Clinical trials: Acute Cardiac Syndrome
Acute Coronary Syndrome, Venous Thromboembolism
The Effect of Reduced Dose of Enoxaparin on the Outcomes of Treatment With Enoxaparin
We hypothesize that reduced dose of enoxaparin in elderly patients will result in reduced proportion of patients with therapeutic anti Xa activity and reduced clinical efficacy.
- Conditions
- Acute Coronary Syndrome, Venous Thromboembolism, Atrial Fibrillation, Hypercoagulability
- Trial name
- NCT00354796
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Hadassah Medical Organization
Acute Coronary Syndrome
Genotype Guided Versus Conventional Approach in Selection of Oral P2Y12 Receptor Blocker in Chinese Patients Suffering From Acute Coronary Syndrome
This study aims to compare the outcome between genotype guided versus clinical guided approach in selection of oral P2Y12 receptor blocker in Chinese patients suffering from acute coronary syndrome.
- Trial name
- NCT01994941
- Testing
- Clopidogrel, Ticagrelor
- Where
- Hong Kong
- Volunteers
- 133 people
- Sponsor
- The University of Hong Kong
Acute Coronary Syndrome
Point of Care Evaluation of High-sensitivity Cardiac Troponin
In this observational research project the investigators wish to test new technologies that could allow them to either detect or rule out heart attacks earlier.
- Trial name
- POC-ET (NCT05665127)
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Edinburgh
Frailty Syndrome, Ischaemic Heart Disease
Cardiac Rehabilitation and Additional Physical Training in Elderly Patients After Acute Coronary Syndrome
The aim of this study is to evaluate functional and physical capacity, health-related quality of life and associations with frailty in older patients after ischemic heart disease and interventional treatment with an…
- Trial name
- NCT04768283
- Testing
- Additional balance and resistance training - 1, Additional balance and resistance training - 2
- Where
- Lithuania
- Volunteers
- 100 people
- Sponsor
- Lithuanian University of Health Sciences
Non ST Elevation Myocardial Infarction, Unstable Angina
Conservative Non-Invasive Versus Routine Invasive Management in Coronary Artery Bypass Surgery Patients with Non ST Elevation Elevation Acute Coronary Syndrome
Background: Most coronary artery bypass grafts (CABG) are diseased or blocked within 10 years of surgery meaning CABG survivors have an ever increasing risk of recurrent angina, heart attack and death.
- Trial name
- CABG-ACS (NCT01895751)
- Testing
- Invasive management
- Where
- 5 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS National Waiting Times Centre Board
Respiratory Distress Syndrome, Adult, Ventricular Dysfunction, Right
The Value of Combined Critical Care Ultrasound and PAC Monitor Oriented Therapy Protocol to Patients of ARDS With ACP
We hypothesize that combined critical care ultrasound and PAC monitoring-oriented therapy protocol (CUP protocol), would improve prognosis of patients of ARDS with right ventricular dysfunction.
- Trial name
- NCT03971331
- Testing
- PAC catheter and critical care ultrasound examination
- Volunteers
- 236 people
- Sponsor
- Kang Yan
Preoperative KIDNEY FAILURE, CHRONIC, Postoperative KIDNEY FAILURE, ACUTE
NGAL Predictive Value of Acute Kidney Failure After Cardiac Surgery in Patients With Preoperative Chronic Kidney Failure
Primary endpoint: To evaluate predictive value of plasmatic levels of Neutrophil Gelatinase Associated Lipocalin (NGAL) to reveal acute kidney failure after cardiac surgery in patients with preoperative chronic kidney failure…
- Conditions
- Preoperative KIDNEY FAILURE, CHRONIC, Postoperative KIDNEY FAILURE, ACUTE, Cardiac Surgical Procedures
- Trial name
- NGAL-CKF (NCT01227122)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hopital Jean Minjoz
Thrombosis, Acute Coronary Syndrome
Safety, Pharmacokinetic and -Dynamic Study of PR-15, an Inhibitor of Platelet Adhesion
Primary objective: To evaluate safety and tolerability, adverse events (AEs), vital signs, ECG, bleeding time, evaluation of antibody titer and safety laboratory tests Secondary objectives: To evaluate the pharmacokinetics and…
- Conditions
- Thrombosis, Acute Coronary Syndrome, Myocardial Infarction, Stroke
- Trial name
- PR-15/01 (NCT01042964)
- Testing
- revacept (PR-15)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AdvanceCor GmbH
Acute Coronary Syndrome, Myocardial Infarction
Utilization of Diagnostic Ultrasound in the Detection and Therapy of Acute Coronary Syndromes
The study will see if mechanical impulses delivered by an echocardiographic probe during a continuous infusion of MRX 801 are capable of improving blood flow in smaller heart vessels in patients with acute coronary syndromes.
- Trial name
- NCT00955136
- Testing
- Use of intermittent high MI impulses during echocardiogram
- Sponsor
- University of Nebraska
Chest Pain, Telemetry
Telemetry for Chest Pain of Low Risk for Acute Coronary Syndrome Pts
This is a randomized controlled, multi-center, non-blinded non-inferiority study examining the utility of telemetry monitoring in patients admitted who are low risk for acute coronary syndrome.
- Conditions
- Chest Pain, Telemetry, Acute Coronary Syndrome, Health Care Resource Utilization
- Trial name
- NCT02330328
- Testing
- No Telemetry Monitoring, Telemetry Monitoring
- Sponsor
- Carilion Clinic
Acute Coronary Syndrome
Impact of MEditerranean Diet, Inflammation and Microbiome After an Acute Coronary Syndrome
In the MEDIMACS project, the investigators will use a randomized clinical-trial design to address the effects of mediterranean diet on atherosclerotic plaque vulnerability and coronary endothelial function in order to decipher…
- Trial name
- MEDIMACS (NCT03842319)
- Testing
- Microbiota analysis, Immunological analysis, Proteome analysis
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Acute Myocardial Infarction, Unstable Angina
Exploring the Mechanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and Computational Fluid Dynamics II (EMERALD II) Study
The EMERALD II study is a multinational, multicenter, and retrospective study. ACS patients who underwent CCTA from 1 months to 3 years prior to the event will be retrospectively identified.
- Trial name
- EMERALD II (NCT03591328)
- Testing
- Coronary CT angiography
- Where
- South Korea
- Volunteers
- 429 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease, Acute Coronary Syndrome
Double Randomization of a Monitoring Adjusted Antiplatelet Treatment Versus a Common Antiplatelet Treatment for DES Implantation, and Interruption Versus Continuation of Double Antiplatelet Therapy
Our first hypothesis is that dose adjustment of aspirin and clopidogrel based on biological monitoring reduces the rate of severe cardiovascular complications compared to a conventional strategy in patients scheduled for drug…
- Trial name
- ARCTIC (NCT00827411)
- Testing
- Aspirin and clopidogrel / Prasugrel, VerifyNow, Aspirin
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness, Heart Failure
Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress
Serious acute heart and lung illnesses like heart failure, severe COVID, and sepsis often leave survivors struggling not only physically, but also with lasting depression, anxiety, and stress.
- Conditions
- Critical Illness, Heart Failure, Sepsis, Ards
- Trial name
- Lift 3 (NCT07634419)
- Testing
- Lift mobile mindfulness, Enlighten Recovery education program
- Where
- 3 sites in United States
- Volunteers
- 450 people
- Sponsor
- Duke University
Myocardial Ischemia, Acute Coronary Syndrome
Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement
The purpose of the study is the evaluation of multiple biomarkers related to acute coronary syndromes, including myeloid-related protein 8/14 (MRP 8/14), along with established clinical markers, for early diagnosis and risk…
- Conditions
- Myocardial Ischemia, Acute Coronary Syndrome, Myocardial Infarction, Coronary Occlusion
- Trial name
- MyRiAD (NCT00657436)
- Where
- Switzerland
- Volunteers
- 403 people
- Sponsor
- University of Zurich
Angina Pectoris, Angina, Stable
Intracoronary Thrombus Detection by Magnetic Resonance Imaging
This study involves the use of Magnetic Resonance Imaging (MRI) to determine whether blood clots can be identified within the blood vessels supplying blood to the heart in patients with angina and who have recently suffered a…
- Conditions
- Angina Pectoris, Angina, Stable, Angina, Unstable, Myocardial Infarction
- Trial name
- NCT02776657
- Testing
- Magnetic Resonance Imaging, Optical Coherence Tomography, Invasive Coronary Angiography
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
C.Surgical Procedure; Cardiac
Acute Normovolemic Hemodilution in High Risk Cardiac Surgery Patients.
Transfusions are one of the most overused treatments in modern medicine, and saving blood is one important issue all around the world.
- Trial name
- ANH (NCT03913481)
- Testing
- Acute normovolemic hemodilution, Standard care
- Where
- 32 sites in United States, Bahrain and 9 more
- Volunteers
- 2,000 people
- Sponsor
- Università Vita-Salute San Raffaele
Sleep Apnea, Obstructive, Acute Coronary Syndrome
Effects of Inspiratory Muscles Strengthening Among Coronary Patients on the Sleep Apnea Obstructive Syndrome
Obstructive sleep apnea (OSA) syndrome affects up to 5% of the general population. The prevalence is multiplied by 13 in coronary artery disease (CAD) patients.
- Trial name
- RICAOS (NCT02494648)
- Testing
- POWERbreathe Fitness Plus, (POWERbreathe International Ltd, UK) [Inspiratory muscles strengthening], Control
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Chronic Obstructive Pulmonary Disease, Acute Coronary Syndromes
Screening for Chronic Obstructive Pulmonary Disease in Patients With Acute Coronary Syndromes
Several studies and registries suggested that the concomitant presence of acute coronary syndromes (ACS) and chronic obstructive pulmonary disease (COPD) is significantly associated with poor prognosis.
- Trial name
- SCAP (NCT02324660)
- Testing
- screening test
- Where
- Italy
- Volunteers
- 137 people
- Sponsor
- University Hospital of Ferrara
Acute Coronary Thrombose, Plaque Rupture
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS
Thirty patients scheduled to coronary angiography and IVUS in according to their treating physician decision will be enrolled in the study.
- Conditions
- Acute Coronary Thrombose, Plaque Rupture, Acute Coronary Syndrome
- Trial name
- IVUS (NCT00466050)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Ziv Hospital
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