Clinical trials: Acute Cardiac Syndrome
Dual Antiplatelet Therapy, Acute Coronary Syndrome
De-escalating Antiplatelet Therapy to Assess Platelet Reactivity and Outcomes in High Bleeding Risk Patients With Recent ACS
High bleeding risk (HBR) patients, comprising up to 50% of those presenting with acute coronary syndrome (ACS), are a high-risk group that is increasing in size due to an aging population.
- Conditions
- Dual Antiplatelet Therapy, Acute Coronary Syndrome, Coronary Artery Disease
- Trial name
- DESC-HBR (NCT05903976)
- Testing
- P2Y12 inhibitor de-escalation
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Acute Coronary Syndrome, Acute Chest Pain
Better Evaluation of Acute Chest Pain With Computed Tomography Angiography
The purpose of this study is to determine whether cardiac CT can improve triage of acute chest pain patients in the emergency department.
- Trial name
- BEACON (NCT01413282)
- Testing
- Cardiac CT
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Erasmus Medical Center
Acute Coronary Syndrome
Short and Long Term Outcomes of Acute Coronary Syndrome in Patients With Non Obstructive Coronary Atherosclerosis
The purpose of the study is to assess short and long term outcomes of acute coronary syndrome in patients with non obstructive coronary atherosclerosis, to optimize the algorithm for diagnosis and to evaluate its effectiveness
- Trial name
- NOCA (NCT02655718)
- Testing
- Patients with ACS, MRI
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Russian Academy of Medical Sciences
Acute Coronary Syndromes, Flow Mediated Dilation
A Prospective, Single-center, Observational Study Aiming to Assess the Predictive Role of Flow Mediated Dilatation in Acute Coronary Syndromes, Combined With Echocardiographic and Biochemical Indices
A prospective, single-center, observational study aiming to assess the predictive role of flow mediated dilatation in acute coronary syndromes, combined with echocardiographic and biochemical indices.
- Conditions
- Acute Coronary Syndromes, Flow Mediated Dilation, Endothelial Function (FMD)
- Trial name
- FLARE-ACS (NCT06890013)
- Testing
- Observation group
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Acute Coronary Syndrome, Myocardial Infarction
Safety and Efficacy of LMWH Versus Rivaroxaban in Chinese Patients Hospitalized With Acute Coronary Syndrome
H-REPLACE trial is a prospective, randomized, open-label, active-controlled, multicenter study in participants with ACS (STEMI or NSTEMI, unstable angina).
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Myocardial Ischemia, Unstable Angina
- Trial name
- H-REPLACE (NCT03363035)
- Testing
- Rivaroxaban 2.5 mg, Rivaroxaban 5 mg, Enoxaparin
- Where
- 24 sites in China
- Volunteers
- 2,055 people
- Sponsor
- Second Xiangya Hospital of Central South University
Acute Coronary Syndrome, Coronary Artery Disease
3rd Generation Resorbable Magnesium Scaffolds vs Biodegradable Polymer Stents in NSTE/ACS
This is a multicentre, prospective, randomized controlled trial that will investigate the role and performance of the 3rd generation resorbable magnesium scaffolds "DREAMS 3G" labeled under the name "Freesolve" vs contemporary…
- Trial name
- NCT06409117
- Testing
- Percutaneous coronary intervention
- Where
- 7 sites in Belgium, Greece and 1 more
- Sponsor
- Konstantinos Toutouzas
Acute Coronary Syndrome
Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS
This is a placebo-controlled, randomized, double-blind, parallel group, phase 3 multicenter study in subjects recently hospitalized for ACS and with the appropriate genetic profile.
- Trial name
- dal-GenE-2 (NCT05918861)
- Testing
- Dalcetrapib
- Where
- 231 sites in United States, Canada and 1 more
- Volunteers
- 2,000 people
- Sponsor
- DalCor Pharmaceuticals
Myocardial Ischemia(Implanted Drug-eluting Stents Because of Ischemic Heart Disease(Stable Angina, Acute Coronary Syndrome))
Impact of IntraVascular UltraSound Guidance on the Outcomes of Xience Prime Stents in Long Lesions (IVUS-XPL Study): Retrospective and Prospective Follow-up Study
The investigator aimed to evaluate the long-term (up to 10 years) follow-up of the patients who enrolled the IVUS-XPL study (Impact of IntraVascular UltraSound Guidance on the Outcomes of Xience Prime Stents in Long Lesions)…
- Trial name
- NCT03866486
- Where
- South Korea
- Volunteers
- 1,400 people
- Sponsor
- Yonsei University
Coronary Heart Disease, Acute Myocardial Infarction
The Effect of Tongguan Capsule for MicroRNA Profiles in Coronary Heart Disease Patients
The purpose of this study is to test the expression of microRNAs related to the syndromes after the intervention of Tongguan capsule,preliminarily to investigate the mechanism of the effects of Tongguan capsule, and provide the…
- Trial name
- NCT02850627
- Testing
- Tongguan capsule
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
CA-AKI - Contrast-Associated Acute Kidney Injury, Coronary Artery Disease
Efficacy of Phentolamine in Prevention of Contrast-Associated Acute Kidney Injury After Complex PCI
To evaluate the efficacy and safety of phentolamine in prevention of CA-AKI following complex PCI in patients at high risk of CA-AKI.
- Conditions
- CA-AKI - Contrast-Associated Acute Kidney Injury, Coronary Artery Disease, Acute Coronary Syndrome, Adrenergic Receptor Antagonist Adverse Reaction
- Trial name
- NCT06286059
- Testing
- Phentolamine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Helwan University
Acute Coronary Syndromes, Dyslipidemia
Early Triple Lipid-Lowering Therapy With Bempedoic Acid After Acute Coronary Syndrome
This randomized clinical trial will evaluate whether starting bempedoic acid in addition to high-intensity statin therapy and ezetimibe within 72 hours after percutaneous coronary intervention improves low-density lipoprotein…
- Trial name
- EARLY-BIRD ACS (NCT07824323)
- Testing
- bempedoic acid, Ezetimibe, High-Intensity Statin Therapy
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taipei Medical University Hospital
Stable Coronary Artery Disease, Acute Coronary Syndromes
Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease
Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages.
- Conditions
- Stable Coronary Artery Disease, Acute Coronary Syndromes, Critical Limb Ischemia, Intermittent Claudication
- Trial name
- NCT07588295
- Testing
- Optical Coherence Tomography assessment
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Maria Cecilia Hospital
Acute Coronary Syndrome
Statins Evaluation in Coronary Procedures and Revascularization Trial
The purpose of this study is to determine whether a loading dose of atorvastatin before percutaneous intervention procedures in acute coronary syndromes is effective to reduce major cardiovascular events(MACE).
- Trial name
- SECURE-PCI (NCT01448642)
- Testing
- Atorvastatin
- Where
- Brazil
- Volunteers
- 4,191 people
- Sponsor
- Hospital do Coracao
Acute Coronary Syndrome
MT1002 Phase II Study in ACS Patients With PCI
This is an open-label, sequential-dose escalation/de-escalation trial testing 3 dose levels of MT1002 in patients undergoing PCI due to ACS with NSTEMI.
- Trial name
- NCT04723186
- Testing
- MT1002 for Injection
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Shaanxi Micot Pharmaceutical Technology Co., Ltd.
Acute Chest Syndrome
ST Elevation in Acute Chest Pain; Could Measurement of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) be Helpful to the Clinician?
A blood test (2-3 cc peripheral venous blood) drawn /used from already available required lab tests to distinguish between pericarditis accompanied with electrocardiogram (ECG) signs mimicking infarction.
- Trial name
- NCT01041339
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexhander Izhaki
MYOCARDIAL INFARCTION
Assessment of an Early De-Escalation to a Low-potency Single Antiplatelet Therapy Guided by Genetics Versus a Systematic High-Potency Single Antiplatelet Therapy to Neutralize Bleeding Complications in Patients With High Bleeding Risk Beyond One Month After an Acute Coronary Syndrome
Patients who suffered from acute coronary syndrome (ACS) are usually treated with a long-term dual antiplatelet therapy (DAPT) to reduce stent thrombosis and recurrent ischemic event.
- Trial name
- ADEN (NCT05577988)
- Testing
- single-antiplatelet with a low-potency antiplatelet (aspirin or clopidogrel) guided by genetic testing.
- Where
- France
- Volunteers
- 2,468 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Coronary Syndrome
Serum Soluble ST2 and Plaque Vulnerability in Patients With Acute Coronary Syndrome
This study aimed to assess the association between serum sST2 level and plaque vulnerability in ACS patients. It is hypothesized that serum sST2 level may be related to plaque components and closely associated with plaque…
- Trial name
- NCT04797819
- Testing
- Coronary plaque components
- Where
- China
- Volunteers
- 120 people
- Sponsor
- RenJi Hospital
Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI), High Bleeding Risk
Genotype-Guided Abbreviated DAPT Versus Un-Guided De-escalation Therapy in Patients With ACS and HBR
The aim of this study is to assess the safety and efficacy of the CYP2C19 genotype-guided abbreviated dual antiplatelet therapy (DAPT) strategy versus the un-guided stepwise intensity de-escalation of DAPT strategy in patients…
- Trial name
- GUIDE-HBR (NCT06763744)
- Testing
- P2Y12 antagonist monotherapy, clopidogrel + aspirin
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Samsung Medical Center
ACS - Acute Coronary Syndrome
Telemedicine Follow-up for Post-ACS Patients
The aim is to compare the safety of using telemedicine and office visit follow-up in post-acute coronary syndrome patients
- Trial name
- NCT04485754
- Testing
- Telemedicine FU, Office FU
- Where
- Russia
- Volunteers
- 88 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Acute Coronary Syndrome, Stroke
Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SP-8008
This is a single-centre, double-blind, randomised, placebo-controlled single oral-dose escalation study in healthy male subjects. It is planned to enrol approximately 48 subjects into up to 6 planned dose level cohorts.
- Trial name
- NCT04770194
- Testing
- SP-8008 Prototype Capsule A, SP-8008 Prototype Capsule B
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
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