Clinical trials: Acute Brain Injuries, open to volunteers
Acute Ischemic Stroke, Cerebral Infarction
Safely Quenching Complement in Stroke Survivors
This study will include adults (ages 18-80) who have had a stroke caused by a large blood clot blocking blood flow in the brain.
- Trial name
- SUCCESS (NCT07495722)
- Testing
- Pegcetacoplan Injection [Empaveli]
- Volunteers
- 20 people
- Sponsor
- Columbia University
Acute Brain Injury Coma, Neurocritical Care
Development and Validation of a Prognostic Model for Neurocritical Patients Using Multimodal Brain Monitoring
This study aims to develop and validate a prognostic model for neurocritical patients using multimodal brain monitoring data. By combining data from various monitoring techniques such as EEG, TCD, and NIRS, this model will help…
- Conditions
- Acute Brain Injury Coma, Neurocritical Care, Cerebral Infarction, Intracranial Hemorrhages
- Trial name
- NCT07115459
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Post-Concussion Syndrome, COVID Long-Haul
Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)
The purpose of this study is to test the effect of Auricular Percutaneous Electrical Nerve Field Stimulation (a Neurostim device) on children with pain and Post Concussion symptoms.
- Conditions
- Post-Concussion Syndrome, COVID Long-Haul, COVID-19
- Trial name
- NCT04978571
- Testing
- percutaneous electrical nerve-field stimulation, PENFS, percutaneous electrical nerve-field stimulation, PENFS (COVID active device)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Children's Hospital of Orange County
Acute Renal Failure, Neonatal Morbidity
SafeBoosC-IIIv - Does Cerebral Oximetry Monitoring Affect Renal Outcomes
Cerebral oximetry monitoring allows clinicians to optimize blood flow to the brain and oxygenation using the SafeBoosC treatment guideline. The guideline's interventions aims to stabilize blood pressure and oxygen levels.
- Trial name
- SBIIIvR (NCT06926946)
- Testing
- Intervention Arm- Cerebral Oximetry + Treatment Guideline
- Where
- India
- Volunteers
- 1,000 people
- Sponsor
- St. John's Research Institute
Neurogenic Dysphagia, Traumatic Brain Injury
Register Study: Implementation of Pharyngeal Electrostimulation Therapy for the Treatment of Acute Neurogenic Dysphagia
Neurogenic dysphagia occurs with disruption of neurological systems or processes involved in the execution of coordinated and safe swallowing.
- Conditions
- Neurogenic Dysphagia, Traumatic Brain Injury, Stroke, Dysphagia
- Trial name
- R:IphEst (NCT05190718)
- Testing
- Pharyngeal electrostimulation
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Karl Landsteiner University of Health Sciences
Sepsis, Septic Shock
Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients
NUROPI is a single-centre, prospective, non-interventional study in the Intensive Care Unit (ICU) of Erasme Hospital (Hôpital Universitaire de Bruxelles, Brussels, Belgium).
- Conditions
- Sepsis, Septic Shock, Cardiac Arrest (CA), Pancreatitis
- Trial name
- NuROPI (NCT07184593)
- Testing
- Plasma H3.1 nucleosome measurement
- Volunteers
- 1,000 people
- Sponsor
- Erasme University Hospital
Stroke, Acute Ischemic Stroke
Head Cooling in Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy (COOLHEAD-2b)
COOLHEAD-2b is a multicentre, phase 2, prospective, randomised, controlled, open-label, blinded-endpoint trial evaluating the safety and efficacy of non-invasive convective head cooling as an adjunct to endovascular thrombectomy…
- Conditions
- Stroke, Acute Ischemic Stroke, Brain Ischemia, Ischaemic Stroke
- Trial name
- COOLHEAD-2B (NCT07526649)
- Testing
- Non-invasive convective head cooling, Standard of Care (SOC)
- Where
- New Zealand
- Volunteers
- 182 people
- Sponsor
- Auckland City Hospital
Delirium - Postoperative, Postoperative Cognitive Dysfunction (POCD)
Value of the Time-Weighted Average (TWA) of Mean Arterial Pressure (MAP) and Cerebral Oximetry (rSO₂) as Predictors of Postoperative Tissue Perfusion Impairment in Patients Undergoing Cardiac Surgery
Neurological problems after heart surgery are common and include confusion, memory loss, and difficulty thinking clearly. These issues may appear hours or days after surgery and can negatively affect recovery.
- Conditions
- Delirium - Postoperative, Postoperative Cognitive Dysfunction (POCD), Postoperative Acute Kidney Injury, Postoperative Morbidity
- Trial name
- NCT07510711
- Testing
- Continuous intraoperative monitoring of MAP and rSO₂; observational study with no therapeutic intervention.
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pediatric Traumatic Brain Injury
Extradural Hematoma in Pediatrics After Acute Head Injury: Surgical and Clinical Outcome
Acute extradural hematoma (EDH) is a potentially life-threatening neurosurgical emergency in children, commonly resulting from traumatic head injury.
- Trial name
- NCT07696598
- Testing
- evacuation of hematoma
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University
Brain Injury, Acute
Non-Invasive Monitoring Methods in Patients With Acute Brain Injury
Life-threatening mass effect (LTME) arises when brain swelling displaces or compresses crucial midline structures subsequent to acute brain injuries (ABIs) like traumatic brain injury (TBI), ischemic stroke (IS), and…
- Trial name
- NIMABI (NCT06504238)
- Where
- United States
- Volunteers
- 720 people
- Sponsor
- Boston Medical Center
Concussion (Diagnosis), Gait Abnormality
Supplementary Neuromuscular Rehabilitation During Acute Concussion Recovery
Approximately 1.6 to 3.8 million mild traumatic brain injuries, or concussions, occur yearly in the United States. Although most individuals progress through return-to-activity (RTA) using symptom-guided aerobic and functional…
- Trial name
- NCT07801482
- Testing
- Exercise, Return to Activity Progression
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northern Illinois University
Acute Neurological Injury, Acute Medical Conditions
Transcutaneous Auricular Vagus Enhanced Recovery in the NeuroICU
This study will demonstrate the impact of taVNS on reducing adverse events in NeuroICU patients, determine if taVNS reduces length of stay, and quantify the economic benefits of taVNS implementation in a broader neurocritical…
- Trial name
- TAVERN (NCT07219108)
- Testing
- Auricular Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Washington University School of Medicine
Amputation, Traumatic, Pain, Phantom
Feasibility of Using an App for Managing Phantom Limb Pain Associated with Combat Injury in Ukraine (PAMELA)
In Ukraine, since the beginning of the full-scale war on February 24, 2022, a large number of individuals have lost a limb(s). Many of these amputees cannot access appropriate care in terms of pain management and rehabilitation.
- Conditions
- Amputation, Traumatic, Pain, Phantom, Pain, Acute, Pain, Chronic
- Trial name
- PAMELA (NCT06604507)
- Testing
- non-pharmacological app
- Where
- 5 sites in Ukraine
- Volunteers
- 200 people
- Sponsor
- Winfried Meißner
Traumatic Brain Injury
Sovateltide for the Treatment of Acute Traumatic Brain Injury
Traumatic brain injury (TBI) remains a leading cause of global disability, yet current clinical management is limited to supportive care and pressure stabilization using hyperosmolar therapies like mannitol and hypertonic saline.
- Trial name
- RESTORE-TBI (NCT07861126)
- Testing
- Sovateltide
- Volunteers
- 214 people
- Sponsor
- Pharmazz, Inc.
Stroke, Acute, Traumatic Brain Injury
Natural Evolution of Muscle Structure and Stiffness Following Brain Lesion
We propose to carry out a single center, prospective, interventional trial to assess the natural evolution of lower limb muscle structure and muscle stiffness of hemiparetic patients following brain damage.
- Trial name
- Navomuss (NCT06718608)
- Testing
- imaging
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Neurologic Decompensation, Acute, Traumatic Brain Injury
Ventilatory Parameters in Acute Neurological Injury
The goal of this observational study is to test the association between baseline ventilatory parameters (in particular mechanical power (MP), mechanical power normalized to predicted body weight (MP/PBW) and driving pressure (DP)…
- Conditions
- Neurologic Decompensation, Acute, Traumatic Brain Injury, Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT06192342
- Where
- Argentina
- Volunteers
- 19 people
- Sponsor
- Ramos Mejía Hospital
Traumatic Brain Injury, Intracranial Hemorrhages
Efficacy and Feasibility Trial of a Portable Near Infra-Red Hematoma Imager (NIRD-HI)
Traumatic Brain Injury (TBI) is a leading cause of death and disability among military personnel, Veterans, and civilians. One of the most dangerous complications of moderate-to-severe TBI is intracranial hemorrhage (ICH).
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Combat Casualty Care, Point of Care
- Trial name
- NIRD-HI (NCT07338383)
- Testing
- NIRD-HI scan at the time of enrollment, Secondary NIRD-HI scan when a planned repeat CT is performed
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Geneva Foundation
Fibrinogen, Albumin
Fibrinogen-to-Albumin Ratio as a Predictor of Acute Respiratory Distress Syndrome in Traumatic Brain Injury
this study aims to assess the ability of fibrinogen-to-albumin ratio to predict the development of Acute respiratory distress syndrome in traumatic brain injury patients.
- Conditions
- Fibrinogen, Albumin, ARDS, TBI (Traumatic Brain Injury)
- Trial name
- FARDS (NCT07664358)
- Testing
- Fibrinogen-to-albumin ratio
- Where
- Egypt
- Volunteers
- 350 people
- Sponsor
- Tanta University
Acute Ischemic Stroke
Rapid Local Ischemic Postconditioning on Stroke After Thrombectomy
The main goal of this study is to find out if a new, quick "brain rescue" procedure can help people recover better from a severe stroke caused by a large vessel occlusion.
- Trial name
- RAPIDIMPROVE (NCT07598799)
- Testing
- High-dose RL-IPostC, Low-dose RL-IPostC
- Where
- China
- Volunteers
- 448 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Mechanical Ventilator Weaning, Acute Brain Injury
Brain-injured Patients Extubation Readiness Study
The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.
- Conditions
- Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation
- Trial name
- Biper (NCT04080440)
- Testing
- Extubation readiness clinical score, Usual Care
- Where
- 21 sites in France
- Volunteers
- 660 people
- Sponsor
- University Hospital, Clermont-Ferrand