Clinical trials: Acute Cardiac Failure
Congestive Heart Failure
TARGET: A Study to Evaluate the Treatment of Patients With Acute Decompensated Heart Failure (ADHF) Using an Automated Fluid Management System
This is a prospective, single arm, early feasibility study designed to evaluate the safety and device performance of The RenalGuard System in the management of patients admitted with signs and symptoms of congestive heart failure…
- Trial name
- NCT03897842
- Testing
- Reprieve Cardiovascular System
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- CardioRenal Systems, Inc.
Cardiogenic Shock
Cardiogenic Shock Working Group Registry
The Cardiogenic Shock Working Group is a multicenter registry where we collect de-identified clinical variables from the medical records and follow-up phone calls of shock patients from multiple institutions and centralize this…
- Trial name
- CSWG (NCT04682483)
- Testing
- Vasopressor, Inotrope, Acute Mechanical Circulatory Support Devices
- Where
- 16 sites in United States
- Volunteers
- 20,000 people
- Sponsor
- Tufts Medical Center
Acute Heart Failure
Evaluation of Acute Cardiogenic Dyspnoea With Thorax Echography and Pro-BNP in the Emergency Department
LUNG ULTRASOUND IN THE MANAGEMENT OF DISPNEIC PATIENTS IN EMERGENCY DEPARTMENT Introduction This is a prospective randomized trial realized in the Emergency Department of the University Hospital of Siena, Italy.
- Trial name
- ECO/TOR (NCT02122640)
- Where
- Italy
- Sponsor
- Comitato Etico di Area Vasta Sud Est
Acute Decompensated Heart Failure (ADHF), Chronic Kidney Disease (CKD)
Comparative Assessment of Efficacy & Safety of Sacubitril/Valsartan Versus Ramipril in Patients With Renal Dysfunction Hospitalized With Acute Decompensated Heart Failure
Sacubitril/valsartan is an established medication for heart failure. However, data still lags in its use in heart failure patients with chronic kidney disease.
- Trial name
- CAESAR (NCT07023016)
- Testing
- Sacubitril / Valsartan, Ramipril (ACE-inhibitor)
- Where
- 2 sites in Egypt
- Volunteers
- 515 people
- Sponsor
- National Heart Institute, Egypt
Acute Hypoxemic Respiratory Failure, Post-cardiac Surgery
Automated Analysis of EIT Data for PEEP Setting
First: to develop a computerized algorithm for automated analysis of the electrical impedance tomography (EIT) data. The algorithm calculates the "optimal" positive end-expiratory pressure (PEEP) and inspiratory pressure defined…
- Trial name
- NCT03653806
- Testing
- computerized algorithm for automated analysis
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center
Central Nervous System Diseases, Acute Respiratory Failure
Clinical Evaluation of Swallowing Disorders as a Predictor of Extubation Failure
Patients with failed extubation stay significantly longer in an intensive care unit (ICU) and have a higher mortality rate, than those intubated successfully.
- Conditions
- Central Nervous System Diseases, Acute Respiratory Failure, Shock, Heart Failure
- Trial name
- EVAKIN (NCT00780078)
- Testing
- extubation
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury, Fluid Overload
Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury
Fluid overload is associated with adverse outcomes in patients with severe acute kidney injury. It remains unclear if fluid overload is merely a marker of disease severity or if organ congestion is a mediator of complications.
- Conditions
- Acute Kidney Injury, Fluid Overload, Ultrasonography
- Trial name
- ECHO-AKI (NCT04095143)
- Testing
- Portal vein flow, Intra-renal flow, Hepatic vein flow
- Where
- 6 sites in United States, Canada
- Volunteers
- 125 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Congestive Heart Failure
Sodium-glucose Cotransporter Type 2 Inhibitors for Acute Cardiorenal Syndrome Prevention
The effect of sodium-glucose cotransporter type 2 inhibitors (SGLT2i) on the parameters of renal function in acute decompensation of chronic heart failure (ADHF) compared to standard therapy will be analyzed.
- Trial name
- NCT04778787
- Testing
- Standard list of drugs used for acute decompensation of CHF (loop diuretics, vasodilators, digoxin, inotropic agents, vasopressors), plus dapagliflozin (Forxiga; MP-002596)
- Where
- 2 sites in Russia
- Volunteers
- 370 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Acute Heart Failure (AHF), Fluid Over-load
Training Medical Residents in the Use of the Venous Excess UltraSound (VExUS) Score for Bedside Volume Assessment.
This randomized controlled trial evaluates the effectiveness of two training approaches (in-person versus remote) for teaching medical residents to apply the Venous Excess Ultrasound (VExUS) score for bedside volume assessment in…
- Conditions
- Acute Heart Failure (AHF), Fluid Over-load, Congestion, Congestion, Venous
- Trial name
- NCT07541768
- Testing
- In-person VExUS Training Program, Remote VExUS Training Program, No intervention
- Where
- Switzerland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Myocardial Infarction, Acute, Myocardial Infarction First
MSCs for Prevention of MI-induced HF
Results from recent clinical trials on bone marrow mononuclear cell (BM-MNC) transplantation show that this intervention can help reduce the incidence of heart failure (HF) after acute myocardial infarction (AMI).
- Conditions
- Myocardial Infarction, Acute, Myocardial Infarction First, Myocardial Infarction, Anterior Wall, Cardiac Remodeling, Ventricular
- Trial name
- PREVENT-TAHA8 (NCT05043610)
- Testing
- Umbilical Cord-Derived Wharton's Jelly Mesenchymal Stem Cells (WJ-MSCs), Conventional Treatment
- Where
- 3 sites in Iran
- Volunteers
- 420 people
- Sponsor
- Shiraz University of Medical Sciences
Heart Decompensation, Acute, Acute Kidney Injuries
POCUS-Guided Diuresis for Decompensated Heart Failure
Heart failure occurs when the heart cannot pump blood effectively, leading to fluid buildup in the body. This can cause problems such as difficulty breathing, swelling, and extreme tiredness.
- Trial name
- POCUSHF-GD (NCT06921603)
- Testing
- Furosemide (Standard Diuretic) Treatment, POCUS-Assessed Diuretic Management
- Where
- 5 sites in United States
- Volunteers
- 588 people
- Sponsor
- University of Pittsburgh
Kidney Failure, Acute
Fenoldopam in Pediatric Cardiac Surgery
The purpose of this study is to determine whether fenoldopam infusion during cardiopulmonary bypass in young children with congenital heart disease is able to reduce indicators of acute kidney injury (biomarkers reduction…
- Trial name
- NCT00982527
- Testing
- Fenoldopam
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Hyponatremia, Acute Decompensated Heart Failure
Safety and Efficacy of Conivaptan in Hyponatremic Patients With Symptomatic Acute Decompensated Heart Failure (ADHF)
This study will evaluate the safety and effectiveness of Conivaptan, a vasopressin antagonist, in the treatment of hyponatremic subjects having symptomatic acute decompensated heart failure (ADHF).
- Trial name
- CONVERT-H (NCT00843986)
- Testing
- conivaptan
- Where
- 4 sites in India
- Volunteers
- 9 people
- Sponsor
- Cumberland Pharmaceuticals
Cardiogenic Shock, Postresuscitation Disease
Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure
Testing the association between circulating candidate proteins and the level of vascular leakage for three distinct forms of circulatory failure: cardiogenic shock, septic shock, and post-resuscitation syndrome.
- Conditions
- Cardiogenic Shock, Postresuscitation Disease, Septic Shock
- Trial name
- NCT05586282
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Heart Failure
Identification of Patient Phenotypes Associated With Elevated Aldosterone Levels
Post-discharge mortality and re-hospitalization for acute heart failure (AHF) affects 15% and 30% of patients respectively, within 90 days.
- Trial name
- NCT01614860
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Northwestern University
Heart Failure, Myocardial Infarction
Impact of Intracoronary Injection of Autologous BMMC for LV Contractility and Remodeling in Patients With STEMI
This is multicentre, randomised open-label, controlled, parallel-group phase III study. Its aim is to demonstrate that a triple intracoronary infusion of autologous bone marrow-derived mononuclear cells in addition to state of…
- Trial name
- RACE-STEMI (NCT02323620)
- Testing
- Intracoronary infusion of BM-MC
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- American Heart of Poland
Cirrhosis, Acute Liver Failure
Evaluation of Cardiac Function in Acutely Decompensated Cirrhosis
This project aims to investigate cardiac function in patients with cirrhosis in the acute setting. Acute decompensation and acute-on-chronic liver failure are major events in the life of a patient as they herald disease…
- Conditions
- Cirrhosis, Acute Liver Failure, Cardiomyopathies
- Trial name
- DYNACORD-AD (NCT05413083)
- Where
- Romania
- Volunteers
- 70 people
- Sponsor
- Clinical Hospital Colentina
Acute Heart Failure
Efficacy and Safety of Levosimendan in Severe Acute Heart Failure in Critical Children
To evaluate the efficacy and safety of levosimendan versus conventional intensified inotropic treatment, in critical children with severe acute heart failure which persists despite of having received conventional inotropic…
- Trial name
- NCT01301313
- Testing
- Levosimendan, Conventional intensified inotropic treatment
- Where
- 19 sites in Spain
- Volunteers
- 116 people
- Sponsor
- Jose Luis Vazquez Martinez
Acute Decompensated Heart Failure
Oral Metolazone and Intermittent Intravenous Furosemide Versus Continuous Infusion Furosemide in Acute Heart Failure
The purpose of this prospective, randomized, open-label study is to compare two diuretic strategies in patients with acute decompensated heart failure (ADHF): the addition of an oral thiazide diuretic to intravenous bolus (IVB)…
- Trial name
- NCT00904488
- Testing
- Addition of oral Metolazone, Furosemide dose escalation
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of North Carolina, Chapel Hill
Stroke, Myocardial Injury
Mechanisms And Prognosis of Stroke-Heart Syndrome
The incidence of stroke-heart syndrome following acute stroke, which encompasses both acute ischemic stroke and acute intracerebral hemorrhage, is notably high and is strongly associated with increased mortality and poor outcomes…
- Conditions
- Stroke, Myocardial Injury, Heart Failure, Acute Coronary Syndromes
- Trial name
- MAP-SHS (NCT06954103)
- Where
- China
- Volunteers
- 658 people
- Sponsor
- Chensheng Pan
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.