Clinical trials: Acute Cardiac Syndrome
Acute Chest Pain, Acute Coronary Syndrome
The Evaluation and Management of Patients With Acute ChesT Pain in China
EMPACT is the first attempt to comprehensively evaluate the current emergency care of acute chest pain from a regional representative sample in China.Findings will allow new opportunities to facilitate the clinical quality…
- Trial name
- EMPACT (NCT02536677)
- Where
- China
- Volunteers
- 8,374 people
- Sponsor
- Yuguo Chen
Coronary Artery Disease
Assessment of Distal Protection Device in Patients at High Risk for Distal Embolism in Acute Coronary Syndrome (ACS)
Attenuated plaque ≥ 5mm by intravascular ultrasound(IVUS) was reported to be high risk for distal embolism in Acute coronary syndrome(ACS).
- Trial name
- VAMPIRE3 (NCT01460966)
- Testing
- Filtrap™ + Thrombus aspiration catheter, Thrombus aspiration catheter
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Yokohama City University Medical Center
Acute Coronary Syndrome, Pulmonary Embolism
Prehospital Translation of Chest Pain Tools
Decision aids such as the HEART Pathway, Emergency Department Assessment of Chest Pain Score (EDACS), Revised Geneva Score and PERC Score have similar ability to accurately risk stratify Emergency Department (ED) patients with…
- Trial name
- RESCUE (NCT03494556)
- Testing
- Data Collection
- Where
- 2 sites in United States
- Volunteers
- 365 people
- Sponsor
- Wake Forest University Health Sciences
Frailty, Acute Coronary Syndrome
Role of Frailty in Bleeding Risk Prediction in Acute Coronary Syndrome
Studying the incremental role of frailty in predicting in-hospital, short-term (30 days), and mid-term (6 months) bleeding in ACS patients.
- Conditions
- Frailty, Acute Coronary Syndrome, Bleeding
- Trial name
- NCT07158788
- Volunteers
- 850 people
- Sponsor
- Assiut University
Acute Coronary Syndrome, Angina Pectoris
Comparison of BIOdegradable Polymer and DuRablE Polymer Drug-eluting Stents in an All COmeRs PopulaTion (BIO-RESORT)
The introduction of drug-eluting stents (DES) in the treatment of coronary artery disease has led to a significant reduction in morbidity.
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Angina, Unstable, Myocardial Infarction
- Trial name
- BIO-RESORT (NCT01674803)
- Testing
- Orsiro, Synergy, Resolute Integrity
- Where
- Netherlands
- Volunteers
- 3,514 people
- Sponsor
- Foundation of Cardiovascular Research and Education Enschede
Acute Coronary Syndromes, Angioplasty, Transluminal, Percutaneous Coronary
Randomized Comparison of Radiological Exposure With TRIPTable® in Patients With Acute Coronary Syndromes
Excessive radiation received by the operator has been described as a possible drawback of the radial catheterization technique when compared with the femoral access.
- Trial name
- TRIPTABLE (NCT02200783)
- Testing
- TripTable, Radial, Femoral
- Where
- Brazil
- Volunteers
- 99 people
- Sponsor
- Marilia Medicine School
Coronary Disease, Myocardial Infarction
ASSessing the Effect of Anti-IL-6 Treatment in Myocardial Infarction: The ASSAIL-MI Trial
The main goal of this study is to evaluate the ability of a single administration of tocilizumab to reduce myocardial damage in patients presenting with an acute ST-segment elevation myocardial infarction (STEMI).
- Trial name
- ASSAIL-MI (NCT03004703)
- Testing
- Tocilizumab, Sodium chloride 0.9%
- Where
- 3 sites in Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Acute Respiratory Distress Syndrome, Right Heart Failure
Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is an inflammatory injury of the lungs caused by various serious illnesses, such as a bacterial or viral lung infection.
- Trial name
- IVOLIA (NCT07450846)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Bicetre Hospital
Treatment of Acute Coronary Syndrome (ACS).
REalWorld Insights on the INitiation and Treatment Duration of ticagrEloR & Other Oral Antiplatelets (OAP) in Patients With Acute Coronary Syndrome (ACS) in Be/Lux.
REWINDER is a multinational, multicentre, non-interventional, retrospective study of patients treated with an oral antiplatelet (ticagrelor, prasugrel or clopidogrel) while in hospital after an acute coronary syndrome (ACS)…
- Trial name
- REWINDER (NCT02190123)
- Testing
- ACS patients treated with OAP
- Where
- 15 sites in Belgium
- Volunteers
- 430 people
- Sponsor
- AstraZeneca
ACS - Acute Coronary Syndrome, CYP2C19 Polymorphism
CYP2C19 Genotype-Guided P2Y12 Receptor Inhibitor Selection After Complex Percutaneous Coronary Intervention
In Ease Asia clinical trials, P2Y12 inhibitor (ticagrelor or clopidogrel) monotherapy after 3-month dual antiplatelet therapy (DAPT) resulted in a lower incidence of clinically significant bleeding, without increasing risk of…
- Trial name
- NCT06283888
- Testing
- CYP2C19 Genotype Guided DAPT, Conventional DAPT
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Zunyi Medical College
Acute Coronary Syndrome
The ACS Ethnicity Platelet Function Study
This study is being done to assess the effects of the CTP inhibitor on the function of your platelets (cells within your blood that are involved in the formation of blood clots) and to assess whether you have responded to the…
- Trial name
- NCT01829659
- Testing
- Ticagrelor
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medstar Health Research Institute
Heart Failure, Obstructive Sleep Apnea
The Role of Sleep Apnea in the Acute Exacerbation of Heart Failure
This study will evaluate whether treating sleep apnea while in the hospital would help heart failure, and assist recovery from the worsening of the heart function more than the current clinical standard of waiting for treatment…
- Conditions
- Heart Failure, Obstructive Sleep Apnea, Heart Failure, Congestive
- Trial name
- NCT00679549
- Testing
- CPAP Therapy
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Ohio State University
Acute Respiratory Distress Syndrome
Assessment of Cardiac Output in Patients With ARDS Implanted With Venous-venous ECMO.
In patients with severe acute respiratory distress syndrome, extracorporeal membrane oxygenation (ECMO), which also as known as extracorporeal life support, may be used.
- Trial name
- PiCCMO (NCT05164484)
- Testing
- Transpulmonary thermodilution
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome)
RECOMMEND Platform Trial
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main…
- Conditions
- Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome), Intensive Care Medicine, Cardiac Arrest (CA)
- Trial name
- RECOMMEND (NCT06526533)
- Testing
- Liberal RBC Transfusion, Restrictive RBC Transfusion
- Where
- 3 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Acute Coronary Syndrome, TIA
Early Psychological Intervention to Prevent Cardiovascular Event-Induced PTSD (REACH Sub-study)
The overall purpose of this project is to determine the feasibility of conducting a randomized clinical trial that compares written exposure therapy with usual care among patients at risk for cardiovascular event-induced PTSD.
- Conditions
- Acute Coronary Syndrome, TIA, Stroke, Cardiac Arrest
- Trial name
- NCT03605693
- Testing
- Written Exposure Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
Myocardial Infarction, Cardiogenic Shock
Aortic Balloon Counterpulastion in Myocardial Infarction Related Shock
The role of intra aortic balloon counterpulsation in patients experiencing acute myocardial infarction with shock is not established. We hypothesised that use of such a device would lead to improved outcomes in these patients.
- Trial name
- IABPSHOCK (NCT00469248)
- Testing
- Intra-aortic balloon pump counterpulsation
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Coronary Artery Disease, Chronic Stable Angina
LEADERS FREE IV (RCT): BioFreedom™ Ultra vs BioFreedom™ in HBR Patients
This study aims to demonstrate that the BioFreedom™ Ultra Drug Coated Stent (DCS) is non-inferior to the BioFreedom™ DCS, with respect to in-stent late lumen loss, and that it has safety characteristics similar to the BioFreedom™…
- Conditions
- Coronary Artery Disease, Chronic Stable Angina, Unstable Angina, Silent Ischemia
- Trial name
- NCT06657326
- Testing
- BioFreedom™ Ultra cobalt-chromium Biolimus A9™-coated stent, BioFreedom™ stainless steel Biolimus A9™-coated stent
- Where
- 6 sites in Malaysia
- Volunteers
- 444 people
- Sponsor
- Biosensors Europe SA
Coronary Artery Disease, Ischemic Heart Disease
Comparing T-stenting And Minimal Protrusion With External Minicrush for Treatment of Complex Coronary Bifurcation
Nowadays, no studies compare the T-stenting And Minimal Protrusion (TAP) and External Minicrush techniques in treating complex coronary bifurcation, so eventually, procedural, clinical and safety differences remain unknown.
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Chronic Coronary Syndrome, Acute Coronary Syndrome
- Trial name
- NCT06484647
- Testing
- Percutaneous Coronary Intervention
- Where
- Italy
- Volunteers
- 382 people
- Sponsor
- San Luigi Gonzaga Hospital
Acute Coronary Syndrome, Acute Myocardial Infarction
VerifyNow to Optimise Platelet Inhibition in Coronary Acute Syndrome
The objective of the study is to establish a de-scaling strategy of P2Y12 inhibitors (P2Y12 i) with a decrease in hemorrhagic events without increasing ischemic complications based on a Platelet Function Test (PFT).
- Conditions
- Acute Coronary Syndrome, Acute Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- VERONICA (NCT04654052)
- Testing
- Clopidogrel, Previous treatment
- Where
- 19 sites in Spain
- Volunteers
- 637 people
- Sponsor
- Fundación EPIC
Coronary Disease, Hypercholesterolemia
Yokohama Assessment of Fluvastatin, Pravastatin, Pitavastatin and Atorvastatin in Acute Coronary Syndrome (Yokohama-ACS)
The purpose of this study is to compare the effects of fluvastatin, pravastatin, pitavastatin, and atorvastatin on coronary plaque volume in patients with acute coronary syndrome, and to clarify the impact of moderate and…
- Trial name
- Yokohama-ACS (NCT00549926)
- Testing
- Fluvastatin, Pravastatin, Pitavastatin
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Yokohama City University Medical Center
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