Clinical trials: Activation, Patient
Spinal Cord Injury
Changes of Parameters of Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury
CNS reorganization is evidenced in patients with CNS lesion, no exception to the patients with spinal cord injury. The paraplegics have to increase their loading of upper extremities to compesate the lost function of lower…
- Trial name
- NCT00228085
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Type 2 Diabetes
INVESTIGATION OF THE EFFECT OF DIFFERENT ACTIVATION TECHNIQUES ON TLR9, IL6, IL10, TNF-ALFA LEVELS IN HEALTHY AND TYPE 2 DIABETIC PATIENTS WITH APICAL PERIODONTITIS REQUIRING RETREATMENT
The subject of this thesis study is the effects of SWEEPS laser and ultrasonic activation methods on the immune response in the treatment of apical periodontitis in healthy individuals and patients with Type 2 diabetes requiring…
- Trial name
- TLR9 in T2DM (NCT07389772)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- bengisu yüksel
Fractures, Bone
Behavioral Activation in Orthopaedic Trauma Patients: A Pilot Study
This is a prospective observational pilot study designed to evaluate feasibility and acceptability as well as preliminary efficacy of a behavioral activation intervention among orthopaedic trauma patients after discharge home…
- Trial name
- NCT04426981
- Testing
- Behavioral Activation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Glioblastoma
Immuno-Positron Emission Tomography (PET)-Glioma Study, a Proof-of-principle Imaging Study
Imaging of proinflammatory activated microglia by Purine 2X7 (P2X7) receptor scintigraphy in Positron Emission Tomography (PET) scanner in Glioblastoma patients.
- Trial name
- NCT05753995
- Testing
- PET imaging
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kepler University Hospital
Sickle Cell Disease
Role of Inflammasome in Platelet Activation in Sickle Cell Disease Patient
Sickle cell disease is characterized by chronic hemolytic anemia, painful crisis called vaso-occlusive crisis and chronic inflammation.
- Trial name
- DrePlaquette (NCT06986837)
- Where
- Guadeloupe
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Gestational Diabetes
Active Patient GDM
Among women with GDM, the investigators will determine if a strategy of (1) a website-based information and motivational resource bank; (2) biosensor/ePlatform-based physical activity and GWG tracking; and/or (3) a health coach…
- Trial name
- NCT03802877
- Testing
- Resource bank, ePlatform, Health coach
- Where
- 6 sites in Canada
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Vestibular Schwannoma, Unilateral Vestibular Deficit
Mapping of Vestibular Centers Activation Using fMRI in Patients With Vestibular Schwannoma
The goal of this clinical trial is to visualize the possible activation of vestibular centers in the brain using in patiens with unilateral vestibular damage, specifically in patients after vestibular schwannoma surgery.
- Conditions
- Vestibular Schwannoma, Unilateral Vestibular Deficit, Healthy
- Trial name
- NCT07130851
- Testing
- vestibular schwannoma resection
- Where
- Czechia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Marketa Bonaventurova
Intervention Group, Control Group
Innovative Web-based Service Platform Called Adult Wellbeing CheckUp (AWC) to Assess Older Adults Wellbeing, Obtain Evidence-based Recommendations, and Receive Support to Take Action.
The goal of this clinical trial is to learn whether a web-based program called the Adult Wellbeing CheckUp (AWC) can help older adults improve their wellbeing and take actions to support healthy aging.
- Trial name
- NCT07489170
- Testing
- Adult Wellbeing CheckUp (AWC), General Healthy Aging Information
- Where
- United States
- Volunteers
- 496 people, healthy volunteers welcome
- Sponsor
- BellAge Inc.
Physiology
Physiopathology of Lower Cortical Activation in COPD Patients: Contribution of Cortical Neuromodulation
Patients with COPD have lower cortical activation and higher cortical inhibitory levels. The purpose of this study is to test the reversibility the lower cortical activation by counterbalancing the increased cortical inhibitory…
- Trial name
- NCT03368703
- Testing
- Anodal transcranial direct-current-stimulation
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- 5 Santé
Cerebral Metastases Patients
Neurococognitive and Functioal Assessment of Patients With Brain Metastases
The investigators seek to perform an observational study in patients with brain metastases that are to undergo whole brain radiation therapy (WBRT) or stereotactic radiosurgery (SRS) treatment in order to quantify any baseline…
- Trial name
- NCT01861405
- Testing
- neuropsychological testing and quality of life assessments, Standard of Care WBRT or SRS, Functional magnetic resonance imaging
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Cardiovascular Disease
Cerebrovascular Outcomes in Ischemic Heart Disease
This project will examine the association between (cardio)vascular disease, blood supply to the brain, and cerebrovascular endothelial activation.
- Trial name
- IHD (NCT02715661)
- Testing
- exercise
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Anorexia Nervosa
Incomplete Total Body Protein Recovery in Adolescent Patients With Anorexia Nervosa
The study aimed to assess protein accretion during weight gain in adolescent patients with Anorexia nervosa
- Trial name
- NCT03334032
- Testing
- Inpatient treatment for Anorexia nervosa
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Patient Engagement, Physician's Role
OPEN & ASK: Improving Patient-Centered Communication in Primary Care
This large scale multi-center cluster randomized controlled trial (RCT) is designed to assess the comparative effectiveness of three interventions in diverse ambulatory care settings and patient populations.
- Conditions
- Patient Engagement, Physician's Role, Physician-Patient Relations, Patient Activation
- Trial name
- NCT03385512
- Testing
- OPEN High Touch, OPEN High Tech, ASK Poster in Exam Rooms
- Where
- 3 sites in United States
- Volunteers
- 5,565 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Schizophrenia, Mental Disorders
Study of the Activation of Proinflammatory Pathways of Toll-like Receptors in Schizophrenia Patients
The study of immune pathways involved in the etiopathogeny of schizophrenia would be an important advance to understand the mechanisms involved in the development of this disease and it would be a turning point in drug therapy.
- Conditions
- Schizophrenia, Mental Disorders, Psychotic Disorders
- Trial name
- PAFIP_TLR (NCT02897167)
- Testing
- Retrospective study of frozen samples, Prospective study of fresh samples
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fundación Marques de Valdecilla
Healthy Volunteers, Amyotrophic Lateral Sclerosis
Evaluation of Microglial Activation in ALS With [18F]PBR06 (Peripheral Benzodiazepine Receptor-06) PET
The overall goal of this protocol is to evaluate microglial activation in the brain using [18F]PBR06 in patients with amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT03876002
- Testing
- [18F]PBR06
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Molecular NeuroImaging
Depression - Major Depressive Disorder
Effectiveness of Behavioral Activation Group Therapy for Patients With Depression at the Community in Thanh Hoa
This study aimed to evaluate whether the 8-week BA group therapy delivered at commune health stations (CHSs) improves depressive symptom severity, psychological distress, behavioral activation, resilient coping, and…
- Trial name
- not yet (NCT07527312)
- Testing
- Behaviral activation group therapy
- Where
- Vietnam
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Hanoi Medical University
Pemphigus
Coagulation Activation in Patients With Pemphigus
Aim of work: 1. To evaluate the plasma markers of coagulation activation: prothrombin F1+2 and d-dimer levels in pemphigus patients with active disease and compare them with age and sex-matched controls. 2.
- Trial name
- NCT06285435
- Testing
- prothrombin fragment 1+2
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Assiut University
Trauma, Sepsis
System-level Monitoring of Immune Activation Concerning Susceptibility to Sepsis in Trauma Patients
Sepsis remains a common entity in critical care patients with remarkable mortality. Despite extended research activities, no reliable bio-markers or scoring systems attributing the individual risk of developing sepsis have been…
- Trial name
- NCT01472952
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Knee Osteoarthritis, Osteearthritis
Effect of 0° and 50° N-K Table Load Angles on Quadriceps Activation in Knee Osteoarthritis
Knee osteoarthritis (OA) is a common degenerative joint disease that leads to pain, reduced mobility, and functional limitation. Quadriceps femoris weakness plays a significant role in disease progression and disability.
- Trial name
- NCT07456254
- Testing
- Isotonic Quadriceps Exercise Using NK Table
- Where
- Indonesia
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
HIV
Effects of Probiotics on Microbial Translocation and Immune Activation Markers in HIV-positive Patients on Combined Antiretroviral Therapy
Combined antiretroviral therapy (cART)-treated patients have increased mortality and morbidity compared to age-matched seronegative individuals.
- Trial name
- PROBIO-HIV (NCT02164344)
- Testing
- probiotics
- Where
- 2 sites in Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza