Clinical trials: Acute Cardiac Failure
Acute Heart Failure
Early Treatment With a Sodium-glucose Co-transporter 2 Inhibitor in High-risk Patients With Acute Heart Failure
The EMPA-AHF trial is a multicentre, randomized, double-blind, placebo-controlled trial designed to evaluate the efficacy and safety of early initiation of once-daily oral empagliflozin 10 mg in patients hospitalized for patients…
- Trial name
- EMPA-AHF (NCT05392764)
- Testing
- Empagliflozin 10 MG
- Where
- 69 sites in Japan
- Volunteers
- 444 people
- Sponsor
- Juntendo University
Acute Heart Failure, Acute Decompensation of Chronic Heart Failure
Tezosentan in the Treatment of Acute Heart Failure
The randomized patients with acute heart failure will be stratified based on the presence or absence of a Swan-Ganz catheter and assigned to receive either tezosentan 5 mg/h for the first 30 minutes and 1 mg/h thereafter or…
- Conditions
- Acute Heart Failure, Acute Decompensation of Chronic Heart Failure, New Onset of Heart Failure
- Trial name
- VERITAS 2 (NCT00524433)
- Testing
- tezosentan
- Where
- 42 sites in United States, Australia and 6 more
- Volunteers
- 713 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Venous Congestion, Heart Failure Acute
Vexus Assessment and Natriuresis-guided Diuretic Therapy in Acute Heart Failure
This study evaluates whether natriuresis-guided diuretic therapy improves outcomes in patients with acute heart failure (AHF) and severe congestion.
- Conditions
- Venous Congestion, Heart Failure Acute, VExUS, Diuretics
- Trial name
- VANTAGE-HF (NCT07558798)
- Testing
- Natriuresis-guided escalation of loop diuretics
- Where
- 2 sites in Norway
- Volunteers
- 270 people
- Sponsor
- University Hospital, Akershus
Acute Myocardial Infarction, Heart Failure
Peri-treatment of SGLT-2 Inhibitor on Myocardial Infarct Size and Remodeling Index in Patients With Acute Myocardial Infarction and High Risk of Heart Failure Undergoing Percutaneous Coronary Intervention
We aimed to identify whether SGLT-2 inhibitor administration before and after coronary intervention is effective in reducing the size of infarction and myocardial remodeling in patients with acute myocardial infarction (AMI) and…
- Trial name
- PRESTIGE-AMI (NCT04899479)
- Testing
- SGLT2 inhibitor, Control
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Heart Failure, Chronic Heart Failure
A Multicenter Registry to Study the Characteristics and Outcomes of Jordanian Heart Failure Patients.
Heart Failure research registry is a collection of computerized information about individuals with heart failure. The database in this registry is obtained from several Jordanian medical centers which will represent an extremely…
- Conditions
- Heart Failure, Chronic Heart Failure, Acute Heart Failure
- Trial name
- JoHFR (NCT04829591)
- Testing
- observational
- Where
- Jordan
- Volunteers
- 2,219 people
- Sponsor
- Jordan Cardio Vascular Research Group
Acute Circulatory Failure
Time Course Evolution of Cardiac Output
Fluid expansion is the first therapeutic option in patients presenting acute circulatory failure but the duration of its hemodynamic effects (persistency and time of maximal increase in cardiac output) is unknown.
- Trial name
- TCCO (NCT03694717)
- Testing
- Saline Solution for Injection
- Volunteers
- 58 people
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
COPD, Hyperinflation
Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients
Chronic Obstructive Pulmonary disease (COPD) is one of the major clinical entities that causes thousands of deaths every year all over the world and weights a lot on the health care system of every country in terms of direct and…
- Conditions
- COPD, Hyperinflation, Right Cardiac Failure
- Trial name
- NCT01996124
- Testing
- Indacaterol Fumarate
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
Heart Failure, Congestive, Dyspnea
Double Blind Randomized Placebo Controlled Trial of Natrecor in Acute Decompensated Heart Failure With Normal EF
Heart failure (HF) is a disease that is caused by a reduced heart muscle function. Reduced heart muscle function can occur as a consequence of reduced pumping activity from a weak heart muscle or because of a stiff heart muscle.
- Conditions
- Heart Failure, Congestive, Dyspnea, Pulmonary Edema
- Trial name
- NCT00505791
- Testing
- Nesiritide
- Where
- United States
- Sponsor
- University of Medicine and Dentistry of New Jersey
Acute Heart Failure
Identification of Patient Phenotypes Associated With Elevated Aldosterone Levels
Post-discharge mortality and re-hospitalization for acute heart failure (AHF) affects 15% and 30% of patients respectively, within 90 days.
- Trial name
- NCT01614860
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Northwestern University
Heart Failure
Determining Optimal Dose and Duration of Diuretic Treatment in People With Acute Heart Failure (The DOSE-AHF Study)
Heart failure is a disorder in which the heart does not pump blood adequately. This can lead to several serious problems, including reduced blood flow throughout the body, congestion of blood in the veins and lungs, and fluid…
- Trial name
- NCT00577135
- Testing
- Furosemide-Q12 hour bolus, Furosemide-Continuous Infusion, Furosemide-Low Intensification
- Where
- 9 sites in United States, Canada
- Volunteers
- 308 people
- Sponsor
- Duke University
Acute Decompensated Heart Failure
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve Decongestion Management System (DMS)
The objective of this study is to prospectively compare decongestive therapy administered by the Reprieve DMS system to Optimal Diuretic Therapy (ODT) in the treatment of patients diagnosed with acute decompensated heart failure…
- Trial name
- FASTR (NCT05174312)
- Testing
- Reprieve Decongestion Management System, Diuretic
- Where
- 16 sites in United States
- Volunteers
- 100 people
- Sponsor
- Reprieve Cardiovascular, Inc
Heart Failure, Cardiovascular Disease
Use of Nesiritide in the Management of Acute Diastolic Heart Failure
Primary objective is to assess the effect of nesiritide in decreasing left ventricular (LV) filling pressure, defined as pulmonary artery capillary wedge pressure (PCWP) in a group of patients admitted with acute diastolic heart…
- Conditions
- Heart Failure, Cardiovascular Disease, Acute Heart Failure, Diastolic Heart Failure
- Trial name
- NCT00083772
- Testing
- Nesiritide
- Volunteers
- 9 people
- Sponsor
- M.D. Anderson Cancer Center
Acute Decompensated Heart Failure
Cardiac Perfusion and Metabolism With [11C] Acetate PET/CT is Associated With Hematopoietic System Activation in Acute Decompensated Heart Failure: An Imaging Sub-study
The purpose of this sub-study is to use positron emission tomography and computed tomography imaging (PET/CT) with an investigational drug called [11C] acetate to see if inflammation in patients with acute decompensated heart…
- Trial name
- NCT03924102
- Testing
- Cardiac Perfusion and Metabolism with [11C] Acetate PET/CT
- Where
- United States
- Sponsor
- University of Alabama at Birmingham
Dyspnea
Systolic Time Intervals in the Diagnosis of Heart Failure in Emergency Departement
the gold standard for the diagnostic of acute heart failure is based on clinical, biological (BNP levels) and echocardiographic findings, but still in some cases, the diagnosis is difficult and requires further investigations.
- Trial name
- STA/AHF (NCT02161445)
- Testing
- the acoustic cardiographic parameters were calculated
- Where
- Tunisia
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Congestive Heart Failure, Copd
A Mobile Integrated Health Intervention to Manage Congestive Health Failure and Chronic Obstructive Pulmonary Disease
Episodic and disjointed medical care for older, community-dwelling adults with chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF) leave them vulnerable to adverse events such as worsening disease…
- Trial name
- NCT05540158
- Testing
- Mobile Integrated Health Intervention
- Sponsor
- University of Massachusetts, Worcester
Takotsubo Cardiomyopathy
Cyclosporine In Takotsubo Syndrome
The goal of this clinical trial is to investigate the impact of repetitive acute Cyclosporine A (CsA) bolus therapy in patients suffering from TTS with an elevated risk of impaired outcome.
- Trial name
- CIT (NCT05946772)
- Testing
- Cyclosporine A
- Where
- 24 sites in Germany
- Volunteers
- 204 people
- Sponsor
- University Hospital Heidelberg
Acute Heart Failure
FranceLEVO - Zimino Registry (FZR)
The French National Authority for Health (Haute Autorité de santé) requested a registry study to obtain post-market surveillance data to describe baseline clinical profiles, management and outcome of patients treated with…
- Trial name
- FZR (NCT04252404)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Arcothova
Heart Decompensation
Study of the Sudden Heart Failure Participant Population in the US
An observational study using data from a large US electronic health record database to find participants hospitalized with ADHF who do not have a concurring heart attack
- Trial name
- NCT03566264
- Testing
- Non-Interventional
- Where
- 2 sites in United States
- Sponsor
- Bristol-Myers Squibb
C.Surgical Procedure; Cardiac, Acute Kidney Injury
Portal Flow Pulsatility as a Risk Factor for Acute Kidney Injury After Cardiac Surgery
The purpose of this study is to evaluate the possible association between portal vein flow pulsatility and acute kidney injury after cardiac surgery.
- Conditions
- C.Surgical Procedure; Cardiac, Acute Kidney Injury, Postoperative Complications, Right-Sided Heart Failure
- Trial name
- PP-AKI (NCT02831907)
- Testing
- Cardiac surgery
- Where
- Canada
- Volunteers
- 146 people
- Sponsor
- Montreal Heart Institute
Heart Failure, Kidney Failure
New Biomarkers in Heart- and Renal Failure
In this study, prognostically relevant biomarkers for cardiovascular / renal insufficiencies will be clinically evaluated, to improve the course of assessment of such disease and to gain new insights into the typical course of…
- Trial name
- IM19 Register (NCT02830464)
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- RWTH Aachen University