Clinical trials: Acute Blood Loss Anemia
Acute Blood Loss Anemia, Osteoarthritis, Knee
Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty
This study aims to assess postoperative blood loss and transfusion rates in total knee replacement after one-time administration of topical tranexamic acid.
- Trial name
- NCT01370460
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Henry Ford Health System
Postpartum Hemorrhage, Uterine Atony
Uterine Cooling During Cesarean Delivery to Reduce Blood Loss and Incidence of Postpartum Hemorrhage
The objective of the study is to demonstrate whether cooling the uterine smooth muscle during cesarean section (following delivery of the fetus) will promote better uterine contraction and involution resulting in lower blood…
- Trial name
- NCT02229513
- Testing
- Uterine Cooling
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Acute Myeloid Leukemia, Neutropenia
UCMSC-Exo for Chemotherapy-induced Myelosuppression in Acute Myeloid Leukemia
The purpose of the study is to explore the safety and efficacy of UCMSC-Exo in consolidation chemotherapy-induced myelosuppression in patients with acute myeloid leukemia after achieving complete remission.
- Conditions
- Acute Myeloid Leukemia, Neutropenia, Anemia, Thrombocytopenia
- Trial name
- NCT06245746
- Testing
- umbilical cord derived mesenchymal stem cells exosomes (UCMSC-Exo)
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Acute Posthemorrhagic Anemia
Study to Evaluate Efficacy and Safety of BGE-117 in Moderately to Severely Anemic Older Individuals After Major Hip Surgery
The purpose of this study is to explore the safety and tolerability of BGE-117 and gain information on the effectiveness of different doses when given to patients 65 years or older with moderate to severe anemia following major…
- Trial name
- NCT05152641
- Testing
- BGE-117, 4mg, Ferrous Sulfate, BGE-117, 12mg
- Where
- Australia
- Sponsor
- BioAge Labs, Inc.
Acute Leukemia, Acute Myeloid Leukemia (AML)
Biomarkers in Patients With Anemia-Induced Thrombocytopenic Bleeding
This pilot study aims to gather preliminary evidence on how different hemoglobin levels impact blood biomarkers related to bleeding. The feasibility of conducting a future larger clinical trial will also be assessed.
- Conditions
- Acute Leukemia, Acute Myeloid Leukemia (AML), Acute Lymphocytic Leukaemia
- Trial name
- BAIT (NCT06947044)
- Testing
- RBC transfusion strategy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Donald Arnold
Postoperative Hemorrhage, Postoperative Anemia
Autologous Whole Blood Management for Transfusion Reduction in Adult Cardiac Surgery Patients
The goal of this pilot trial is to test a protocol for a planned Canada-wide clinical trial looking at whether or not the use of a patients own blood works as good as the current standard of care using donated blood products to…
- Conditions
- Postoperative Hemorrhage, Postoperative Anemia, Postoperative Blood Loss
- Trial name
- NCT05889494
- Testing
- Autologous Whole Blood Management, Standard Care involving allogenic and/or derivative transfusion.
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Hematopoietic Stem Cell Transplantation (HSCT), Acute Myeloid Leukemia (AML)
High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT)
The High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT) study is the first prospective real-world cohort of hematologic diseases and transplantation in the Qinghai-Tibet Plateau.
- Conditions
- Hematopoietic Stem Cell Transplantation (HSCT), Acute Myeloid Leukemia (AML), Leukemias, Acute Myeloid, Myeloid Leukemias, Acute
- Trial name
- HALO-SCT (NCT07205523)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Yigeng Cao,MD,PhD
Subarachnoid Hemorrhage
Correlation of Various Laboratory Parameters With Outcome in Patients Suffering From Acute Non-traumatic Subarachnoid Hemorrhage - Prospective Case Series
In this prospective study, the investigators aim to investigate the effect of the following three factors on the development of vasospasm and patient outcome: (1.) the role of anemia; (2.) the role of plasma fibrinolytic…
- Trial name
- NCT05403970
- Where
- Hungary
- Volunteers
- 300 people
- Sponsor
- University of Debrecen
Trauma Injury, Trauma
The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery.
- Conditions
- Trauma Injury, Trauma, Critical Illness, Microbiome
- Trial name
- NCT06606119
- Testing
- Data and tissue collection
- Where
- 3 sites in United States
- Volunteers
- 275 people
- Sponsor
- University of Florida
Surgery, Blood Loss, Surgical
Investigation of the Transfusion Practices in Surgical Patients in Turkey
The aim of this study is to describe the transfusion practices in patients undergoing major surgery in Turkey. The transfusion rates of red blood cells (RBC), fresh frozen plasma (FFP) and platelets; the transfusion predictors…
- Conditions
- Surgery, Blood Loss, Surgical, Blood Loss Anemia, Blood Transfusion
- Trial name
- CeKATU (NCT03468738)
- Testing
- Blood transfusion
- Where
- 61 sites in Turkey (Türkiye)
- Volunteers
- 6,481 people
- Sponsor
- Diskapi Teaching and Research Hospital
Acute Blood Loss Anemia, Fracture
Single-dose Intravenous Iron Therapy for Anemia After Orthopaedic Trauma
Acute blood loss in orthopaedic trauma and operative fracture care contributes substantially to perioperative anemia, which places participants at increased risk for complications including surgical site infection, cardiovascular…
- Trial name
- NCT05292001
- Testing
- Iron-Dextran Complex Injection [InFed]
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Oregon Health and Science University
Blood Loss, Surgical, Blood Loss Anemia
Oral and Intravenous Tranexamic Acid in Lumbar Spine Surgery
The purpose of this project is to compare the effectiveness of two different but well accepted routes of administration of tranexamic acid in order to reduce blood loss and need for transfusion in patients undergoing lumbar spine…
- Trial name
- NCT03037515
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Revision Total Knee Arthroplasty, Revision Total Hip Arthroplasty
Tranexamic Acid in Revision Total Joint Arthroplasty
To determine the optimal dosing regimen and route of administration of tranexamic acid (TXA) [single dose intravenous (IV), double dose intravenous, intravenous + topical, and oral repeated dosing] to minimize post-operative…
- Conditions
- Revision Total Knee Arthroplasty, Revision Total Hip Arthroplasty, Acute Blood Loss Anemia
- Trial name
- NCT02877381
- Testing
- Revision Total Knee Arthroplasty (TKA), Revision Total Hip Arthroplasty (THA)
- Where
- 3 sites in United States
- Volunteers
- 175 people
- Sponsor
- Rush University Medical Center
Multiple Myeloma, Acute Myeloid Leukemia
National Longitudinal Cohort of Hematological Diseases
Background Hematological diseases are disorders of the blood and hematopoietic organs. The current hematological cohorts are mostly based on single-center or multi-center cases, or cohorts with limited sample size in China.
- Conditions
- Multiple Myeloma, Acute Myeloid Leukemia, Hemophilia, Hemophilia A
- Trial name
- NICHE (NCT04645199)
- Where
- China
- Volunteers
- 2,300 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Blood Loss Anemia
Small-Volume Tubes to Reduce Anemia and Transfusion (STRATUS)
STRATUS will evaluate the use of small-volume ("soft-draw") blood collection tubes for laboratory testing in reducing anemia and transfusion in intensive care unit patients without significant adverse consequences.
- Trial name
- NCT03284944
- Testing
- Small-Volume, Standard-Volume
- Where
- Canada
- Volunteers
- 369 people
- Sponsor
- Population Health Research Institute
Hemorrhagic Shock, Acute Blood Loss Anemia
Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
Adult male patients brought to the emergency department as Level A trauma activations who are receiving emergency blood transfusion. Objectives 1.
- Conditions
- Hemorrhagic Shock, Acute Blood Loss Anemia, Traumatic Brain Injury
- Trial name
- NCT05081063
- Testing
- Routine labs
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- Loma Linda University
Anemia, Blood Loss Anemia
Patient Blood Management In CARdiac sUrgical patientS
Nowadays up to 40% of patients undergoing cardiac surgery receives at least 1 unit of red blood cell transfusion during surgery or during the first week after surgery.
- Conditions
- Anemia, Blood Loss Anemia, Iron-deficiency, Iron Deficiency Anemia
- Trial name
- ICARUS (NCT04744181)
- Testing
- Ferric carboxymaltose, B vitamin, Folic acid
- Where
- Italy
- Volunteers
- 479 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Upper Gastrointestinal Bleeding
Awareness of Iron Status Evaluation in UGIB
BACKGROUND: Data on the awareness of the need to evaluate iron status and IDA prevalence in acute UGIB are limited. OBJECTIVES: This study aimed to investigate the rate of evaluation of iron status and prevalence of iron…
- Trial name
- AISE (NCT06299007)
- Where
- Thailand
- Volunteers
- 867 people
- Sponsor
- Hat Yai Medical Education Center
Acute Blood Loss Anemia, Osteoarthritis, Hip
Topical Tranexamic Acid and Acute Blood Loss in Total Hip Arthroplasty
This study aims to assess postoperative blood loss and transfusion rates in total hip replacement after one-time administration of topical tranexamic acid.
- Trial name
- NCT01683955
- Testing
- Tranexamic acid
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- Henry Ford Health System
Mucositis, Graft-versus-host Disease
Tacrolimus and Mycophenolate Mofetil (MMF) in GVHD Prophylactic Regimen Compared to Tacrolimus and Methotrexate (MTX
A comparative trial where all patients will receive daily doses of tacrolimus (TAC) until day +60 when tapering will begin, in the absence of graft-versus-host disease (GVHD), and discontinued by day +180.
- Trial name
- NCT00360685
- Testing
- Tac+MTX, TAC + MMF
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute