Clinical trials: Acid Base Disorder
Neonatal Encephalopathy, Cell Damage
Inflammation and Metabolic Acidosis at Birth (AGAIN: AutophaGy AcIdosis Newborn)
Protection of brain development is a major aim in the Neonatal Intensive Care Unit. Neonatal encephalopathy (NE) occurs in 1.8 to 7.7 infants per 1000 births.
- Conditions
- Neonatal Encephalopathy, Cell Damage, Metabolic Acidosis, Inflammation
- Trial name
- AGAIN (NCT03897101)
- Where
- 2 sites in Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Acidosis, Renal Tubular
Renal Tubular Acidosis is Highly Prevalent in Critically Ill Patients
The aim of this study was to investigate the prevalence, type, and possible risk factors of RTA in critically ill patients using a physical-chemical approach.
- Trial name
- NCT02392091
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Cicatrix, Post-Surgical Complication
Class I Medical Device on Post-surgical Scars
To compare the effect of a class I pullulan based medical device containing Allium cepa \& HA versus a class I medical device silicone gel on new post-surgical wounds
- Conditions
- Cicatrix, Post-Surgical Complication, Scar Itching, Keloid
- Trial name
- NCT05412745
- Testing
- Kaloidon Plus, silicone gel
- Where
- 2 sites in Italy
- Volunteers
- 64 people
- Sponsor
- University of Rome Tor Vergata
PKU, Phenylketonurias
Market Research - Acceptability Trial for a New PKU Amino Acid Based Protein Substitute
The aim of this study is to demonstrate that a new protein substitute is acceptable and well tolerated in children with PKU.
- Conditions
- PKU, Phenylketonurias, Inborn Errors of Metabolism, Metabolic Disease
- Trial name
- NCT04309331
- Testing
- Motion
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Dr. Schär AG / SPA
Type 2 Diabetes
Lactic Acidosis and Prior Metformin Treatment
Metformin is a drug frequently prescribed to patients with type 2 diabetes. Furthermore, diabetes can lead to micro- and macrovascular complications that may cause chronic organ failure.
- Trial name
- MALA (NCT07300293)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
COPD, Respiratory Acidosis
Evaluation of the Effects on Carbon Dioxide (paCO2) of a New Oronasal Mask in Patients With Severe COPD Exacerbation Requiring Non-Invasive Mechanical Ventilation
This single-center, crossover study aims to investigate the effects of the new OptiNIV oronasal mask used during NIV in COPD patients with respiratory acidosis following an exacerbation.
- Trial name
- OPTIMUS-MASK (NCT07081776)
- Testing
- OptiNIV, Visairo
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Acute Renal Failure, Dialysis Related Complication
Simplified Regional Citrate Anticoagulation Protocols for CVVH, CVVHDF and SLED: a Pilot Study
The aim of the study are: 1) To evaluate the occurrence of acid-base alterations and the incidence of hypophosphatemia during different modalities of Renal Replacement Terapy (RRT) in critically ill patients [CVVH, CVVHDF and…
- Conditions
- Acute Renal Failure, Dialysis Related Complication, Hypophosphatemia, Hypomagnesemia
- Trial name
- NCT03976440
- Testing
- Renal Replacement Therapy (RRT) start
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Parma
Child Behavior Problem, Attention Deficit Hyperactivity Disorder
Fatty Acids and Attention Deficit and Hyperactivity Disorder Symptoms
This study aimed to evaluate the longitudinal association between n-6:n-3 LCPUFAs ratio in cord blood and child ADHD symptoms at 4 and 7 years old.
- Conditions
- Child Behavior Problem, Attention Deficit Hyperactivity Disorder, Fatty Acid Deficiency
- Trial name
- NCT03283579
- Volunteers
- 2,644 people
- Sponsor
- Barcelona Institute for Global Health
Mild Cognitive Impairment, Dementia
COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE
This retrospective study is a more extensive, confirmatory analysis of the cognitive and functional outcomes initially seen in 2 groups of MCI/dementia patients in Springfield, MA and compares specialized dementia care and a…
- Conditions
- Mild Cognitive Impairment, Dementia, Hypoxia, Hyperhomocysteinemia
- Trial name
- NCT02860338
- Volunteers
- 900 people
- Sponsor
- Clionsky Neuro Systems Inc.
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Chronic Heart Failure
Nutritional Ketosis in Heart Failure
Chronic, ambulatory heart failure patients will be given ketone ester dietary supplementation to determine therapeutic efficacy, metabolic adaptation, pharmacokinetics, associated cognitive changes, and safety within this patient…
- Trial name
- INNKA-HF (NCT04370600)
- Testing
- beta hydroxybutyrate (BHB) ester
- Volunteers
- 16 people
- Sponsor
- Thomas Jefferson University
Ketosis, Blood Glucose
The Effect of Different Ketone Supplements on β-OHB and Blood Glucose in Healthy Individuals
Ketone bodies are a fuel source and signaling molecule that are produced by your body during prolonged fasting or if you consistently eat at low-carbohydrate diet.
- Trial name
- NCT05273411
- Testing
- (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester, Beta-hydroxybutyric acid, 1,3-Butanediol
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Ketogenic Dieting, Ketoses, Metabolic
Ketogenic Diet Health and Longevity
The goal of this pilot intervention is to learn about how a well-formulated ketogenic diet (WFKD) impacts various health factors in generally healthy adults.
- Conditions
- Ketogenic Dieting, Ketoses, Metabolic, Ketosis
- Trial name
- KDHL (NCT05939011)
- Testing
- Well-formulated Ketogenic Diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Diabetes Mellitus, Type 1, Diabetic Ketoacidosis
Early Administration of Long-acting Insulin Treatment of Diabetic Ketoacidosis in Pediatric Type 1 Diabetes
The management goals of diabetic ketoacidosis (DKA) in the pediatric type 1 diabetes (T1DM) population are fluid and electrolyte repletion, insulin administration, and correction of acidosis in order to stabilize the patient.
- Trial name
- NCT02548494
- Testing
- Glargine, IV insulin, Electrolyte Correction
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Chattanooga-Hamilton County Hospital Authority
Gastrointestinal Infections, Ketosis
Oral Glucose Intervention for Children With Gastroenteritis and Ketosis
Fasting ketoacidosis adds morbidity to children affected by gastrointestinal infections. The investigators investigate oral glucose gel for its effectiveness in rapidly reducing ketoacidosis and for improvements in oral hydration…
- Trial name
- NCT02729870
- Testing
- Oral Glucose Gel
- Sponsor
- University of Florida
Ketosis, Metabolic
Effect of Diet Induced Ketosis on LDL Turnover Rates
There have been concerning case reports of marked elevations of LDL-c in some individuals consuming a KD and Dr. Lewis has been referred a number of these cases to his lipid clinic, some of whom have had extreme elevations of LDL…
- Trial name
- NCT05103761
- Testing
- Study diet, Low glycemic index treatment diet
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Dehydration
Effects of Amino Acid/Electrolyte-based Beverages on Hydration Status
Older adults typically do not drink later in the day to avoid the necessity of interrupting sleep to urinate. Sometimes they also limit ingestion of fluids to avoid the need to urinate when engaged in certain activities such as…
- Trial name
- NCT03559101
- Testing
- Distilled water, Medical Food 1, Medical Food 2
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- W. Larry Kenney
Obesity, Pregnancy
Diet and Physical Activity Counseling and n3-long Chain (PUFA) Supplementation in Obese Pregnant Women
In Chile, 1 out of 4 pregnant women is obese (BMI > 30 kg/m2). This impacts negatively the health of the mother and the offspring during pregnancy.
- Trial name
- MIGHT (NCT02574767)
- Testing
- Lifestyle counseling, PUFA Supplementation, Routine diet & PA
- Where
- Chile
- Volunteers
- 1,002 people
- Sponsor
- University of Chile
Esophageal Atresia With Tracheo-esophageal Fistula, Congenital Diaphragmatic Hernia
Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases
This is a pilot randomised controlled trial comparing open versus thoracoscopic surgery for repair of oesophageal atresia with tracheo-oesophageal fistula or congenital diaphragmatic hernia in neonates.
- Trial name
- CO2 (NCT01467245)
- Testing
- Hypercapnia during thoracoscopy, Open surgery
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Hypoxia, Ketosis
Ketone Esters for Optimization of Cognitive Performance in Hypoxia
This study will investigate the effects of ketone ester drinks on cognitive performance in hypoxia.
- Trial name
- NCT03659825
- Testing
- Ketone Ester, Hypoxic exposure
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- HVMN Inc