Clinical trials: Acute Cardiac Failure
Heart Failure, Respiratory Insufficiency
A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients
The purpose of this study is to evaluate the efficacy and safety of rivaroxaban compared with placebo in the prevention of symptomatic venous thromboembolism (VTE) events and VTE-related death post-hospital discharge in…
- Conditions
- Heart Failure, Respiratory Insufficiency, Stroke Acute, Infectious Diseases
- Trial name
- MARINER (NCT02111564)
- Testing
- Rivaroxaban, 10 mg, Rivaroxaban, 7.5 mg
- Where
- 593 sites in United States, Argentina and 35 more
- Volunteers
- 12,024 people
- Sponsor
- Janssen Research & Development, LLC
Acute Decompensated Heart Failure, Heart Failure
The Influence of Beta Blocker Therapy on the Hemodynamic Response to Inotrope Infusion in Patients With Acute Decompensated Heart Failure
Purpose: To compare the hemodynamic effects of dobutamine and milrinone in hospitalized patients who are receiving Beta Blocker Participants: Patients who are admitted to the General Cardiology and Heart Failure Services at the…
- Trial name
- NCT01971944
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of North Carolina, Chapel Hill
Heart Failure with Reduced Ejection Fraction, Heart Failure
Prediction of Heart-Failure with Machine Learning
In this monocentric observational study the research question is to what extent data collected via Apple Watch can predict the heart failure status of decompensated HF patients.
- Conditions
- Heart Failure with Reduced Ejection Fraction, Heart Failure, Heart Failure，Congestive, Heart Failure Acute
- Trial name
- PRE-HF-ML (NCT06819618)
- Testing
- Monitoring with Apple Watch
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University Medical Center Goettingen
Acute Aortic Dissection, Surgery (Cardiac)
Immune-Inflammatory Markers in Aortic Dissection
Identifying early on which patients with acute aortic dissection require closer monitoring may help with care planning. If simple, inexpensive values obtained from routine blood tests can provide additional information for…
- Conditions
- Acute Aortic Dissection, Surgery (Cardiac), Systemic Immune-inflammation Index, Postoperative Death
- Trial name
- NCT07683260
- Where
- Turkey (Türkiye)
- Volunteers
- 127 people
- Sponsor
- Bursa City Hospital
Acute Heart Failure, Congestive Heart Failure
Clinical Evaluation of the TRVD™ System in ADHF
A prospective, multi-national, open-label clinical study which is conducted to asses the safety, feasibility and performance of the TRVD™ System in hospital-admitted patients with Acute Decompensated Heart Failure (ADHF) and…
- Conditions
- Acute Heart Failure, Congestive Heart Failure, Heart Failure, Congestive
- Trial name
- TRVD (NCT03621436)
- Testing
- TRVD Therapy
- Where
- 3 sites in Belgium, Croatia and 1 more
- Volunteers
- 13 people
- Sponsor
- Magenta Medical Ltd.
Myocardial Infarction, Heart Failure
Omega-3 Fatty Acids in Elderly Patients With Acute Myocardial Infarction
The aim of the present study is to investigate the possible effects of supplementation with 1.8 g/day of n-3 polyunsaturated fatty acids on cardiovascular morbidity and mortality during a follow-up period of 2 years in an elderly…
- Conditions
- Myocardial Infarction, Heart Failure, Myocardial Revascularization, Atrial Fibrillation
- Trial name
- OMEMI (NCT01841944)
- Testing
- Pikasol, Corn oil
- Where
- 4 sites in Norway
- Volunteers
- 1,027 people
- Sponsor
- Oslo University Hospital
Heart Failure
Management of Acute Heart Failure: Contribution of Ultrasound Daily "in Bed Patient" Adjustment on Therapy With Impact Measure on re Hospital Rate During 30 Days
Our hypothesis: a daily bedside echocardiographic assessment, protocolized, simple and reproducible estimation of filling pressures with an evaluation of mitral inflow and the inferior vena cava, allow a more reliable estimate of…
- Trial name
- JECICA (NCT02892227)
- Testing
- Transmitral flow estimation
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Dyspnea, Heart Failure
Dyspnea and Biomarkers in a Prehospital Setting
In patients presenting with acute dyspnea in a pre-hospital setting, the early and correct diagnosis may present a significant clinical challenge.
- Conditions
- Dyspnea, Heart Failure, Asthma, COPD
- Trial name
- NCT00878475
- Where
- Slovenia
- Volunteers
- 546 people
- Sponsor
- Community Healthcare Center dr. Adolf Drolc Maribor (HCM)
Acute Decompensated Heart Failure
The Hemodynamic Effects of SGLT2i in Acute Decompensated Heart Failure
The main purpose of this study is to observe hemodynamic effects of initiating sodium-glucose co-transporter 2 inhibitors (SGLT2i) in patients admitted to the intensive care unit (ICU) with acute decompensated heart failure.
- Trial name
- NCT05346653
- Testing
- SGLT2i, No SGLT2i
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Chicago
Acute Heart Failure
Early Aldosterone Blockade in Acute Heart Failure: An Exploratory Safety Study
Over one million hospitalizations for acute heart failure (AHF) occur over every year in the United States, resulting in high mortality, re-hospitalizations, and incurred financial costs; yet nearly every attempt over the last 10…
- Trial name
- NCT02299726
- Testing
- Spironolactone
- Sponsor
- Indiana University
Acute Respiratory Failure Requiring Reintubation
CPAP Reduces Hypoxemia After Cardiac Surgery
The aim of study is to evaluate whether the application of a continuous positive airway pressure (CPAP) after extubation in patients undergoing cardiac surgery can reduce hypoxemia and re-intubation rate.
- Trial name
- CRHACS (NCT01726140)
- Testing
- Helmet CPAP, Venturi Mask
- Where
- Italy
- Volunteers
- 407 people
- Sponsor
- University of Turin, Italy
Acute Coronary Syndrome, Congestive Heart Failure
Mind-body Interventions in Cardiac Patients
This study is investigating whether a series of psychological exercises, called positive psychology, provides benefit to patients who have been hospitalized for heart disease (an 'acute coronary syndrome' or heart failure).
- Trial name
- NCT01270568
- Testing
- Positive Psychology, Relaxation Response, Recollection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Heart Failure, Left Bundle-Branch Block
Optimised MultiSite Pacing Vector Study
The objective of this clinical investigation is to evaluate the clinical benefits of an MultiSite pacing (MSP) with patient specific left ventricular vector optimization in patients receiving cardiac resynchronization therapy…
- Conditions
- Heart Failure, Left Bundle-Branch Block, Systolic Dysfunction
- Trial name
- NCT03938090
- Testing
- Optimised MultiSite Pacing, Standard biventricular pacing
- Where
- United Kingdom
- Sponsor
- Barts & The London NHS Trust
Acute Heart Failure
A Phase IIb Study to Investigate the Efficacy and Tolerability of Lower Doses Cinaciguat (25 µg/h, 10 µg/h) Given Intravenously to Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF)
A placebo controlled, double-blind and randomized study to assess different doses of a new drug (BAY58-2667) given intravenously, to evaluate if it is safe and can help to improve the well-being of patients with acute…
- Trial name
- COMPOSE 2 (NCT01067859)
- Testing
- Cinaciguat (BAY58-2667)
- Where
- 30 sites in United States, Argentina and 7 more
- Volunteers
- 5 people
- Sponsor
- Bayer
Congestive Heart Failure, Medication Adherence
Assay to Measure Beta Blocker Adherence
This study will assess the feasibility and efficacy of using serum assay developed by Quest Diagnostics to detect the presence of beta blockers, specifically carvedilol and metoprolol succinate, in patients with heart failure.
- Trial name
- NCT05251974
- Testing
- Quest beta blocker assay
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Summa Health System
Myocardial Infarction
Effects of Early Statin Treatment After Acute Myocardial Infarction (AMI) in Japanese Patients
Statins have been shown to prevent coronary artery disease and to preserve left ventricular function in dilated cardiomyopathy. The investigators hypothesized that the early use of statins would reduce cardiovascular events…
- Trial name
- NCT00128024
- Testing
- lipid-lowering treatment
- Where
- Japan
- Volunteers
- 460 people
- Sponsor
- Kumamoto University
Acute Heart Failure, NSTEMI - Non-ST Segment Elevation MI
Metabolomics and Microbiomics in Cardiovascular Diseases
"MEtabolomics and MicrObiomics in caRdIovAscular diseases Mannheim (MEMORIAM) " is a single-center, prospective and observational study investigating to identify disease-specific metabolic, respectively microbiomic, patterns of…
- Conditions
- Acute Heart Failure, NSTEMI - Non-ST Segment Elevation MI, STEMI - ST Elevation Myocardial Infarction, Myocardial Infarction, Acute
- Trial name
- MEMORIA (NCT04146701)
- Testing
- Blood draw
- Where
- Germany
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Myocardial Ischemia, Heart Failure
sST2 Biomarker Level in Acute/Chronic Coronary Syndrome After Revascularization
The role of soluble circulating suppression of tumorigenicity 2 biomarker (sST2) in the ischemic heart disease patient is a debatable point.
- Conditions
- Myocardial Ischemia, Heart Failure, Coronary Intervention
- Trial name
- ST2 (NCT05686057)
- Testing
- percutanous coronary angiography with stenting
- Where
- 2 sites in Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Heart Disease, Acute Renal Failure
N-Acetylcysteine for Preventing Renal Injury After Cardiac Surgery
Cardiac surgery improves the survival and quality of life of people with heart disease. Nonetheless, several complications continue to adversely affect outcomes following cardiac surgery.
- Trial name
- NCT00188630
- Testing
- N-acetylcysteine, 5% dextrose solution
- Where
- Canada
- Volunteers
- 176 people
- Sponsor
- University Health Network, Toronto
Any Condition Underlying Critical Illness
SWedish Intensive Care Biobank
The goal of this observational study is to understand the genetic and molecular risk factors for developing critical illness in adult intensive care unit (ICU) patients in Sweden.
- Trial name
- SWIC-B (NCT07582601)
- Volunteers
- 25,000 people
- Sponsor
- Uppsala University
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