Clinical trials: Acute Cardiac Syndrome
Cardiorenal Syndrome
Sodium-Glucose Cotransporter-2 Inhibitor for Acute Cardiorenal Syndrome: A Feasibility Study
The long-term objective of this study is to test whether the addition of SGLT2 inhibitors to usual care during acute heart failure management in patients who develop kidney injury shortens the time to achieving symptomatic…
- Trial name
- SGLT2i in CRS (NCT06111768)
- Testing
- Dapagliflozin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
ST-segment Elevation Myocardial Infarction (STEMI)
Fast Radial Pharmaco-invasive Strategy In ST Elevation Myocardial Infarction Trial
INTRODUCTION: The pharmaco-invasive strategy is a safe alternative to primary percutaneous coronary intervention (PCI) in patients with ST elevation acute myocardial infarction, who cannot be in the cathlab in less than 120…
- Trial name
- FARADMI (NCT04300582)
- Testing
- Cardiac catheterization standard strategy, Cardiac catheterization fast strategy
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Coronary Syndrome, STEMI
Usefulness of High-frequency QRS Analysis in the Evaluation of Patients With Chest Pain
Accurate detection of a heart attack (an acute myocardial infarction) is one of the most pressing needs in medicine. Recordings of the electrocardiogram (ECG) (electrical activity of the heart) are one of the first tools used to…
- Conditions
- Acute Coronary Syndrome, STEMI, NSTEMI, Unstable Angina
- Trial name
- NCT01185899
- Where
- Israel
- Volunteers
- 324 people
- Sponsor
- Ori Galante
Spontaneous Coronary Artery Dissection
International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry
The aim of "iSCAD," the International Spontaneous Coronary Artery Dissection (SCAD) Registry, is to serve as an internationally collaborative, multicenter registry coordinated by an experienced and centralized coordinating center…
- Trial name
- NCT04496687
- Where
- 31 sites in United States, Australia
- Volunteers
- 2,000 people
- Sponsor
- SCAD Alliance
ST Elevation Acute Myocardial Infarction
COMBinAtion Therapy in Myocardial Infarction: The COMBAT-MI Trial
Remote ischemic conditioning (RIC) and intravenous exenatide administered immediately before primary angioplasty have been found to limit infarct size in patients with STEMI (ST segment elevation myocardial infarction), but the…
- Trial name
- COMBAT-MI (NCT02404376)
- Testing
- Exenatide, Remote Ischemic Conditioning (RIC)
- Where
- 6 sites in Spain
- Volunteers
- 378 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Coronary Syndrome
Positive Psychology to Improve Healthy Behaviors After an Acute Coronary Syndrome
In this proof-of-concept study, the investigators will assess the ease and usefulness of a positive psychology program in patients with acute coronary syndrome and less-than-optimal adherence to health behaviors.
- Trial name
- PEACE II (NCT02004158)
- Testing
- Positive psychology intervention
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
Giant Cell Arteritis (GCA), Acute Coronary Syndrome (ACS)
Aspirin for the Prevention of Ischemic Complications in Giant Cell Arteritis
The ASPIRE-GCA Pilot trial will assess the feasibility of a future randomized controlled trial (RCT) evaluating the efficacy of low-dose ASA in preventing ischemic complications in patients with Giant Cell Arteritis (GCA).
- Conditions
- Giant Cell Arteritis (GCA), Acute Coronary Syndrome (ACS), Ishemic and Thrombotic Complications
- Trial name
- ASPIRE-GCA (NCT07908082)
- Testing
- Acetyl Salicylic Acid (ASA)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Stroke, Ischemic, Stroke, Acute
Ischemic Strokes While on NOAC - How Compliance Matters
This study is aimed to depict the epidemiological trend, aetiologies, clinical characteristics, treatment options of IS-NOAC in face of the rapidly increasing NOAC usage.
- Conditions
- Stroke, Ischemic, Stroke, Acute, Stroke Syndrome, Stroke, Cardiovascular
- Trial name
- NCT04607070
- Where
- Hong Kong
- Volunteers
- 91 people
- Sponsor
- Chinese University of Hong Kong
Acute Coronary Syndrome
Efficacy and Safety of Lornoxicam in Patients With Acute Coronary Syndrome
The purpose of this study is to determine whether nonsteroidal antiinflammatory drug lornoxicam in combination with low dose aspirin (100mg/day) is effective and safe in patients with Acute Coronary Syndrome without persistent…
- Trial name
- PLEA (NCT00997750)
- Testing
- Lornoxicam
- Where
- Russia
- Volunteers
- 85 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Acute Coronary Syndrome, Coronary Artery Disease
Pilot Safety Study of Coronary CTA for the Diagnosis of Acute Coronary Syndrome in the Emergency Room
The Diagnosis of acute coronary syndrome in patients presenting with acute chest pain is problematic when both, electrocardiogram and serum troponins are normal.
- Conditions
- Acute Coronary Syndrome, Coronary Artery Disease, Cardiac Death, Myocardial Infarction
- Trial name
- NCT01682096
- Testing
- computed coronary angiography, Exercise stress echocardiography
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- José Ortiz
Acute Coronary Syndrome
Effectiveness of the Tiger Catheter on Transradial Coronariography: Randomized Compared to JudKins cathETers
The aim of this study was to assess effectiveness and safety of Tiger (5Fr) vs Judkins (5Fr) catheters, in coronariography via the right transradial approach. This was a prospective, randomized, study of paralled design.
- Trial name
- TICKET (NCT03273218)
- Testing
- Tiger catheter, Judkins catheter
- Where
- Argentina
- Volunteers
- 120 people
- Sponsor
- Marcelo Alberto OLIVA
Acute Coronary Syndromes, STEMI
Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX
This protocol describes a study to compare intended trans-radial versus trans-femoral intervention and bivalirudin monotherapy versus current European standard of care consisting of unfractionated heparin (UFH) plus provisional…
- Conditions
- Acute Coronary Syndromes, STEMI, NSTEMI
- Trial name
- MATRIX (NCT01433627)
- Testing
- trans-radial and short-term bivalirudin, trans-radial and long-term bivalirudin infusion, trans-radial and standard of care pharmacology
- Where
- 62 sites in Italy
- Volunteers
- 7,200 people
- Sponsor
- Italian Society of Invasive Cardiology
Acute Myocardial Infarction
Investigating Variation in Hospital Acute Coronary Syndrome Outcomes
To investigate the causes of hospital variation in outcomes from acute coronary syndromes in England and develop recommendations for improving patient care.
- Trial name
- NCT01808027
- Where
- United Kingdom
- Volunteers
- 5,555 people
- Sponsor
- University of Leeds
Myocardial Infarction, Cardiovascular Death
Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin
This study is being carried out to see if a new drug called ticagrelor given twice daily in addition to the ASA therapy decreases the frequency of cardiovascular events (e.g., death from heart disease, heart attack, or stroke).
- Conditions
- Myocardial Infarction, Cardiovascular Death, Atherothrombosis, Stroke
- Trial name
- PEGASUS (NCT01225562)
- Testing
- Ticagrelor 90 mg, Ticagrelor 60 mg
- Where
- 826 sites in United States, Argentina and 29 more
- Volunteers
- 21,379 people
- Sponsor
- AstraZeneca
Acute Coronary Syndrome, Cytokines
Vitamin D and Inflammatory Cytokine Levels After Acute Myocardial Infraction (MI)
Vitamin D is known to have immune-modulator effects including suppression of proinflammatory cytokine expression and regulation of immune cell activity.
- Trial name
- NCT01115842
- Testing
- Vitamin D
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Meir Medical Center
Acute Coronary Syndrome, Chest Pain
Database of Patients Undergoing Cardiac Computed Tomographic Angiography at William Beaumont Hospital (CT DATABASE)
The purpose of the study is to establish an overarching database of information containing historical, demographical, clinical, and intermediate and long-term outcome data from all William Beaumont Hospital (WBH) patients…
- Trial name
- CTDATABASE (NCT00922662)
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Kavitha Chinnaiyan
Acute Coronary Syndrome
Phase 2 Study in Vascular Inflammation on Patients After an Acute Coronary Syndrome Event
The purpose of this study is to determine the effect of VIA-2291 as compared to placebo on vascular inflammation following 24 weeks of dosing.
- Trial name
- NCT00552188
- Testing
- VIA-2291
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Tallikut Pharmaceuticals, Inc.
Acute Myocardial Infarction
Investigating Variation in Hospital Acute Coronary Syndrome Outcomes
To investigate the causes of hospital variation in outcomes from acute coronary syndromes in England and develop recommendations for improving patient care.
- Trial name
- NCT01819103
- Volunteers
- 5,555 people
- Sponsor
- University of Leeds
Acute Coronary Syndrome
Observational Registry on Acute Coronary Syndromes in Campania
This registry aims to collect data related to management of patients affected by acute coronary syndromes and hospitalized in the Campania Region of Italy
- Trial name
- Campania RESCA (NCT02650323)
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- Federico II University
Coronary Artery Disease, Acute Coronary Syndromes
Aspirin 50mg vs 100mg Combined With P2Y12 Inhibitor After PCI
This is a randomized, open-label, active-controlled, non-inferiority clinical trial (the ASPIRE-LD trial) conducted in China. It aims to compare the efficacy and safety of low-dose aspirin (50 mg once daily) versus standard-dose…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndromes, Chronic Coronary Syndrome, Percutaneous Coronary Intervention
- Trial name
- ASPIRE-LD (NCT07846462)
- Testing
- Aspirin, P2Y12 inhibitor
- Where
- China
- Volunteers
- 2,640 people
- Sponsor
- Jilin University
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