Clinical trials: Acute Anterior ST-Segment Elevation Myocardial Infarction
Myocardial Ischemia, Acute Coronary Syndrome
EARLY ACS: Early Glycoprotein IIb/IIIa Inhibition in Patients With Non-ST-segment Elevation Acute Coronary Syndrome (Study P03684AM2)(COMPLETED)
The purpose of this study is to see if early INTEGRILIN® (eptifibatide) therapy in patients with non-ST-segment elevation acute coronary syndrome (ACS) reduces the occurence of death, heart attack and urgent cardiac intervention…
- Trial name
- NCT00089895
- Testing
- Eptifibatide (Integrilin)
- Volunteers
- 9,406 people
- Sponsor
- Organon and Co
Acute Myocardial Infarction, STEMI
Evaluation in STEMI Patients Using FDY-5301
To assess the effect of FDY-5301 on cardiovascular mortality and acute heart failure events in subjects with an anterior STEMI undergoing pPCI.
- Conditions
- Acute Myocardial Infarction, STEMI, Percutaneous Coronary Revascularization
- Trial name
- IOCYTE AMI-3 (NCT04837001)
- Testing
- FDY-5301
- Where
- 52 sites in United States, Canada and 4 more
- Volunteers
- 2,351 people
- Sponsor
- Faraday Pharmaceuticals, Inc.
STEMI, Anterior MI
Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) in Acute Myocardial Infarction
The objective of this study is to assess efficacy and safety of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) therapy started post flow restoration but prior to stenting during percutaneous coronary…
- Trial name
- PiCSO-AMI-I (NCT03625869)
- Testing
- PiCSO
- Where
- 17 sites in Denmark, France and 4 more
- Volunteers
- 145 people
- Sponsor
- Miracor Medical SA
ST Elevated Myocardial Infarction
Rituximab in Patients With ST-elevation Myocardial Infarction
The main objective is to compare the effect of a single injection of two doses of rituximab versus placebo on 6 months left ventricular systolic function, using CMR, in patients who have had an acute anterior STEMI.
- Trial name
- RITA-MI2 (NCT05211401)
- Testing
- Active arm 1000 mg
- Where
- France
- Volunteers
- 372 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Myocardial Infarction, ST Elevation Myocardial Infarction
A Study of the Safety and Efficacy of Injectable Thymosin Beta 4 for Treating Acute Myocardial Infarction
The objective of this study is to evaluate the safety and tolerability of two active doses of RGN-352 (thymosin beta 4, Tβ4, Injectable Solution) in patients with acute myocardial infarction receiving percutaneous coronary…
- Conditions
- Acute Myocardial Infarction, ST Elevation Myocardial Infarction, STEMI
- Trial name
- NCT01311518
- Testing
- Drug: Injectable Thymosin beta 4
- Sponsor
- RegeneRx Biopharmaceuticals, Inc.
Acute Myocardial Infarction (AMI), Acute Myocardial Infarction of Anterior Wall
Recombinant Human Thymosin Beta 4 for Injection(NL005) for Acute Myocardial Infarction
The goal of this phase IIc clinical trial is to learn if recombinant human thymosin beta 4 injection (NL005) works to treat heart damage in people who have had a serious type of heart attack called ST-segment elevation myocardial…
- Conditions
- Acute Myocardial Infarction (AMI), Acute Myocardial Infarction of Anterior Wall, Acute Myocardial Infarction With ST Elevation, Acute Myocardial Infarction of Left Ventricle
- Trial name
- NCT07586865
- Testing
- Recombinant Human Thymosin Beta 4 Injection (NL005)
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Beijing Northland Biotech. Co., Ltd.
Acute Anterior ST-Segment Elevation Myocardial Infarction
A Research Study to Evaluate the Efficacy and Safety of SGC001 in Patients With Anterior Wall ST-Segment Elevation Myocardial Infarction
This is a multicenter, randomized, double-blind, placebo-controlled, single-dose, Phase II clinical study to evaluate the efficacy, safety, and pharmacokinetic (PK) characteristics of SGC001 injection administered in addition to…
- Trial name
- NCT07306182
- Testing
- SGC001 injection
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Beijing Sungen Biomedical Technology Co., Ltd
Myocardial Infarction, Myocardial Reperfusion Injury
Efficacy of Endovascular Catheter Cooling Combined With Cold Saline for the Treatment of Acute Myocardial Infarction
The purpose of this study is to determine whether treatment of patients suffering from ST-elevation myocardial infarction (STEMI) with 1-2 liters of cold saline and central venous catheter cooling with Philips InnerCool RTx…
- Conditions
- Myocardial Infarction, Myocardial Reperfusion Injury, Anterior Wall Myocardial Infarction, Inferior Wall Myocardial Infarction
- Trial name
- CHILL-MI (NCT01379261)
- Testing
- Cooling
- Where
- 10 sites in Austria, Denmark and 2 more
- Volunteers
- 120 people
- Sponsor
- Region Skane
Acute Myocardial Infarction, STEMI
Delivery SSO2 Therapy for 60 Min in Anterior MI Patients With PCI ≤ 6 Hours of Symptoms Onset Compared to Standard.
A multi-center randomized post-approval evaluation of delivery of intracoronary hyperoxemic supersaturated Oxygen therapy for 60 minutes in anterior AMI patients with successful reperfusion (via PCI) within 6 hours after onset of…
- Trial name
- NCT04743245
- Testing
- TherOx DownStream System, PCI
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- TherOx
ST Elevation Myocardial Infarction, Heart Failure
Effect of Levosimendan on Left Ventricular Systolic Function and Heart Failure After PCI in Patients With Acute Anterior Myocardial Infarction
Reperfusion therapy for acute ST segment elevation myocardial infarction (STEMI) can significantly reduce mortality, but patients may still have heart failure and adverse cardiovascular events due to massive myocardial loss.
- Trial name
- NCT04970238
- Testing
- Levosimendan
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhijun Sun
Left Ventricular Thrombus
Relation of Laboratory Indices to Left Ventricular Thrombus Formation in Patients With Acute Anterior ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention or Thrombolytic Therapy
to find the relationship between the different hematological indices including platelet indices, and blood cell ratios, to the development of LV thrombus in acute anterior STEMI patients managed by primary percutaneous coronary…
- Trial name
- NCT06152939
- Testing
- Primary percutaneous coronary intervention or thrombolytic therapy
- Volunteers
- 400 people
- Sponsor
- Assiut University
Myocardial Infarction, Acute, Myocardial Infarction First
MSCs for Prevention of MI-induced HF
Results from recent clinical trials on bone marrow mononuclear cell (BM-MNC) transplantation show that this intervention can help reduce the incidence of heart failure (HF) after acute myocardial infarction (AMI).
- Conditions
- Myocardial Infarction, Acute, Myocardial Infarction First, Myocardial Infarction, Anterior Wall, Cardiac Remodeling, Ventricular
- Trial name
- PREVENT-TAHA8 (NCT05043610)
- Testing
- Umbilical Cord-Derived Wharton's Jelly Mesenchymal Stem Cells (WJ-MSCs), Conventional Treatment
- Where
- 3 sites in Iran
- Volunteers
- 420 people
- Sponsor
- Shiraz University of Medical Sciences
Myocardial Infarction
AMI-DC in Patients With Anterior Wall Myocardial Infarction
The purpose of this trial is to assess the safety of AMI-DC treatment. The participants who voluntarily sign the consent form will be screened according to the inclusion/exclusion criteria then allocated either to the…
- Trial name
- AMI-DC (NCT05554484)
- Testing
- Autologous peripheral blood-derived tolerogenic dendritic cells
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- The Catholic University of Korea
Acute Myocardial Infarction With ST Segment Elevation
3 Nehb Precordial Leads Anterior, Dorsalis and Inferior Allow Accurate Diagnostics of Different Heart Conditions
The method of ECG recording with the use of three bipolar leads A (anterior), D dorsalis) and J (or I - inferior) was introduced in 1938 by German electrophysiologist W. Nehb.
- Trial name
- Nehb-STEMI (NCT00623896)
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Acute Anterior ST-Segment Elevation Myocardial Infarction
Prophylactic IABP in Delayed-Presentation Anterior STEMI
PROACTIVE-AMI is a prospective, multicenter, randomized, open-label trial with blinded endpoint adjudication evaluating whether prophylactic intra-aortic balloon counterpulsation (IABP) initiated before primary percutaneous…
- Trial name
- PROACTIVE-AMI (NCT07761455)
- Testing
- Intra-Aortic Balloon Pump, Primary Percutaneous Coronary Intervention
- Where
- 4 sites in China
- Volunteers
- 504 people
- Sponsor
- Qilu Hospital of Shandong University
Acute Anterior ST Segment Elevation Myocardial Infarction
Effect of Nivolumab vs Placebo in Patients With Acute Myocardial Infarction: A Randomized Clinical Trial
Myocardial infarction (MI) is a major contributor to morbidity and mortality in China. The goal of this interventional, randomised controlled clinical trial is to evaluate the effectiveness and safety of a single administration…
- Trial name
- NCT05887830
- Testing
- Nivolumab
- Volunteers
- 96 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Anterior Myocardial Infarction
The INFUSE - Anterior Myocardial Infarction (AMI) Study
This is a multicenter, open-label, controlled, single-blind, randomized study with up to 452 subjects enrolled in up to 50 US and European sites.
- Trial name
- NCT00976521
- Testing
- Abciximab local infusion, No local infusion, Thrombus aspiration
- Where
- 38 sites in United States, Austria and 4 more
- Volunteers
- 452 people
- Sponsor
- Atrium Medical Corporation
Acute Myocardial Infarction With ST Elevation, Anterior Wall Myocardial Infarction
Deferred Stenting in Patients With Anterior Wall STEMI
Trial Name) Impact of Immediate SteNt ImplaNtatiOn Versus Deferred Stent ImplAntaTION on Clinical Outcomes in Patients with AnteRior Wall ST-segment Elevation Myocardial Infarction (INNOVATION-CORE) Objectives) To evaluate the…
- Trial name
- INNOVATIONCORE (NCT03744000)
- Testing
- Immediate stenting, Deferred stenting
- Where
- South Korea
- Volunteers
- 185 people
- Sponsor
- Korea University Anam Hospital
AMI
Effect of Lantus and Apidra in Patients With Acute ST Elevation Myocardial Infarction
Primary objective: To demonstrate that in hyperglycemic subjects with anterior STEMI (ST Elevation Myocardial Infarction) undergoing Percutaneous Coronary Intervention (PCI), tight glycemic control using insulin glulisine and…
- Trial name
- INTENSIVE (NCT00670228)
- Testing
- Insulin Glargine (LANTUS), Insulin Glulisine (Apidra), Standard Therapy
- Where
- 5 sites in United States, Argentina and 3 more
- Volunteers
- 34 people
- Sponsor
- Sanofi
Vascular Diseases, Cardiovascular Diseases
Changes in Myocardial Biomechanics and Early Short-term Doxycycline Therapy in Patients With Primary Anterior STEMI
The purpose of the study is to investigate the changes of myocardial biomechanics and efficacy of doxycycline in patients with primary anterior STEMI.
- Conditions
- Vascular Diseases, Cardiovascular Diseases, Acute Myocardial Infarction
- Trial name
- MASTARD (NCT02562651)
- Testing
- Doxycycline, Standard care for STEMI
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Russian Academy of Medical Sciences