Clinical trials: Acute Adrenal Insufficiency
Adrenal Insufficiency
Prospective Study on the Incidence of Adrenal Crisis in Patients With Chronic Adrenal Insufficiency
Prospective study to evaluate incidence, causes and potential risk factors for adrenal crisis in patients with chronic adrenal insufficiency.
- Trial name
- NCT01184209
- Where
- 2 sites in Germany
- Volunteers
- 444 people
- Sponsor
- University of Wuerzburg
Septic Shock, Acute Adrenal Insufficiency
Adrenal Insufficiency in Septic Shock
Randomized controlled trial evaluating the duration of steroid replacement therapy in patients with adrenal insufficiency and septic shock.
- Trial name
- NCT00842933
- Testing
- Corticosteroid
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- The Methodist Hospital Research Institute
Digestive Diseases, Adrenal Insufficiency
Adrenal Insufficiency in Critical Emergencies in Digestive Diseases
Observational study about the incidence of relative adrenal insufficiency in patients with cirrhosis and acute variceal bleeding; in patients with acute peptic gastrointestinal bleeding and without liver disease; and in patients…
- Conditions
- Digestive Diseases, Adrenal Insufficiency, Gastrointestinal Bleeding, Variceal Bleeding
- Trial name
- NCT00562445
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Addison Syndrome
Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure
Effects of adrenal steroids is generelly drawn from studies of hypercortisolism. The effects of physiological cortisol substitution and withdrawal is studied and related to the clinical syndrome of adrenal insufficiency.
- Trial name
- NCT00442390
- Testing
- hydrocortisone substitution therapy versus withdrawal
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Adrenal Insufficiency
National Education Programme for Patients With Chronic Adrenal Insufficiency
Even under established replacement therapy, patients with adrenal insufficiency still suffer from impaired quality of life and experience adrenal crises. Patient education is regarded as important preventive measure.
- Trial name
- NCT02694926
- Testing
- Education
- Where
- Germany
- Volunteers
- 528 people
- Sponsor
- Wuerzburg University Hospital
Essential Hypertension, Liver Cancer
A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
The human gut microbiome has been associated with many health factors but variability between studies limits the exploration of effects between them.
- Conditions
- Essential Hypertension, Liver Cancer, Nasopharyngeal Cancer, Pancreatic Cancer
- Trial name
- NCT05638269
- Testing
- no intervention
- Where
- 50 sites in China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Adrenal Insufficiency
Adherence in Chronic Adrenal Insufficiency
Adherence, concerns and satisfaction with information in German patients with adrenal insufficiency as well as the influence of a standardized education program will be assessed by a compared cross-sectional and longitudinal…
- Trial name
- NCT03399383
- Testing
- Patient education
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Wuerzburg University Hospital
Adrenal Insufficiency, Addison's Disease
Survey in Patients With Chronic Adrenal Insufficiency in Germany
The purpose of this survey is to assess patients with chronic primary or secondary adrenal failure regarding subjective health status, incidence and causes of adrenal crisis, hormone replacement regimens and concomitant endocrine…
- Trial name
- NCT00444119
- Where
- 2 sites in Germany
- Sponsor
- University of Wuerzburg
Adrenal Insufficiency
Vaginal Prednisone Administration for Prevention of Adrenal Crisis
Patients with chronic adrenal insufficiency need to adapt their glucocorticoid replacement dose in conditions of physical or psychological stress to prevent life threatening adrenal crisis.
- Trial name
- Vapreda (NCT02689960)
- Testing
- 100mg prednisone suppository
- Volunteers
- 12 people
- Sponsor
- Wuerzburg University Hospital
Adrenal Insufficiency
Study to Investigate Adrenal Crisis (Six-year Follow-up)
Patients with adrenal insufficiency are at risk to suffer from life threatening adrenal crisis. The aim of this trial was to reevaluate the frequency of adrenal crisis and risk factors for crisis within a prospective study…
- Trial name
- NCT03499990
- Volunteers
- 268 people
- Sponsor
- Wuerzburg University Hospital
Adrenal Insufficiency
The Treatment of Adrenal Crisis With Inhaled Prednisolone
Rationale: An adrenal crisis is an acute life-threatening event which may occur in patients with adrenal insufficiency. The initial emergency treatment consists of an intramuscular injection with 100 mg hydrocortisone…
- Trial name
- TRACER (NCT05639127)
- Testing
- Prednisolone
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Acute Hepatitis
ADRENAL FUNCTION IN PATIENTS WITH ACUTE HEPATITIS
A high frequency of adrenal dysfunction (AD) has been reported in severe acute hepatitis (SAH) using the dosage of serum total cortisol (STC).
- Trial name
- CORT-HEPAT (NCT02859584)
- Testing
- Measure OF SERUM TOTAL CORTISOL, SERUM FREE AND SALIVARY CORTISOL
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Liver Cirrhosis, Acute Kidney Injury
RAI & HRS: Relationship Between Relative Adrenal Insufficiency and Failure of Treatment in Hepatorenal Syndrome
Hepatorenal syndrome is a life-threatening medical condition and a serious complication of advanced liver scarring (cirrhosis). It consists of a deterioration of the function of the kidneys caused by a severe alteration in the…
- Conditions
- Liver Cirrhosis, Acute Kidney Injury, Hepato-Renal Syndrome
- Trial name
- NCT04273750
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University Hospital Plymouth NHS Trust
Adrenal Insufficiency
Management of Adrenal Emergency in Germany
The management of adrenal crisis is often problematic and the time to adequate treatment is frequently delayed.The aim of the study is to evaluate the management of adrenal emergencies requiring parenteral glucocorticoid…
- Trial name
- MAdEy (NCT03426332)
- Testing
- No intervention
- Volunteers
- 150 people
- Sponsor
- Wuerzburg University Hospital
Hematologic Malignancies, Inborn Errors of Metabolism Disorders
Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood Transplants
The objective of this study is to make T-cell depleted stem cells from a family member who is a half match (haplo-identical) available on an expanded access basis to patients receiving one or two unrelated cord blood transplants…
- Conditions
- Hematologic Malignancies, Inborn Errors of Metabolism Disorders, Immune Deficiencies
- Trial name
- NCT01881334
- Testing
- CliniMACS CD34 Reagent System
- Where
- United States
- Sponsor
- Joanne Kurtzberg, MD
Acute Respiratory Distress Syndrome, Adrenal Insufficiency
Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS)
The purpose of this study is to see if stress doses of hydrocortisone improve early outcome in patients who are in early stage of ARDS and with relative adrenal insufficiency.
- Trial name
- NCT00773058
- Testing
- hydrocortisone
- Volunteers
- 100 people
- Sponsor
- Southeast University, China
Leukemia, Myeloid, Acute, Leukemia, B-cell
Precision Exercise in Children With Malignant Hemopathies
In the early years of life and during adolescence, physical activity is crucial for good development of motor skills. It is even more so for those children and young people who are forced to undergo anti-cancer therapies and…
- Conditions
- Leukemia, Myeloid, Acute, Leukemia, B-cell, Leukemia, T Cell, Lymphoma, Hodgkin
- Trial name
- SportTherapy (NCT04090268)
- Testing
- Sport Therapy
- Where
- Italy
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Adrenal Insufficiency, Leukemia, Lymphoblastic, Acute, Pediatric
A Swiss Assessment of Hypothalamic-pituitary-adrenal Axis Suppression After Glucocorticoid Therapy for Leukemia and Lymphoblastic Lymphoma in Children
Plain Language Summary: Background Glucocorticoids are stress hormones produced by the human body to control inflammation and regulate the immune system. Cortisol is the most well-known example of a glucocorticoid.
- Conditions
- Adrenal Insufficiency, Leukemia, Lymphoblastic, Acute, Pediatric, Lymphoma, Lymphoblastic
- Trial name
- LeukemiaCort (NCT06861530)
- Where
- 2 sites in Switzerland
- Volunteers
- 40 people
- Sponsor
- University Children's Hospital Basel
Adrenal Insufficiency
Predisposing Factors for the Incidence of Adrenal Crisis
Within this clinical study patients with chronic adrenal insufficiency will be investigated by clinical and biochemical examination as well as questionnaire to identify predisposing factors for adrenal crisis.
- Trial name
- PIA (NCT03410160)
- Testing
- Clinical and biochemical examination.
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- Wuerzburg University Hospital
Mucopolysaccharidosis I, Mucopolysaccharidosis VI
Human Placental-Derived Stem Cell Transplantation
The purpose of this clinical trial is to investigate the safety of human placental-derived stem cells (HPDSC) given in conjunction with umbilical cord blood (UCB) stem cells in patients with various malignant or nonmalignant…
- Conditions
- Mucopolysaccharidosis I, Mucopolysaccharidosis VI, Adrenoleukodystrophy, Niemann-Pick Disease
- Trial name
- HPDSC (NCT01586455)
- Testing
- Human Placental Derived Stem Cell
- Where
- 3 sites in United States
- Volunteers
- 43 people
- Sponsor
- New York Medical College