Clinical trials: Acid Base Disorder
Chronic Heart Failure
Nutritional Ketosis in Heart Failure
Chronic, ambulatory heart failure patients will be given ketone ester dietary supplementation to determine therapeutic efficacy, metabolic adaptation, pharmacokinetics, associated cognitive changes, and safety within this patient…
- Trial name
- INNKA-HF (NCT04370600)
- Testing
- beta hydroxybutyrate (BHB) ester
- Volunteers
- 16 people
- Sponsor
- Thomas Jefferson University
Alcohol Withdrawal, Lactic Acidosis
Alcohol: Thiamine and or Magnesium 1
Patients who suffer Alcohol Use Disorder (AUD) have a 30-80% incidence of thiamine deficiency causing Wernicke's Encephalopathy (WE).
- Conditions
- Alcohol Withdrawal, Lactic Acidosis, Vitamin B1 Deficiency, Magnesium Deficiency
- Trial name
- AToM1 (NCT03466528)
- Testing
- Magnesium Sulfate, Pabrinex
- Where
- United Kingdom
- Volunteers
- 127 people
- Sponsor
- Glasgow Royal Infirmary
Feeding Intolerance, Preterm Infants
Protocol for Feeding Intolerance in Preterm Infants
Background: Feeding intolerance is a common problem in preterm infants, which is associated with increased risk of infections, prolonged hospitalization, and increased economic costs.
- Trial name
- NCT05347706
- Testing
- formula
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Metabolic Acidosis, Chronic Kidney Disease
Evaluation of Effect of TRC101 on Progression of Chronic Kidney Disease in Subjects With Metabolic Acidosis
The purpose of this study is to evaluate the effect of TRC101 on the progression of chronic kidney disease (CKD) and to evaluate the safety profile of TRC101 in CKD patients with metabolic acidosis.
- Trial name
- VALOR-CKD (NCT03710291)
- Testing
- TRC101
- Where
- 203 sites in United States, Albania and 32 more
- Volunteers
- 1,480 people
- Sponsor
- Tricida, Inc.
Type1diabetes
Type 1 Diabetes Management Using a Very Low Carbohydrate Versus Standard Diet
Despite major technological advances, management of type one diabetes mellitus (T1D) remains suboptimal, putting millions of people at risk for immediate and long-term complications.
- Trial name
- NCT03710928
- Testing
- very low carbohydrate diet, standard carbohydrate diet
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Boston Children's Hospital
Trauma, Hemorrhagic Shock
Phase 2c Dose Comparison Study of MP4OX in Trauma
MP4OX is being developed as an ischemic rescue therapy to perfuse and oxygenate tissues at risk during hemorrhagic shock. MP4OX is a pegylated hemoglobin-based colloid designed to improve perfusion and target delivery of oxygen…
- Conditions
- Trauma, Hemorrhagic Shock, Lactic Acidosis
- Trial name
- NCT01973504
- Testing
- MP4OX, Control
- Where
- 31 sites in Australia, Belgium and 9 more
- Sponsor
- Sangart
Dyslipidemia, Metabolic Syndrome (MetS)
Polyunsaturated Fatty Acids-based Bars Effect on Metabolic Syndrome Patients
This study aimed to manage dyslipidemia through Polyunsaturated fatty acids based bar among patients with metabolic syndrome.
- Trial name
- NCT07627555
- Testing
- Jelly Candy, PUFA Bar
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Lahore
Heart Failure, Ketosis
Modulation of Circulating Levels of the Ketone Body 3-hydroxybutyrate in Patients With Chronic Heart Failure: Cardiovascular Effects
The ketone body 3-hydroxybutyrate (3-OHB) is a naturally occurring energy substrate, and is associated with increased life span and improved health.
- Conditions
- Heart Failure, Ketosis, Ketonemia
- Trial name
- KETO-KINETICS1 (NCT04443426)
- Testing
- Oral 3-hydroxybutyrate salts, Ketone Monoester
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- University of Aarhus
Heart Failure, Systolic, Ketonemia
Effects of Ketones and Niacin in Heart Failure Patients
Ketones, 3-hydroxybutyrate (3-OHB), have shown to have beneficial hemodynamics effect in patients with hearth failure with reduced ejection fraction.
- Trial name
- KETO-COX (NCT04703361)
- Testing
- Niacin, Na-3-OHB
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Diet, Healthy, Health
Medium Chain Fatty Acids and Ketones
16 participants were randomized to complete two seven-day intervention periods with twice-daily consumption of Medium-chain fatty acids (MCT) or long-chain fatty acids (LCT) oil.
- Trial name
- MCFA (NCT06289296)
- Testing
- Fatty acid intake in lean and obese males
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Metformin Associated Lactic Acidosis
Study of Metformin Overdose
The objective of the METINFO study is an observational single-center retrospective and descriptive study. The main objective is to estimate the real mortality rate associated to a Metformin overdose.
- Trial name
- METINFO (NCT04762966)
- Testing
- Metformin
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction
Chronic Exogenous Ketosis in HFpEF
The goal of this clinical research study is to test what effects a ketone drink will have in people with heart failure with preserved ejection fraction (HFpEF), including on exercise and heart function.
- Conditions
- Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction, Heart Failure, Diastolic
- Trial name
- NCT06937320
- Testing
- Exogenous Ketone Drink
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Lipedema
Effect of Ketosis on Pain and Quality of Life in Patients With Lipedema
Lipedema is a female progressive fat disorder, characterized by a symmetrical increase in subcutaneous adipose tissue in the lower extremities with the exception of the waist.
- Trial name
- Lipodiet (NCT04632810)
- Testing
- Ketogenic low energy diet, non-ketogenic low energy diet
- Where
- 2 sites in Norway
- Volunteers
- 70 people
- Sponsor
- Helse Nord-Trøndelag HF
Short Bowel Syndrome
Amino Acid-based Oral Rehydration Solution in Children With Short Bowel Syndrome
This study will assess the tolerability and palatability of an amino acid based oral rehydration solution (enterade®) compared to current oral rehydration solution among children with short bowel syndrome .
- Trial name
- NCT03105362
- Testing
- Enterade® oral rehydration solution
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston Children's Hospital
Stunting
Food-based Approach Development to Fulfil Amino Acid Gap by Considering the Intestinal Permeability of Children
This study will be comprised of 2 phases. Phase 1 study is a comparative cross-sectional study which will be conducted among children aged 12-24 months living in agricultural area.
- Trial name
- NCT04157413
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Nia Novita Wirawan
Schizophrenia, Schizophrenia and Related Disorders
Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling
The goal of this randomized clinical trial is to be adequately powered to evaluate the effect of ketogenic metabolic therapy on the quality of life in serious mental illness, schizophrenia, bipolar disorder, major depressive…
- Conditions
- Schizophrenia, Schizophrenia and Related Disorders, Bipolar Disorder, Bipolar and Related Disorders
- Trial name
- NCT06748950
- Testing
- LCHF Ketogenic Diet, Diet-as-Usual (DAU)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Stanford University
Scalp Dermatitis, Dermatitis
Effects on the Scalp Microbiota of a 1% Selenium Disulfide and 1% Salicylic Acid Shampoo After 2% Ketaconazole Foaming Gel Treatment for Scalp Seborrheic Dermatitis
The aim of this study was to investigate the changes in the scalp bacterial and fungal microbiota in subjects afflicted with a scalp seborrheic dermatitis (SSD) during a 2% ketoconazole-based treatment followed by a maintenance…
- Trial name
- NCT04057950
- Testing
- cosmetic product
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- L'Oreal
Exercise, Healthy Male/Female Subjects
Ketone Administration During Inactivity and Retraining
The aim of this study is to investigate the effect of oral ketone administration during inactivity-induced muscle atrophy and retraining-induced regeneration.
- Trial name
- NCT05398042
- Testing
- Ketone ester, Medium Chain Triglyceride (MCT) oil
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Diabetic Ketoacidosis, Insulin
Relapse Among Diabetic Ketoacidosis Patients Maintained Basal Bolus Insulin Administration in Combination With Continuous Intravenous Insulin Infusion VS Non Maintaining Basal Insulin Patients
This study aimed to assess intensive care unit stay and relapse among patients of Diabetic ketoacidosis (type 1 diabetes mellitus) maintained basal bolus insulin and patients non maintaining along with intervenors insulin…
- Conditions
- Diabetic Ketoacidosis, Insulin, Intensive Care Unit Stay
- Trial name
- NCT07423559
- Testing
- insulin infusion without basal insulin, insulin infusion with basal insulin, Insulin infusion with basal insulin and bolus
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Protein Malabsorption, Nutritional Deficiency
Bioavailability of Proteins From Plant Based Diets
Proteins play an important role as structural and functional components for the human body and prevent stunting. Protein quality has a great importance in meeting the nutritional needs of populations across the world throughout…
- Conditions
- Protein Malabsorption, Nutritional Deficiency, Nutritional Stunting
- Trial name
- NCT04866927
- Testing
- Use of stable isotopic dilution to assess protein digestibility from Faba bean and to evaluate amino acid bioavailability
- Where
- Morocco
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- International Atomic Energy Agency