Clinical trials: Acid Base Disorder
Aging, Metabolism Disorder
The Metabolic Effects of β-hydroxybutyrate on Working Skeletal Muscle
The goal of this clinical trial is to test ketone bodies in healthy elderly and young individuals. The main question it aims to answer are: Do ketone bodies improve skeletal muscle function? Participants will ingest a ketone…
- Conditions
- Aging, Metabolism Disorder, Ketonemia, Muscle Disorder
- Trial name
- NCT05732909
- Testing
- D-β-hydroxybutyrate/D 1,3 butanediol monoester
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Urinary Tract Infection (Diagnosis)
Efficacy of Collagen, Propolis Plus Quercetin (Proqutin®), Bacillus Coagulans, Hyaluronic Acid and Chondroitin Sulphate and D-Mannose to Avoid Symptoms and Prevents Recurrence in Women With Recurrent Urinary Tract Infections
The aim of this study is to evaluate whether a dietary supplement based on D-mannose, collagen, hyaluronic acid, chondroitin sulphate, enhanced by the properties of quercetin plus propolis (Proqutin ®) and Bacillus Coagulans…
- Trial name
- IMProBaCist-Q (NCT06659016)
- Testing
- Fosfomycin 3 g, Uroxin 4G, Combination of dietary supplement and fosfomycin
- Where
- Italy
- Volunteers
- 148 people
- Sponsor
- University of Campania Luigi Vanvitelli
Energy Supply; Deficiency, Carbohydrate Availability
Endocrinological and Physiological Responses to Short-term Reduced Carbohydrate Availability in Males
Using a randomised crossover design, nine weight-stable men, aged 18 - 40 years old, will be recruited via convenience sampling from the staff and student body of LJMU and local area.
- Trial name
- NCT05551455
- Testing
- Nutritional/dietary intake manipulation ('Normal'), Nutritional/dietary intake manipulation ('Low')
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Critical Illness, Fasting State
Ketosis, Immune Function and Metabolic Adaptation in Response to Short-term Fasting in Critical Illness
KETO-FAST is a pre-planned translational substudy of the FAST-ICU cluster-randomized cross-over trial. The substudy will characterize ketone body production and associated metabolic, autophagy-related, and immune cellular…
- Conditions
- Critical Illness, Fasting State, Ketosis, Nutrition
- Trial name
- KETO-FAST (NCT07738536)
- Testing
- Delayed nutrition, Standard nutrition, Fasting
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Heart Failure With Reduced Ejection Fraction
Ketone Pharmacokinetic Study in HFrEF
The purpose of this study is to test whether an over-the-counter ketone ester drink is well tolerated in people with heart failure on, and not on, a heart failure medication class called SGLT2 inhibitors.
- Trial name
- NCT05757193
- Testing
- DeltaG (250 mg/kg), DeltaG (500 mg/kg)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Diabetic Ketoacidosis
Impact of Clinical Nursing Guideline on Outcomes of Children With Diabetic Ketoacidosis.
Diabetic ketoacidosis (DKA) is a serious and potentially life-threatening complication of diabetes mellitus in children and requires timely and structured management to prevent morbidity and mortality.
- Trial name
- PED-DKA (NCT07467616)
- Testing
- Evidence-Based Nursing Guideline for Children with Diabetic Ketoacidosos
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- Hawler Medical University
Periodontitis (Stage 3)
Effects of the Adjunctive Use of Hyaluronic Acid-based Gel in the Surgical Periodontal Treatment of Periodontitis
This study aimed to assess the effect of Hyaluronic Acid-based gel as an adjunctive chemotherapeutic agent in surgical periodontal treatment on clinical parameters and cytokine levels (IL-6, IL-8, IL-10, IL-17A, TOS, and TAS) in…
- Trial name
- Periodontit (NCT06842511)
- Testing
- open flap debridement and Hyaluronic Acid-Based Gel application, open flap debridement
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Ordu University
Ketosis, Epilepsy
Market Research - Acceptability Study for a Range of MCT Products
This is a market research, observational study to evaluate the tolerability and acceptability of MCT supplements for young children and young people with intractable epilepsy, GLUT-1 or PDHD from 3 years to adulthood.
- Conditions
- Ketosis, Epilepsy, Ketogenic Diet, Fatty Acid Oxidation Disorder
- Trial name
- NCT04309149
- Testing
- MCT fats
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people
- Sponsor
- Dr. Schär AG / SPA
Lysosomal Acid Lipase Deficiency, Obesity
Metabolic Effects of Very Low Carbohydrate Ketogenic Diet in Subjects With Severe Obesity
The very low carbohydrates diet (VLCKD) induces liver steatosis amelioration. Lysosomal acid lipase (LAL) deficiency plays a role in fats accumulation in liver. To date, no studies have assessed LAL activity in morbid obesity.
- Conditions
- Lysosomal Acid Lipase Deficiency, Obesity, Ketogenic Dieting, Ketosis
- Trial name
- NCT03564002
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Diabetic Ketoacidosis
Comparison of a Low Dose to a Standard Dose of Insulin in Adult DKA in ICU to Reduce Metabolic Complications
Diabetic ketoacidosis (DKA), a frequent complication of diabetes, is the consequence of a profound insulin deficiency responsible for osmotic polyuria and thus major losses of water, glucose, sodium and potassium as well as a…
- Trial name
- LOSTINDIAB (NCT05443802)
- Testing
- Insulin 0.05 IU/kg/h, Insulin 0.10 IU/kg/h
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Iron Deficiencies
Iron Absorption From Naturally Dephytinized Legumes
Consumption of less meat and more plant-based protein can greatly reduce the negative impact of food production on the environment. Studies show that vegan diets can decrease greenhouse gas emissions, land use, and water.
- Trial name
- LINDA (NCT06032832)
- Testing
- soy protein concentrate-meat analog, soy protein concentrate-meat analog_dephytinization, pork meat
- Where
- Switzerland
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Diego Moretti
Overweight and Obesity, Cognitive Change
The Effect of Ketone Ester Supplementation and Ketogenic Diet on Brain Plasticity in Overweight/Obese Adults
This project comprises an initial crossover placebo-controlled neurophysiological study to ascertain the effect of acute ketone ester ingestion on motor cortex plasticity, followed by a second 2-week intervention study aimed to…
- Conditions
- Overweight and Obesity, Cognitive Change, Psychophysiologic Reaction
- Trial name
- NCT06368297
- Testing
- Ketone Monoester Supplementation, Ketogenic diet
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Macau
Ketosis
Does a Ketogenic Diet Causes Ketosis in Patients on Intensive Care?
The purpose of this study is to assess if an enteral ketogenic feed will cause a ketotic state in critically ill patients on intensive care.
- Trial name
- NCT02763553
- Testing
- Ketogenic Feed, Standard Feed
- Volunteers
- 10 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
Chronic Kidney Disease, Metabolic Acidosis
Alkali Therapy in Chronic Kidney Disease
Kidney disease is a common medical condition. Individuals with kidney disease develop a build-up of acid in their blood. This acid can affect their muscles, bones, glucose metabolism and kidneys.
- Trial name
- NCT01452412
- Testing
- Sodium bicarbonate
- Where
- 2 sites in United States
- Volunteers
- 149 people
- Sponsor
- Albert Einstein College of Medicine
Mild Pre-eclampsia, Severe Pre-eclampsia
Evaluation of Metabolic Acid-base Abnormalities in Pre-eclamptic Women Applying the Stewart-Fencl Approach
Acid/base imbalances are not well understood in pre-eclamptics, and better tools are needed to allow a thorough and meaningful evaluation.
- Trial name
- NCT02164370
- Where
- 2 sites in United States, South Africa
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Washington
Chronic Kidney Disease
Acid-Base Compensation in Chronic Kidney Disease
The purpose of this study is to evaluate changes in urine net acid excretion, blood pressure and body chemistry that occur when the dietary acid load is lowered by using a drug/dietary supplement similar to baking soda.
- Trial name
- ABC (NCT02427594)
- Testing
- Sodium bicarbonate, Controlled diet
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Duke University
Renal Tubule Acidosis
Incidence of Renal Tubular Acidosis in Nephrology Unit in Assiut University Childern Hospital
Providing summarized information on the clinical and biochemical characteristics and types of renal tubular acidosis in children in Assiut University Childern Hospital.
- Trial name
- NCT03268460
- Testing
- Arterial blood gases, Blood anion gap, serum electrolytes
- Volunteers
- 100 people
- Sponsor
- Assiut University
Healthy Adults
Comparing the Ketogenic Effect of Coconut Oil and Different MCTs
The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults.
- Trial name
- MCT-Coco (NCT02679222)
- Testing
- Coconut oil, Coconut oil + MCT, MCT
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Severe Malaria
Clinical Prediction Models for Pediatric In-Hospital Death Risk in Congolese Severe Malaria Children Using Machine Learning Based-Algorithms
The goal of this observational study is to optimize the management of severe childhood malaria, based on understanding and controlling the severity factors of the disease in Congolese children aged 2 to 9 years (the age group at…
- Trial name
- NCT07355426
- Testing
- Puncture of the radial artery for instant arterial blood gaz as well as for venous biochemistry
- Where
- Democratic Republic of the Congo
- Volunteers
- 100 people
- Sponsor
- University of Kinshasa
Stunting
Food-based Approach Development to Fulfil Amino Acid Gap by Considering the Intestinal Permeability of Children
This study will be comprised of 2 phases. Phase 1 study is a comparative cross-sectional study which will be conducted among children aged 12-24 months living in agricultural area.
- Trial name
- NCT04157413
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Nia Novita Wirawan