Clinical trials: Acute Cardiac Failure
Heart Failure, Left Bundle-Branch Block
Optimised MultiSite Pacing Vector Study
The objective of this clinical investigation is to evaluate the clinical benefits of an MultiSite pacing (MSP) with patient specific left ventricular vector optimization in patients receiving cardiac resynchronization therapy…
- Conditions
- Heart Failure, Left Bundle-Branch Block, Systolic Dysfunction
- Trial name
- NCT03938090
- Testing
- Optimised MultiSite Pacing, Standard biventricular pacing
- Where
- United Kingdom
- Sponsor
- Barts & The London NHS Trust
Heart Failure
Ultrasound Evaluation of the IVC in Addition to Clinical Assessment to Guide Decongestion in ADHF
CAVA-ADHF is designed as a prospective, randomized, controlled, patient-blinded, multicenter, parallel-group trial. The objective is to test whether evaluation of the inferior vena cava diameter in addition to clinical assessment…
- Trial name
- CAVA-ADHF (NCT03140566)
- Testing
- Ultrasound evaluation of the inferior vena cava diameter
- Where
- Germany
- Volunteers
- 388 people
- Sponsor
- University of Luebeck
Heart Failure, Congestive
A Method Validation Study for Evaluation of Novel Treatments Limiting Pulmonary Oedema in Cardiac Failure
Transient receptor potential vanilloid 4 (TRPV4) channel blockade may be promising in the treatment of pulmonary oedema and dyspnoea in heart failure (HF) and acute decompensated heart failure (ADHF) patients by re-establishing…
- Trial name
- NCT02135861
- Testing
- DCE-MRI scans, Gadobutrol
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Heart Failure, Arrhythmias, Cardiac
Cardiology Research Dubrava Prospective Registry
Cardiology Research Dubrava registry is a prospective, single centre registry including patients with acute coronary syndrome with and without ST segment elevation, patients with heart failure who were prescribed with SGLT-2…
- Conditions
- Heart Failure, Arrhythmias, Cardiac, Atrial Fibrillation, Acute Coronary Syndrome
- Trial name
- CaRDr (NCT06090591)
- Testing
- SGLT-2 inh therapy, CIED implantation, thromboaspiration,
- Where
- Croatia
- Volunteers
- 3,000 people
- Sponsor
- University Hospital Dubrava
Heart Failure, Acute Heart Failure
Telemonitoring Program in the Vulnerable Phase After Hospitalization for Heart Failure
This pragmatic clinical trial aims to evaluate the impact of a telemonitoring program with an electronic alert system compared to standard treatment on the perception of self-care in patients after hospitalization for…
- Trial name
- NCT05972746
- Testing
- Telemonitoring with electronic alerts, Standard of care
- Where
- Argentina
- Volunteers
- 110 people
- Sponsor
- Instituto Cardiovascular de Buenos Aires
Acute Heart Failure (AHF)
Early Gliflozin for Elderly Patients With Acute Decompensated Heart Failure in the Emergency Department
Background: SGLT2 inhibitors reduce CHF morbidity/mortality but are underutilized in elderly patients with acute decompensated CHF (ADCHF) admitted outside cardiology departments.
- Trial name
- GlifloFastER (NCT07392788)
- Testing
- Early initiation of dapagliflozin 10mg daily within 24h of emergency department admission, Telephone follow-up by cardiac nurse practitioner at 1 month, Standard acute decompensated heart failure care
- Volunteers
- 144 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Myocardial Infarction
Effects of Early Statin Treatment After Acute Myocardial Infarction (AMI) in Japanese Patients
Statins have been shown to prevent coronary artery disease and to preserve left ventricular function in dilated cardiomyopathy. The investigators hypothesized that the early use of statins would reduce cardiovascular events…
- Trial name
- NCT00128024
- Testing
- lipid-lowering treatment
- Where
- Japan
- Volunteers
- 460 people
- Sponsor
- Kumamoto University
Pulmonary Arterial Hypertension, Heart Failure
Effects of Apelin on the Lung Circulation in Pulmonary Hypertension
The purpose of this study is to determine the effects of Apelin on the lung circulation. The investigators hypothesise that Apelin will relax the lung blood vessels and improve the pumping ability of the heart.
- Trial name
- NCT01457170
- Testing
- Apelin
- Where
- 3 sites in United Kingdom
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Golden Jubilee National Hospital
Hospitalization Rate, Mortality Rate
Efficacy of Multi-disciplinary Integrated Post-acute Care in Patients Admission for Heart Failure
Background: Clinical heart failure patients always suffering from (1) worsen symptoms such as decreased activity tolerance, end-to-end breathing and excessive body fluid volume; (2) high medical expenses results from…
- Conditions
- Hospitalization Rate, Mortality Rate, Functional Recovery, Left Ventricle Ejection Fraction
- Trial name
- NCT04638179
- Testing
- Not intervention.Use retrospective case contrl study.
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Acute Decompensated Heart Failure (ADHF), Acute Cardiogenic Pulmonary Edema (ACPE)
Acute Congestive Heart Failure
The aim of the study is to determine the feasibility of collecting respiratory parameters during recompensation following ADHF (Acute Decompensated Heart Failure)with non-invasive measurements.
- Trial name
- AcuteCHF (NCT01885403)
- Testing
- non-invasive respiratory parameter measurements
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- RWTH Aachen University
Cardiogenic Shock, Postresuscitation Disease
Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure
Testing the association between circulating candidate proteins and the level of vascular leakage for three distinct forms of circulatory failure: cardiogenic shock, septic shock, and post-resuscitation syndrome.
- Conditions
- Cardiogenic Shock, Postresuscitation Disease, Septic Shock
- Trial name
- NCT05586282
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Embolism
Comparison of Thrombgolytic and Anticoagulation Therapy in Submassive Pulmonary Embolism
Currently there is no clear guidance for the treatment of moderate risk of pulmonary embolism. The aim of the study is to compare two different therapeutic modalities - standard anticoagulation versus thrombolytic treatment…
- Trial name
- CONTACT-SPE (NCT02132689)
- Testing
- Actilyse (Thrombolytic therapy), Heparine (Standard anticoagulation therapy)
- Where
- 2 sites in Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Ostrava
Symptomatic Decompensated Congestive Heart Failure, Congestive Heart Failure in Acute Coronary Syndrome
A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure.
The purpose of this study is to compare the hemodynamic (blood flow) and clinical effects of the study drug, Natrecor (nesiritide, a recombinant form of the natural human peptide normally secreted by the heart in response to…
- Trial name
- NCT00270374
- Testing
- nesiritide
- Volunteers
- 498 people
- Sponsor
- Scios, Inc.
Acute Heart Failure
Safety and Efficacy of Early, seQUential Oral dIuretic Nephron blockAde In Acute Heart Failure
The SEEQUOIA-AHF (Safety and Efficacy of Early, seQUential oral dIuretic nephron blockAde in Acute Heart Failure) trial is a multicenter, randomized, open-label, parallel-arm trial assessing the impact of early sequential nephron…
- Trial name
- SEEQUOIA-AHF (NCT04062760)
- Testing
- Standard diuretic therapy, Early sequential nephron blockade
- Where
- Italy
- Volunteers
- 206 people
- Sponsor
- University of Parma
Cardiovascular Diseases
A Registry Study of Biomarkers in Progression of Acute Heart Failure(BIOMS-POAHF)
The registry study aims to discover the prognostic value of bio-markers in acute heart failure
- Trial name
- NCT04108182
- Where
- China
- Volunteers
- 850 people
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Acute Heart Failure (AHF), Sarcopenia
Sarcopenia in Older Patients Hospitalized for Acute Heart Failure.
Acute heart failure (AHF) is the leading cause of hospitalization in people over 65, with the group with preserved ejection fraction (HFpEF) being the most closely related to aging.
- Conditions
- Acute Heart Failure (AHF), Sarcopenia, Heart Failure
- Trial name
- MUSICA (NCT07530029)
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Acute Heart Failure
Hemodynamic Responses to RLX030 Infusion in Subjects With Acute Heart Failure
This study will assess the hemodynamic effect of RLX030 infusion in subjects with acute heart failure. In addition safety and effects on renal function and biomarkers will be assessed.
- Trial name
- NCT01543854
- Testing
- RLX030
- Where
- 20 sites in Argentina, Germany and 4 more
- Volunteers
- 71 people
- Sponsor
- Novartis Pharmaceuticals
Bradyarrhythmia, Dyspnea
The Safety and Efficacy of FFR Protocol in NTUH System
FFR-guided PCI has been performed in National Taiwan University Hospital(NTUH) for many years. Nevertheless, the method of FFR measurement in NTUH is different from that in literature.
- Conditions
- Bradyarrhythmia, Dyspnea, Acute Respiratory Failure
- Trial name
- NCT03693157
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Functional Mitral Regurgitation, Heart Failure
The BOSS Study: An Acute Evaluation of Anatomical and Geometric Changes Using the Bladder on a Stick System (BOSS)
The objective of the BOSS Study is to assess acute anatomical and geometric annular and ventricular changes that occur when strategically positioned an external inflatable chambers are applied to the outside of the heart.
- Trial name
- BOSS (NCT03228381)
- Testing
- BOSS Device
- Where
- 3 sites in United States, Paraguay
- Volunteers
- 4 people
- Sponsor
- Mardil Medical
Kidney Failure
PROMISS: Simvastatin Prevents the Contrast Induced Acute Renal Failure in Patients With Renal Insufficiency Undergoing Coronary Angiography
The contrast induced kidney toxicity has been known to affect the mortality and morbidity in the patients undergoing coronary angiography. But the mechanism and therapeutic strategy for it is not well known.
- Trial name
- NCT00259441
- Testing
- Simvastatin
- Where
- South Korea
- Volunteers
- 320 people
- Sponsor
- Seoul National University Hospital
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