Clinical trials: Acute Cardiac Failure
Acute Decompensated Heart Failure
Furosemide-induced Diuresis With Matched Dehydration Compared to Standard Diuretic Therapy in Patients With Acute Heart Failure and Overt Fluid Overload
Acute decompensated heart failure (ADHF) is a complex clinical syndrome caused by cardiac abnormalities compromising the ability of the heart to provide a blood supply adequate to the metabolic needs of peripheral tissues.
- Trial name
- MYTHOS-HF (NCT05807152)
- Testing
- RenalGuard device
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- Centro Cardiologico Monzino
Sepsis, Cardiac Failure Acute
Clinical Assessment of Arterial Dynamic Elastance in ICU Patients, Dependent on Inotropic or Vasopressor Drugs.
The primary goal of the study is to determine Eadyn ( = PPV/SVV) as a functional measure of arterial load, in conjunction with other actual afterload indices, systemic vascular resistance and arterial elastance.
- Trial name
- NCT03621618
- Testing
- dobutamine, norepinephrine
- Where
- Belgium
- Sponsor
- Universitair Ziekenhuis Brussel
Myocardial Infarction, Acute
COLchicine to Prevent Sympathetic Denervation After an Acute Myocardial Infarction
This study evaluates the benefit of colchicine on induced denervation after myocardial infarction. Patients who have suffered a documented De Novo myocardial infarction and completed a revascularization procedure will receive…
- Trial name
- COLD-MI (NCT04420624)
- Testing
- Colchicine
- Where
- France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Montpellier
Chronic Renal Insufficiency, Diabete Mellitus
Safety Study of GE-145 320 mg I/mL Injection vs. Iopamidol 370 mg I/mL in Elderly Subjects Undergoing Coronary Procedure
To evaluate cardio-renal and overall safety profile of GE 145 320 mg I/ml Injection when compared to iopamidol 370 mg I/mL. The study will focus on elderly subjects with either chronic renal insufficiency, or diabetes mellitus…
- Conditions
- Chronic Renal Insufficiency, Diabete Mellitus, Congestive Heart Failure
- Trial name
- NCT01252810
- Testing
- GE-145
- Where
- United States
- Volunteers
- 284 people
- Sponsor
- GE Healthcare
Dyspnea; Cardiac
Contribution LUS in the Diagnosis of Acute Heart Failure (AHF) in Patients Admitted to the ED
This study assesses the potential of lung ultrasonography to diagnose heart failure.
- Trial name
- NCT03717779
- Testing
- lung ultrasound
- Where
- Tunisia
- Volunteers
- 600 people
- Sponsor
- University of Monastir
Myocardial Infarction
Effects of Early Statin Treatment After Acute Myocardial Infarction (AMI) in Japanese Patients
Statins have been shown to prevent coronary artery disease and to preserve left ventricular function in dilated cardiomyopathy. The investigators hypothesized that the early use of statins would reduce cardiovascular events…
- Trial name
- NCT00128024
- Testing
- lipid-lowering treatment
- Where
- Japan
- Volunteers
- 460 people
- Sponsor
- Kumamoto University
Acute Renal Failure
Fenoldopam and Acute Renal Failure
Patients undergoing cardiac surgery could develop postoperative acute renal failure requiring renal replacement therapy. Fenoldopam, already used for patients with hypertensive emergencies, could improve renal function in…
- Trial name
- FENO HSR (NCT00621790)
- Testing
- fenoldopam
- Where
- 19 sites in Italy
- Volunteers
- 667 people
- Sponsor
- Università Vita-Salute San Raffaele
Cardiogenic Shock, Postresuscitation Disease
Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure
Testing the association between circulating candidate proteins and the level of vascular leakage for three distinct forms of circulatory failure: cardiogenic shock, septic shock, and post-resuscitation syndrome.
- Conditions
- Cardiogenic Shock, Postresuscitation Disease, Septic Shock
- Trial name
- NCT05586282
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypervolemic Hyponatremia
International, Multicenter, Open-Label and Randomized Withdrawal Study of Oral Lixivaptan in Heart Failure Patients With Chronic Hyponatremia
To demonstrate that after 12 weeks of open-label lixivaptan treatment, serum sodium is maintained in hyponatremic patients continuing to receive lixivaptan compared to placebo during the 4 week double blind treatment period.
- Trial name
- NCT00876876
- Testing
- Lixivaptan
- Volunteers
- 300 people
- Sponsor
- CardioKine Inc.
Heart Failure
Exploratory Study on Bio-signal Telemonitoring Using Electronic Textiles in a Pediatric Acute and Critical Care Setting
The primary research objective is to determine the safety, feasibility, usability and validity of textile-enabled monitoring systems designed to capture physiologic variables, or "biological signals," related to cardiopulmonary…
- Trial name
- NCT05961176
- Testing
- Skiin pediatric band and Skiin biometric pod
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- The Hospital for Sick Children
Heart Failure, Acute Decompensated Heart Failure
Use of POC Pocket Ultrasound in the Estimation of Left and Right Atrial Pressures
This study will assess the reliability of POC ultrasound in estimating right and left atrium pressures in patients with acute decompensated heart failure.
- Trial name
- POCUSP (NCT03897647)
- Testing
- General Electric (GE) VScan
- Sponsor
- Montefiore Medical Center
Acute Heart Failure (AHF)
Restrictive Versus Liberal Fluid Intake in Acute Decompensated Heart Failure
The aim of this clinical trial is to learn whether a thirst-driven, liberal fluid-intake strategy is comparable to a fluid-restriction strategy in patients hospitalized for acute decompensated heart failure (ADHF).
- Trial name
- RELIEF-AHF (NCT07400991)
- Testing
- Fluid restriction strategy, Thirst-driven, liberal fluid intake
- Where
- Denmark
- Volunteers
- 420 people
- Sponsor
- Gødstrup Hospital
Heart Failure，Congestive
Artificial Intelligence and Smart Wearable Technologies for Early Detection of Acute Heart Failure
Heart failure is the major pandemic of the 21st century. The number of patients and of Heart Failure-related deaths is progressively increasing. This means a devastating economic and health organization burden.
- Trial name
- weHeartClinic (NCT05591443)
- Volunteers
- 120 people
- Sponsor
- Centro Cardiologico Monzino
Acute Decompensated Heart Failure
Add-on Diuretics in Acute Decompensated Heart Failure
The aim of this study is to compare the efficacy and safety of empagliflozin, acetazolamide, and metolazone as add-on therapies to loop diuretics in patients with acute decompensated heart failure.
- Trial name
- NCT07372040
- Testing
- empagliflozin, Acetazolamide, metolazone
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Tanta University
Heart Failure; With Decompensation
Targeting LOXL2 and Cardiac Fibrosis for Post-acute Heart Failure Treatment- A Prospective Study
A previous study demonstrated that a multidisciplinary cardiac rehabilitation (CR) program was associated with reduced medium- to long-term all-cause mortality in a retrospective propensity score-matched study.
- Trial name
- NCT05498584
- Testing
- exercise based cardiac rehabilitation
- Where
- Taiwan
- Volunteers
- 130 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Decompensated Heart Failure
Gas Exchange for Predicting Hospital Heart Failure Readmissions
To determine whether, and if so, which gas exchange parameters measured on the Shape-HF Cardiopulmonary Exercise Testing System predict 30 and 180 day re-hospitalization in subjects discharged from hospitalization for an episode…
- Trial name
- NCT01960218
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- Shape Medical Systems, Inc.
Chronic Kidney Diseases, Heart Failure With Reduced Ejection Fraction
Lokelma for RAAS Maximisation in CKD & Heart Failure.
Background: CKD in patients with heart failure (HF) is common and associated with poor prognosis. Despite evidence of benefit with Renin-Angiotensin-Aldosterone-System inhibitor (RAASi) agents, they are avoided due to fear of…
- Conditions
- Chronic Kidney Diseases, Heart Failure With Reduced Ejection Fraction, Hyperkalemia, ACE Inhibitor Induced Hyperkalaemia
- Trial name
- LIFT (NCT05004363)
- Testing
- Lokelma Oral Product
- Where
- United Kingdom
- Volunteers
- 112 people
- Sponsor
- St George's, University of London
Myocardial Infarction, Death
Serum Magnesium Levels in Desalination Tap Water and Outcomes in Acute Myocardial Infarction Patients
Association between serum magnesium and clinical outcome in patients with acute MI (AMI) with 1 year follow-up in 300 patients in regions supplied by desalinated drinking water (DSW) (Sheba MC) and 150 patients in regions with…
- Conditions
- Myocardial Infarction, Death, Congestive Heart Failure, Acute-MI
- Trial name
- NCT02356393
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Sheba Medical Center
Unstable Angina, Acute Myocardial Infarction
Prevalence of Sleep Disordered Breathing
A novel technique in identifying unspecified sleep apnea has been developed. This technique uses signals typical acquired from a bedside monitor that is found in critical care environments.
- Conditions
- Unstable Angina, Acute Myocardial Infarction, Congestive Heart Failure
- Trial name
- NCT01011647
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- GE Healthcare
Acute Congestive Heart Failure, Heart Failure With Reduced Ejection Fraction
Circulating RNAs in Acute Congestive Heart Failure
The purpose of this American Heart Association-funded and NIH-funded study is to examine circulating RNAs in the acute CHF setting, how they change with decongestive therapy, and their function in vitro and in vivo.
- Conditions
- Acute Congestive Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Normal Ejection Fraction
- Trial name
- CRUCiAL (NCT03345446)
- Testing
- Cardiac MRI
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.