Clinical trials: Acid Base Disorder
Ketosis, Hypoxia
Effect of Ketone Ester Supplementation on Sleep and Recovery in Hypoxia
This study specifically aims to elucidate the effects of IEK on sleep and recuperation in hypoxia, after training in normoxia. These conditions are in line with the widely applied live-high train-low strategy.
- Conditions
- Ketosis, Hypoxia, Sleep
- Trial name
- NCT06060093
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Prostate Cancer
Prostatic Acid Phosphatase (PAP) Vaccine in Patients With Prostate Cancer
The investigators are trying to find new methods to treat prostate cancer. The approach they investigators are taking is to try to enhance patients own immune response against the cancer.
- Trial name
- NCT00582140
- Testing
- pTVG-HP with rhGM-CSF
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Wisconsin, Madison
Renal Transplant Disorder
Renal Tubular Acidosis in Incident Renal Transplant Recipients
Metabolic acidosis is a common complication in incident renal transplant recipients. Protracted acidosis may be associated with osteoporosis, inflammation, negative protein balance and malnutrition, and last but not least may…
- Trial name
- NCT01283880
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hypochlorhydria
Assessment of Gastric pH Changes Induced by Ascorbic Acid Tablets
This study evaluates the use of ascorbic acid, vitamin C, to temporary reduce gastric pH in individuals with omeprazole induced hypochlorhydria.
- Trial name
- NCT04199624
- Testing
- Omeprazole 20mg, Vitamin C
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alcohol Use Disorder, Alcohol Withdrawal
Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
The goal of this clinical trial is to learn the effects of ketone supplement compared to placebo on alcohol withdrawal symptoms during a 4 day alcohol withdrawal management treatment in adults with moderate to severe alcohol use…
- Conditions
- Alcohol Use Disorder, Alcohol Withdrawal, Ketosis
- Trial name
- KSAW (NCT06559995)
- Testing
- ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,, magnetic resonance imaging session
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Healthy Adults
Comparing the Ketogenic Effect of Coconut Oil and Different MCTs
The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults.
- Trial name
- MCT-Coco (NCT02679222)
- Testing
- Coconut oil, Coconut oil + MCT, MCT
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Ketosis, Glucose Metabolism
Ketone Supplements and Substrate Oxidation and Physical Performance
The objective of this randomized crossover study is to examine the influence of consuming a ketone ester plus carbohydrate (KE+CHO) supplement on substrate oxidation and physical performance in 15 healthy adults.
- Trial name
- NCT04737694
- Testing
- Ketone ester, Glucose
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Urinary Tract Stones
Multicenter Study to Develop a Model to Identify Uric Acid Urinary Tract Stones Using CT and Lab Tests
Urinary tract stones are a common condition affecting the kidney, ureter, bladder, and urethra. Uric acid stones represent an important subtype of urinary stones and require different prevention and treatment strategies compared…
- Trial name
- UAS-Model (NCT07328932)
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 1,650 people
- Sponsor
- Jian Zhuo
Lactic Acidosis
Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia
OBJECTIVES: I. Determine the pharmacokinetics of sodium dichloroacetate (DCA) in patients with congenital lactic acidemia. II. Determine the efficacy of DCA in decreasing the frequency and/or severity of acute episodes of…
- Trial name
- NCT00004493
- Testing
- sodium dichloroacetate
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, San Diego
Diabetes, Diabetic Ketoacidosis
Evaluation of a Non-invasive Brain Compliance Measurement Device
This is a research study to understand how diabetic ketoacidosis may affect the brain and learning and to see if these changes are transient or permanent.
- Trial name
- NCT01753921
- Testing
- this is not an intervention study, MRI
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Stanford University
Hypertensive Disease
Retention of Potassium From Potatoes and Potassium Gluconate, and the Effect on Blood Pressure.
This study is designed to compare the effect of different dietary potassium sources on uptake and retention of potassium, as well as to determine the effect of potassium intake on blood pressure and acid-base balance.
- Trial name
- NCT02697708
- Testing
- Potassium control diet, Potassium gluconate diet, Potato Diet
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Purdue University
Hyperemesis Gravidarum, Pregnancy Related
The Levels of the Orexin, Galanin and aMSH and CART in Patients With Hyperemesis Gravidarum
Hyperemesis gravidarum is a disease of unknown etiology that is frequently encountered in pregnant women and seriously impairs their quality of life.
- Trial name
- NCT05446025
- Testing
- Blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Siirt University
Osteoporosis
Feasibility of Doctors' Rooms-based Infusion of Zoledronic Acid
1. The study will assess the safety and tolerability of a single-infusion of zoledronic acid 5 mg administered in a private medical practice setting by a nurse provided by a nationwide infusion service.
- Trial name
- LISA (NCT00745485)
- Testing
- zoledronic acid
- Where
- 14 sites in Australia
- Volunteers
- 186 people
- Sponsor
- Novartis Pharmaceuticals
COVID-19 Vaccines
A Study of COVID-19 Vaccine(s) in Children and Adults
The purpose of this study is to learn about the safety and effects of updated COVID-19 vaccines (called BNT162b2) in participants 5 Through 64 Years of Age with risk factors for Severe COVID-19, and Participants 65 Years of Age…
- Trial name
- NCT07798648
- Testing
- BNT162b2
- Where
- 14 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Large Bowel Cancer
Effects of Different Strategy of Fluids Administration on Acid/Base Disorders and Inflammatory Mediators
Aim of the study is to ascertain whether a different strategy of fluids administration can be responsible of differences in terms of acid/base disorders (Stewart approach), pro-inflammatory and inflammatory mediators.
- Trial name
- NCT01320891
- Testing
- balanced solutions, not balanced
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università degli Studi di Ferrara
Diabetic Ketoacidosis, Hyperglycemia
Continuous Glucose Monitoring Using a New Subcutaneous Insulin Protocol for Mild to Moderate Diabetic Ketoacidosis
Using a prospective, mixed methods study design, the investigators will assess the feasibility, usefulness, and care team acceptability of CGM in conjunction with FSBG during implementation of the new subQ DKA/HHS protocol at…
- Trial name
- NCT06693115
- Testing
- CGM with alerts
- Where
- United States
- Sponsor
- HealthPartners Institute
Septic Shock, Shock, Septic
Thiamine Supplementation in Patients With Septic Shock
To determine if intravenous thiamine would decrease the time to reversal of shock in patients with septic shock.
- Conditions
- Septic Shock, Shock, Septic, Lactic Acidosis, Thiamine Deficiency
- Trial name
- NCT03122678
- Testing
- Thiamine
- Where
- United States
- Sponsor
- The Cleveland Clinic
Chronic Kidney Disease, Metabolic Acidosis
Comparison of Standard Versus Low Bicarbonate Hemodialysis
This study will compare acid-base changes during hemodialysis treatments with a standard dialysis bath versus a lower bicarbonate dialysis bath, and aims to define the factors that limit equilibration of the bicarbonate…
- Trial name
- NCT01777178
- Testing
- Low bicarbonate dialysis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Albert Einstein College of Medicine
Exercise, Ketosis
The Effects of Acute Ketone Monoester Supplementation on Exercise Efficiency and the Influence of Dose and Intensity
Diet can alter blood ketone levels and this in turn may affect exercise capacity. This study will determine if the acute ingestion of a ketone supplement alters cycling exercise efficiency.
- Trial name
- NCT05665855
- Testing
- Ketone monoester
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- McMaster University
Ketoacidosis, Diabetes Mellitus Type 1
A Study of Intracellular Signaling in Muscle and Fat Cells During Ketosis
Hypothesis 1. To define whether stimulation of ATGL and suppression of G0/G1 switch gene occur in the initial phases of diabetic ketoacidosis and thus can be identified as the primary mechanisms behind this life threatening…
- Trial name
- NCT02157155
- Testing
- LPS
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- University of Aarhus