Clinical trials: Acid Base Disorder
Diabetes (DM), Diabetic Ketoacidosis
Phase 1 Trial of Arginine Hydrochloride for the Management of Diabetic Ketoacidosis in Type 2 Diabetes
Diabetic ketoacidosis (DKA) is increasingly recognized in adults with "ketone-prone" type 2 diabetes. In many of these patients, the pancreas can still make insulin but becomes temporarily "stunned" during severe, prolonged high…
- Conditions
- Diabetes (DM), Diabetic Ketoacidosis, Ketosis Prone Diabetes, Hyperglycaemia (Diabetic)
- Trial name
- NCT07167693
- Testing
- Arginine hydrochloride, Sodium Chloride 0.9%
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- David K Carroll
Morbid Obesity, Acidosis
Intraoperative Fluid Management in Laparoscopic Bariatric Surgery
The objective of this study is to evaluate the effects of 'high' versus 'low' volume intraoperative fluid administration (Ringer Lactate, RL) on intra- and postoperative parameters, in obese patients undergoing laparoscopic…
- Conditions
- Morbid Obesity, Acidosis, Intra-Abdominal Abscess, Hemorrhage
- Trial name
- NCT00905502
- Testing
- Lactated Ringer's solution
- Where
- Israel
- Volunteers
- 107 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Metabolic Acidosis
Value of Fetal Scalp Lactate Sampling During Labour in Cases of Abnormal Fetal Heart Rate
ST-analysis of the foetal ECG (STAN®) is another second line technique for intrapartum foetal monitoring. Combining ST-analysis with standard CTG interpretation aims to identify hypoxic foetuses more accurately than CTG alone.
- Trial name
- NCT05259202
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Clinical Stabilization of Hypercapnia: NIPPV v HVNI
This study will evaluate the ability of High Velocity Nasal Insufflation [HVNI] to effect ventilation and related physiologic responses in hypercapnic patients when compared to noninvasive positive pressure ventilation [NIPPV].
- Conditions
- Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Dyspnea, Hypercapnic Acidosis
- Trial name
- HYPERACT (NCT04709562)
- Testing
- High Velocity Nasal Insufflation (HVNI), Noninvasive Positive Pressure Ventilation (NIPPV)
- Where
- 7 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Vapotherm, Inc.
Periodontitis
Hyaluronic Acid for Residual Periodontal Pockets Adjunctive Treatment
Objective: To evaluate the adjunctive effect of hyaluronic acid (HA) gel in the treatment of residual periodontal pockets over a 12-month period.
- Trial name
- NCT04702334
- Testing
- Hyaluronic Acid, Lidocain
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Overweight, Mood
Effects of a Ketogenic Diet on Psychological Outcomes
The aim of the study is to investigate how glycemia and ketonemia variations during three different diet protocols: a ketogenic diet without any restriction on calories intake (KD), a calorie-restricted ketogenic-mediterranean…
- Conditions
- Overweight, Mood, Appetitive Behavior
- Trial name
- NCT04086498
- Testing
- Mediterranean diet, KEMEPHY, KD
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Padova
Acidosis
Evaluation of TRC101 in Subjects With Chronic Kidney Disease and Metabolic Acidosis
This was a double-blind, placebo-controlled, parallel-design, 6-arm, fixed dose study. The study enrolled 135 adult male and female subjects with Stage 3 or 4 chronic kidney disease and low serum bicarbonate levels.
- Trial name
- NCT02809183
- Testing
- TRC101
- Where
- 5 sites in Bulgaria, Georgia
- Volunteers
- 135 people
- Sponsor
- Tricida, Inc.
Shortness of Breath, Chest Pain
Checklists Resuscitation Emergency Department
The study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.
- Conditions
- Shortness of Breath, Chest Pain, Abdominal Pain, Altered Mental Status
- Trial name
- NCT05649891
- Testing
- Emergency Manual
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
Ketosis, Epilepsy
Market Research - Acceptability Study for New MCT Fat Products
This is a market research, observational study to evaluate the tolerability and acceptability of MCT supplements for young children, young people and adults with intractable epilepsy, GLUT-1 or PDHD from 3 years to adulthood.
- Conditions
- Ketosis, Epilepsy, Fatty Acid Oxidation Disorder, Malabsorption
- Trial name
- NCT04309214
- Testing
- MCT fats
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Dr. Schär AG / SPA
Diabetic Ketoacidosis, Postoperative Care
Postoperative Euglycemic Ketoacidosis Frequency in Sodium-Glucose Cotransporter-2 Inhibitor Users
The goal of this observational study is to determine the frequency of postoperative euglycemic diabetic ketoacidosis (EDKA) in patients receiving Sodium- Glucose Cotransporter-2 (SGLT-2) inhibitors.
- Trial name
- SGLT-2I (NCT07127406)
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital
Type 2 Diabetes, Ketoses, Metabolic
Keto Drinks as a Meal Primer in Patients With Type 2 Diabetes
The main objective of this clinical trial is to study the effects of orally administered ketone drinks containing the ketone body, 3-hydroxybutyrate (3-OHB), just before a meal in patients with type 2 diabetes.
- Trial name
- NCT05263401
- Testing
- 3-hydroxybutyrate
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- University of Aarhus
Lung Cancer - Non Small Cell, Lung Metastases From Any Primary
Transbroncheal Novel PDT Peripheral Lung Tumor Ablation With 5-ALA
Photodynamic therapy (PDT) involves the use of special light-sensitive drugs that are selectively absorbed by cancer cells. When exposed to a specific wavelength of light, these drugs are activated within the tumor cells…
- Trial name
- 5ALA-TBPDT (NCT06679712)
- Testing
- Transbronchial PDT lung tumor ablation
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- Taoyuan General Hospital
Prostatitis
CBD-based Therapy to Attenuate Non-bacterial Prostatitis Symptoms
Efficacy and safety of the medical device rectal CANNEFF® SUP suppositories containing two active ingredients cannabidiol (CBD) and hyaluronic acid (HA) in alleviating non-bacterial prostatitis symptoms and improving quality of…
- Trial name
- Urol-CBD (NCT06968910)
- Testing
- CANNEFF® SUP rectal suppositories
- Where
- Czechia
- Volunteers
- 35 people
- Sponsor
- Palacky University
Ketonemia, Exercise Performance
Ketone Supplementation, Glycogen Replenishment and Time Trial Performance Following Glycogen Lowering Exercise
20 healthy trained males will volunteer to participate in this study. there will be 2 treatments: Carbohydrate- ketone supplementation and carbohydrate alone.
- Conditions
- Ketonemia, Exercise Performance, Ketosis
- Trial name
- NCT04004676
- Testing
- 20 km time trial performance, Glycogen lowering exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Mitochondrial Disorders, Mitochondrial Genetic Disorders
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
The North American Mitochondrial Disease Consortium (NAMDC) maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.
- Conditions
- Mitochondrial Disorders, Mitochondrial Genetic Disorders, Mitochondrial Diseases, Disorder of Mitochondrial Respiratory Chain Complexes
- Trial name
- NAMDC (NCT01694940)
- Where
- 17 sites in United States, Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Metabolic Ketoacidosis, Ketoacidemia
0.9% Saline Versus Balanced Solutions in Severe Diabetic Ketoacidosis
Severe diabetic ketoacidosis (DKA) is a potentially serious complication of diabetes mellitus. The treatment regimen is based on insulin and rehydration. The choice of rehydration solution is a question that remains open.
- Conditions
- Metabolic Ketoacidosis, Ketoacidemia, Acetonemia, Acetonuria
- Trial name
- NCT05808972
- Testing
- Sodium chloride 0.9% (SC), Ringer lactate (RL)
- Where
- Tunisia
- Volunteers
- 92 people
- Sponsor
- Tunis University
Erythema, Radiation Therapy, Secondary Skin Reactions
Evaluation of a Novel Amino Acid Based Moisturizing Cream as Part of the Daily Standard Skincare Regimen Recommended During Radiation Therapy
The goal of this clinical study is to evaluate a novel amino acid based moisturizing cream as part of the daily standard skincare regimen recommended during radiation therapy.
- Trial name
- NCT06016361
- Testing
- VS-200Cr, Standard of care
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Entrinsic Bioscience Inc.
Mechanical Ventilation Complication, Respiratory Acidosis
VentilO Prospective Study
This is a randomized, open-label study comparing intial settings made by clinicians with settings recommandation made by the VentilO application immediately after intensive care unit admission.The study will allow direct…
- Trial name
- VentilO (NCT06826794)
- Testing
- Clinicians, VenitlO
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Laval University
Ketosis
Comparison Between Breath Acetone and Blood Beta-Hydroxybutyrate
Subjects will provide blood and breath samples to evaluate the relationship between breath acetone and two blood-bound species: beta-hydroxybutyrate and glucose.
- Trial name
- NCT03299543
- Testing
- LEVL (Medamonitor)
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Medamonitor
Diabetes Mellitus, Type 2
Examining the Effect of Exogenous Ketone Supplementation on Glucose Control in Type 2 Diabetes
Ketone bodies are a fuel source and signaling molecule that are produced by the body during prolonged fasting or if an individuals consistently eats a low-carbohydrate "keto" diet.
- Trial name
- NCT05155410
- Testing
- Exogenous Ketone Monoester
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia