Clinical trials: Acoustic Stimulation
Parkinson's Disease
Rhythmic Auditory Stimulation Optimalization for Gait Improvement in Parkinson's Disease - BeatPark Study
The beneficial effects of rhythmical auditory stimulation (RAS) on spatio-temporal gait characteristics in Parkinson's disease (PD) are attested by clinical research.
- Trial name
- BeatPark (NCT02438124)
- Testing
- Neuropsychological evaluation
- Where
- 3 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Healthy, Mild Cognitive Impairment
Does Acoustic Stimulation During Sleep Boost Slow Wave Sleep and Memory Performance?
With aging the amount of slow wave sleep decreases drastically and this disruption is markedly exaggerated in older adults suffering from mild cognitive impairment and Alzheimer's disease.
- Conditions
- Healthy, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT04277104
- Testing
- Closed loop acoustic stimulation
- Where
- Switzerland
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Bern
Depression, Healthy
Sleep Modulation as Antidepressant Randomized Trial
The goal of this clinical trial is to learn about the effects of phase-targeted auditory stimulation in depressed patients and healthy controls.
- Trial name
- SMART (NCT05685771)
- Testing
- Phase-targeted auditory stimulation
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Giulia Da Poian
Aging, Music
Brain Imaging and Behavioural Changes Following Cued-movement Training of Finger Sequences in Healthy Older Adults
The goal of this study is to examine changes in the brain, behavior, and personal experience when music is used to guide learning of finger movement sequences (compared to visual stimuli alone) in healthy older adults.
- Conditions
- Aging, Music, Motor Activity, Magnetic Resonance Imaging
- Trial name
- NMSOA (NCT06174740)
- Testing
- Music-cued audiovisual motor training, Visually-cued motor training
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universiteit Leiden
Alzheimer Disease (AD), Mild Cognitive Impairment (MCI)
Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease
Alzheimer's Disease (AD) is associated with impairments in both gait and cognition, significantly increasing fall risk. Falls are a leading cause of injury-related disability in older adults, and individuals with AD experience a…
- Trial name
- NCT07659964
- Testing
- Metronome
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Healthy
Study of Cerebral Activation by fNIRS During Gait With Different Rhythmic Auditory Stimulations in Healthy Subjects
The purpose of this study is to investigate the cerebral activation in healthy subjects in 4 conditions of gait : Gait at preferred cadence without auditory stimulation (Gait1) Gait with low tempo rhythmic auditory stimulation by…
- Trial name
- MoveNIRS (NCT05789121)
- Testing
- walking 25 m in 4 different conditions
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
The Role of the LC-NA System in Sleep Regulation
The Role of the LC-NA System in Experimental Sleep Fragmentation
Sleep-wake regulation affects every person's life, yet the molecular mechanisms underlying these processes remain poorly understood.
- Trial name
- DMTN_FragSleep (NCT07167316)
- Testing
- DMTN, Auditory Stimulation, Placbo
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hans-Peter Landolt
Schizophrenia
Effects of Auditory Stimulation on Sleep and Memory in Schizophrenia
The investigators will test the hypothesis that auditory stimulation (playing quiet sounds during sleep) can normalize brain activity during sleep and improve memory in patients with schizophrenia.
- Trial name
- NCT04783571
- Testing
- Auditory Stimulation
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Autonomic Nervous System, Cardiorespiratory Parameters
Musical Auditory Stimulation and Exercise
Check the effects of musical auditory stimulation on the autonomic modulation and cardiorespiratory parameters during and after aerobic exercise.
- Trial name
- NCT03200483
- Testing
- Control Protocol, Classical Music Protocol, Rock Music Protocol
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Acoustic Stimulation, Parkinson Disease
Effects and Mechanisms of RAS Training on Upper-limb Movements in PD Patients
Introduction Bradykinesia (i.e., slow movements) is one of the most prominent symptoms of Parkinson's disease (PD) and has a negative impact on quality of life.
- Conditions
- Acoustic Stimulation, Parkinson Disease, Electroencephalography
- Trial name
- NCT05782322
- Testing
- Upper-limb training involving RAS, Upper-limb training without the aid of RAS
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
NREM Parasomnias, Sleepwalking
Acoustic Stimulation to Study and Modulate Sleepwalking and Related Arousal Disorders
Disorders of Arousal (DoA)-such as sleepwalking, sleep terrors, and confusional arousals-are common sleep problems that happen during deep, non-dreaming sleep.
- Conditions
- NREM Parasomnias, Sleepwalking, Sleep Terrors, Confusional Arousals
- Trial name
- DoA-CLAS (NCT07754838)
- Testing
- Closed-Loop/Open-Loop Acoustic Stimulation (CLAS)
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Anna Castelnovo
Concussion Post Syndrome
Auditory Slow Wave Enhancement After Concussion
The prevalence of a traumatic brain injury (TBI) in children and adolescents is around 30% with 70-90% being classified as mild (concussion).
- Trial name
- NCT04770116
- Testing
- Auditory Stimulation
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Schizophrenia, Psychosis
Effects of Rhythmic Auditory Stimulation on Movements in Individuals at Risk for Psychotic Onset and Schizophrenia Patients
The purpose of this research is to examine effects of movement training with the aid of rhythmic auditory stimulation (RAS) on reducing severity of dyskinesia and bradykinesia in at-risk individuals and schizophrenia patients.
- Conditions
- Schizophrenia, Psychosis, Parkinsonism, Dyskinesias
- Trial name
- NCT04553835
- Testing
- Rhythmic auditory stimulation (RAS) for schizophrenia patients, No RAS for schizophrenia patients, RAS for at-risk individuals
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr WANG Shumei
Chest Pain, Anxiety
The Effects of Use of Auditory Stimulation Methods on Cardiac Patients' Clinical Outcomes
This study will be used to compare the effects of two auditory stimulation methods on improving vital signs parameters, reducing the severity of chest pain, and improving the sleep quality of cardiac patients.
- Conditions
- Chest Pain, Anxiety, Sleep
- Trial name
- NCT06670027
- Testing
- Family voice, Nature sound
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Schizophrenia
The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia
In this research study the investigators will use sleep headbands to measure brain rhythms and to improve their coordination across brain regions. The headbands will be worn at home for multiple nights.
- Trial name
- NCT06386588
- Testing
- Closed loop auditory stimulation during sleep
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Dyspnea, Sleep Quality
Visual and Auditory Stimulation in Intensive Care Patients
This study is a randomized controlled experimental clinical trial designed to investigate the effects of visual and auditory stimulation on dyspnea severity, sleep quality, and anxiety levels in patients receiving noninvasive…
- Conditions
- Dyspnea, Sleep Quality, Anxiety, Intensive Care Patients
- Trial name
- NCT07895030
- Testing
- The Northern Lights and White Noise
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Sleep, Sedation Complication
Closed Loop Acoustic Stimulation During Sedation With Dexmedetomidine
Prospective within-subject study of dexmedetomidine sedation paired with CLAS conditions in repeated blocks. Intervention will consist of CLAS in-phase with EEG slow waves.
- Trial name
- CLASS-D (NCT04206059)
- Testing
- MRI, Quantitative Sensory Testing (QST), Home sleep study
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Stress, Anxiety
Cereset Research Long-Term Healthcare Worker Study
Randomized, controlled study of long-term maintenance Cereset Research after an initial 4-session intervention bolus versus usual care control following an initial 4-session intervention bolus.
- Conditions
- Stress, Anxiety, Autonomic Dysregulation, Acoustic Stimulation
- Trial name
- LT-HW (NCT05994261)
- Testing
- Cereset Research
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Schizophrenia
Restoring Spindle and Thalamocortical Efficiency in Early-Course Schizophrenia Patients Using Auditory Stimulation
The purpose of this research is to identify differences in brain activity during sleep between health individuals and individuals with schizophrenia, schizophreniform, or schizoaffective disorder.
- Trial name
- RESPITE (NCT05956951)
- Testing
- Closed-loop auditory stimulation
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fabio Ferrarelli
Tinnitus
Acoustic and Electrical Stimulation for the Treatment of Tinnitus
Tinnitus, or ringing in the ears, affects 10% to 30% of the population. Of those, 20% have tinnitus bothersome enough to seek medical attention. In many people, tinnitus can significantly affect the quality of life.
- Trial name
- NCT03511807
- Testing
- Electrical, Acoustic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine