Clinical trials: Acute Care Medical
Chemical Injury, Chemicals; Intoxication
The Medical Management in Patients Exposed to Weapons of Mass Destruction
Observation study measuring medical response in contaminated environment.
- Conditions
- Chemical Injury, Chemicals; Intoxication, Acute Respiratory Distress Syndrome, Distress Respiratory Syndrome
- Trial name
- CBRNEObs (NCT05026645)
- Testing
- Clinical interventions performed in acute settings (contaminated environment), Protection (clinician and patient), Decontamination (clinician and patient)
- Where
- 15 sites in United States, Canada and 4 more
- Volunteers
- 1,000 people
- Sponsor
- St. Justine's Hospital
Coronary Heart Disease, Myocardial Infarction
Monitoring and Adjustment of Medication Therapy for Patients With Heart Disease
Existing trials for the patient with coronary heart disease evaluate the interdisciplinary team dynamic where pharmacists (pharmacotherapists) provide therapeutic recommendations in the inpatient environment.
- Trial name
- MUMPS (NCT01427218)
- Testing
- Titration of medications, Lifestyle Counseling, Medication Counseling
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Middle Tennessee Research Institute
Dyspnea, Heart Failure
The Triple A Initiative Study ("Aktionsbündnis Akute Atemnot")
Acute dyspnea is a common chief complaint of patients presenting to the emergency department. Patients with acute dyspnea display a high mortality rate.
- Trial name
- NCT02049853
- Testing
- NTproBNP measurement with point of care device "Cobash232" in the POCT group
- Where
- 6 sites in Germany
- Volunteers
- 67 people
- Sponsor
- Prof. Dr. Michael Christ
Critical Illness, Acute Kidney Injury
Isotonic Solutions and Major Adverse Renal Events Trial in the Non-Medical Intensive Care Unit (SMART-SURG)
The administration of intravenous fluids is ubiquitous in the care of the critically ill. Commonly available isotonic crystalloid solutions contain a broad spectrum electrolyte compositions including a range chloride…
- Trial name
- SMART-SURG (NCT02547779)
- Testing
- 0.9% Saline, Physiologically-balanced isotonic crystalloid
- Where
- United States
- Volunteers
- 10,421 people
- Sponsor
- Vanderbilt University
Respiratory Tract Infections
Observation of Initial Procalcitonin and the Clinical Course of Patients With Acute Respiratory Tract Infections
Observation of the initial Procalcitonin values and the clinical course of consecutively included patients with Acute Respiratory Tract Infections at general medical practices in greater Hannover.
- Trial name
- NCT00827060
- Where
- Germany
- Volunteers
- 702 people
- Sponsor
- Hannover Medical School
COVID-19
A Study to Evaluate Safety and Efficacy of Convalescent Methylene Blue Treated (MBT) Plasma From Donors Recovered From Coronavirus Disease 2019 (COVID-19)
The purpose of the study is to determine if Convalescent anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Methylene Blue Treated (MBT) plasma plus Standard Medical Treatment (SMT) can reduce all-cause mortality…
- Trial name
- NCT04547127
- Testing
- Convalescent anti-SARS-CoV-2 MBT Plasma, Standard Medical Treatment
- Where
- 12 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Instituto Grifols, S.A.
Abdomen, Acute
Geographic Influences on Emergency Laparotomy Outcomes
Introduction 'Emergency Laparotomy' is an umbrella term for a set of commonly performed procedures which are known to carry a significant risk of mortality and morbidity.
- Trial name
- NCT02017977
- Where
- United Kingdom
- Volunteers
- 40,000 people
- Sponsor
- University of Edinburgh
Acute on Chronic Liver Failure
Safety and Performance Trial of DIALIVE Liver Dialysis Device in Acute On Chronic Liver Failure Patients
The First-In-Man study is a multi-centre, randomised, controlled, study to generate data for the evaluation of safety and performance of DIALIVE Liver Dialysis Device in 24 evaluable patients with Acute on Chronic Liver Failure…
- Trial name
- DIALIVE _ACLF (NCT03065699)
- Testing
- DIALIVE Liver Dialysis Device
- Where
- 12 sites in Austria, Belgium and 6 more
- Volunteers
- 30 people
- Sponsor
- Yaqrit Ltd
Orthostatic Hypotension
State of Knowledge Among Nurses Regarding the Screening for Orthostatic Hypotension in Elderly Individuals in Acute Geriatric Medicine and Medical and Rehabilitation Services
Orthostatic hypotension is a common geriatric syndrome associated with an increased risk of falls, syncope, functional decline and mortality in older adults.
- Trial name
- HTO-IDE (NCT07738666)
- Testing
- Administration of questionnaires on nurses' knowledge of orthostatic hypotension, its measurement, diagnosis and management
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hôpital NOVO
Acute Myocardial Infarction, Cardiogenic Shock
Extracorporeal Life Support in Cardiogenic Shock
The aim of the study is to examine whether treatment with extracorporeal life support (ECLS) in addition to revascularization with percutaneous coronary intervention (PCI) or alternatively coronary artery bypass grafting (CABG)…
- Trial name
- ECLS-SHOCK (NCT03637205)
- Testing
- ECLS insertion, Revascularisation and optimal medical treatment
- Where
- 46 sites in Germany, Slovenia
- Volunteers
- 420 people
- Sponsor
- Helios Health Institute GmbH
Respiratory Infections
Improving Antibiotic Use in Acute Care Treatment
Purpose The emergence and rapid rise in antibiotic resistance among common bacteria are adversely affecting the clinical course and health care costs of community-acquired infections.
- Trial name
- IMPAACT (NCT00144040)
- Testing
- Physician & patient education on appropriate antibiotic use, Rapid C-reactive protein testing to guide antibiotic treatment
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- US Department of Veterans Affairs
COVID-19
Study to Evaluate the Safety and Efficacy of High Dose Intravenous Immune Globulin (IVIG) Plus Standard Medical Treatment (SMT) Versus SMT Alone in Participants in Intensive Care Unit (ICU) With Coronavirus Disease (COVID-19)
The purpose of the study is to determine if a high dose of Intravenous Immune Globulin (IVIG) plus Standard Medical Treatment (SMT) can reduce all-cause mortality versus SMT alone in hospitalized participants with COVID-19…
- Trial name
- NCT04480424
- Testing
- GAMUNEX-C, Standard Medical Treatment
- Where
- 18 sites in United States
- Volunteers
- 100 people
- Sponsor
- Grifols Therapeutics LLC
Pressure Ulcers
Simplified Acute Physiology Score 2 and Pressure Ulcer Prediction in ICU.
Critically ill patients admitted in intensive care units are at high risk of developing pressure ulcer (also known as pressure injury).
- Trial name
- IGS-2-MIR (NCT07732517)
- Testing
- Pressure ulcer
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Bordeaux
Pressure Ulcer, Noninvasive Positive Pressure Ventilation
The ROTAtional-USE of Interface STUDY
In this trial investigators will explore if a protocolized rotational use of interfaces i.e., masks, during noninvasive positive pressure ventilation (NPPV) compared to standard care is clinically effective and cost-effective in…
- Conditions
- Pressure Ulcer, Noninvasive Positive Pressure Ventilation, Acute Hypercapnic Respiratory Failure
- Trial name
- ROTA-USE (NCT05513508)
- Testing
- Protocolized rotational use of interfaces, Standard of care
- Where
- Italy
- Volunteers
- 478 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Children With Medical Complexity, Respiratory Tract Infections (RTI)
Automatic Versus As-Needed Follow-up After Hospitalization for Children With Medical Complexity
Children with medical complexity often receive a recommendation to see an outpatient clinician soon after leaving the hospital. It is uncertain whether every child needs this routine visit or whether follow-up can be guided by…
- Conditions
- Children With Medical Complexity, Respiratory Tract Infections (RTI), Urinary Tract Infection (UTI), Acute Gastroenteritis
- Trial name
- AFTERCARE (NCT07864636)
- Testing
- Automatic follow-up recommendation, As-needed follow-up recommendation
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Seattle Children's Hospital
Acute Coronary Syndromes, ST Elevation Myocardial Infarction
Smartphone AI Assistance for Prehospital ECG Interpretation
Prehospital providers interpret 12-lead electrocardiograms (ECGs) under time pressure and without immediate expert support. Missed acute coronary occlusion - occlusion myocardial infarction (OMI) - delays reperfusion, while false…
- Conditions
- Acute Coronary Syndromes, ST Elevation Myocardial Infarction, Non-ST Elevated Myocardial Infarction, Myocardial Infarction (MI)
- Trial name
- ECG-IA (NCT07810686)
- Testing
- Smartphone large language model assistance (GPT-4o, version-locked)
- Where
- Switzerland
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- École Supérieure de Soins Ambulanciers - College of Higher Education in Prehospital Care
Acute Cerebrovascular Accident, Myocardial Infarction (MI)
Clinical Profile of a Patient After MI and ACVA Based on Outpatient Register Data
This is a retrospective observational study using the methodology of creating medical registries. The expected number of patients included in the registry is about 2000 patients with myocardial infarction and/or ACVD of any…
- Trial name
- NCT07159698
- Where
- Belarus
- Volunteers
- 1,520 people
- Sponsor
- State Institution "Republican Scientific and Practical Center" Cardiology, Belarus
Acute Renal Insufficiency
Effect of Medical Care on Health Status in Acute Kidney Injury
Various forms of organisation in the care of patients with akute kidney injury are investigated. In this prospective study the investigators compare the effect of usual care with the effect of intensive care.
- Trial name
- EMESA (NCT04929730)
- Testing
- Nephrology care bundle
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Medizinisches Versorgungszentrum Diaverum Potsdam
Pressure Ulcer, Skin Lesion
Prevention of Skin Damage in the Patient in Prone Position: Development of Education Interventions Based on a Training Needs Assessment Study.
This is study 1 of 3 - of the overall project: The ProneTection Quality Improvement Project. The three aims of this study, study 1 are: 1.
- Conditions
- Pressure Ulcer, Skin Lesion, Acute Respiratory Distress Syndrome
- Trial name
- NCT05238870
- Testing
- Interviews for the needs analysis. No intervention.
- Where
- 2 sites in Belgium
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Ghent
Emergencies, Cardiopulmonary Arrest
Simulation Trial of Telemedical Support for Paramedics
In the United States, the current standard of prehospital (i.e. outside of hospitals) emergency care for children with life-threatening illnesses in the community includes remote physician support for paramedics providing…
- Conditions
- Emergencies, Cardiopulmonary Arrest, Acute Respiratory Failure, Status Epilepticus
- Trial name
- R01 (NCT06441760)
- Testing
- Video teleconsultation, Audio support
- Where
- 9 sites in United States
- Volunteers
- 420 people
- Sponsor
- Boston Medical Center