Clinical trials: Activation, Patient
Indolent Systemic Mastocytosis
Midostaurin in Indolent Systemic Mastocytosis
Rationale: Patients with indolent or smoldering systemic mastocytosis can have severe disabling symptoms. Almost all patients have fatigue, a compromised quality of life, hampering normal functioning.
- Trial name
- NCT01920204
- Testing
- Midostaurin,
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Carcinoma, Non-small Cell Lung
Phase 2 Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin for Non-Small Cell Lung Cancer With KRAS or EGFR Activation
The purpose of this Phase 2 study is to investigate whether intravenous administration of a wild type reovirus (REOLYSIN®) in combination with paclitaxel and carboplatin is effective and safe in the treatment of Non-Small Cell…
- Trial name
- NCT00861627
- Testing
- REOLYSIN®, Carboplatin, Paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Oncolytics Biotech
Diagnosis, Psychiatric
Testing the Right Question Project (RQP) Health Education Strategy in a Mental Health Setting
The purpose of this pilot project is to test the effectiveness of three 20 minute health education modules on patient empowerment, patient activation and retention in care.
- Trial name
- RQP (NCT00134615)
- Testing
- RQP patient health education module
- Where
- 2 sites in United States
- Volunteers
- 231 people
- Sponsor
- Massachusetts General Hospital
Fragile X Associated Tremor-ataxia Syndrome, FXTAS
Brain Network Activation and Gait and Posture in FXTAS
In this study the investigators aim to identify and characterize a potential neurophysiological biomarker by mapping functional networks of brain activity (Brain Network Activation, BNA) based on analysis of evoked response…
- Trial name
- FXTAS-BNA (NCT02936531)
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Sheba Medical Center
Chronic Heart Failure
Effect at 6 Months of Renal Denervation in Chronic Heart Failure d'Insuffisance Cardiaque
Management of chronic heart failure (CHF) is a major public health problem. It is associated with high mortality, frequent hospitalization and represents a large cost to the health care system.
- Trial name
- DENRENIC (NCT02471729)
- Testing
- EnligHTN™ Renal Denervation System
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Institute Arnault Tzanck, France
COPD
Impact of Ibis on Patients With Advanced COPD
The purpose of this research is to determine if Ibis™, a digital therapeutics solution developed by Senscio Systems, reduces the emergency room visits and hospitalizations of patients with COPD.
- Trial name
- NCT03131622
- Testing
- Digital Therapeutics
- Volunteers
- 240 people
- Sponsor
- Senscio Systems
Depression and CVD
A Patient Activation Approach to Implementing Depression Treatment in Cardiac Patients
This study, which is being conducted as part of a Quality Improvement (QI) Initiative at Columbia University Irving Medical Center, will test whether delivering the iHeart DepCare tool increases real world reach and adoption of…
- Trial name
- iHeart_2 (NCT07390331)
- Testing
- iHeart Depcare tool
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbia University
Lymphoma
Donor T Cells, Low-Dose Aldesleukin, and Low-Dose GM-CSF After Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
RATIONALE: Giving high doses of chemotherapy before a donor stem cell transplant helps stop the growth of cancer cells. It also stops the patient's immune system from rejecting the donor's stem cells.
- Trial name
- NCT00521261
- Testing
- anti-CD3 x anti-CD20 bispecific antibody-armed activated T cells
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Chronic Myelogenous Leukemia, Acute Myelogenous Leukemia
Trial of Donor Lymphocyte Infusion (DLI) and Activated DLI Following Relapse After Allogeneic Stem Cell Transplant
This study is for patients with relapsed of disease after allogeneic bone marrow The donor's T cells are activated by exposure to 2 compounds or antibodies that bind (or stick to) two compounds on T cells called CD3 and CD28.
- Conditions
- Chronic Myelogenous Leukemia, Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome
- Trial name
- NCT00674427
- Testing
- CD3/CD28 Activated T cells
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Pennsylvania
COVID-19 Pneumonia
Efficacy and Safety of Oral Immunotherapy With GcMAF in Hospitalized Patients With COVID-19 Pneumonia
As of August 16, 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for more than 21 294 000 infections and about 760 000 deaths worldwide.
- Trial name
- COral-MAF1 (NCT04845971)
- Testing
- Saisei Maf capsules
- Where
- Italy
- Volunteers
- 97 people
- Sponsor
- Dr. Spadera Lucrezia
Femoroacetabular Impingement
Reproducibility of Strength Testing and Functional Testing of the Hip for the Return to Sport of Patients Activated by a Femoroacetabular Impingement: Comparison Between a Group of Patients and a Group of Healthy Controls
Reproducibility of strength testing and functional testing of the hip for the return to sport of patients activated by a femoroacetabular impingement: comparison between a group of patients and a group of healthy controls…
- Trial name
- H-Repro (NCT05391204)
- Testing
- Functional Tests
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Carcinoma, Non Small Cell Lung
A Study of Pemetrexed and Gefitinib Versus Gefitinib in Non-Small Cell Lung Cancer (NSCLC)
The purpose of this study is to compare the combination of pemetrexed and gefitinib versus gefitinib alone, in terms of progression-free survival.
- Trial name
- NCT01469000
- Testing
- Gefitinib, Pemetrexed
- Where
- 25 sites in China, Japan and 2 more
- Volunteers
- 195 people
- Sponsor
- Eli Lilly and Company
Carcinoma, Non-Small-Cell Lung, Thyroid Neoplasms
A Study of LOXO-260 in Cancer Patients With a Change in a Particular Gene (RET) That Has Not Responded to Treatment
The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-260. LOXO-260 may be used to treat cancer that has a change in a particular gene (known as the RET gene).
- Trial name
- NCT05241834
- Testing
- LOXO-260
- Where
- 16 sites in United States, France
- Volunteers
- 70 people
- Sponsor
- Eli Lilly and Company
Bipolar Disorder
Efficacy and Safety of Task-activated rTMS in Improving Cognitive Function in Patients With Bipolar Disorder
1. To clarify the efficacy and safety of task-based repetitive transcranial magnetic stimulation (rTMS) on cognitive function in patients with stable bipolar disorder. 2.
- Trial name
- NCT06782763
- Testing
- Repetitive transcranial magnetic stimulation device
- Where
- China
- Volunteers
- 82 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Type 2 Diabetes Mellitus, Postprandial Hyperglycemia
Effects of Insulin Treatment on Postprandial Platelet Activation in Patients With Non-insulin-dependent Diabetes Mellitus (NIDDM)
The postprandial phase in diabetic patients is characterized by a rapid increase in blood glucose levels, increase in platelet aggregation, LDL oxidation and over production of thrombin.
- Trial name
- NCT00771693
- Testing
- Insulin aspart (Novorapid®)
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Karolinska Institutet
Diabetes Mellitus, High Blood Pressure
Comparative Effectiveness of Family vs. Individually Focused Diabetes Education and Support
The objective of this study is to compare the effectiveness of a novel program-Family Support for Health Action (FAM-ACT) - to individual patient-focused diabetes self-management education and support (I-DSMES).
- Conditions
- Diabetes Mellitus, High Blood Pressure, High Blood Sugar, Hypertension
- Trial name
- NCT03812614
- Testing
- FAM ACT, I-DSMES
- Where
- 2 sites in United States
- Volunteers
- 444 people
- Sponsor
- University of Pittsburgh
Salivary Gland Tumor, Urothelial Carcinoma
A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
This is a first-in-human (FIH), Phase 1 open-label, multicentre dose escalation study investigating AVA6000 monotherapy administered intravenously in patients with locally advanced (unresectable) or metastatic solid tumours that…
- Conditions
- Salivary Gland Tumor, Urothelial Carcinoma, Ovarian Carcinoma, Breast Cancer
- Trial name
- NCT04969835
- Testing
- AVA6000
- Where
- 9 sites in United States, United Kingdom
- Volunteers
- 158 people
- Sponsor
- Avacta Life Sciences Ltd
Schizophrenia, Psychosis
Psychosis-Associated Neuroinflammation in Schizophrenia
Previous research has suggested central nervous system inflammatory activity to be critically involved in disease development and progression in schizophrenia, with a complex interplay of inflammatory mechanisms leading to the…
- Trial name
- PANS (NCT02009826)
- Testing
- [18F]-PBR111 Positron Emission Tomography (PET), Cognitive and psychomotor tasks, Blood sampling
- Where
- 3 sites in Belgium
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
SIJ - Sprain of Sacroiliac Joint, Weakness, Muscle
Gluteal Activation With or Without Traction Straight Leg Raise Technique
This study was a Randomized clinical trial conducted to determine the Effects of gluteal activation with or without traction straight leg raise technique among patients of sacroiliac joint syndrome so that in future this study…
- Conditions
- SIJ - Sprain of Sacroiliac Joint, Weakness, Muscle, Tightness of Back Muscles
- Trial name
- NCT04757415
- Testing
- Traction straight leg raise technique for hamstring, Gluteal activation exercises,Hotpack
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Retinal Degeneration, Retinitis Pigmentosa
Safety & Efficacy of Subretinal Implants for Partial Restoration of Vision in Blind Patients
Patients who are legally blind, caused by retinal degeneration of photoreceptor rods \& cones (e.g. Retinitis pigmentosa), receive a subretinal implant to restore vision partially.
- Trial name
- NCT01497379
- Testing
- surgical implantation of subretinal device
- Where
- Hong Kong
- Volunteers
- 2 people
- Sponsor
- Retina Implant AG