Clinical trials: Acute Cardiopulmonary Disease
Congenital Heart Disease, Acute Kidney Injury
Nitric Oxide During CPB to Reduce AKI in Neonates
This is a prospective, randomized, double-blind, placebo-controlled pilot study to investigate whether supplemental Nitric Oxide (NO) gas delivered during cardiac surgery with cardiopulmonary bypass (CPB) reduces the incidence…
- Trial name
- NCT03946462
- Testing
- NO gas delivered during cardiac surgery
- Where
- United States
- Sponsor
- Fabio Savorgnan
Cardiac Surgery Associated - Acute Kidney Injury, Cardiac Surgery With Cardiopulmonary Bypass
Inhaled Nitric Oxide for Prevention of Postoperative AKI in High-Risk Cardiac Surgery Patients
The goal of this clinical trial is to learn if giving inhaled nitric oxide during heart surgery can prevent acute kidney injury (AKI) in patients who are at high risk of developing this complication.
- Trial name
- NCT07544147
- Testing
- Inhaled Nitric Oxide (iNO)
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Zhongshan Hospital
Heart Valve Disease
Effect of Remote Ischemic Preconditioning on Acute Kidney Injury in Patients Undergoing Heart Valve Replacement Surgery With Cardiopulmonary Bypass
The purpose of this study is to study the effect of remote ischemic preconditioning on acute kidney injury in patients undergoing heart valve replacement surgery with cardiopulmonary bypass.
- Trial name
- NCT01023152
- Testing
- Automated cuff-inflator
- Volunteers
- 74 people
- Sponsor
- Yonsei University
Acute Lung Injury, Sepsis
Extracardiac Complications After Cardiac Surgery
Hypothesis of the study is that patients undergoing major cardiac surgery can develop extracardiac complications correlated to cardiopulmonary by pass.
- Conditions
- Acute Lung Injury, Sepsis, Infections, Acute Kidney Injury
- Trial name
- NCT01187004
- Where
- Italy
- Volunteers
- 164 people
- Sponsor
- University of Turin, Italy
Acute Kidney Injury
Fluid Chloride and AKI in Cardiopulmonary Bypass
Acute kidney injury (AKI) is a potential complication of cardiac surgery. In animal models, excess exogenous Cl- ion in the bloodstream is associated with AKI.
- Trial name
- NCT02668952
- Testing
- 0.9% Normal Saline (0.9% Sodium Chloride) injection, Isolyte S injection
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of New Mexico
Kidney Injury
Advance Targeted Transfusion in Anemic Cardiac Surgical Patients for Kidney Protection: A Proof of Concept Pilot Study
One of the major complications of heart surgery is kidney injury, which occurs in up to 30% of patients and is associated with poor outcomes including death.
- Trial name
- NCT00861822
- Testing
- Advanced red blood cell transfusion
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Acute Respiratory Distress Syndrome
Personalized Tidal Volume in ARDS (VT4HEMOD)
Treatment of acute respiratory distress syndrome (ARDS) relies on invasive mechanical ventilation with supposedly protective settings (low tidal volume ventilation).
- Trial name
- VT4HEMOD (NCT05406570)
- Testing
- Standardized ventilation, Personalized ventilation
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hospices Civils de Lyon
Medical Condition Requiring Extracorporeal Organ Support
The University of Freiburg Medical Center Extracorporeal Organ Support Device Registry
A prospective registry collecting pseudonymized clinical and treatment data from all patients treated with extracorporeal organ support (i.e., VV ECMO, VA ECMO, ECPR, Impella, IABP, and others) on the wards of the Department of…
- Trial name
- NCT05811780
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- University Hospital Freiburg
Kidney Failure, Acute
Evaluation of Neutrophil Gelatinase-associated Lipocalin (NGAL) in Early and Evolving Acute Kidney Injury
Some patients who undergo cardiovascular surgery requiring cardiopulmonary bypass will develop a kidney injury following their surgery.
- Trial name
- EVOLVE (NCT00445809)
- Where
- 11 sites in United States, Canada
- Volunteers
- 355 people
- Sponsor
- Abbott RDx Cardiometabolic
Heart Disease, Acute Renal Failure
N-Acetylcysteine for Preventing Renal Injury After Cardiac Surgery
Cardiac surgery improves the survival and quality of life of people with heart disease. Nonetheless, several complications continue to adversely affect outcomes following cardiac surgery.
- Trial name
- NCT00188630
- Testing
- N-acetylcysteine, 5% dextrose solution
- Where
- Canada
- Volunteers
- 176 people
- Sponsor
- University Health Network, Toronto
Acute Kidney Injury, Osmolality Disturbance
Hyperosmolality and Acute Kidney Injury After Cardiac Surgery
The goal of this randomized controlled trial is to test if a hyperosmolar prime solution used for cardiopulmonary bypass increases the risk for acute postoperative kidney injury.
- Conditions
- Acute Kidney Injury, Osmolality Disturbance, Cardiopulmonary Bypass
- Trial name
- NCT05914896
- Testing
- HighOsmo
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Aortic Aneurysm, Aortic Dissection
Freestyle Prosthesis for Aortic Root-replacement With and Without Hemiarch Replacement
The Freestyle® prosthesis (Medtronic plc, Dublin, Ireland) is a biological, porcine aortic root implanted in various combinations and techniques since the 1990s.
- Conditions
- Aortic Aneurysm, Aortic Dissection, Endocarditis, Root Abscess
- Trial name
- NCT04068337
- Testing
- Aortic root replacement with Freestyle biological prosthesis with and without hemiarch replacement
- Where
- Switzerland
- Volunteers
- 278 people
- Sponsor
- Triemli Hospital
Pulmonary Embolism With Acute Cor Pulmonale, Pulmonary Embolism
Standard-dose Apixaban AFtEr Very Low-dose ThromboLYSis for Acute Intermediate-high Risk Acute Pulmonary Embolism
The purpose of this study is to examine the degree to which pulmonary embolism (clot) can be dissolved when treated with a very low dose of a systemic thrombolytic drug (clot buster) along with standard anticoagulant therapy as…
- Conditions
- Pulmonary Embolism With Acute Cor Pulmonale, Pulmonary Embolism, Pulmonary Embolism With Pulmonary Infarction, Pulmonary Embolism Subacute Massive
- Trial name
- SAFE-LYSE (NCT03988842)
- Testing
- Alteplase, Unfractionated heparin, Apixaban
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Victor Tapson, MD
Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery
Near Infrared Spectroscopy for the Detection of Acute Kidney Injury in Children Following Cardiac Surgery
One in a hundred children is born with a heart defect. Some children require heart surgery within the first few days of life, while others can wait until they are older.
- Conditions
- Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery, Children
- Trial name
- NCT01382758
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
ACS (Acute Coronary Syndrome), HF - Heart Failure
A Clinical Study on the Effect of Cardiopulmonary Function and Quality of Life in Patients With Acute Coronary Syndrome Complicated by Heart Failure by "Lying-Sitting-Standing" Sequential Baduanjin
This study investigates the effects of a sequential "lying-sitting-standing" Baduanjin intervention on patients with acute coronary syndrome complicated by heart failure.
- Trial name
- NCT07486791
- Testing
- standard treatment and routine rehabilitation nursing guidance, "Lying-Sitting-Standing" Sequential Baduanjin
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Xiling Qi
Acute Kidney Injury
Bicarbonate in Cardiac Surgery
With over one million operations a year, cardiac surgery with cardiopulmonary bypass is one of the most common major surgical procedures worldwide (1).
- Trial name
- NCT00878956
- Testing
- Sodium Bicarbonate, Sodium Chloride
- Where
- 4 sites in Australia, New Zealand
- Volunteers
- 427 people
- Sponsor
- Austin Health
Coronary Heart Disease (CHD), Cardio-pulmonary Bypass
Protective Effect of EECP Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery
Enhanced external counterpulsation (EECP) is a noninvasive, non-pharmacologic intervention proven to increase nitric oxide bioavailability in patients with coronary artery disease.
- Conditions
- Coronary Heart Disease (CHD), Cardio-pulmonary Bypass, Congestive Heart Failure Chronic, Cardiogenic Shock Acute
- Trial name
- PANDA (NCT06728605)
- Testing
- Enhanced External Counterpulsation (EECP)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanjing Medical University
Acute Kidney Injury Due to Circulatory Failure (Disorder)
The Effects of Oxiris on Systemic Inflammation and Endothelial dysFunction
CS-AKI occurring in 20% to 70% of cases depending of the type of cardiac surgery. The systemic inflammatory response is often observed and associated with increased risk of AKI.
- Trial name
- EOSIEF (NCT04257006)
- Testing
- oXiris membrane
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Acute Lung Injury(ALI), Liver Cirrhosis
Digital Early Warning System for Acute Lung Injury in Liver Surgery
This study aims to develop an explainable machine learning model that takes into account the characteristics of cardiopulmonary interactions.
- Conditions
- Acute Lung Injury(ALI), Liver Cirrhosis, ARDS, Human, MASLD
- Trial name
- NCT07070362
- Where
- 4 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute
Repeated Examinations for Typing Pulmonary Embolism
PURPOSE The two related purposes of the RE-TyPE study are: 1. To improve understanding of the early clinical course of intermediate-high risk pulmonary embolism and its association with outcome and 2.
- Conditions
- Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute, Pulmonary Embolism With Acute Cor Pulmonale, Pulmonary Embolism With Right Ventricle Enlargement
- Trial name
- RE-TyPE (NCT07491094)
- Where
- 3 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Sahlgrenska University Hospital