Clinical trials: Acute Cardiac Syndrome
Acute Coronary Syndrome, Chest Pain
High-Sensitivity Cardiac Troponin T to OPtimize Chest Pain Risk Stratification
This is a prospective observational cohort study of ED patients with acute chest pain or other symptoms suggestive of ACS. Blood samples will be collected from study participants for High-Sensitivity Cardiac Troponin T (hs-cTnT)…
- Trial name
- STOP CP (NCT02984436)
- Testing
- Blood Sample, HEART Score
- Where
- 6 sites in United States
- Volunteers
- 1,572 people
- Sponsor
- University of Florida
Acute Coronary Syndrome
Patients Returning to Work After Acute Coronary Syndrome
The literature is quite rich concerning the factors which influence the return to work after acute coronary syndrome. They can be divided into three categories: factors linked to the patient, those linked to the workstation and…
- Trial name
- ACS (NCT05145777)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Coronary Syndromes, Unstable Angina (UA)
Oregano and Basil Leaves and Coronary Artery Disease
The present study will examine the effects of increasing dietary polyphenol intake by consumption of oregano and basil leaves, on plasma inflammatory and lipid factors and total urinary polyphenol levels in patients who have…
- Trial name
- NCT07123181
- Testing
- Control (Standard treatment), Higher polyphenol intake by consumption of oregano and basil
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Atrial Fibrillation, Acute Coronary Syndromes
DUAL Antithrombotic Therapy in Patients With AF and ACS
The study aims to show inferiority of rivaroxaban plus ticagrelor when compared to rivaroxaban plus clopidogrel in terms of safety.
- Trial name
- NCT04023630
- Testing
- Rivaroxaban 15 MG Oral Tablet, Clopidogrel 75 Mg Oral Tablet, Ticagrelor 90 MG Oral Tablet
- Volunteers
- 4,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Coronary Syndromes (ACS), Cardiac Rehabilitation
Patient-centered Personalized Cardiac Rehabilitation in Post Acute Coronary Syndrome (BREAK-trial)
The primary objective of this study is to compare an integrated, multidisciplinar patient-centered CRP (Cardiac Rehabilitation Program) (intervention group) especially focused on covering the needs for the female and fragile…
- Conditions
- Acute Coronary Syndromes (ACS), Cardiac Rehabilitation, Frailty, Women
- Trial name
- BREAK (NCT07038265)
- Testing
- Personalised treatment, Usual Care
- Where
- Spain
- Volunteers
- 202 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Acute Coronary Syndrome
The Contemporary Role of Beta Blockers in Patients With Acute Myocardial Infarction
The use of beta blockers after acute myocardial infarction is a core component of drug therapy, but evidence is primarily derived from patients who did not receive reperfusion therapy and secondary prophylaxis.In contemporary…
- Trial name
- NCT04564365
- Testing
- beta-blocker
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Chongqing Medical University
Delirium, QT-prolongation
Risk of QT-prolongation and Torsade de Pointes in Patients Treated With Acute Medication in a University Hospital
A prospective, observational study in a university hospital (UZ Leuven). Patients are included when they are treated with a potentional QT-prolonging drug: haloperidol for delirium, antibiotics (moxifloxacin, levofloxacin…
- Trial name
- RISQ-PATH (NCT02068170)
- Testing
- Haloperidol, azi/clari/erythromycin, levo/moxifloxacin, co-trimoxazole, vori/keto/flu/itraconazole, methadone, tacrolimus, sunitinib
- Where
- Belgium
- Volunteers
- 178 people
- Sponsor
- KU Leuven
Non ST Segment Elevation Acute Coronary Syndrome
MCG for Identification of Myocardial Ischemia in Suspected NSTE-ACS Patients
The goal of this multi-center observational study is to learn about the effectiveness of magnetocardiography in rapid and accurate identification of ischemia in patients with suspected NSTE-ACS.
- Trial name
- NCT06197724
- Testing
- Magnetocardiography
- Where
- China
- Volunteers
- 14,090 people
- Sponsor
- Qilu Hospital of Shandong University
Acute Coronary Syndrome
Tailored Antiplatelet Therapy Versus Recommended Dose of Prasugrel
The purpose of this study is to demonstrate the superiority of a strategy of platelet monitoring (Monitoring Arm) with down-adjustment of the dose of prasugrel in high responders and up-adjustment of the dose of prasugrel in low…
- Trial name
- ANTARCTIC (NCT01538446)
- Testing
- Modification of Prasugrel based on a biological assay, prasugrel / clopidogrel, Verify Now
- Where
- 2 sites in France
- Volunteers
- 880 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Drug Therapy, Acute Coronary Syndrome
Registry Study on Drug Therapy and Clinical Outcomes in Patients With Acute Coronary Syndrome
Registry Study on Drug Therapy and Clinical Outcomes in Patients With Acute Coronary Syndrome
- Trial name
- NCT04184583
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Myocardial Ischemia, Myocardial Infarction
Prehospital Evaluation and Economic Analysis of Different Coronary Syndrome Treatment Strategies - PREDICT
Despite remarkable gains in treatment over the last decade short-term mortality for those who survive to hospital with AT-elevation acute myocardial infarction (STEMI) remains high (5%-10%).
- Trial name
- PREDICT (NCT00747656)
- Where
- 5 sites in Canada
- Volunteers
- 446 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Acute Coronary Syndrome, Acute Aortic Syndrome
VOCs in Patients With Acute Cardiogenic Chest Pain
The goal of this observation study is to compare VOCs in cardiogenic chest pain population/health conditions, to answer：Establishment and promotion of the application system of emergency rapid detection of expiratory Volatile…
- Trial name
- NCT06277895
- Testing
- VOCs
- Where
- China
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Acute Coronary Syndrome
Positive Psychology for ACS Patients: a Factorial Design Study
This trial is part of a multi-phase study to develop and test positive psychology (PP) interventions in patients hospitalized for an acute coronary syndrome (ACS).Using a factorial design, the investigators will: (a) assess the…
- Trial name
- PEACEIII (NCT02754895)
- Testing
- Positive Psychology (PP), Motivational Interviewing (MI)
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Massachusetts General Hospital
Familial Hypercholesterolemia, Familial Hypercholesterolemia Due to Genetic Defect of Apolipoprotein B
Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia
ACCURATE will test the hypothesis that opportunistic genetic testing for Familial Hypercholesterolemia (FH) in patients admitted to hospital with an acute coronary syndrome will increase the diagnosis of FH and will impact…
- Conditions
- Familial Hypercholesterolemia, Familial Hypercholesterolemia Due to Genetic Defect of Apolipoprotein B, Familial Hypercholesterolemia Due to Heterozygous LDL Receptor Mutation, Familial Hypercholesterolemia - Heterozygous
- Trial name
- ACCURATE (NCT05218005)
- Testing
- Research-based genetic test for Familial Hypercholesterolemia
- Where
- 2 sites in Canada
- Volunteers
- 140 people
- Sponsor
- University of British Columbia
Acute Coronary Syndrome
A NIS Registry of the Prospective Structured Care In Acute Coronary Syndrome
The purpose of the study is to analyse patient's acceptance and willingness to participate in a Structured Care Program (SCP) over 12 months following hospital discharge after Acute Coronary Syndrome (ACS) index event.
- Trial name
- ProAcor (NCT01490645)
- Where
- 45 sites in Germany
- Volunteers
- 1,006 people
- Sponsor
- AstraZeneca
Thoracic Aortic Aneurysm
The CardiOvascular Remodeling Following Endovascular Aortic Repair (CORE) Study
The use of TEVAR is increasing rapidly and patients even in younger patients. However, current endografts are several orders of magnitude stiffer than the native aorta.
- Trial name
- CORE (NCT02735720)
- Testing
- TEVAR, Non-TEVAR medical treatment
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Michigan
Acute Coronary Syndromes, Acute Myocardial Infarction
Effect of Adjunctive Intracoronary Streptokinase on Late Term Left Ventricular Infarct Size and Volumes in Patients With Acute Myocardial Infarction
The investigators hypothesized that complementary intracoronary streptokinase administration to primary percutaneous intervention in patients with acute myocardial infarction may provide limitation infarct size and improvement in…
- Conditions
- Acute Coronary Syndromes, Acute Myocardial Infarction, Reperfusion Injury
- Trial name
- NCT00627809
- Testing
- Streptokinase, primary percutaneous coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul University
Cardiovascular Diseases, Coronary Artery Disease
Optimising Secondary Prevention and Quality of Life in Early Cardiac Rehabilitation
The primary aim of this research is to explore the adherence and drop-out from early cardiac rehabilitation (CR), to inform interventions to support patient's adherence to CR and facilitate maintenance.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Myocardial Infarction, Acute Coronary Syndrome
- Trial name
- OSPREY-CR (NCT04781699)
- Where
- 6 sites in United Kingdom
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Acute Coronary Syndrome, Myocardial Infarction
Stent For Life Observatory
Observatory multicenter, prospective, to support the acute phase of acute coronary syndromes with ST segment elevation ST (myocardial infarction).
- Trial name
- SFL (NCT01251198)
- Where
- France
- Volunteers
- 460 people
- Sponsor
- French Cardiology Society
Thromboembolism
OASIS-6 : The Safety and Efficacy of Fondaparinux Versus Control Therapy in Patients With ST Segment Elevation Acute Myocardial Infarction
This is a randomized, double blindcontrolled, parallel group, multi-center, multinational study of fondaparinux vs. control in patients with STEMI (ST segment myocardial infarction) randomized within 24 hours of the onset of…
- Trial name
- NCT00064428
- Testing
- fondaparinux - UFH not indicated, Control - UFH not indicated, Fondaparinux - UFH indicated
- Volunteers
- 12,092 people
- Sponsor
- GlaxoSmithKline
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