Clinical trials: Acute Calculous Cholecystitis
Cholecystitis, Acute
PT-GBD to EUS-GBD Conversion Versus Standard Management in High-Risk Acute Cholecystitis Patients
Acute cholecystitis in high-risk surgical patients is commonly managed with percutaneous trans-hepatic gallbladder drainage (PT-GBD).
- Trial name
- EPIC-GBD (NCT07575360)
- Testing
- EUS-GUIDED INTERNALIZATION OF PERCUTANEOUS CHOLECYSTOSTOMY (EPIC-GBD), Standard cholecystostomy (PT-GBD) management
- Where
- Italy
- Volunteers
- 484 people
- Sponsor
- University of Bologna
Cholecystitis, Acute, Cholecystitis, Chronic
Study of Pain Perception Between Males and Females Following Laparoscopic Cholecystectomy
This study looks at the differences in inflammatory mediators in gallbladder tissue between males and females and the possibility that these differences contribute to a higher perception of post-operative pain in females…
- Trial name
- NCT00575276
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Acute Cholecystitis
Cholecystectomy Could be Performed in Older Adults With Acute Cholecystitis
The goal of this retrospective cohort observational study is to learn about the long-term and short-term effects of cholecystectomy in people aged 80 or over the age of 80, who have mild to moderate acute cholecystitis.
- Trial name
- NCT06601855
- Testing
- Cholecystectomy
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Acute Cholecystitis
External Validation os the ACME Scoring System
Acute calculous cholecystitis (ACC) is the second most frequent surgical condition in emergency departments. The recommended treatment is surgical treatment (ST) and the accepted mortality is <1%, but in severe and/or fragile…
- Trial name
- ACME_2 (NCT06228027)
- Volunteers
- 10,000 people
- Sponsor
- Hospital del Mar
Gallbladder Inflammation
Vitamin C Efficacy in Reducing Post Operative Pain
Opioids are the corner stone in the treatment of post operative pain. Because of the several side effects of opiods, non-steroidal anti-inflammatory drugs are usually added postoperatively to decrease the total requirements of…
- Trial name
- NCT01322061
- Testing
- Ascorbic Acid
- Where
- Lebanon
- Volunteers
- 80 people
- Sponsor
- American University of Beirut Medical Center
Acute Cholecystitis
A Randomized Controlled Trial on EGBD vs PC for Acute Cholecystitis.
Acute cholecystitis commonly occurs in elderly patients that are high-risk candidates for surgery. Percutaneous cholecystostomy (PC) is frequently employed for gallbladder drainage in these patients.
- Trial name
- DRAC (NCT02212717)
- Testing
- EUS-guided gallbladder drainage (EGBD), Percutaneous cholecystostomy (PC)
- Where
- 4 sites in China, Japan and 1 more
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Fluorenscent Image Guided Surgery, Indocyanide Green
Intra-gallbladder or Systemic Indocyanide Green Injection Facilitate Cholecystectomy.
The investigators will collect the pre-operative medical history and arrange physical examination, life quality evaluation, blood and biochemical test.
- Trial name
- NCT03024892
- Testing
- ICG GB, ICG IV, LC conventional
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- Chang Gung Memorial Hospital
Cholecystitis, Acute
Percutaneous Drainage Versus EUS-guided Gallbladder Drainage in Poor Surgical Patients With Cholecystitis
The goal of this clinical trial is to learn if endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) works better than percutaneous gallbladder drainage (PT-GBD) for people with acute cholecystitis (inflammation of the…
- Trial name
- EUSCAPE (NCT07792486)
- Testing
- Endoscopic ultrasound guided gallbladder drainage (EUS-GBD) with lumen apposing metal stents (LAMS), Percutaneous gallbladder drainage
- Where
- Netherlands
- Volunteers
- 212 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Biliary Obstruction, Acute Cholecystitis
Gallbladder Stenting in FC-SEMS
The goal of this randomized controlled trial is to determine whether primary prophylaxis with transpapillary gallbladder drainage prevents acute cholecystitis after fully-covered self-expandable metal stents placement during…
- Trial name
- NCT06820541
- Testing
- Double plastic pigtail stent plus fully covered self-expandable metal stent, Fully covered self-expandable metal stent
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Acute Cholecystitis
Magnetic Resonance Cholangiography and Intraoperative Cholangiography in Acute Cholecystitis
The treatment of choice for acute cholecystitis is cholecystectomy performed as soon as possible after onset of symptoms. Up to 9-22% of patients undergoing cholecystectomy due to cholecystitis have common bile duct stones.
- Trial name
- NCT04059601
- Testing
- Magnetic resonance cholangiography, Intraoperative cholangiography
- Where
- Finland
- Volunteers
- 180 people
- Sponsor
- Jyväskylä Central Hospital
Cholecystitis; Acute, Choledocholithiasis
Early MRI in Acute GallstonE Disease
This pilot study aims to determine the utility of direct Magnetic Resonance Cholangiopancreatography (MRCP) in the assessment of suspected acute gallstone disease presentations.
- Trial name
- E-MAGED (NCT03709030)
- Testing
- magnetic resonance cholangiopancreatography (MRCP)
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- Perspectum
Cholecystitis, Acute
Effectiveness of Empirical Antibiotic Use in Mild to Moderate Acute Inflammatory Gallbladder Disease
This clinical trial is an exploratory clinical trial that evaluates the necessity and effectiveness of empirical antibiotic use in mild and moderate acute inflammatory gallbladder diseases that require surgery, and the incidence…
- Trial name
- NCT05339282
- Testing
- Laparoscopic cholecystectomy
- Where
- South Korea
- Volunteers
- 370 people
- Sponsor
- Seoul St. Mary's Hospital
Gall Stone, Gall Stones, Common Bile Duct
Influence of Gut Microbiome in Gallstone Disease
The goal of this prospective observational study is to explore the role of the gut microbiome in patients with gallstone disease.
- Conditions
- Gall Stone, Gall Stones, Common Bile Duct, Pancreatitis, Acute Cholecystitis
- Trial name
- NCT05732480
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Acute Calculous Cholecystitis, Gallbladder Empyema
Role of Intra-Operative Aspiration in Distended GB in LC
Laparoscopic cholecystectomy (LC) is a standard procedure for gallstones and the standard surgical approach for acute calcular cholecystitis, superseding open cholecystectomy for gallbladder (GB) pathologies.
- Conditions
- Acute Calculous Cholecystitis, Gallbladder Empyema, Gallbladder Mucocele
- Trial name
- NCT07378410
- Testing
- Laparoscopic needle
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Aswan University
Acute Cholecystitis, Percutaneous Cholecystostomy
Early Versus Delayed Cholecystectomy After Percutaneous Cholecystostomy in Moderate and Severe Cholecystitis (ESCAPE)
Abstract: Acute cholecystitis (AC) is typically managed according to the 2018 Tokyo Guidelines, with treatment strategies determined by the severity of the disease, patient comorbidities, and hospital capabilities.
- Conditions
- Acute Cholecystitis, Percutaneous Cholecystostomy, Laparoscopic Cholecystectomy
- Trial name
- ESCAPE (NCT07161960)
- Testing
- Laparoscopic cholecystectomy
- Where
- Thailand
- Volunteers
- 64 people
- Sponsor
- Yada Suwan
Cholecystitis, Cholecystitis, Acute
M-Tapa Block for Laparoscopic Cholesistectomy
Modified Perichondral Approach Thoracoabdominal Nerve (M-TAPA) block is a novel block that provides effective analgesia of the anterior and lateral thoracoabdominal walls during laparoscopic surgery, in which local anesthetic is…
- Conditions
- Cholecystitis, Cholecystitis, Acute, Cholecystitis, Chronic
- Trial name
- NCT05179629
- Testing
- M TAPA block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Cholecystitis, Acute, Cholecystitis; Gallstone
Observation vs Early Removal of LAMS in EUS Guided Cholecystoenterostomy
The study will compare the outcomes of patients with gallstone related cholecystitis who are poor surgical candidates undergoing EUS guided cholecystoenterostomy via a lumen apposing metal stent (LAMS).
- Trial name
- NCT04167072
- Testing
- Stent removal
- Where
- United States
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Sepsis, Community-acquired Pneumonia
A Phase 2 Study Evaluating Efficacy, Safety and Tolerability of Different Doses and Regimens of Allocetra-OTS for the Treatment of Organ Failure in Adult Sepsis Patients
A Phase 2, Multi-Center, Randomized, Placebo-Controlled, Dose-Finding Study Evaluating Efficacy, Safety and Tolerability of Different Doses and Regimens of Allocetra-OTS for the Treatment of Organ Failure in Adult Sepsis Patients
- Conditions
- Sepsis, Community-acquired Pneumonia, Urinary Tract Infections, Cholecystitis, Acute
- Trial name
- NCT04612413
- Testing
- Allocetra-OTS
- Where
- 31 sites in Belgium, France and 3 more
- Volunteers
- 148 people
- Sponsor
- Enlivex Therapeutics Ltd.
Acute Cholecystitis
TEXTBOOK OUTCOMES OF EMERGENCY CHOLECYSTECTOMIES IN ELDERLY PATIENTS
Textbook outcome is a measure used to assess the quality of surgical practice. The goal of this observational study is to compare textbook outcomes of elderly patients (≥65 years) in emergency cholecystectomies with younger…
- Trial name
- NCT06743217
- Where
- Turkey (Türkiye)
- Volunteers
- 212 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Cholecystitis, Acute
Ultrasonically Activated Scalpel Versus Electrocautery Based Dissection in Acute Cholecystitis Trial
The present study aims at analyzing whether ultrasonic tissue coagulation dissection technique offers a smoother peri- and postoperative course and reduces the risk for conversion from laparoscopic to open surgery in acute…
- Trial name
- NCT03014817
- Testing
- Ultrasonically activated scalpel, Electrocautery
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Karolinska Institutet