Clinical trials: Acid Base Disorder
Severe Obesity
VLCD by Enteral Route for Weight Loss
Body weight excess, from overweight to overt obesity, is associated with adverse health outcomes. In view of the time-trends of the obesity epidemic and the related cost burden, the search for effective strategies for weight…
- Trial name
- NEP (NCT01965990)
- Testing
- NEP
- Where
- Italy
- Volunteers
- 364 people
- Sponsor
- San Giuseppe Moscati Hospital
Metabolic Acidosis, Shock
SODium BICarbonate for Metabolic Acidosis in the ICU
This trial aims to assess if, among adults in the ICU with metabolic acidosis, an infusion of sodium bicarbonate diluted in 5% dextrose, compared with an infusion of 5% dextrose, reduces Major Adverse Kidney Events within 30 days…
- Trial name
- SODa-BIC (NCT05697770)
- Testing
- Sodium bicarbonate, 5% Dextrose
- Where
- 55 sites in Australia, Brazil and 5 more
- Volunteers
- 500 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Metabolic Acidosis, Chronic Kidney Disease
Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD
This is a pilot, randomized, double-blinded, placebo-controlled, 12-month trial of 50 patients with CKD stage 3b-4 with metabolic acidosis to examine the effect of sodium bicarbonate therapy on cognitive and cerebrovascular…
- Conditions
- Metabolic Acidosis, Chronic Kidney Disease, Cognitive Dysfunction
- Trial name
- NCT04600323
- Testing
- Sodium Bicarbonate Tablets
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Colorado, Denver
Overweight and Obese Volunteers
Weight Reduction With the Low-Insulin-Method - Self Monitoring of Breath Acetone
The goal of this clinical trial is to learn if lifestyle intervention with information about ketosis state supports weight reduction in overweight adults.
- Trial name
- WeR-LIM-SMBA (NCT06745362)
- Testing
- self-monitoring of breath acetone, lifestyle-intervention via LIM-App
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- West German Center of Diabetes and Health
Ketosis, Metabolic
Effect of Diet Induced Ketosis on LDL Turnover Rates
There have been concerning case reports of marked elevations of LDL-c in some individuals consuming a KD and Dr. Lewis has been referred a number of these cases to his lipid clinic, some of whom have had extreme elevations of LDL…
- Trial name
- NCT05103761
- Testing
- Study diet, Low glycemic index treatment diet
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
CKD, Metabolic Acidosis
A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis
The purpose of this study is is to evaluate the efficacy and safety of veverimer in treating adults with moderate-to-severe chronic kidney disease (CKD) and metabolic acidosis.
- Trial name
- NCT07355062
- Testing
- Veverimer
- Where
- 28 sites in United States
- Volunteers
- 150 people
- Sponsor
- Renibus Therapeutics, Inc.
Asthma
Nutrition for Asthmatics
Determine to what extent three distinct dietary approaches improve asthma control and lung function.
- Trial name
- INHALE (NCT06151405)
- Testing
- DGA Diet, MCT Diet, KETO Diet
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Pennington Biomedical Research Center
ADPKD
Ketogenic Dietary Interventions in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
A mild reduction in food intake significantly inhibits renal cyst growth in mouse models of ADPKD. The underlying mechanism was unknown at the time.
- Trial name
- Keto-ADPKD (NCT04680780)
- Testing
- Ketogenic diet, 3-days water-fasting, Control
- Where
- Germany
- Volunteers
- 63 people
- Sponsor
- University of Cologne
Acute Ischemic Stroke, Cerebrovascular Disorders
Brain, Blood And Clot or Tissue Registry And Collaboration
This is a prospective open enrollment biorepository to collect and evaluate blood and tissue collected during cerebrovascular procedures, which will then be used for the purposes of identifying biological markers, inflammatory…
- Trial name
- BACTRAC (NCT03153683)
- Testing
- Registry
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Justin Fraser
Metabolic Acidosis
A Study on Bedside Formate Assay as a Diagnostic Tool in Methanol Poisoning
Methanol poisoning is a serious issue, particularly in low- and middle-income countries (LMICs), where outbreaks can devastate communities.
- Trial name
- NCT06881641
- Where
- 6 sites in Bangladesh, India
- Volunteers
- 6,120 people
- Sponsor
- University of Edinburgh
Sickle Cell Anemia, Chronic Kidney Disease
Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease
The objective of this study is to assess the effect of alkali administration on bicarbonate and potassium levels in patients with Sickle Cell Disease (SCD) and depressed serum bicarbonate levels.
- Conditions
- Sickle Cell Anemia, Chronic Kidney Disease, Metabolic Acidosis
- Trial name
- NCT01894594
- Testing
- Sodium Bicarbonate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University Hospitals Cleveland Medical Center
Diabetic Ketoacidosis, Type 1 Diabetes
Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management
Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management
- Conditions
- Diabetic Ketoacidosis, Type 1 Diabetes, Type 2 Diabetes
- Trial name
- NCT04567225
- Testing
- Early Glargine, Late Glargine, IV insulin infusion
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- The Cleveland Clinic
Mpox (Monkeypox), Smallpox
A Randomized Clinical Trial Investigating the Safety, Reactogenicity, and Immunogenicity After Immunization With an mRNA-based Mpox Vaccine Candidate in Africa
This is a randomized, double-blind, placebo-controlled study which aims to assess the safety, reactogenicity, and immunogenicity after one and two doses of BNT166a or placebo in healthy participants.
- Conditions
- Mpox (Monkeypox), Smallpox, Orthopoxvirus Infection
- Trial name
- NCT07379580
- Testing
- BNT166a
- Where
- 6 sites in Democratic Republic of the Congo, South Africa
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Dyslipidemia, Diabetes
Meta-analyses of the Effect of Important Food Sources of Sugars on Cardiometabolic Risk Factors
Fructose-containing sugars have been implicated in the epidemics of obesity, diabetes and related cardiometabolic disorders. This view is supported by lower quality evidence from ecological observations, animal models, and select…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT02716870
- Testing
- Fructose-containing Sugars
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Brain Neoplasms
Treatment of Recurrent Brain Tumors: Metabolic Manipulation Combined With Radiotherapy
Recurrent brain tumours are extremely aggressive and despite optimal treatment, median survival is less than two years. One of the standard treatment options in this situation is radiation therapy.
- Trial name
- SMC 0712-13 (NCT02149459)
- Testing
- Partial brain re-irradiation., Metformin, low carbohydrate diet
- Where
- Israel
- Volunteers
- 18 people
- Sponsor
- Sheba Medical Center
Type 1 Diabetes Mellitus, Diabetic Ketoacidosis
Biomarkers of Acute Organ Injury in Pediatric Newly Diagnosed Type 1 Diabetes
Diabetic ketoacidosis (DKA) is a severe metabolic complication in children with newly diagnosed type 1 diabetes mellitus (T1DM) and may be associated with early injury of vital organs such as the kidneys and the heart.
- Trial name
- NCT07483879
- Testing
- Biomarker and Echocardiographic Assessment
- Where
- Greece
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Canavan Disease
A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire Clinical Trial)
The main objective of this trial is to evaluate the safety, tolerability, and pharmacodynamic activity of BBP-812, an investigational AAV9-based gene therapy, in pediatric participants with Canavan disease.
- Trial name
- NCT04998396
- Testing
- AAV9 BBP-812
- Where
- 4 sites in United States
- Volunteers
- 26 people
- Sponsor
- Aspa Therapeutics
Sepsis, Shock, Septic
Comparison of Peripheral Perfusion Indicators and Lactate Levels
In patients with septic shock undergoing intensive care unit monitoring, routine assessment of arterial and/or venous blood gas is conducted.
- Conditions
- Sepsis, Shock, Septic, Hypotensive, Lactate
- Trial name
- NCT06727318
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people
- Sponsor
- Gulhane Training and Research Hospital
Postoperative Cognitive Dysfunction
Evaluation of the Ketogenic Diet to Improve Post Operative Cognitive Decline in Cardiac Surgery
Postoperative cognitive decline (POCD) is a significant neurological problem that commonly follows coronary artery bypass grafting surgery (CABG) in elderly patients.
- Trial name
- NCT06480708
- Testing
- Ketogenic diet, Control diet
- Where
- United States
- Sponsor
- University of Missouri-Columbia
Chronic Kidney Diseases, Metabolic Acidosis
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease.
- Conditions
- Chronic Kidney Diseases, Metabolic Acidosis, Fatigue, Physical Endurance
- Trial name
- Senergy-CKD (NCT04984226)
- Testing
- Sodium bicarbonate
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Davis