been known to show alacrima (decreased secretion of…
- Trial name
- AAAS (NCT00856921)
- Volunteers
- 19 people
- Sponsor
- Asan Medical Center
Achalasia, Gastric Outlet Obstruction
Endoscopic Surgery for Gastrointestinal Disorders: A Multicenter Registry Study
Currently, there is limited multi-center data on endoscopic surgery outcomes in western populations. Evaluation of these measurement would help the investigators compare them to conventional treatment modalities within current…
- Conditions
- Achalasia, Gastric Outlet Obstruction, Gastroparesis, GERD
- Trial name
- NCT05041608
- Testing
- Endoscopic Surgery
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Advanced Endoscopy Research, Robert Wood Johnson Medical School Rutgers University
Achalasia
Efficacy of Dark Chocolate in Achalasia Patients
Flavanols, present in dark chocolate, were shown to induce Nitric Oxide synthesis. Since Nitric Oxide facilitates smooth muscle relaxation, it might ease the relaxation of the LES (lower esophageal sphincter)as well.
- Trial name
- NCT00790465
- Testing
- dark chocolate
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Achalasia Cardia, Tumor
Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures
This prospective study aims to evaluate the performance of a novel Artificial Intelligence (AI) clinical decision support tool during third space endoscopic procedures, such as Endoscopic Submucosal Dissection (ESD) and Peroral…
- Trial name
- NCT07399652
- Testing
- AI generated segmentation mask for sub-mucosal blood vessels
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Asian Institute of Gastroenterology, India
Esophageal Achalasia
POEM for Spastic Esophageal Disorders
This study evaluates the efficacy and safety of the Per-Oral Endoscopic Myotomy (POEM) technique for lower esophageal sphincter myotomy in patients suffering from spastic esophageal disorders such as achalasia at a Canadian…
- Trial name
- NCT02425033
- Testing
- POEM
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Esophageal Motility Disorders
Monopolar and Bipolar Current RFA Knife in POEM
Per Oral Endoscopic Myotomy (POEM) is performed for various esophageal muscular disorders, including achalasia and other spastic esophageal conditions.
- Trial name
- NCT05272046
- Testing
- Per-oral Endoscopic Myotomy, Speedboat (Bipolar electrocautery knife)
- Where
- 3 sites in United States, India and 1 more
- Volunteers
- 104 people
- Sponsor
- Baylor College of Medicine
Histopathology
Esophageal Mucosal Changes in Achalasia Cardia and Reversibility After Per Oral Endoscopic Myotomy - A Pilot Study
Esophageal mucosal changes in long standing achalasia cardia and reversibility after per oral endoscopic myotomy - A pilot study Aims and Objectives: To study mucosal changes in patients with achalasia cardia To study potential…
- Trial name
- NCT04463095
- Testing
- PER ORAL ENDOSCOPY MYOTOMY (POEM)
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Weight Gain, Nutritional Imbalance
COMPREHENSIVE ANALYSIS OF NUTRITIONAL PARAMETERS IN PATIENTS WITH IDIOPATHIC ACHALASIA: A PROSPECTIVE STUDY.
A total of 100 patients aged 18-60 years with confirmed diagnosis of achalasia cardia will be recruited prospectively. In this study, patients diagnosed with achalasia cardia (prior to per oral endoscopic myotomy treatment) will…
- Trial name
- POEM (NCT05161923)
- Testing
- Per oral endoscopy myotomy
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Asian Institute of Gastroenterology, India
Achalasia
redoPOEM : Failure of a First POEM
observational study, measurement of efficacy in the cohort.
- Trial name
- redoPOEM (NCT06044155)
- Where
- 14 sites in France
- Volunteers
- 111 people
- Sponsor
- University Hospital, Bordeaux
Esophageal Achalasia
Bacteremia and Procalcitonin Levels in Peroral Endoscopic Myotomy for Achalasia
Peroral Endoscopic Myotomy (POEM) is a novel, promising endoscopic technique for achalasia because it is safer and more effective than traditional Heller's myotomy.
- Trial name
- NCT01750385
- Testing
- no antibiotic prophylaxis, second-generation cephalosporin
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
Esophageal Motility Disorders
The Clinical Manifestation and Prognosis of Pediatric Esophageal Motility Disorders
Background: Abnormal esophageal peristalsis mostly occurs in adults, but some patients have onset in childhood. Most of the symptoms of esophageal motility disorders in children are not as clear as those described by adult…
- Trial name
- NCT06629025
- Testing
- High-resolution impedance manometry
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Symptoms and Signs, Quality of Life
Quality of Life After Surgery for End-stage Achalasia
Therapy for end-stage achalasia is under debate: comparative data on the long-term functional results of myotomy and oesophagectomy are lacking.
- Trial name
- NCT04152902
- Testing
- Objective outcome, Quality of life
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Bologna
Comparison of Short- Term Success Rates of POEM With LHM, Comparison of Long-term Success Rates of POEM With LHM
Comparison of Peroral Endoscopic Myotomy (POEM) With Laparoscopic Heller Myotomy (LHM) for Treatment of Achalasia
For the treatment of Achalasia, LHM has been the only surgical therapy. Recently, an endoscopic approach for this therapy has been developed (peroral endoscopic Myotomy POEM).
- Trial name
- POEM3 (NCT02018705)
- Where
- 5 sites in Denmark, Germany and 2 more
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Achalasia
Per-Oral Endoscopic Myotomy (POEM) for the Treatment of Achalasia, Database Repository
POEM (Per-Oral endoscopic myotomy (creating a muscle [esophagus] opening), an incision-less (no cutting of the surface of the body) endoscopic procedure, is an effective non-surgical alternative to release the muscle \& sphincter…
- Trial name
- POEM (NCT02770859)
- Testing
- POEM (Per Oral Endoscopic Myotomy)
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Indiana University
Achalasia
Development of Endoscopic Treatment for Achalasia
Per Oral Endoscopic Myotomy (POEM); comparison of two surgical techniques division all the esophageal muscle layers versus division the inner circular muscle layer of the esophagus only.
- Trial name
- POEM (NCT04180241)
- Testing
- POEM
- Where
- 2 sites in Sweden
- Volunteers
- 55 people
- Sponsor
- Karolinska Institutet