Clinical trials: Acquired Immunodeficiency Syndrome
HIV
The PeerCARE Study (Peer Community-based Assistant in REtention)
The provision of HIV care and prevention services in resource-limited settings (RLS) entails substantial challenges due to a human resource crisis.[1] One strategy to address this human resource crisis is task shifting-the…
- Trial name
- PeerCARE (NCT01366690)
- Testing
- Peer Support
- Where
- Uganda
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins University
Sepsis
The Effects of HIV Protease Inhibitors in Severe Sepsis
Sepsis is the leading cause of death in critically ill patients in the United States. It develops in approximately 750,000 Americans annually, and more than 210,000 of them die.
- Trial name
- NCT00346580
- Testing
- Nelfinavir
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
HIV Infections
Trial of SAVVY Vaginal Gel and HIV in Nigeria
Heterosexual contact is now the primary route of transmission for HIV worldwide. This study is a phase 3 trial designed to determine the effectiveness and safety of the 1.0% C31G (SAVVY) vaginal gel for the prevention of…
- Trial name
- NCT00130078
- Testing
- 1.0% C31G SAVVY vaginal gel
- Where
- 2 sites in Nigeria
- Volunteers
- 2,142 people, healthy volunteers welcome
- Sponsor
- Biosyn
HIV Infections
Observational Study on Anti-Tat Immune Response in HIV-1-infected Asymptomatic Adult Subjects
The present study is designed as a prospective observational study directed at evaluating the frequency, magnitude, quality and persistence (primary endpoint) of the anti-Tat immune response in HIV-1 infected asymptomatic…
- Trial name
- ISS OBS T-003 (NCT01029548)
- Where
- 10 sites in Italy
- Volunteers
- 73 people
- Sponsor
- Barbara Ensoli, MD
HIV Infections
Evaluating the Safety and Immunogenicity of Polyvalent DNA/gp120 HIV Vaccine in Healthy, HIV-uninfected Adults
The purpose of the study is to evaluate the safety, tolerability, and immunogenicity of polyvalent env (A,B,C,A/E)/gag (C) DNA and gp120 (A,B,C,A/E) protein vaccines (PDPHV201401) co-administered together with or without adjuvant…
- Trial name
- NCT04927585
- Testing
- env (A,B,C,A/E)/gag (C) DNA Vaccine, gp120 (A,B,C,A/E) Protein Vaccine, GLA-SE adjuvant
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Worcester HIV Vaccine
HIV/AIDS
The Late Presenter Treatment Optimisation Study
The main purpose of this study is to compare two different types of HIV treatments, in terms of effectiveness and improvement of side effects, for patients who are diagnosed with a more advanced HIV infection.
- Trial name
- LAPTOP (NCT03696160)
- Testing
- Biktarvy, Symtuza
- Where
- 53 sites in Belgium, France and 5 more
- Volunteers
- 447 people
- Sponsor
- NEAT ID Foundation
Syphilis
Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection
This is a phase 4, randomized, open-label, multicenter trial to evaluate the efficacy of a single injected dose of Benzathine Penicillin G (BPG) 2.4 MU (Arm 1) compared to three successive weekly injected doses of BPG 2.4 MU (Arm…
- Trial name
- NCT03637660
- Testing
- Benzathine Penicillin
- Where
- 10 sites in United States
- Volunteers
- 249 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Malaria
Drug Interaction Study Between Antimalarial and Anti-HIV Medications
The purpose of this study is to find out whether taking certain anti-HIV medicines with certain antimalarial medicines affects the amount of the medicines in the blood.
- Trial name
- NCT00266058
- Testing
- Lopinavir/Ritonavir, Efavirenz, Artemether/lumefantrine
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Lymphoma, Nonneoplastic Condition
Biomarkers in Blood Samples From Patients With HIV Infection and Stage III or Stage IV Hodgkin Lymphoma Undergoing Chemotherapy
RATIONALE: Studying samples of blood in the laboratory from patients undergoing treatment with HIV infection and Hodgkin lymphoma may help doctors learn more about the effects of therapy on HIV.
- Trial name
- NCT01319526
- Testing
- DNA analysis, RNA analysis, laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- AIDS Malignancy Consortium
HIV Infections
A Pharmacokinetic (PK) Study of a Combination of Indinavir, Ritonavir, and Amprenavir
When individuals who are infected with HIV are started on treatment with HIV medications, the effect of these drugs only lasts for a limited period of time, often because of development of drug resistance by the HIV virus.
- Trial name
- NCT00148785
- Testing
- Indinavir/Ritonavir/Fosamprenavir
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Emory University
HIV Infections
Changes in Lipids and Lipoproteins in HIV Infected Women After Switch From Protease Inhibitor to Raltegravir
This is a 24-week, one arm, open-label, interventional, non-comparative multicenter study to evaluate lipid changes in HIV infected women with hyperlipidemia on boosted PI based regimen after switching their boosted PI to…
- Trial name
- NCT02097108
- Testing
- Raltegravir
- Where
- 3 sites in Austria
- Volunteers
- 11 people
- Sponsor
- Arbeitsgemeinschaft medikamentoese Tumortherapie
To Study Immunostatus of HIV-cancer Patients Who Recived RT Befor RT and Last Week of RT, To Study HIV Viral Load of HIV-cancer Patients Who Recived RT Befor RT and Last Week of RT
Observational Study of Effect of Radiation Therapy to Immuno Status in HIV-cancer Patients
Objectives: To study immunostatus (CD4) and HIV viral load in HIV-cancer patients before RT and last weeks of RT .
- Trial name
- NCT01546376
- Testing
- Radiation therapy, Venepuncture
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
HIV Infection
Clinical Trial to Reduce Drinking in Women With HIV
The primary objective of this study is to evaluate whether an intervention that involves the medication naltrexone, will reduce drinking and improve health outcomes in women with HIV infection and hazardous drinking.
- Trial name
- WHATIF (NCT01625091)
- Testing
- Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of Florida
HIV Antibody Testing
Use of OraQuick for Screening HIV in Children Less Than Eighteen Months Old
Blood is the most commonly used specimen to test for HIV. In the past 20 years, use of saliva as an alternative specimen for HIV testing has been explored.
- Trial name
- NCT00378118
- Testing
- Abbott-rapid HIV antibody test, OraQuick Rapid HIV-1/2 Antibody test
- Where
- Zambia
- Volunteers
- 1,000 people
- Sponsor
- Thrasher Research Fund
HIV Infections
An Open-Label Safety Program for the Use of Zalcitabine (Dideoxycytidine; ddC) in Pediatric Patients With Symptomatic HIV Infection Who Have Failed or Are Intolerant to AZT Monotherapy, or Who Have Completed Other ddC Protocols, or Are Ineligible for Other Ongoing Clinical Studies
To allow, on a compassionate use basis, zalcitabine (ddC) for pediatric patients with symptomatic HIV disease who have failed treatment or who are intolerant to zidovudine (AZT), or who have completed other ddC protocols, or who…
- Trial name
- NCT00002118
- Testing
- Zalcitabine
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Hoffmann-La Roche
HIV Infections
A Study Comparing Two Forms of Didanosine in HIV-infected Patients
The purpose of this study is to see if the coated-capsule form of didanosine (ddI) is as safe and absorbed by the body as well as the chewable-tablet form of ddI. Didanosine (ddI) is an anti-HIV drug.
- Trial name
- NCT00002360
- Testing
- Didanosine
- Volunteers
- 30 people
- Sponsor
- Bristol-Myers Squibb
Intimate Partner Violence, HIV
The SASA! Study: An Evaluation of a Community Intervention to Address Gender-based Violence and Reduce HIV/AIDS Risk in Uganda
The SASA! Study is a cluster randomized trial of a community mobilization intervention for the prevention of HIV and gender based violence. The study is being conducted in Kampala, Uganda.
- Trial name
- SASA! (NCT00790959)
- Testing
- SASA!, Control
- Where
- Uganda
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Proteinuria, HIV
MARCH Renal Substudy
Chronic kidney disease (CKD) is an emerging problem in patients with treated HIV. Antiretroviral therapy associated renal dysfunction has been predominantly described in terms of reduced glomerular filtration (eGFR).
- Trial name
- MARCHrenal (NCT01637259)
- Testing
- arm 1 nucleotide analogue reverse transcriptase inhibitors and boosted protease inhibitors, Arm 2 boosted protease inhibitors and maraviroc, Arm 3 nucleotide analogue reverse transcriptase inhibitors and maraviroc
- Where
- 15 sites in Argentina, Australia and 6 more
- Volunteers
- 76 people
- Sponsor
- Kirby Institute
HIV Infections
Treatment Plan to Decrease Drug Exposure in HIV Infected Adolescents
This study will attempt to stimulate the immune system in HIV infected adolescents and young adults so that it can better control the HIV infection.
- Trial name
- NCT00067574
- Testing
- Structured treatment interruption
- Where
- 4 sites in United States
- Sponsor
- University of North Carolina, Chapel Hill
HIV, Substance-Related Disorders
Increasing MSM in the Continuum of Care in Kazakhstan
This study addresses the disproportionate representation of men who have sex with men (MSM) in the human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) pandemic in Kazakhstan, a country that has seen some…
- Trial name
- NCT02786615
- Testing
- Peer Unity
- Where
- 2 sites in United States, Kazakhstan
- Volunteers
- 987 people, healthy volunteers welcome
- Sponsor
- Columbia University
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