Clinical trials: Active Control
Metabolic Syndrome
Precision Nutrition Impact on Health-Related Behavior Change
A prospective, randomized, controlled trial enrolling up to 150 service members (SMs) from two sites; Joint Base Lewis McChord (JBLM) in the Northwest and Joint Base San Antonio (JBSA)-Lackland in the Southwest.
- Trial name
- NCT04959318
- Testing
- Professional nutrition counseling, No professional nutrition counseling
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Madigan Army Medical Center
Healthy Volunteers
A Study of LY2484595 on the Electrical Activity of the Heart
The purpose of this study is to evaluate the effect on the electrical activity of the heart as measured by an electrocardiogram (ECG) after dosing with 10 days of LY2484595 compared to 10 days of placebo in relation to a single…
- Trial name
- NCT01537887
- Testing
- LY2484595, Moxifloxacin
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy
A Study of the Cardiac Effects of ALXN1840 in Healthy Adults
This study will evaluate the effect of a supratherapeutic dose of ALXN1840 on the heart rate (HR)-corrected QT interval (QTc) in healthy adult participants. Moxifloxacin will be used as the active control.
- Trial name
- NCT04560816
- Testing
- ALXN1840, Moxifloxacin
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Alexion Pharmaceuticals, Inc.
Risk Reduction Behavior, Suicide Prevention
SAFEGUARD Level Up Study
This project will evaluate the effectiveness of Level Up: Boost Your Life Skills ("Level Up"), a strengths based, military-specific life skills training program.
- Conditions
- Risk Reduction Behavior, Suicide Prevention, Risky Behavior, Mental Health
- Trial name
- NCT07286955
- Testing
- Level Up
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Elevated Blood Pressure
Mindfulness and Neural Cardiovascular Control in Humans
This study evaluates the impact of mindfulness-based stress reduction (MBSR) on sympathetic nerve activity and arterial stiffness.
- Trial name
- NCT03626363
- Testing
- Stress Management
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Michigan Technological University
Obesity
Enhanced Internet Behavior Therapy for Treating Obesity
The purpose of this study is to compare two Internet-based behavioral weight loss programs.
- Trial name
- NCT00212238
- Testing
- internet behavioral weight loss program
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Schizophrenia, Cognitive Impairment
Eye-Movement Intervention for Cognitive Impairment Across Schizophrenia Spectrum
The goal of this clinical trial is to determine whether a gamified eye-movement intervention can improve cognitive function in individuals across the schizophrenia spectrum, including clinical high-risk individuals, first-episode…
- Conditions
- Schizophrenia, Cognitive Impairment, Clinical High Risk for Psychosis
- Trial name
- NCT07702526
- Testing
- Eye-Movement Training, Finger-Controlled Game Training
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Dental Caries
Impact of Detecting Initial and Active Caries Lesions in Primary Teeth
The present study aims to evaluate the impact of detecting active initial caries lesions in primary teeth regarding effectiveness, cost-effectiveness, applicability (acceptability and satisfaction) and quality of life.
- Trial name
- NCT02473107
- Testing
- Advanced caries lesions detection (no activity assessment), All caries lesions detection (+activity assessment)
- Where
- Brazil
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Learning Disorders, Learning Disabilities
Efficacy of the MovinCog Intervention in Children
This study aims to test the efficacy of the MovinCog Intervention to enhance cognitive abilities in children 7-15 yrs. The intervention consists of two parts: a physical exercise regimen, based on high-intensity training, and a…
- Conditions
- Learning Disorders, Learning Disabilities, Cognitive Change
- Trial name
- NCT03255499
- Testing
- Exercise, Cognitive, Active control
- Where
- New Zealand
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Fitness Trackers, Physical Activity
Full-scale Intervention Study: Genetic Risk Communication and Wearables
Background: Communication of information about risk of type 2 diabetes (T2D) alone has not been associated with changes in habitual behaviors among individuals of European ancestry.
- Conditions
- Fitness Trackers, Physical Activity, Exercise, Genetic Predisposition to Disease
- Trial name
- NCT05524909
- Testing
- Genetic Risk Estimate, Genetic Risk Estimate + Fitbit Functions
- Where
- Hong Kong
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Chronic HBV Infection
A Study of EDP-514 in Healthy Subjects (Part 1) and Patients With Chronic Hepatitis B Virus Infection (Part 2)
Part 1 is a randomized, double-blind, placebo-controlled study. It will assess the safety, tolerability, and pharmacokinetics of single and multiple orally administered doses of EDP-514 in healthy adult subjects.
- Trial name
- NCT04008004
- Testing
- EDP-514
- Where
- 15 sites in United States, Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc
Healthy Volunteers
A Study of RSV-HMPV Bivalent Vaccine VXB-241 in Older Adults
The main purposes of this study are to assess the safety, reactogenicity and immunogenicity of 4 dose levels of the bivalent combination Respiratory Syncytial Virus (RSV) / human Metapneumovirus (hMPV) vaccine candidate VXB-241…
- Trial name
- NCT06556147
- Testing
- VXB-241 60 mcg (Low Dose), VXB-241 120 mcg (Medium Dose), VXB-241 240 mcg (Medium-high Dose)
- Where
- 4 sites in Australia
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Sanofi
Osteoporosis, Bone Loss
Bone Response to Exercise in Women on Antiresorptive Medications
Performing resistance training and impact exercise at a moderate to high intensity may help prevent bone loss. However, medications used to treat bone diseases such as osteoporosis reduce the activity of bone cells.
- Trial name
- BRRIE (NCT04275011)
- Testing
- Progressive Resistance and Impact Exercise, Static Balance and Postural Exercise
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Physical Activity
Parents and Children Active Together Study
The purpose of this study is to examine physical activity habit formation in parents and if this can increase moderate to vigorous physical activity behavior in their children over six months.The Primary Research Question is…
- Trial name
- NCT03055871
- Testing
- Habit formation intervention, Physical activity planning intervention
- Where
- Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Victoria
Influenza
Acute Respiratory Infection Consortium
Recently, the emergence and rapid global dissemination of novel swine-origin influenza A virus (H1N1) with unique epidemiologic characteristics has heightened awareness and concern of this viral pathogen, and its potential for…
- Trial name
- ARIC (NCT01021098)
- Where
- 5 sites in United States
- Volunteers
- 2,018 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Irritable Bowel Syndrome
Randomised Double-blind Active vs. Placebo Clinical Trial on the Effect of a Food Supplement on IBS in Children
The goal of this clinical trial is to test a food supplement in children of 3-17 years with IBS. The main questions it aims to answer are: Is the tested supplement able to improve and/or reduce IBS-related symptoms? After…
- Trial name
- NCT06123234
- Testing
- Verum
- Where
- Italy
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Pregnancy
Effect of Regular Exercise on Maternal Cardiovascular System During Pregnancy
The main aim of this study was to analysed the security of a supervised exercise program on maternal cardiovascular system and assess the positive effects of this program on maternal cardiovascular function and structure
- Trial name
- NCT01723098
- Testing
- Exercise group
- Where
- Spain
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Technical University of Madrid
Endometriosis
A Study of Pharmacokinetic/Pharmacodynamic Profile of Orally Administered Leuprolide in Healthy Female Volunteers
This Phase 2a, pharmacokinetic/pharmacodynamic study will determine the safety and provide evaluation of the PK/PD metrics of three different oral doses selected upon the results of the study LOPDT-PH1-01 - 4 mg oral tablets…
- Trial name
- NCT02807363
- Testing
- Leuprolide Oral Tablet 4-mg QD, Leuprolide Oral Tablet 4-mg BID, Leuprolide Depot
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Enteris BioPharma Inc.
Exercise, Physical Activity
The Active by Choice Today (ACT) Trial to Increase Physical Activity
The increasing prevalence of obesity in U.S. children and adolescents is a major health threat to our society, especially among minority and low social economic status (SES) populations.
- Conditions
- Exercise, Physical Activity, Obesity
- Trial name
- ACT (NCT01028144)
- Testing
- Physical Activity Program, General Health Program
- Where
- United States
- Volunteers
- 1,422 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Acne Vulgaris
A Study Comparing Tretinoin Gel Microsphere, 0.1% and RETIN-A MICRO ® Gel Microsphere, 0.1% in the Treatment of Acne Vulgaris
To demonstrate the therapeutic equivalence and safety of Tretinoin Gel Microsphere, 0.1% (Taro Pharmaceuticals U.S.A, Inc.) and RETIN-A MICRO® (Tretinoin) Gel Microsphere, 0.1% (Valeant) in the treatment of acne vulgaris.
- Trial name
- NCT04883736
- Testing
- Tretinoin Gel Microsphere, 0.1%, RETIN-A MICRO® (Tretinoin) Gel Microsphere, 0.1%
- Where
- United States
- Volunteers
- 973 people, healthy volunteers welcome
- Sponsor
- Sun Pharmaceutical Industries, Inc.