Clinical trials: Acquired Immune Deficiency Syndrome (AIDS)
Kaposi Sarcoma, Human Immunodeficiency Virus
Impact of Valganciclovir on Severe IRIS-Kaposi Sarcoma Mortality: an Open-label, Parallel, Randomized Controlled-trial.
Kaposi sarcoma (KS) has an unpredictable course, patients with disseminated KS starting combined Antiretroviral Therapy can develop Immune Reconstitution Syndrome (IRIS), with a severe clinical presentation and high mortality…
- Conditions
- Kaposi Sarcoma, Human Immunodeficiency Virus, Immune Reconstitution Syndrome
- Trial name
- NCT03296553
- Testing
- Valganciclovir, Antiretroviral Combinations
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- National Institute of Cancerología
HIV/AIDS
Direct and Spillover Impacts of a Community-Level HIV/AIDS Program
The HIV/AIDS crisis in Sub-Saharan Africa has left millions of children orphaned. These children, who are potentially infected with HIV themselves, are highly vulnerable and face some serious risks to their health and overall…
- Trial name
- FCC (NCT03880175)
- Testing
- FCC (Força à Comunidade e Crianças) program- direct beneficiary, FCC (Força à Comunidade e Crianças) program- non-direct beneficiary, Anti Stigma Information
- Where
- Mozambique
- Volunteers
- 3,658 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Human Immunodeficiency Virus, Tuberculosis
Usability Study of IeHS in Indonesia
Technology that has a particular focus on patients' needs and ease-of-use and -access plays a significant role in the development of e-health and m-health.
- Conditions
- Human Immunodeficiency Virus, Tuberculosis, Interpersonal Relations, Mobile Phone Use
- Trial name
- NCT04179344
- Testing
- Integrated e-healthcare services (IeHS) web-based app
- Where
- 3 sites in Indonesia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bekasi City Public Hospital
HIV/AIDS
An mHealth Intervention to Improve Outcomes for Women With HIV/AIDS
The purpose of this study is: 1. To develop a new mobile health (mHealth) system that will send text messages to remind both pregnant and non-pregnant women with HIV to adhere to their treatment plan (like keeping appointments…
- Trial name
- NCT03738410
- Testing
- Mobile Health Messaging application, Standard of Care Treatment
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Miami
AIDS, HIV Infection
The Adult Antiretroviral Treatment and Resistance Study (Tshepo)
The "Adult Antiretroviral Treatment and Resistance Study," hereafter referred to as "The Tshepo Study," is the first large-scale research study of antiretroviral therapy to treat AIDS and HIV infection in Botswana.
- Trial name
- NCT00197613
- Testing
- (A) zidovudine, lamivudine and nevirapine, (B) zidovudine, lamivudine and efavirenz, (C) zidovudine, didanosine, and nevirapine
- Where
- Botswana
- Volunteers
- 650 people
- Sponsor
- Harvard School of Public Health (HSPH)
HIV Infections
Viral and Host Factors in the Transmission and Pathogenesis of HIV
To study the collection of blood from individuals known to be at high risk for HIV-infection or who have been recently infected with HIV.
- Trial name
- NCT00219947
- Testing
- blood draw
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- Rockefeller University
Hepatitis C, Hiv
Zepatier in Patients with Substance Use
The goal of this study is to assess hepatitis C virus (HCV) treatment with Zepatier (elbasvir/grazoprevir) in HCV monoinfected and human immunodeficiency virus (HIV)-HCV co-infected, HCV treatment-naïve or…
- Conditions
- Hepatitis C, Hiv, Coinfection, HIV, Substance Use Disorders
- Trial name
- NCT04048850
- Testing
- Elbasvir/Grazoprevir 50 MG-100 MG Oral Tablet [ZEPATIER]
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Illinois Chicago
HIV Infections, Cancer
A Multicenter Phase II/III, Placebo-Controlled Study of SNX-111 Administered Intrathecally to Cancer and AIDS Patients With Chronic Pain
To determine the safety and efficacy of SNX-111 in controlling severe, chronic pain in cancer and AIDS patients.
- Conditions
- HIV Infections, Cancer, Pain
- Trial name
- NCT00002160
- Testing
- Ziconotide
- Where
- 44 sites in United States
- Volunteers
- 100 people
- Sponsor
- Neurex
HIV Infections
Antiviral Activity of and Resistance to Lamivudine in Combination With Zidovudine, Stavudine, or Didanosine
To evaluate the efficacy, safety, and pharmacokinetics of lamivudine (3TC) combined with zidovudine (AZT), stavudine (d4T), or didanosine (ddI) in comparison with d4T or ddI monotherapy in HIV-infected patients with no prior…
- Trial name
- NCT00000838
- Testing
- Lamivudine, Stavudine, Zidovudine
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 256 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS
Evaluating Demand Creation Strategies for Voluntary Medical Male Circumcision (VMMC) in Kenya
The purpose of this study is to evaluate the impact of two interventions - Inter-Personal Communication [IPC] and Dedicated Service Outlets [DSOs] - in recruiting men aged 25-39 years for Voluntary Medical Male Circumcision…
- Trial name
- TASCO (NCT02497989)
- Testing
- Inter-personal Communication (IPC), Dedicated Service Outlets (DSO)
- Where
- Kenya
- Volunteers
- 2,785 people, healthy volunteers welcome
- Sponsor
- Impact Research & Development Organization
HIV, HIV Infections
Efficacy of Tenofovir Alafenamide Versus Placebo Added to a Failing Regimen Followed by Treatment With Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Plus Atazanavir in HIV-1 Positive, Antiretroviral Treatment-Experienced Adults
The primary objective of this study is to evaluate the efficacy of tenofovir alafenamide (TAF) versus placebo, each administered with the existing, failing antiretroviral (ARV) regimen.
- Conditions
- HIV, HIV Infections, Acquired Immunodeficiency Syndrome
- Trial name
- NCT01967940
- Testing
- TAF, E/C/F/TAF, Current failing ARV regimen
- Where
- 15 sites in United States, Dominican Republic and 3 more
- Volunteers
- 55 people
- Sponsor
- Gilead Sciences
HIV/AIDS
Minority AIDS Initiative Retention and Re-Engagement Project
The purpose of this study is to determine whether an enhanced peer intervention is effective in retaining and re-engaging at-risk people of color living with HIV/AIDS into care.
- Trial name
- NCT01616940
- Testing
- Enhanced Peer Intervention
- Where
- 4 sites in United States, Puerto Rico
- Volunteers
- 348 people
- Sponsor
- Boston University
HIV Infections
A Randomized, Unblinded Trial of Zidovudine Versus ddC in the Treatment of Patients Status Post PCP Who Received Long-Term Zidovudine Therapy in Protocol ACTG 002
To evaluate the efficacy of AZT versus ddC in terms of survival, antiviral effects, neurological status, and health status in patients post Pneumocystis carinii pneumonia (PCP) who received long-term AZT therapy in ACTG protocol…
- Trial name
- NCT00000682
- Testing
- Zidovudine, Zalcitabine
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, Metabolic Diseases
Study of Lifestyle Modification in HIV Lipodystrophy
This study is designed to determine the effects of an intensive lifestyle modification program in patients with HIV and Metabolic Syndrome.
- Trial name
- NCT00111358
- Testing
- Lifestyle Modification, No lifestyle modification
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
HIV/AIDS, Medication Adherence
An Integrated Intervention Using a Pill Ingestible Sensor System
This study integrates technology-based adherence measures with alerts for social and behavioral determinants of health (SBDOH) to improve HIV treatment outcomes.
- Conditions
- HIV/AIDS, Medication Adherence, Social Determinants of Health (SDOH)
- Trial name
- Sensor-SBDOH (NCT06480578)
- Testing
- ISS-SBDOH arm
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of California, Los Angeles
Hiv
Multi-product PrEP Delivery to Young Women Seeking Reproductive Health Services and Coverage of HIV Prevention
Following on the heels of large implementation science projects that participated in the launch of widespread daily oral PrEP availability, investigators will launch and study the integration of novel PrEP products - beginning…
- Trial name
- PrEMIA (NCT07076043)
- Testing
- Multiple Product PrEP Program, Routine Oral PrEP
- Where
- Kenya
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Infection, Human Immunodeficiency Virus
PENTA Fosamprenavir Study
Twice daily fosamprenavir, in combination with low dose ritonavir (FPV/RTV BID), is indicated for the treatment of HIV-infected adults, adolescents and children of 6 years of age and above for use in combination with other…
- Trial name
- NCT01077635
- Testing
- Exposure to licensed dose of FPV (+/- 20% of 18mg/kg BID + RTV)
- Volunteers
- 1 people
- Sponsor
- ViiV Healthcare
HIV/AIDS
Evaluation of Pre-Exposure Prophylaxis for High Risk Adolescent Girls and Young Women
To provide preliminary evidence about feasibility and acceptability of delivering PrEP to AGYW identified as potentially at high risk of HIV infection in Lilongwe city communities and two public facilities in Lilongwe, Malawi.
- Trial name
- NCT04044235
- Testing
- PrEP Cohort
- Where
- 2 sites in Malawi
- Volunteers
- 1,032 people, healthy volunteers welcome
- Sponsor
- Lighthouse Trust
Pneumocystis Carinii Pneumonia
Corticosteroids Therapy and Pneumocystis Jirovecii Pneumonia (PCP)
To explore the effects of corticosteroid therapy on pulmonary fibrosis and potentially pneumothorax in patients with mild PCP (pO2 >70mmHg) combined with the standard of care treatment of antibiotic therapy.
- Trial name
- NCT00636935
- Testing
- Antibiotics only, Antibiotics + Corticosteroids, Corticosteroids + antibiotics
- Where
- United States
- Sponsor
- George Washington University
Pneumonia, Pneumocystis Carinii, HIV Infections
A Study of Neutrexin Plus Leucovorin in the Treatment of Pneumocystis Carinii Pneumonia (PCP)
To evaluate the safety and efficacy of trimetrexate glucuronate with leucovorin protection in patients with Pneumocystis carinii pneumonia (PCP) who are refractory to or have demonstrated severe or life-threatening toxicities to…
- Trial name
- NCT00002434
- Testing
- Trimetrexate glucuronate, Leucovorin calcium
- Where
- United States
- Sponsor
- U.S. Bioscience
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