Clinical trials: Acquired Immune Deficiency Syndrome (AIDS)
Peripheral Neuropathy, HIV
Acupuncture/Moxibustion (Acu/Moxa) for Distal Symmetric Peripheral Neuropathy (DSP) in HIV
This preliminary study will investigate the use of Acupuncture and Moxibustion (Acu/Moxa) for distal symmetric peripheral neuropathy (DSP) associated with HIV applying traditional Chinese medicine (TCM) evaluations conducted by a…
- Conditions
- Peripheral Neuropathy, HIV, AIDS, HIV Infections
- Trial name
- TCMAcuPilot (NCT00826345)
- Testing
- Acupuncture / Moxibustion, Acupuncture/Moxibustion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Human Immunodeficiency Virus
Safety And Efficacy Study Of CP-675,206 In HIV-Infected Patients
The purpose of this study is to determine if CP-675,206, a monoclonal antibody to CTLA4, is safe and well-tolerated, reduces viral load, and improves immune function in patients infected with HIV.
- Trial name
- NCT00488995
- Testing
- CP-675,206
- Sponsor
- Pfizer
Tuberculosis, Hiv
Kharituwe TB Contact Tracing Study
The purpose of this study is to characterize the role of human mobility in fueling TB epidemics and estimate the potential impact of innovative case finding interventions tailored to mobile populations
- Trial name
- NCT04520113
- Testing
- Household contact tracing
- Where
- 2 sites in South Africa
- Volunteers
- 10,579 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Alcohol Dependence, Problem Drinking
Alcohol Pharmacotherapy for HIV+ Prisoners
This is a randomized controlled trial of injectable intramuscular naltrexone (XR-NTX) versus intramuscular placebo among HIV-infected prisoners meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition…
- Conditions
- Alcohol Dependence, Problem Drinking, Hazardous Drinking, Human Immunodeficiency Virus
- Trial name
- INSPIRE (NCT01077310)
- Testing
- Vivitrol- Intramuscular naltrexone (depot-formulation)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Human Immunodeficiency Virus Type 1
Study to Evaluate Efficacy and Safety of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Regimen Versus Boosted Protease Inhibitor (bPI) Along With Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) Regimen in Virologically-Suppressed, HIV-1 Infected Participants
The purpose of this study is to demonstrate non-inferiority in efficacy while switching to a once-daily single-tablet regimen containing darunavir (DRV)/ cobicistat (COBI)/ emtricitabine (FTC)/ tenofovir alafenamide (TAF)…
- Trial name
- NCT02269917
- Testing
- D/C/F/TAF, Boosted Protease Inhibitor (bPI), FTC/TDF
- Where
- 79 sites in United States, Belgium and 8 more
- Volunteers
- 1,149 people
- Sponsor
- Janssen R&D Ireland
HIV/AIDS
Pre-exposure Prophylaxis (PrEP) at Home
This study is a randomized clinical trial of PrEP@Home, a home care system for Human Immunodeficiency Virus (HIV) Pre-Exposure Prophylaxis (PrEP).
- Trial name
- PrEP@Home (NCT03569813)
- Testing
- PrEP@Home System, Standard of Care
- Where
- 5 sites in United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Emory University
Substance Use, HIV/AIDS
Trauma Informed Prevention for Substance Use and Risky Sex
The purpose of this research study is to determine the usefulness of the TIPS iPad app in the treatment of adolescent patients who qualify for Trauma Focused-Cognitive Behavioral Therapy (TF-CBT).
- Trial name
- TIPS (NCT03710720)
- Testing
- TIPS app, Trauma Focused-Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Medical University of South Carolina
HIV Infections
A Phase I Trial of HIV-1 C4-V3 Polyvalent Peptide Vaccine in HIV-1 Infected Persons
To determine the safety of immunization with HIV-1 C4-V3 polyvalent peptide vaccine in HIV-infected persons. To determine the proportion of study participants immunized who develop new specificities or increased levels of…
- Trial name
- NCT00001060
- Testing
- HIV-1 C4-V3 Polyvalent Peptide Vaccine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hiv
Optimizing Reversal of HIV Latency With Combination Therapy
The ORBIT trial is part of a worldwide search for a functional cure of HIV. One such cure strategy aims to reverse HIV in the reservoir from latency by increasing cell-associated HIV-RNA, which will lead to increased antigen…
- Trial name
- ORBIT (NCT06240520)
- Testing
- Panobinostat 20 MG Oral Capsule, Pyrimethamine 200mg Oral Tablet, Lenalidomide 25 MG Oral Capsule
- Where
- 3 sites in Netherlands
- Volunteers
- 49 people
- Sponsor
- Erasmus Medical Center
HIV/AIDS, Cardiovascular Diseases
Pathways to Cardiovascular Disease Prevention (DCRI Central and Statistical Coordinating Center)
The goal of this research is to generate evidence-based recommendations for the management of cardiovascular disease (CVD) risk in People Living with HIV (PLWH).
- Trial name
- NCT04025125
- Where
- United States
- Volunteers
- 2,039 people
- Sponsor
- Duke University
Reproductive Health
RH and Adolescents
This study will create a model of reproductive health services for HIV-positive female adolescents in Asia.
- Trial name
- NCT02713750
- Testing
- reversible contraceptive methods
- Where
- 4 sites in Thailand
- Volunteers
- 77 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Human Papilloma Virus, Hiv
Efficacy of Human Papillomavirus (HPV) Vaccination to Prevent Infection Among Women Living With HIV.
The Efficacy of Human Papillomavirus (HPV) Vaccination to Prevent Infection Among Women Living with HIV: A Prospective, Individual, Double-Blind, Randomized Controlled Study is evaluating immediate or delayed single-dose…
- Trial name
- HOPE II (NCT06436274)
- Testing
- GARDASIL®9, Menveo®/Menactra®
- Where
- 3 sites in Botswana, Rwanda and 1 more
- Volunteers
- 778 people
- Sponsor
- Massachusetts General Hospital
HIV/AIDS, Diabetes Mellitus
Study on the Impact of Patient Navigators on the Health Education and Quality of Life in Formerly Incarcerated Patients
This is a 3-year prospective randomized comparative study of the efficacy of patient navigation on health education, health related quality of life, healthcare utilization, and medical outcomes in formerly incarcerated…
- Conditions
- HIV/AIDS, Diabetes Mellitus, Hypertension, Substance Use
- Trial name
- NCT02259634
- Testing
- Patient Navigation
- Where
- 2 sites in United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
HIV/AIDS, Dysbiosis
SHIFT: Studying HIV Immunology After Fecal Transplant
SHIFT is a randomized, longitudinal, prospective, blinded, three-arm study to determine the safety and tolerability of Fecal Microbiota Transplant (FMT) in HIV-infected participants on stable antiretroviral therapy (ART).
- Conditions
- HIV/AIDS, Dysbiosis, Inflammation
- Trial name
- SHIFT (NCT03163784)
- Testing
- Fecal Inoculum Capsule, Antibiotic
- Sponsor
- Massachusetts General Hospital
HIV, Depression
Inflammation and Depression in People With HIV
The purpose of this 10-week, double-blind, placebo-controlled study is to determine whether inflammation impacts reward and motor neural circuitry to contribute to depressive symptoms like anhedonia and psychomotor slowing in…
- Conditions
- HIV, Depression, Anhedonia
- Trial name
- NCT05849038
- Testing
- Baricitinib
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Emory University
HIV Infections, AIDS
Test Albuvirtide in Experienced Patients
The purpose of this study is to evaluate the efficacy and safety of albuvirtide combined with lopinavir-ritonavir (LPV/r) in HIV-1-infected patients who failed first-line antiretroviral therapy (ART).
- Trial name
- TALENT (NCT02369965)
- Testing
- albuvirtide, lopinavir-ritonavir, tenofovir
- Where
- 12 sites in China
- Volunteers
- 418 people
- Sponsor
- Frontier Biotechnologies Inc.
Candidiasis, Oral, HIV Infections
An Open Study of the Effect of Itraconazole Oral Solution for the Treatment of Fluconazole Refractory Oropharyngeal Candidiasis in HIV-Positive Subjects.
To assess the efficacy and safety of itraconazole oral solution in HIV-seropositive patients with oropharyngeal candidiasis that is refractory to fluconazole.
- Trial name
- NCT00002133
- Testing
- Itraconazole
- Where
- 18 sites in United States
- Sponsor
- Janssen, LP
HIV
Comparison of Two Intrauterine Devices (IUDs) Among Cape Town HIV-positive Women
This study will inform international medical guidelines as to whether the Levonorgestrel intrauterine device (LNG IUD), a highly effective long-acting reversible contraceptive method, is safe and acceptable as compared to the…
- Trial name
- NCT01721798
- Testing
- Mirena levonorgestrel IUD, Copper T-380a IUD
- Where
- South Africa
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV-Infection
Dual Therapy With Boosted Darunavir + Dolutegravir
A switch strategy to investigate whether a dual therapy with Ritonavir-boosted (RTV) Darunavir (DRV) + Dolutegravir (DTG) over 48 weeks is non-inferior to a continuous standard of care therapy with RTV-boosted DRV in combination…
- Trial name
- Dualis (NCT02486133)
- Testing
- Prezista, Norvir, Tivicay
- Where
- Germany
- Volunteers
- 269 people
- Sponsor
- Technical University of Munich
HIV/AIDS, Substance Use Disorder
Acceptance and Compassion to Enhance Self-care Pilot
Innovative approaches are needed to optimize the benefits of treatment as prevention (TasP) among HIV+ substance users, who experience profound health disparities that amplify onward transmission risk.
- Trial name
- ACES Pilot (NCT02535455)
- Testing
- ACES Pilot
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco