Clinical trials: Acid Base Imbalance
Ketoacidosis
Management in Intensive Care Unit of Life-threatening Keto-Acidosis
Patients hospitalized in intensive care between January 2014 and December 2023 for ketoacidosis complicated by organ failure in participating departments.
- Trial name
- MILKA (NCT05488262)
- Where
- 4 sites in France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lactic Acidosis, Metformin
Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis
Metformin is the first line drug of choice for the treatment of type II diabetes. Lactic acidosis can develop as a side effect, especially when renal failure leads to drug accumulation.
- Trial name
- NCT00942123
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
PCOS
Exogenous Ketone Ester in Women with Polycystic Ovary Syndrome.
Polycystic ovarian syndrome (PCOS) is characterized by elevated androgens such as testosterone. Clinical studies suggest that ketogenic diets lower the levels of androgens.
- Trial name
- NCT05762822
- Testing
- 3-OHB (KE4), water
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Brain Neoplasms
Treatment of Recurrent Brain Tumors: Metabolic Manipulation Combined With Radiotherapy
Recurrent brain tumours are extremely aggressive and despite optimal treatment, median survival is less than two years. One of the standard treatment options in this situation is radiation therapy.
- Trial name
- SMC 0712-13 (NCT02149459)
- Testing
- Partial brain re-irradiation., Metformin, low carbohydrate diet
- Where
- Israel
- Volunteers
- 18 people
- Sponsor
- Sheba Medical Center
Spinal Surgery
The Aim of This Investigation is to Compare the Influence of 0.9% Saline and Plasmalyte Solution on Acid-base Balance and Electrolytes in Healthy Patients Undergoing Major Spine Surgeries.
Chloride-rich isotonic crystalloid solutions have been shown to exert electrolyte imbalance and metabolic acidosis in critically ill patients.
- Trial name
- NCT01855542
- Testing
- 0.9% normal saline, plasmalyte
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Metabolic Acidosis, Shock
SODium BICarbonate for Metabolic Acidosis in the ICU
This trial aims to assess if, among adults in the ICU with metabolic acidosis, an infusion of sodium bicarbonate diluted in 5% dextrose, compared with an infusion of 5% dextrose, reduces Major Adverse Kidney Events within 30 days…
- Trial name
- SODa-BIC (NCT05697770)
- Testing
- Sodium bicarbonate, 5% Dextrose
- Where
- 55 sites in Australia, Brazil and 5 more
- Volunteers
- 500 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Diabetic Ketoacidosis
A Multi-Disciplinary Technology-Based Care for Diabetic Ketoacidosis in Patients With Type 1 Diabetes
The study team proposes that use of a novel multi-disciplinary approach with continuous glucose monitoring technology can significantly improve glycemic control and reduce readmissions among those with type 1 diabetes mellitus…
- Trial name
- DKA (NCT06471322)
- Testing
- Continuous Glucose Monitoring (CGM), Standard of Care
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The Cleveland Clinic
Mild Cognitive Impairment
Proof of Mechanism of a New Ketogenic Supplement Using Dual Tracer PET (Positron Emission Tomography)
A six month, placebo-controlled, parallel group project in which MCI participants will receive 30 g/day of a custom-made MCT-based ketogenic supplement or a matching placebo.
- Trial name
- BENEFIC (NCT02551419)
- Testing
- ketogenic drink
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Université de Sherbrooke
Depression, Ketosis
Ketogenic Intervention in Depression
The goal of this study is to examine whether a well-formulated ketogenic diet (KD) can be implemented into a university counseling treatment program for major depression and to test whether such a program has any benefit on…
- Trial name
- KIND (NCT06080932)
- Testing
- Ketogenic Diet, NIH Toolbox, gradCPT
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Metabolic Acidosis, CKD on Hemodialysis Patients
Bicarbonate HD Study
The primary goal of this single centre observational study is to look at factors that affect serum bicarbonate levels in patients on maintenance dialysis.
- Trial name
- NCT07779200
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- East and North Hertfordshire NHS Trust
Diabetic Ketoacidosis
Compliance With American Diabetes Association Treatment Guidelines for Adult Ketoacidosis
At this time, Saint Mary's Medical Center is currently in the process of implementing a standardized diabetic ketoacidosis (DKA) protocol.
- Trial name
- NCT00589680
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Marshall University
Diabetes, Hyperglycemia
Examining the Feasibility of Prolonged Ketone Supplement Drink Consumption in Adults With Type 2 Diabetes
Ketones are a source of energy and signaling molecule that are produced by the body when not consuming any food or consistently eating a low-carbohydrate "keto" diet.
- Conditions
- Diabetes, Hyperglycemia, Ketosis
- Trial name
- NCT05477368
- Testing
- D-β-hydroxybutyric acid with R-1,3-butanediol
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Diabetic Ketoacidosis
Balanced Multi-Electrolyte Solution Versus Saline Trial for Diabetic KetoAcidosis
The goal of this blinded, cluster cross-over, randomised controlled trial is to determine whether fluid therapy with Plasma-Lyte® 148 increases the number of days alive and days out of hospital to day-28 compared to 0.9% sodium…
- Trial name
- BEST-DKA (NCT05752279)
- Testing
- Plasma-Lyte 148, 0.9% sodium chloride
- Where
- 21 sites in Australia
- Volunteers
- 547 people
- Sponsor
- The George Institute
End-stage Renal Disease (ESRD), Chronic Hemodialysis
Pilot Trial of Oral Sodium Bicarbonate Versus Higher Dialysate Bicarbonate in Hemodialysis Patients With Metabolic Acidosis
Metabolic acidosis is frequent in chronic hemodialysis patients and is associated with adverse clinical outcomes. Two commonly used strategies to correct acidosis are oral sodium bicarbonate supplementation and increasing the…
- Conditions
- End-stage Renal Disease (ESRD), Chronic Hemodialysis, Metabolic Acidosis
- Trial name
- Bicarbonate-HD (NCT07688434)
- Testing
- Oral sodium bicarbonate, Increased Dialysate Bicarbonate
- Where
- Tunisia
- Volunteers
- 37 people
- Sponsor
- University of Sfax
Angelman Syndrome
Nutritional Formulation for Angelman Syndrome
Low carbohydrate diets such as the ketogenic (KD) and low glycemic index (LGIT) diets have been shown to be effective in treating drug resistant seizures in children with Angelman syndrome (AS).
- Trial name
- FANS (NCT03644693)
- Testing
- Nutritional Formulation Containing Exogenous Ketones
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Chronic Kidney Disease, Metabolic Acidosis
Bicarbonate Administration in CKD
Low serum bicarbonate levels, even within the normal laboratory range, are strongly associated with increased risks of hypertension, endothelial dysfunction, cardiovascular disease and death.
- Trial name
- NCT02915601
- Testing
- Sodium bicarbonate
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- University of Colorado, Denver
Fasting, Dietary Fibre
Combining Fasting and Fibre Interventions to Optimise Their Gut Microbiome-mediated Health Benefits
This study builds on the knowledge that fasting provides metabolic health benefits and that prebiotic interventions can enhance the gut microbiome's metabolic output to likewise improve host health.
- Conditions
- Fasting, Dietary Fibre, Gut Microbiome, Metabolism Changes
- Trial name
- CoFFIe (NCT07691736)
- Testing
- Fibre Arm, Control Arm
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Buchinger Wilhelmi Development & Holding GmbH
Acidosis, Lactic
Whole Body Periodic Acceleration on Blood Lactate and Recovery
Whole-body periodic acceleration (WBPA) is a new, non-invasive, and promising therapy for a diverse and growing list of disorders including cardiovascular disease 6.
- Trial name
- NCT02482597
- Testing
- Whole Body Periodic Acceleration
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- New York Institute of Technology
Lymphedema, Ketogenic Dieting
Nutritional Ketosis: a Novel Metabolic Strategy to Treat Lymphedema Patients?
Lymphedema is a debilitating disorder that severely impairs the quality of life of the patients and requires life-long attention. Treatment for lymphatic dysfunction remains largely symptomatic, without real cure.
- Conditions
- Lymphedema, Ketogenic Dieting, Ketone Ester Supplement
- Trial name
- KETOLYMPH (NCT03991897)
- Testing
- Ketogenic diet, Isocaloric diet, Ketone ester supplementation
- Where
- Belgium
- Volunteers
- 81 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Diabetic Ketoacidosis
REAMBERIN® 1.5% in Rehydration Therapy of Diabetic Ketoacidosis
A number of scientific papers have been published on the efficacy and safety of adding REAMBERIN® (meglumin sodium succinate), a 1.5% infusion solution, to standard therapy for patients with diabetic ketoacidosis (DKA), which…
- Trial name
- NCT06955416
- Testing
- Reamberin
- Where
- 3 sites in Russia
- Volunteers
- 312 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company