Clinical trials: Acquired Immunodeficiency Syndrome
HIV, Cognitive Therapy
Cognitive Therapy in Patients Failing ART
Highly active antiretroviral therapy (HAART) has been the greatest achievement to control the HIV/AIDS epidemic in the world. HAART has been shown to reduce virus replication to undetectable levels and to favor the recovery of…
- Trial name
- CognitiveTher (NCT03751046)
- Testing
- Trial-Based Cognitive Therapy, Control group. Standard healthcare.
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Fundação Bahiana de Infectologia
HIV, Human Immunodeficiency Virus
PRe-Exposure Prophylaxis Acceptability & Readiness Assessments for Toronto gaY, Bisexual and Other Men Who Have Sex With Men-5
Canada continues to see an unrelenting stream of new HIV diagnoses, with a disproportionate burden among gay, bisexual, and other MSM in major centers such as Toronto.
- Trial name
- PREP-5 (NCT02149888)
- Testing
- Tenofovir/emtricitabine
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Infection, Human Immunodeficiency Virus
Relative Bioavailability Study With BMS-955176
The purpose of this study is to select the best dose level (amount of drug given) and best formulation of the study drug (BMS-955176) to develop further.
- Trial name
- NCT02095886
- Testing
- BMS-955176
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Depression, HIV
Trial of Collaborative Depression Care Management for HIV Patients
This project will integrate a depression treatment and brief medication adherence counseling intervention into clinical care at three HIV clinics and will use a randomized controlled trial to assess whether, relative to usual…
- Trial name
- SLAM DUNC (NCT01372605)
- Testing
- Measurement-Based Care collaborative depression management, Enhanced Usual Care
- Where
- 4 sites in United States
- Volunteers
- 304 people
- Sponsor
- Duke University
Behavioral Risk for HIV
Enhancing HIV Risk Reduction Among Indian Women With Risky Husbands
This grant involved the development, implementation, and assessment of the feasibility and acceptability of an HIV prevention intervention for at-risk wives in Mumbai, RHANI Wives (Raising HIV Awareness among Non-Infected Indian…
- Trial name
- RHANI Wives (NCT01592994)
- Testing
- RHANI WIves
- Where
- India
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cervical Cancer, HIV
Evaluation of a Novel Optical Microscope With a Deep Depth of Field (DeepDOF) to Provide Histologic-quality Images on Cervical Biopsies and Loop Electrosurgical Excision Procedure (LEEP) Specimens at the Point-of-care
All patients will be enrolled in Mozambique and Brazil. They will provide informed consent to use their cervical biopsy and/or LEEP specimens for imaging with DeepDOF prior to sending for standard of care processing and…
- Trial name
- NCT06850402
- Testing
- DeepDOF Images
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- M.D. Anderson Cancer Center
HIV Infections, Tuberculosis
Efavirenz (EFV) in HIV-Infected and HIV/Tuberculosis (TB) Coinfected Children
Efavirenz (EFV) is an anti-HIV medicine that is commonly used to treat HIV infection in adults and children older than 3 years of age.
- Trial name
- NCT00802802
- Testing
- Efavirenz (EFV), Rifampin-containing anti-TB therapy
- Where
- 7 sites in India, South Africa and 2 more
- Volunteers
- 67 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sexually Transmitted Infections (Not HIV or Hepatitis), HIV Infections
Overcoming Geography With Technology: Medical Drones Project
In this study, the investigators shall evaluate the use unmanned air vehicles (medical drones) to deliver ART to adult patients eligible/enrolled in community DSD models in Bufumira Islands, Kalangala district.
- Conditions
- Sexually Transmitted Infections (Not HIV or Hepatitis), HIV Infections, COVID-19
- Trial name
- NCT05259761
- Testing
- Unmanned ariel vehicle
- Where
- Uganda
- Volunteers
- 1,450 people, healthy volunteers welcome
- Sponsor
- Makerere University
HIV/AIDS
Accelerated PrEP Access for Black MSM and TW
The investigators will pilot-test an accelerated PrEP initiation approach among young high-risk Black/African American (B/AA) men who have sex with men (MSM) and transgender women (YMSM/TW) at the point of care in community…
- Trial name
- NCT04329442
- Testing
- Emtricitabine / Tenofovir Disoproxil Oral Tablet
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
HIV/AIDS and Infections, Drug Abuse
Preventing HIV/STI in Urban Adolescents Via an mHealth Primary Care Intervention
The study evaluates the preliminary efficacy of an innovative mobile-health (mHealth) intervention (hereon referred to as S4E) to improve human immunodeficiency virus and sexually transmitted infection testing and reduce HIV/STI…
- Conditions
- HIV/AIDS and Infections, Drug Abuse, Adolescent Behavior, Drug Usage
- Trial name
- NCT03368456
- Testing
- S4E, Usual Care
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Michigan
HIV, Alcohol Drinking
Nursing Counseling to the Change of Behavior of Alcohol Consumption in Patients in HAART
The success of treatment in patients with HIV depends not just on the therapeutic regimen used, but also on the adherence or level of compliance with the treatment achieved by the patient.
- Trial name
- NCT04054466
- Testing
- Nursing Counseling in the change of Alcohol Consumption Behavior in patients receiving HAART, Habitual Counseling
- Where
- Peru
- Volunteers
- 233 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Acquired Immunodeficiency Syndrome, HIV Infection
Clinic-based ART Diagnostic Evaluation
The study is funded through the Office of the Global AIDS Coordinator (OGAC #KE-07-0044). The purpose of this study is two-fold.
- Conditions
- Acquired Immunodeficiency Syndrome, HIV Infection, RNA Virus Infections, Virus Diseases
- Trial name
- CLADE (NCT01791556)
- Testing
- HIV-1 viral load testing
- Where
- Kenya
- Volunteers
- 820 people
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
Human Immunodeficiency Virus Type 1 (HIV-1) Infection
A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)
Researchers are looking for new ways to treat HIV-1 (Human Immunodeficiency Virus Type 1). The usual (standard) treatment for HIV-1 is antiretroviral therapy (ART), which includes taking medicines to lower the amount of HIV-1 in…
- Trial name
- NCT07266831
- Testing
- ISL, ULO, BIC/FTC/TAF
- Where
- 55 sites in United States, Argentina and 7 more
- Volunteers
- 570 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV, Drug Users
Project Vuselela Feasibility
To develop an intervention that engages family members in supporting HIV and opioid substitution therapy treatment for those who inject drugs in South Africa, and then conduct a pilot study to understand feasibility and…
- Trial name
- PV (NCT07117656)
- Testing
- Project Vuselela
- Where
- South Africa
- Volunteers
- 80 people
- Sponsor
- Arizona State University
HIV, Drug Use Disorders
HEART to HAART: Smartphone Intervention to Improve HAART Adherence for Drug Users
HIV infected drug users have greater difficulty adhering to highly active antiretroviral therapy compared to non-drug users. As sustained adherence to highly active antiretroviral therapy is critical to reducing HIV related…
- Trial name
- NCT01413529
- Testing
- HEART to HAART, adherence counseling with the addition of smartphone control
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Maryland, Baltimore
HIV Infections
Phase II/III Study of the Tolerance and Efficacy of Combined Use of Didanosine (2',3'-Dideoxyinosine; ddI) and Lentinan in HIV-Positive Patients
To determine the tolerance and side effects of a combination of lentinan and didanosine (ddI) in comparison with ddI alone. To determine whether the combination of lentinan and ddI produces a significant immunorestorative effect…
- Trial name
- NCT00002099
- Testing
- Lentinan, Didanosine
- Where
- United States
- Sponsor
- AJI Pharma USA
Infections, Human Immunodeficiency Virus and Tuberculosis
A Phase 1, Open Label, Placebo-Controlled Study to Evaluate the Effect of GSK1349572 on Iohexol and Para-Aminohippurate Clearance in Healthy Subjects
The current study is designed to confirm the mechanism behind the increase in serum creatinine observed during GSK1349572 therapy; specifically, the study will determine whether GSK1349572 has any effect on glomerular filtration…
- Trial name
- NCT01214993
- Testing
- GSK1349572, Iohexol Injection, Para-aminohippurate infusion
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV, Contraception
Pharmacologic Strategies to Use the Levonorgestrel Implant in HIV-infected Women
The purpose of this study is to determine whether increasing the dose of the levonorgestrel subdermal contraceptive implant will overcome a detrimental drug-drug interaction with efavirenz based antiretroviral therapy.
- Trial name
- NCT02722421
- Testing
- Levonorgestrel, Efavirenz
- Where
- Uganda
- Volunteers
- 28 people
- Sponsor
- University of Nebraska
Alcohol Drinking, HIV Viremia
Using Telehealth to Address Alcohol Misuse in HIV Care
This project will test the effects of a telehealth counseling program on reducing alcohol use and improving HIV viral control among people with HIV who drink heavily.
- Trial name
- ReACH3 (NCT04546971)
- Testing
- Brief Intervention, Telehealth Counseling, Text messaging
- Where
- United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Brown University
HIV Infections, Tuberculosis
TBTC Study 23B:Intensive PK of the Nelfinavir Rifabutin Interaction in Patients With HIV-TB
Primary Objective: To define the impact of nelfinavir (given at 1250mg bid as part of a combination antiretroviral regimen) on peak levels and area under the curve for rifabutin and the rifabutin metabolite, 25-O-desacetyl…
- Trial name
- NCT00023400
- Testing
- Nelfinavir, Rifabutin
- Where
- 23 sites in United States, Canada
- Volunteers
- 20 people
- Sponsor
- Centers for Disease Control and Prevention
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