Clinical trials: Acquired Immune Deficiency Syndrome
Human Immunodeficiency Virus (HIV), HIV Associated Neurocognitive Disorders (HAND)
A Study of the Neurological Effects of Adding Raltegravir to HAART Regimen in Patients With HIV
HIV related cognitive impairment still occurs despite highly active antiretroviral therapy (HAART). HIV disease affects the brain in 20-40% of patients with advancing HIV disease leading to varying degrees of cognitive…
- Trial name
- HANDral (NCT01448486)
- Testing
- Raltegravir
- Where
- 2 sites in Australia
- Volunteers
- 6 people
- Sponsor
- St Vincent's Hospital, Sydney
Human Immunodeficiency Virus, Opioid Use Disorder
Combined Injectable Treatment for HIV and OUD
This is study seeks to evaluate perspectives of a combined injectable treatment for HIV and OUD. Specifically, with the development of new long-acting medications such as cabotegravir co-administered with rilpivirine (CAB/RPV)…
- Trial name
- CHOICE (NCT05991622)
- Testing
- Combined LAI Treatment: Cabenuva and Sublocade
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Pneumonia, Pneumocystis Carinii, HIV Infections
An Open Label Study to Evaluate the Long-Term Safety and Effectiveness of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients
To evaluate the safety, tolerability, and efficacy of long term, bi-weekly administration of aerosol pentamidine when used as a prophylactic agent in patients who have had at least two or more episodes of AIDS-associated…
- Trial name
- NCT00002030
- Testing
- Pentamidine isethionate
- Where
- United States
- Sponsor
- Fisons
Infection, Human Immunodeficiency Virus
A Study to Determine the Effect of Multiple Doses of BMS-955176 on the Electrocardiograph of Healthy Subjects
The purpose of the study is to determine the effect of multiple doses of BMS-955176 on the QT interval corrected with Fridericia's method (QTcF) in healthy subjects.
- Trial name
- NCT02576119
- Where
- United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Pneumonia, Pneumocystis Carinii, HIV Infections
A Double-Blind Placebo-Controlled Group Comparative Study To Evaluate the Safety and Effectiveness of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in Patients With AIDS Post First Episode PCP
To evaluate and compare the safety, tolerability, and efficacy of biweekly administration of aerosol pentamidine versus placebo when used as a prophylactic agent in patients who have recovered from their first episode of…
- Trial name
- NCT00002053
- Testing
- Pentamidine isethionate
- Where
- United States
- Sponsor
- Fisons
HIV Infections
A Phase I Dose Escalation Study of Synthetic Hypericin in HIV-Infected Patients With Less Than 300 CD4 Lymphocytes
To determine the maximum tolerated dose (MTD) of hypericin, to define the types of toxicities that may be observed, and to determine what doses of the drug are associated with improvements in virological and immunological…
- Trial name
- NCT00000645
- Testing
- Hypericin
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus, Medication Adherence
Medication Adherence and Outcomes Among Patients in United States With HIV
With support from the NIH, this pilot study will assess the feasibility of using wireless devices and financial incentives to motivate medication adherence among HIV-positive adults in the U.S., focusing on those with…
- Trial name
- CHANGE (NCT03995745)
- Testing
- Medication adherence and financial incentives
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Hiv, HIV/AIDS
Tough Talks: A Disclosure Intervention for HIV+ Young Men Who Have Sex With Men (YMSM)
Tough Talks is a virtual reality based HIV disclosure intervention that allows HIV+ individuals to practice disclosing to romantic partners.
- Conditions
- Hiv, HIV/AIDS, Disclosure
- Trial name
- NCT03414372
- Testing
- Tough Talks Online, Tough Talks Clinic, Standard of Care
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of North Carolina, Chapel Hill
Human Immunodeficiency Virus (HIV) Infection
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Etravirine Administered in Combination With Other Antiretroviral Agents in Antiretroviral Treatment-Experienced HIV-1 Infected Patients
The purpose of this study is to learn more about the safety and tolerability of etravirine. Etravirine is a type of non-nucleoside reverse transcriptase inhibitor (NNRTI) which has shown high activity against wild-type human…
- Trial name
- NCT01422330
- Testing
- Etravirine
- Where
- 42 sites in United States, Argentina and 9 more
- Volunteers
- 211 people
- Sponsor
- Janssen R&D Ireland
Hiv, Alcohol Problem
Telemedicine for Unhealthy Alcohol Use in Persons Living With HIV Using CETA
This study is designed to examine the efficacy of an alcohol-focused brief intervention alone versus the brief intervention plus referral to a transdiagnostic cognitive-behavioral intervention to address unhealthy alcohol use and…
- Trial name
- TALC (NCT04955795)
- Testing
- Alcohol Brief Intervention (BI), Common Elements Treatment Approach (CETA) via Telemedicine
- Where
- United States
- Volunteers
- 308 people
- Sponsor
- University of Alabama at Birmingham
HIV/AIDS, Mobile Health
Youth Ending the HIV Epidemic
Young adults have a disproportionately high rate of HIV infection, high rates of attrition at all stages of the HIV care continuum, an increased risk of antiretroviral therapy (ART) nonadherence and virologic failure, and a high…
- Conditions
- HIV/AIDS, Mobile Health, Young Adults
- Trial name
- YEHE (NCT05789875)
- Testing
- aDOT-CEI
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Francisco
HIV Infections, Gender Identity
Trans People Living With HIV Throughout Europe
The project will study a European cohort of individuals identifying themselves as transgender or non-binary and living with HIV.
- Conditions
- HIV Infections, Gender Identity, Human Immunodeficiency Virus
- Trial name
- TIME (NCT03922269)
- Where
- 4 sites in Italy, United Kingdom
- Volunteers
- 200 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Cervical Cancer, Hiv
Identifying and Addressing Barriers to Retention in the Cervical Cancer Treatment Cascade Among Women With HIV in South Africa: Part 2
The investigators will conduct the formative work that is necessary to develop a novel, multi-level intervention (inclusive of patient- and provider-level components), which will increase awareness of and modify the complex…
- Trial name
- NCT06182241
- Testing
- Retention in cervical cancer care intervention
- Where
- 3 sites in United States, South Africa
- Volunteers
- 62 people
- Sponsor
- Boston University Charles River Campus
Human Immunodeficiency Virus, Chronic Hepatitis b
Gut Microbiome in People Living With HIV and HBV
Building a Microbiome Data Platform and Conducting Clinical Evidence Research in Individuals Infected with the Human Immunodeficiency Virus (HIV) and Hepatitis B virus.
- Conditions
- Human Immunodeficiency Virus, Chronic Hepatitis b, Gut Microbiome
- Trial name
- NCT06130137
- Volunteers
- 200 people
- Sponsor
- Kangbuk Samsung Hospital
HIV-infection/Aids, Intimate Partner Violence
Improving HIV Care Engagement Among Ugandan Adolescent Girls and Young Women: The Kisoboka Mukwano Intervention
This study will develop and pilot test a couples-based intervention to help adolescent girls and young women living with HIV (WLHIV (15-24 years) living in Uganda access HIV care and improve the outcomes of their HIV treatment by…
- Conditions
- HIV-infection/Aids, Intimate Partner Violence, Domestic Violence, Alcohol Use Disorder
- Trial name
- NCT05947539
- Testing
- Kisoboka Mukwano ("It is possible, my love!") Intervention, Screening and Referral
- Where
- Uganda
- Volunteers
- 80 people
- Sponsor
- Arizona State University
Human Immunodeficiency Virus, Chronic Hepatitis C
Interactions of Hepatitis C Viral (HCV) Dynamics and Immune Activation in HIV Coinfected Patients During HCV Treatment
The purpose of this study is to investigate T-cell mediated immune responses to HIV-1 and HCV and determine how these responses are affected by HCV treatment and correlates to response.
- Trial name
- DICO (NCT00909129)
- Testing
- pegylated interferon-alpha (Pegasys), ribavirin (COPEGUS)
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Karolinska Institutet
Human Immunodeficiency Virus
Bringing South African Men Into HIV Counseling and Testing and Care
This clinical trial seeks to determine if male-centered recruitment increases men's testing for HIV and whether or not individualized introduction to clinics increases male engagement in treatment for HIV.
- Trial name
- NCT03794245
- Testing
- Men-Centered HIV Testing, Linkage to Care for HIV+ Men, Clinic-based HIV Testing
- Where
- South Africa
- Volunteers
- 1,806 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
HIV Infections, AIDS
Safety Study of Maraviroc's Effect on Human Osteoclasts
This study is to investigate the safety of maraviroc by examining whether there is bone metabolism dysfunction in actual use of maraviroc in human body, or not, measuring bone mineral density and markers for bone formation…
- Trial name
- MVC-Bone (NCT01428986)
- Testing
- Maraviroc
- Where
- Japan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Center for Global Health and Medicine, Japan
Atherosclerosis
Inflammation, Viral Replication, and Atherosclerosis in Treated HIV Infection
This is a longitudinal observational study of HIV-infected patients and HIV-negative control patients that is being conducted to learn more about immunologic factors, inflammation, and cardiovascular risk in patients with HIV…
- Trial name
- NCT01519141
- Where
- United States
- Volunteers
- 579 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Human Immunodeficiency Virus (HIV)
Community Based Screening for HIV Self Testing in FSW in 23 Priority Districts in Indonesia
Indonesia is not yet on course to end HIV and AIDS by 2030. Epidemic transmission of HIV infection among key affected populations (KAPs), specifically FSWs, crucially has contributed to not achieving the target.
- Trial name
- CBS-FSW (NCT04578145)
- Testing
- HIV self-testing among female sex workers
- Where
- Indonesia
- Volunteers
- 1,522 people, healthy volunteers welcome
- Sponsor
- Kerti Praja Foundation
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