Clinical trials: Acquired Immune Deficiency Syndrome Virus
Human Immunodeficiency Virus (HIV) Infection
Investigation Of Safety And Pharmacokinetics Following A Single Oral Dose Of 300 Mg Maraviroc In Healthy Male Japanese Volunteers
To confirm safety and pharmacokinetics of maraviroc following a single oral dose of 300 mg maraviroc in healthy male Japanese volunteers.
- Trial name
- NCT00821535
- Testing
- maraviroc (Selzentry, Celsentri)
- Where
- Singapore
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Human Immunodeficiency Virus, Facial Lipoatrophy
Safety, Efficacy and Psychological Effects of Treating Antiretroviral Drug-Induced Facial Lipoatrophy With Bio-Alcamid
Evaluate and record any changes in the Quality of Life and psychological state of the affected study group following treatment with Bio-Alcamid.
- Trial name
- NCT00333684
- Testing
- BIO-ALCAMID SOFT TISSUE ENDOPROSTHESIS
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Canadian Immunodeficiency Research Collaborative
Acquired Immunodeficiency Syndrome, HIV Infection
Phase I Study of APL 400-003, a Candidate HIV Vaccine, in HIV-Negative Volunteers
This is a randomized, double blind study of the safety and immunogenicity of APL 400-003, a plasmid DNA vaccine encoding the env and rev genes of HIV-1, in HIV-negative volunteers.
- Trial name
- NCT00001538
- Testing
- APL 400-003
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Measles
A Phase II, Comparative Study of Seroconversion of Single-Dose and Two-Dose Measles Vaccination in HIV-Infected and HIV-Uninfected Children: A Multicenter Trial of the Pediatric AIDS Clinical Trials Group
To compare measles seroconversion rates (development of antibodies) at 13 months of age in HIV-infected and uninfected children on one of two immunization schedules: attenuated measles/mumps/rubella virus (M-M-R II) vaccine at 12…
- Trial name
- NCT00000815
- Testing
- Attenuvax, M-M-R-II
- Where
- 46 sites in United States, Puerto Rico
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Influenza
H1N1 Vaccine at Two Dose Levels in HIV Positive Adults
The purpose of this study is to see how the body reacts to different strengths of the H1N1 flu shot in persons infected with human immunodeficiency virus (HIV).
- Trial name
- NCT00992433
- Testing
- Inactivated Influenza H1N1 vaccine
- Where
- 6 sites in United States
- Volunteers
- 192 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Associated Lipodystrophy Syndrome., HIV
Switching From Zidovudine to an NNRTI or Lopinavir/Ritonavir in Patients Treated With Zidovudine/ Lamivudine/Abacavir.
Highly active antiretroviral therapy (HAART) has improved the long time survival of HIV infected individuals. However an increasing number of HIV-patients have developed metabolic and morphological alterations including…
- Conditions
- HIV Associated Lipodystrophy Syndrome., HIV, Hypercholesterolemia, Lipoatrophy
- Trial name
- NCT00139178
- Testing
- Different HAART regimens
- Where
- 4 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Danish HIV Research Group
Human Immunodeficiency Virus Infection (HIV)
Innate-like and NK Signatures in Chronic-Treated HIV Infection INSTINCT-HIV
Infection with the human immunodeficiency virus (HIV) is a chronic condition requiring lifelong antiretroviral therapy (ART). Despite prolonged virological control under suppressive ART, HIV persists in the form of a stable viral…
- Trial name
- INSTINCT-HIV (NCT07849933)
- Testing
- Blood test
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
HIV Infections, HIV/AIDS
Evaluation of a Home-based Community Health Worker Program in Rural Eastern Cape, South Africa
The purpose of this early Phase 2 comparison trial is to evaluate the impact of community health worker (CHW) home visitors on pregnant women and their children in a rural setting in the rural Eastern Cape of South Africa.
- Conditions
- HIV Infections, HIV/AIDS, Depression, Depressive Symptoms
- Trial name
- NCT03517878
- Testing
- Comprehensive CHW Program
- Where
- 2 sites in South Africa
- Volunteers
- 1,490 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
HIV-infection/Aids, Breast Feeding
Promoting Exclusive Breastfeeding Among HIV Infected Women in a PMTCT Program
This study evaluates strategies aimed at promoting exclusive breast feeding for 6 months followed by continued breastfeeding for the next 6 months with introduction of complementary foods among HIV infected women in a resource…
- Trial name
- EBF (NCT03069235)
- Testing
- Family member / peer support, Enhanced intervention with counselor support, standard of care
- Volunteers
- 218 people
- Sponsor
- Johns Hopkins University
HIV Infections
Phase I/II Study of Recombinant Human Interferon-gamma (rIFN-gamma) in HIV-Infected Children
PRIMARY: To determine the safety and toxicity of recombinant interferon gamma-1b ( rIFN-gamma ) in HIV-infected children receiving ongoing zidovudine ( AZT ) or didanosine ( ddI ) therapy.
- Trial name
- NCT00000761
- Testing
- Interferon gamma-1b
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hiv
Early Administration of Romidepsin and 3BNC117 in Treatment-naïve HIV Patients Starting ART
To evaluate the effect of early viral reactivation by latency reversing agents (LRA) and/or administration of potent broadly neutralizing antibodies (bNAb) on the size of the latent HIV-1 reservoir in treatment naïve HIV-1…
- Trial name
- eCLEAR (NCT03041012)
- Testing
- Romidepsin, 3BNC117, Antiretrovirals
- Where
- 7 sites in Denmark, United Kingdom
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
HIV Seropositivity, Acquired Immunodeficiency Syndrome
A Pilot Study to Investigate the Safety and Immunologic Activity AGS-004 an Autologous HIV Immunotherapeutic Agent.
To Investigate the safety and immunologic activity of AGS-004, an autologous HIV Immunotherapeutic, in HIV-infected adults currently on stable antiretroviral therapy (ART) with durable viral suppression.
- Trial name
- NCT00381212
- Testing
- AGS-004
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Development and Validation of Gut Permeability Sensor, Permeability; Increased
Fluorescence Spectroscopy for Gut Permeability Assessment
This research aims to develop portable devices - known as fluorescence spectrometers - to monitor the leakage of fluorescent dyes out of the gut into the blood stream.
- Conditions
- Development and Validation of Gut Permeability Sensor, Permeability; Increased, Celiac Disease, Inflammatory Bowel Diseases
- Trial name
- GutPerm (NCT03434639)
- Testing
- Spectroscopic gut permeability test
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London
HIV, Substance Abuse
Transitions: Linkages From Jail To Community
TRANSITIONS, a novel jail-release program for People Living with HIV/AIDS (PLWHA), will use evidence-based interventions and adapt them to create a comprehensive transitional program in Waterbury and New Haven County…
- Conditions
- HIV, Substance Abuse, HIV Infections
- Trial name
- NCT00841711
- Testing
- Intensive Case Management
- Where
- 2 sites in United States
- Volunteers
- 127 people
- Sponsor
- Yale University
Hiv
Mediterranean Diet and Bacterial Translocation and Immune-activation in Patients With HIV
Evaluate if a change to a Mediterranean diet supplemented with nuts and olive oil decreases bacterial translocation and immune activation by a change in the microbiome in successfully treated HIV-1 infected patients with CD4>…
- Trial name
- NCT03846206
- Testing
- mediterranean diet
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Hospital Clinic of Barcelona
Infection, Human Immunodeficiency Virus
A Study to Evaluate the Effect of Boceprevir and Telaprevir on Dolutegravir Pharmacokinetics in Healthy Adult Subjects (ING115697).
Dolutegravir (DTG, GSK1349572) is an integrase inhibitor that is currently in Phase 3 clinical development for the treatment of human immunodeficiency virus (HIV) infection.
- Trial name
- NCT01563328
- Testing
- DTG, BCV, TVR
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV Infections
The Effect of Stomach Acid on Foscarnet
To see if ranitidine, by reducing stomach acidity, can enhance the effectiveness of foscarnet, by making foscarnet more available to the body. Foscarnet is an antiviral compound.
- Trial name
- NCT00000964
- Testing
- Ranitidine hydrochloride, Foscarnet sodium
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Reproductive Behavior
The Impact of Vaginal Washing on Cervical Inflammation
Vaginal washing is a common practice that many women perceive as hygienic. However, vaginal washing has been linked to adverse reproductive health outcomes including increased HIV acquisition risk.
- Trial name
- NCT06615232
- Testing
- Vaginal washing cessation
- Where
- Kenya
- Volunteers
- 122 people
- Sponsor
- University of Washington
HIV
Study of SystemCHANGE-HIV
The purpose of this study is to assess a new behavioral intervention to help how people living with HIV/AIDS practice self-management skills.
- Trial name
- NCT01256814
- Testing
- SystemCHANGE-HIV
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Case Western Reserve University
Peripheral Neuropathies, HIV Infections
Acupuncture/Moxibustion for Peripheral Neuropathy in HIV
This is a sample-size-limited, randomized, blinded (subject and evaluator), sham acupuncture/placebo moxibustion (sham acu/placebo moxa) controlled clinical trial.
- Trial name
- NCT00317291
- Testing
- Acupuncture/Moxibustion
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
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