Clinical trials: Acid Base Disorder
Mitochondrial Diseases
A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease
A long-term extension study to assess the safety, tolerability and efficacy of cysteamine bitartrate delayed-release capsules (RP103) in children with inherited mitochondrial diseases who previously enrolled into study…
- Trial name
- NCT02473445
- Testing
- Cysteamine Bitartrate
- Where
- 5 sites in United States
- Volunteers
- 22 people
- Sponsor
- Amgen
PKU, Tyrosinemias
GMP Case Studies of Tolerance, Safety and Acceptability in PKU and TYR
Three new protein substitutes have been developed to help with compliance in PKU and TYR patients, which are powdered protein substitutes, low in Phe and, low in Phe and Tyr respectively, with a mixed balance of glycomacropeptide…
- Trial name
- NCT05062226
- Testing
- PKU/TYR GMP Protein Substitute
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Nutricia UK Ltd
Phenylketonurias, PKU
Evaluation of PKU Sphere in Italy
20 participants with PKU will build-up their dietary intake of PKU sphere over 2-16 weeks, depending on their level of metabolic control whilst doing so.
- Trial name
- NCT04679467
- Testing
- PKU sphere
- Where
- 4 sites in Italy
- Volunteers
- 13 people
- Sponsor
- Vitaflo International, Ltd
Dysequilibrium Syndrome, ESRD
Adding Urea to the Final Dialysis Fluid
At times patients with advanced renal failure present with severe hyperkalemia or acidosis and very high serum blood urea nitrogen (BUN) concentrations.
- Conditions
- Dysequilibrium Syndrome, ESRD, Hyperkalemia, Metabolic Acidosis
- Trial name
- Urea dialysate (NCT06366230)
- Testing
- Urea in the dialysate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Diabetic Ketoacidosis
Flexible Catheter for Insulin in Diabetes
Use of a flexible subcutaneous catheter improves comfort in patients with DKA compared to the usual treatment with a metal needle.
- Trial name
- NCT03182569
- Testing
- FLEXIBLE CATHETER, hourly rigid needle puncture
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Hospital General de Niños Pedro de Elizalde
Epilepsy
Internet Administration of the Modified Atkins Diet for Adults With Intractable Epilepsy
This is a prospective, open-label (no control or blind) study to continue to determine whether the modified Atkins diet reduces seizures, creates ketosis, and is well tolerated in adults (not children) with epilepsy.
- Trial name
- NCT00436631
- Testing
- Dietary management of seizures
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Ketosis
A Trial of Intravenous Fluids During Labor
The purpose of this study is to determine if intrapartum use of a glucose-containing solution will improve the outcomes in pregnant women and their babies.
- Trial name
- RARHY (NCT01110005)
- Testing
- D5 Lactated Ringer's Solution (D5LR), Lactated Ringer's Solution (LR)
- Where
- 4 sites in United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Diabetes Mellitus, Diabetes Mellitus, Type 1
The SHINE Study: Safety of Implant and Preliminary Performance of the SHINE SYSTEM in Diabetic Subjects
The objectives of SHINE study are to confirm the safety aspects of the SHINE SYSTEM. Moreover, the goal of this clinical investigation is the initial evaluation of sensor's performance by assessing sensor's ability to…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Ketoacidosis, Diabetic
- Trial name
- NCT05597605
- Testing
- The SHINE SYSTEM
- Where
- 3 sites in Belgium, France and 1 more
- Volunteers
- 6 people
- Sponsor
- Indigo Diabetes NV
Acid-Base Balance Disorder, Metabolic Acidosis
Acid-Base Balance, Metabolism and Minerals
Metabolism is controlled by macro- and micronutrients. Protein-rich diets should lead to latent acidosis at tissue level with further negative implications.
- Trial name
- BASICA (NCT04229069)
- Testing
- alkaline salt mixture
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Type 1 Diabetes
Can the Addition of Pioglitazone to SGLT2 Inhibitor in Type 1 Diabetic Patients Amplify the Decrease in HbA1c and Prevent the Increase in Plasma Ketone Concentration?
Previous data from our clinical trial has demonstrated that the combination of dapagliflozin plus pioglitazone cause robust decrease in the plasma glucose concentration without significant increase in plasma ketone concentration…
- Trial name
- NCT06922656
- Testing
- Dapagliflozin (DAPA), Pioglitazone 45 mg
- Where
- 3 sites in Kuwait, Qatar and 1 more
- Volunteers
- 60 people
- Sponsor
- Dasman Diabetes Institute
Diabetic Ketoacidosis, Uncontrolled Type 1 Diabetes Mellitus
DKA Optic Ultrasound
Diabetic ketoacidosis (DKA) is a complication of type 1, or "insulin-dependent," diabetes (T1DM) and is defined by a high blood glucose level (over 200 mg/dL) coupled with severe acidosis.
- Trial name
- DKA Optic US (NCT02130180)
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Exercise, Ketones
The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or exercise and can be used as an alternative fuel source.
- Conditions
- Exercise, Ketones, Dietary Supplements
- Trial name
- NCT02825823
- Testing
- Ketone Salt
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Glycemic Response to Feeding in Healthy Participants, Postprandial Amino Acid Concentrations
Comparison of Dairy and Plant-based Alternatives in Adolescents and Older Adults
The purpose of the Dairy vs Plant study is to compare the effects of dairy and plant-based alternative products on blood sugar regulation and nutrient quality in adolescents and older adults.
- Conditions
- Glycemic Response to Feeding in Healthy Participants, Postprandial Amino Acid Concentrations, Appetite Regulation
- Trial name
- NCT06874400
- Testing
- Dairy, Plant-based alternative
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Stroke, Diabetic Ketoacidosis
Descriptive Analysis of Near Infrared Spectroscopy in Critically Ill and Injured Pediatric and Neonatal Patients
This study involves looking at Cerebral oximetry measurements in pediatric and neonatal patients who are experiencing a critical illness. Such as Altered mental status, seizures, trauma, sepsis, etc.
- Conditions
- Stroke, Diabetic Ketoacidosis, Increased Intracranial Pressures, Altered Mental Status
- Trial name
- NIRSCI (NCT02950181)
- Testing
- NIRS
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Osteoporosis, Achlorhydria
Does Omeprazole Decrease Intestinal Calcium Absorption?
The purpose of this study is to measure the effect of omeprazole on intestinal calcium absorption in postmenopausal women.
- Conditions
- Osteoporosis, Achlorhydria, GERD, Hip Fracture
- Trial name
- NCT00582972
- Testing
- Omeprazole
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Metabolic Acidosis, Nephrolithiasis
Alkalinization by Urologists & Nephrologists
Metabolic acidosis recovers a wide range of diseases in which an oral alkalinization could be useful. This therapeutic intervention has been said to increase extracellular volume leading to rising blood pressure.
- Conditions
- Metabolic Acidosis, Nephrolithiasis, Extracellular Alteration, Blood Pressure
- Trial name
- AlcalUN (NCT03035812)
- Testing
- Alkali
- Where
- 18 sites in France
- Volunteers
- 156 people
- Sponsor
- Jean-Philippe Bertocchio
Covid19
Ketogenic Diet as Protective Factor During COVID-19
The novel coronavirus disease (COVID-19) is posing a serious challenge to the health-care systems worldwide, with an enormous impact on health conditions and loss of lives.
- Trial name
- NCT04615975
- Testing
- Ketogenic diet with phytoextracts
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- University of Padova
Diabetes, Ketoacidosis
Two Bag System for Hydration in Diabetes
This is a randomized controlled trial comparing the time needed to get the conditions to space hourly controls to controls every 4 hours, using the one bag system versus the two bags system, in the initial treatment of children…
- Trial name
- NCT01631929
- Testing
- One bag, Two bags
- Where
- Argentina
- Volunteers
- 12 people
- Sponsor
- Hospital General de Niños Pedro de Elizalde
Acidosis, Cardiac; Deficiency
The Impact of the pH on Cardiac Function in the Critically Ill Patient
Study Title: The Impact of the pH on cardiac function in the critically ill patient Sponsor: King's College Hospital NHS Foundation Trust Chief Investigator: Dr Sancho Rodríguez-Villar IRAS Number: 227870 Hypothesis: Titration…
- Conditions
- Acidosis, Cardiac; Deficiency, Acid Base Disorder
- Trial name
- NCT04231045
- Testing
- PiCCO device cardiac monitoring
- Where
- 2 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- King's College Hospital NHS Trust
Diabetes Mellitus, Diabetic Ketoacidosis
Starvation in the Treatment of Diabetic Ketoacidosis
Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are common, but serious metabolic disorders are often encountered in intensive care.
- Trial name
- NCT06186245
- Testing
- Early feeding with an oral diet
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center