Clinical trials: Actinic Keratoses
Actinic Keratoses
Photodynamic Therapy Incubation Times for Actinic Keratosis
This is a randomized clinical trial evaluating blue light 5-aminolevulinic acid (ALA) photodynamic therapy with different incubation times for the treatment of actinic keratosis.
- Trial name
- NCT03066843
- Testing
- ALA (5-aminolevulinic acid), Blue light therapy
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Actinic Keratosis
Potential Impact of Patient Vitamin D Status in AK Response to MAL-PDT
In topical photodynamic therapy (PDT) for non-melanoma skin cancers, a photosensitizing prodrug, 5-aminolaevulinic acid (ALA) or its methylated ester, methyl aminolevulinate (MAL), is converted to the endogenous photosensitizer…
- Trial name
- PDT (NCT02878382)
- Testing
- Conventional MAL-PDT, Calcipotriol assisted MAL-PDT
- Where
- 2 sites in Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Non-melanomatous Skin Cancer, Precancerous Condition
Effect of Solar-Simulated Ultraviolet Radiation on Gene Expression in Unprotected and Sunscreen-Protected Skin of Healthy Adults With Fitzpatrick Skin Type II
RATIONALE: Testing of skin that has been exposed to artificial sunlight may help in understanding the genetic processes involved in the development of skin cancer.
- Trial name
- NCT00099112
- Testing
- microarray analysis, biopsy, evaluation of cancer risk factors
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Actinic Keratosis, Photodynamic Therapy
Photodynamic Therapy-Induced Immune Modulation: Part III
This study is designed as a double-blinded proof of concept of feasibility study to define if the immunosuppression associated with photodynamic therapy (PDT) can be blocked by treatment with cyclo-oxygenase-2 (COX-2) inhibitor…
- Trial name
- NCT03643744
- Testing
- Celecoxib 200mg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Wright State University
Healthy, Actinic Keratosis
PEP005 Gel - Evaluation of Local Tolerability After Exposure to Ingenol Mebutate Gel Followed by Hand Washing in Healthy Subjects
The purpose of this phase 1 trial is to investigate the local tolerability on the finger following exposure to PEP005 Gel 0.015% or 0.05% and hand washing once daily, for 2 or 3 consecutive days.
- Trial name
- NCT01302925
- Testing
- PEP005 Gel
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peplin
Actinic Keratoses
Bioequivalence Study of Generic Fluorouracil 0.5% Cream and 0.5% Carac® and Placebo
This is a double-blind, randomized, placebo-controlled, three treatment parallel study in which normal, healthy men and women (age 45-85) with actinic keratosis will be treated on the face once daily for two weeks with…
- Trial name
- NCT01354717
- Testing
- Brand Carac, Generic 0.5% 5-fluorouracil cream
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- Spear Pharmaceuticals
Skin Cancer
Expression Levels of RISC and Microprocessor Complex Components in Epithelial Skin Cancer
MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation.
- Trial name
- NCT01345760
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Actinic Keratoses
An Open-Label 18-Month Safety Study of Fluorouracil Cream 0.5% for the Treatment of Actinic Keratoses
This study is being undertaken to: 1. assess the safety of fluorouracil cream for the treatment of actinic keratoses ("AKs") on other common skin surface areas (e.g., posterior scalp, ears, neck, lips, arms and hands); 2.
- Trial name
- NCT00377273
- Testing
- fluorouracil cream 0.5%
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Sanofi
Skin Neoplasms
Comparison of Two Modes of Photodynamic Therapy for the Treatment of Actinic Keratosis on the Upper Extremities
This study will be a prospective clinical trial performed in a single center, with 20 adult subjects presenting 4-17 clinically confirmed, mild to moderate AKs according to Olsen grading on each of two comparable treatment fields…
- Trial name
- NCT05359419
- Testing
- aminolevulinic acid hydrochloride gel, 10%, aminolevulinic acid HCl topical solution, 20%
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Actinic Keratoses
Earliest Stage Treatment of Aktinic Keratosis With Imiquimod 3.75% Cream
Earliest Stage Treatment of Actinic Keratosis with Imiquimod 3.75% Cream: The study is to demonstrate that Aktinic Keratosis are present before they are clinically visible, i.e. in a subclinical stage.
- Trial name
- NCT04842422
- Testing
- Imiquimod 3.75% Cream
- Where
- Austria
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Actinic Keratosis, Non-melanoma Skin Cancer
Daylight Photodynamic Therapy for the Treatment of Actinic Keratoses in the Northeast United States
In this study, daylight PDT will be administered to interested patients at Dana-Farber/Brigham and Women's Cancer Center. Daylight PDT has been shown to be an effective and painless alternative to traditional PDT.
- Trial name
- DaylightPDT (NCT02867722)
- Testing
- aminolevulinic acid HCl
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Actinic Dermatosis
Efficacy of Topical Calcipotriol-assisted AFL-PDT in Actinic Keratosis
Vitamin D(Vit D) is a pro-differentiation agent that enhances the accumulation of protoporphyrin IX (PpIX) after MAL(methyl-aminolevulinate) incubation in actinic keratosis and may have significant benefit for the treatment of…
- Trial name
- NCT02976727
- Testing
- Topical Vitamin D (Calcipotriol) application, lidocaine/prilocaine (5%) application, 2940-nm Er:YAG AFL pretreatment
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dong-A University
Basal Cell Carcinoma
Basal Cell Carcinoma Chemoprevention Trial
This is an intent-to-treat, parallel design, multicenter randomized trial and the primary intervention is a double-blind comparison of imiquimod (IMQ) vs.
- Trial name
- B3C (NCT05212246)
- Testing
- 5% Imiquimod cream
- Where
- 8 sites in United States
- Volunteers
- 1,630 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Keratosis, Actinic, Actinic Lesion
A Pre-market Study to Evaluate the Performance and Safety of a Skin Preparation Device for Removal of Dry Crusty Skin
In this clinical one-site investigation the performance and safety of a skin preparation device will be evaluated for removing hyperkeratotic skin prior to further medical treatment.
- Conditions
- Keratosis, Actinic, Actinic Lesion, Solar Keratosis/Sunburn, Hyperkeratosis
- Trial name
- NCT05356572
- Testing
- Investigational Skin Preparation Device, GMDN 47102 / Electrode Skin Abrasive Pad, UMDNS 13-230 / Biopsy punch (Dermal Curette)
- Where
- Finland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mirka Ltd
Actinic Keratosis
Efficacy of AFL-assisted PDT With Short Incubation Time in Actinic Keratosis
Photodynamic therapy (PDT) using methyl aminolevulinate (MAL) is an effective first-line treatment for actinic keratosis (AK). Erbium: yttrium-aluminium-garnet (Er:YAG) ablative fractional laser-assisted MAL-PDT (AFL-PDT) has…
- Trial name
- NCT02248298
- Testing
- 2h-AFL-PDT, 3h-AFL-PDT, 3hr-MAL-PDT
- Where
- South Korea
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Dong-A University
Actinic Keratoses
Methyl Aminolevulinate 8% and 16% Incubated by 1 and 3 for Actinic Keratoses Treatment
The objective of this protocol is to compare the efficacy of the topical application of MAL at concentrations of 8% and 16%, mediated by red light, as well as to evaluate the impact of different incubation times (1 or 3 hours) in…
- Trial name
- NCT06507644
- Testing
- light curettage, Pre irradiation of 1 hour, Pre irradiation of 3 hour
- Where
- Brazil
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Actinic Keratoses
Effect of Lipikar Urea 30% Before Actinic Keratoses Treatment
This study is conducted in one center in Germany, in adult subjects having actinic keratoses (grade I or II) lesions on the scalp and meeting specific inclusion/exclusion criteria.
- Trial name
- NCT06274320
- Testing
- Group A: holistic approach, Group B: Tolak® Standard of use
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Actinic Keratoses, Photodamage
Activation of Ameluz With BBL HEROic for the Treatment of Actinic Keratoses and Photodamage
To provide a treatment of both actinic keratoses and photodamage within one treatment.
- Trial name
- NCT07053852
- Testing
- Ameluz, Sciton HEROic
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sherrif Ibrahim
Actinic Dermatosis
Efficacy in Ablative Fractional Laser Assisted Photodynamic Therapy According to Ablative Depth for Actinic Keratosis
Er:YAG ablative fractional laser-assisted photodynamic therapy (AFL-PDT) has shown significant benefit for the treatment of actinic keratosis(AK).
- Trial name
- NCT03325803
- Testing
- lidocaine/prilocaine (5%) application, 2940-nm Er:YAG AFL pretreatment, MAL application
- Where
- South Korea
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Dong-A University
Keratosis
Study to Assess the Safety and Efficacy of Imiquimod 5% Cream for the Treatment of Actinic Keratosis on the Arms and Hands
The purpose of this study is to evaluate the safety and efficacy of imiquimod 5% cream compared to vehicle cream in the treatment of Actinic Keratosis (AK) on the arm and/or hand when the cream is applied once daily 2 days per…
- Trial name
- NCT00115154
- Testing
- Aldara (imiquimod) cream, 5%
- Where
- 18 sites in United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Graceway Pharmaceuticals, LLC