Clinical trials: Acquired Immunodeficiency Syndrome
HIV -1 Infection
Cabotegravir & Rilpivirine Antiretroviral Therapy in Pregnancy
Phase IV, multi-site, open-label, non-randomized study of the pharmacokinetics (PK) of long-acting injectable cabotegravir and rilpivirine (CAB LA + RPV LA) during pregnancy and postpartum.
- Trial name
- CREATE (NCT07637942)
- Testing
- Every 4-week long-acting injectable cabotegravir and rilpivirine
- Where
- 10 sites in United States
- Volunteers
- 40 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
HIV Infections
Study on the Effect of Kaletra + Nevirapine as Maintenance Bitherapy Compared to a Triple Therapy Including Kaletra + Analogues in HIV Patients
The study aims to evaluate the changes in mitochondrial DNA (mDNA) by means of the mDNA/nuclearDNA (nDNA) ratio as a marker of mitochondrial toxicity following the interruption of nucleoside analogues.
- Trial name
- NCT00335686
- Testing
- Lopinavir-rtv (Kaletra): 3 capsules (600 mg)/12 h, Nevirapine (Viramune): 1 comp (200mg)/12h
- Where
- 24 sites in Spain
- Volunteers
- 67 people
- Sponsor
- Germans Trias i Pujol Hospital
HIV/AIDS, Sexually Transmitted Infection
GPS: Adaptation Trial of an HIV Prevention Counselling Program for HIV-positive and HIV-negative Gay and Bisexual Men
GPS is a sexual health promotion and HIV prevention peer-delivered counselling program. The GPS program has 4 parts: information provision about HIV and sexually transmitted infections, motivational interviewing counselling…
- Conditions
- HIV/AIDS, Sexually Transmitted Infection, Health Behavior
- Trial name
- NCT03186183
- Testing
- GPS program
- Where
- 6 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Toronto Metropolitan University
HIV Infections
Safety and Effectiveness of a Combination Anti-HIV Drug Treatment
The purpose of this study is to see if it is safe and effective to give HIV-positive patients a combination of anti-HIV drugs (abacavir [ABC] plus efavirenz [EFV] plus didanosine [ddI]) with and without hydroxyurea (HU).
- Trial name
- NCT00005018
- Testing
- Hydroxyurea, Abacavir sulfate, Efavirenz
- Where
- 23 sites in United States
- Volunteers
- 150 people
- Sponsor
- Glaxo Wellcome
Malaria
Safety and Immunogenicity of GSK Biologicals' Investigational Malaria Vaccine in HIV Infected Infants and Children
The purpose of this study is to assess the safety and immunogenicity of the candidate malaria vaccine in HIV-infected infants and children
- Trial name
- NCT01148459
- Testing
- GSK Biological's Investigational Malaria Vaccine 257049, Human Diploid Cell Vaccine (HDCV) or Purified Vero Cell Rabies Vaccine (PVRV, Verorab) (Aventis Pasteur);, Purified Chick Embryo Cell Culture (PCEC) Rabies Vaccine (Rabipur or equivalent) (Novartis).
- Where
- 2 sites in Kenya
- Volunteers
- 200 people
- Sponsor
- GlaxoSmithKline
HIV Infections
A Study of Cytotoxic T Lymphocyte (CTL) Therapy in HIV-Infected Patients
To define the safety of cytotoxic T lymphocytes (CTLs) generated from sibling-supplied dendritic cells and lymphocytes and infused into an HIV-infected patient.
- Trial name
- NCT00000824
- Testing
- Lymphocytes, Activated
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Post Exposure Prophylaxis, Occupational Exposure HIV Infections Hepatitis B Hepatitis C Post-Exposure Prophylaxis
Impact of Health Education on Knowledge, Attitude and Practice of Post-exposure Prophylaxis
The goal of this study is to learn whether a short education programme helps healthcare workers know more about post-exposure prophylaxis (PEP).
- Trial name
- NCT07330427
- Testing
- Health Education
- Where
- Egypt
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Aswan University
HIV
SEARCH CAB LA Dynamic Choice HIV Prevention Study Extension
The overall purpose of this SEARCH CAB-LA (Cabotegravir Injectable Suspension) randomized extension study is to determine if adding the option of CAB-LA as a prevention choice using a person-centered dynamic choice HIV (human…
- Trial name
- NCT05549726
- Testing
- Cabotegravir Injectable Suspension, Dynamic Choice Delivery Model, Standard of Care
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 984 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Kaposi Sarcoma, HIV Infection
Development of Serologic Assays for Human Herpes Virus-8
Dr. Burbelo and colleagues have developed a technique for rapidly and quantitatively detecting antibody responses in sera to a variety of pathogens using recombinant proteins.
- Trial name
- NCT00395278
- Where
- United States
- Volunteers
- 394 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV Infections, Stomatitis, Aphthous
Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection
PRIMARY: To evaluate the effectiveness and safety of thalidomide for treatment of oral and esophageal aphthous ulcers (those unrelated to a known infection or malignancy) in patients with advanced HIV disease.
- Trial name
- NCT00000790
- Testing
- Thalidomide
- Where
- 40 sites in United States, Puerto Rico
- Volunteers
- 164 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lymphoma
Doxorubicin Hydrochloride Liposome and Rituximab With Combination Chemotherapy in Treating Patients With Newly Diagnosed Burkitt's Lymphoma or Burkitt-Like Lymphoma
RATIONALE: Drugs used in chemotherapy, such as doxorubicin hydrochloride liposome, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00392990
- Testing
- Regimen A, Regimen B
- Where
- 8 sites in United States
- Volunteers
- 25 people
- Sponsor
- Northwestern University
HIV Infections
A Phase I Safety, Efficacy, and Pharmacokinetic Study of 2',3'-Dideoxyinosine (ddI) Administered Twice Daily to Patients With AIDS or AIDS Related Complex
To determine the safety, pharmacokinetics (blood levels), and effectiveness of didanosine (ddI) when administered both intravenously and orally.
- Trial name
- NCT00000710
- Testing
- Didanosine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Participants, Tobacco Use Disorder
Lung HIV Microbiome Project (Michigan Site)
In its original phase, this cohort study recruited subjects who were either HIV-positive or HIV-negative healthy controls, to analyze the community structure of the lung microbiome.
- Conditions
- Healthy Participants, Tobacco Use Disorder, Human Microbiome
- Trial name
- LHMP (NCT02392182)
- Testing
- Fiberoptic bronchoscopy
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Tuberculosis, Human Immunodeficiency Virus
A Pragmatic Trial With Optimized Dose of Rifampicin and Moxifloxacin for the Treatment of Drug Susceptible Pulmonary Tuberculosis
Tuberculosis (TB) remains a major global public health problem, particularly in low- and middle-income countries (LMICs) in Africa, Asia, and Eastern Europe.
- Trial name
- OptiRiMoxTB (NCT05575518)
- Testing
- Optimised rifamycin
- Where
- Tanzania
- Volunteers
- 414 people
- Sponsor
- Stellah Mpagama
Mycobacterium Tuberculosis
Immune Responses to Mycobacterium Tuberculosis
This study, conducted at the University of Mali in the capital city of Bamako, will investigate how the body reacts to infection with Mycobacterium tuberculosis (MTB), the organism that causes tuberculosis.
- Trial name
- NCT00340990
- Where
- Mali
- Volunteers
- 111 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Patient Adherence, HIV
Text Messaging Intervention to Improve ART Adherence Among HIV-positive Youth
The purpose of the proposed study is to test SMS (short message service) text messaging technology to improve medication adherence among youth living with HIV (YLH).
- Trial name
- TXTXT (NCT01354210)
- Testing
- SMS Text Message Reminder
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
HIV Infections
A Clinical Trial in Healthy, HIV-1-Uninfected Adult Participants to Compare the Safety, Tolerability and Immunogenicity of CH505TF gp120 Produced From Stably Transfected Cells to CH505TF gp120 Produced From Transiently Transfected Cells
The purpose of this study is to compare the safety, tolerability, and immunogenicity of CH505TF gp120 produced from stably transfected cells to CH505TF gp120 produced from transiently transfected cells in healthy…
- Trial name
- NCT03856996
- Testing
- Stable CH505TF gp120, Transient CH505TF gp120, Glucopyranosyl Lipid Adjuvant-Stable Emulsion (GLA-SE)
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Obesity, HIV Infections
A Study to Evaluate CJC 1295 in HIV Patients With Visceral Obesity
This is a multicenter, randomized, placebo-controlled, double-blind, Phase 2 study. Patients will be treated for a total of 12 weeks. There will be a 6 week follow-up period after the treatment period ends.
- Trial name
- NCT00267527
- Testing
- CJC 1295
- Volunteers
- 120 people
- Sponsor
- ConjuChem
HIV
Once a Day Use of Lactobacillus Casei Shirota on HIV-infected Patients Infected Patients
In this study, HIV-infected patients with poor recovery of CD4+ T cells and successful viral control after treatment with antiretroviral therapy will be enrolled to receive once a day Lactobcillus casei Shirota or placebo in a…
- Trial name
- NCT02146027
- Testing
- Fermented Milk Drink Yakult 40
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- University of Sao Paulo General Hospital
HIV/AIDS
A Field Experiment to Assess the Demand for HIV Self-Tests in Zimbabwe
This study is a field experiment in peri-urban and rural communities near Harare, Zimbabwe, that seeks to estimate the likelihood that individuals will purchase HIV self-tests under various pricing and distribution strategies.
- Trial name
- NCT03559959
- Testing
- Vouchers for HIV self-testing kits
- Where
- Zimbabwe
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.