Clinical trials: Acid Base Disorder
Aphthous Stomatitis
Hyaluronic Acid in Counteracting Aphthous Stomatitis
Oral mucosal ulcers can determine a real worsening of the quality of life. Conventional therapy usually lasts not less than 2-3 weeks, and carries a high risk of serious side effects; furthermore, ulcers often recur.
- Trial name
- NCT04884464
- Testing
- Hyaluronic acid-based gel, Chlorhexidine Gluconate
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- University of Urbino "Carlo Bo"
Treatment Resistant Depression, Depression
Ketogenic Diet for Treatment-Resistant Depression: Dietary Interventions for MEntal Health Study (DIME)
Depression is a debilitating chronic illness affecting 1 in 6 adults in the United Kingdom (UK) at any one time. Antidepressants and psychological therapy are the main treatments, but some people do not respond to these.
- Conditions
- Treatment Resistant Depression, Depression, Mental Illness, Mental Disorder
- Trial name
- DIME (NCT06091163)
- Testing
- Ketogenic Diet, Phytonutrient Diet
- Where
- United Kingdom
- Volunteers
- 88 people
- Sponsor
- University of Oxford
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
Kidney Transplantation
Major Activation Of NCC in Graft Urinary Exosomes
Hypertension is common disorder after renal transplantation and is associated with mortality. Calcineurin Inhibitor (CNI), by activating NCC cotransporter, may be a major determinant of hypertension, included in a "Gordon like"…
- Trial name
- MANGUE (NCT03503461)
- Testing
- exosomes analysis
- Where
- 2 sites in France, Reunion
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Acidosis, Renal Insufficiency
Preserve-Transplant Study
The aim of this study is to test if alkali treatment will preserve kidney graft function and diminish the progression of chronic kidney disease in renal transplant patients.
- Conditions
- Acidosis, Renal Insufficiency, Kidney Transplantation
- Trial name
- NCT03102996
- Testing
- Nephrotrans
- Where
- 3 sites in Switzerland
- Volunteers
- 240 people
- Sponsor
- University of Zurich
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Clinical Stabilization of Hypercapnia: NIPPV v HVNI
This study will evaluate the ability of High Velocity Nasal Insufflation [HVNI] to effect ventilation and related physiologic responses in hypercapnic patients when compared to noninvasive positive pressure ventilation [NIPPV].
- Conditions
- Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Dyspnea, Hypercapnic Acidosis
- Trial name
- HYPERACT (NCT04709562)
- Testing
- High Velocity Nasal Insufflation (HVNI), Noninvasive Positive Pressure Ventilation (NIPPV)
- Where
- 7 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Vapotherm, Inc.
Diabetes Mellitus, Type 1, Diabetes Complications
Hybrid Closed Loop Effectiveness Trial in Adults With Type 1 Diabetes
Minoritized individuals with type 1 diabetes (T1D) have approximately 2% higher average A1c levels and twice the rate of hospitalizations, complications, and mortality as their white counterparts.
- Trial name
- NCT06236607
- Testing
- Device specific training, Study clinician/educator visit
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Boston Medical Center
Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)
An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM)
The goal of this clinical trial is to evaluate the long-term safety and tolerability of zagociguat in patients with MELAS who completed study medication treatment in the lead-in study TIS6463-203.
- Trial name
- NCT06961344
- Testing
- zagociguat 15mg
- Where
- 16 sites in United States, Australia and 3 more
- Volunteers
- 37 people
- Sponsor
- Tisento Therapeutics
Obstructive Sleep Apnea, Sleep
Impact of Exogenous Ketones on Sleep Apnea
Obstructive Sleep Apnea (OSA) is a common medical disorder that is associated with reduced quality of life and higher risk of cardiovascular disease. Treatments for OSA and limited and not well tolerated.
- Trial name
- KETO-SLEEP 2 (NCT06687655)
- Testing
- Ketone-IQ
- Where
- United States
- Sponsor
- Johns Hopkins University
Knee Osteoarthritis, Osteoarthritis of the Knee
Postmarketing Multicenter Study of Intra-Articular DIART ONE / EASYGO ONE for Knee Osteoarthritis
This study looked at how safe and effective a hyaluronic acid-based injection (called DIART ONE or EASYGO ONE) is for people with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Osteoarthritis of the Knee, Degenerative Joint Disease
- Trial name
- NCT06927934
- Where
- Ukraine
- Volunteers
- 55 people
- Sponsor
- Yuria-Pharm
Acute Respiratory Failure, Acute on Chronic Respiratory Failure
Treatment of Dyspnea in Do-not-intubate Patients
Patients with severe chronic diseases are often admitted to the hospital complaining of shortness of breath. Some of these patients decide that they do not want placement of a breathing tube in the windpipe to assist their…
- Conditions
- Acute Respiratory Failure, Acute on Chronic Respiratory Failure, Dyspnea
- Trial name
- NCT02114944
- Testing
- NIV, CPAP, Standard oxygen
- Where
- 2 sites in United States, Italy
- Volunteers
- 400 people
- Sponsor
- Tufts Medical Center
Hyperemesis Gravidarum, Pregnancy Related
The Levels of the Orexin, Galanin and aMSH and CART in Patients With Hyperemesis Gravidarum
Hyperemesis gravidarum is a disease of unknown etiology that is frequently encountered in pregnant women and seriously impairs their quality of life.
- Trial name
- NCT05446025
- Testing
- Blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Siirt University
End Stage Renal Disease on Dialysis
The Influences of Dialysate Bicarbonate Concentrations on Hemodialysis Patients
Background: Patients with decreased kidney function are in the positive acid balance due to insufficient renal acid excretion. To correct the varying degrees of metabolic acidosis in these HD patients, a high concentration of…
- Trial name
- NCT04070690
- Testing
- Concentration of dialysate bicarbonate
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Camillians Saint Mary's Hospital Luodong
Diabetic Ketoacidosis
Serum Ferritin and Prognosis of DKA
the aim of this study is to: evaluate the association between serum ferritin levels and the clinical presentation and short-term prognosis of patients with DKA.
- Trial name
- NCT06748365
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Dyslipidemia, Diabetes
Meta-analyses of the Effect of Important Food Sources of Sugars on Cardiometabolic Risk Factors
Fructose-containing sugars have been implicated in the epidemics of obesity, diabetes and related cardiometabolic disorders. This view is supported by lower quality evidence from ecological observations, animal models, and select…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT02716870
- Testing
- Fructose-containing Sugars
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Non-Small-Cell Lung Carcinoma
Effect of All-trans Retinoic Acid With Chemotherapy Based in Paclitaxel and Cisplatin as First Line Treatment of Patients With Advanced Non-small Cell Lung Cancer
Purpose: This randomized phase II trial evaluated whether the combination of cisplatin and paclitaxel plus All-trans retinoic acid (ATRA) increases Response rate (RR) and Progression-free survival (PFS) in patients with advanced…
- Trial name
- NCT01048645
- Testing
- ATRA
- Where
- Mexico
- Volunteers
- 107 people
- Sponsor
- National Institute of Cancerología
Sepsis, Acute Kidney Injury
Identifying Risk Factors for Developing AKI in Sepsis
A study to evaluate the prevalence of Acute Kidney Injury (AKI) in patients with Diabetic Ketoacidosis (DKA) and sepsis using data collected prospectively to a patient registry.
- Conditions
- Sepsis, Acute Kidney Injury, Diabetic Ketoacidosis
- Trial name
- NCT04825639
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Cardiff and Vale University Health Board
Diet, Healthy, Health
Medium Chain Fatty Acids and Ketones
16 participants were randomized to complete two seven-day intervention periods with twice-daily consumption of Medium-chain fatty acids (MCT) or long-chain fatty acids (LCT) oil.
- Trial name
- MCFA (NCT06289296)
- Testing
- Fatty acid intake in lean and obese males
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Type 2 Diabetes, Ketonemia
Metabolic Responses of Dapagliflozin vs Sitagliptin in T2DM Patients Inadequately Controlled With Insulin Therapy
The use of sodium glucose co-transporter 2 inhibitors (SGLT2i) has been associated with increased serum ketone levels. However, most previous studies included subjects who were either insulin or even drug naïve with relatively…
- Trial name
- NCT03959501
- Testing
- Dapagliflozin 10 mg, Sitagliptin 100mg
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction
Chronic Exogenous Ketosis in HFpEF
The goal of this clinical research study is to test what effects a ketone drink will have in people with heart failure with preserved ejection fraction (HFpEF), including on exercise and heart function.
- Conditions
- Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction, Heart Failure, Diastolic
- Trial name
- NCT06937320
- Testing
- Exogenous Ketone Drink
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University