Clinical trials: Acute Cerebrovascular Accident
Ischemic Cerebrovascular Accident
Clopidogrel for Acute Ischaemia of Recent Onset
Evaluate the role of loading Clopidogrel in acute ischemic stroke in improving neurological outcome of stroke in cases patients will be non-eligible for, or declined, treatment with or intravenous thrombolysis with rTPA, rTPA is…
- Trial name
- CAIRO (NCT02776540)
- Testing
- Clopidogrel, Aspirin
- Where
- Egypt
- Volunteers
- 188 people
- Sponsor
- Ain Shams University
Acute Ischemic Stroke
A Feasibility Study for the DAISe EZ Thrombectomy Device - Pacific
The study is a prospective, multi-center, single arm, feasibility study that will enroll a maximum of 20 subjects. A maximum of 5 investigational centers in Australia will participate.
- Trial name
- NCT06042335
- Testing
- DAISe EZ
- Volunteers
- 20 people
- Sponsor
- MIVI Neuroscience, Inc.
Stroke, Cardiovascular, Stroke, Acute
Stroke in Egyptian Clinical REgisTry
This is a multi-institutional registry database for the patients with stroke and cerebrovascular diseases. Stroke is the second leading cause of death in the Egypt.
- Conditions
- Stroke, Cardiovascular, Stroke, Acute, Stroke Hemorrhagic, Stroke Spinal Cord
- Trial name
- SECRET (NCT03723382)
- Testing
- SECRET structured 5 bundles of standard healthcare services
- Where
- Egypt
- Volunteers
- 50,000 people
- Sponsor
- Society of Minimally Invasive Neurological Therapeutic Procedures
Ischemic Stroke
Efficacy of Transcranial Direct Current Stimulation in Acute Ischemic Stroke
Non-invasive brain stimulation (tDCS) such as transcranial direct current stimulation (TDCS) has been reported to be effective in improving motor performance and safe in participants with cerebral infarction.
- Trial name
- DAS (NCT04938076)
- Testing
- Transcranial direct current stimulation
- Where
- South Korea
- Volunteers
- 172 people
- Sponsor
- Incheon St.Mary's Hospital
Stroke
Muscle Tone Changes in Acute Stroke According to Brain Injury
The purpose of the study is to examine connections between muscle tones, strength and function after stroke.
- Trial name
- NCT01041560
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Jyväskylä Central Hospital
Ischemic Stroke, Acute
Brain-Oscillation-Synchronized Stimulation to Enhance Motor Recovery in Early Subacute Stroke
We will investigate the therapeutic efficacy of EEG-synchronized noninvasive repetitive transcranial magnetic stimulation (rTMS) in the early subacute phase after ischemic stroke to improve upper limb motor rehabilitation.
- Trial name
- Boss-Stroke (NCT05600374)
- Testing
- Bossdevice
- Where
- 4 sites in Germany
- Volunteers
- 144 people
- Sponsor
- University Hospital Tuebingen
Intracerebral Hemorrhage
Safety of NXY-059 for the Treatment of Patients Who Have Suffered From a Stroke
This study will determine if NXY-059 is safe in patients with an acute stroke caused by bleeding in the central nervous system. The primary objective was to assess the safety and tolerability of NXY-059 compared to placebo.
- Trial name
- NCT00075959
- Testing
- NXY-059
- Where
- 64 sites in United States
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Cerebral Vascular Accident (CVA)
Predictive Value of Copeptin in the Diagnosis of Acute Ischemic Stroke
In the USA, every year 795,000 patients suffer a cerebral vascular accident (CVA), which represents a yearly cost of $73.7 billion.
- Trial name
- NCT01960478
- Testing
- (for each intervention), Blood test
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Strasbourg, France
Stroke Ischemic, Stroke Acute
Posterior Circulation ASTRAL Prognostic Score
The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke…
- Conditions
- Stroke Ischemic, Stroke Acute, Posterior Circulation Brain Infarction, Risk Score
- Trial name
- NCT05906420
- Testing
- ASTRAL prognostic score
- Where
- 2 sites in Greece, Switzerland
- Volunteers
- 2,000 people
- Sponsor
- University of Thessaly
Ischemic Stroke, Intracerebral Haemorrhage
Head Position in Stroke Trial (HeadPoST)
This study is an investigator-initiated and conducted, international collaborative, regionally organised, multicentre, prospective, cluster randomised, crossover, blinded outcome assessment study to compare the effectiveness of…
- Trial name
- HeadPoST (NCT02162017)
- Testing
- The lying flat (0°) head position for 24 hours, The sitting-up (≥30°) head position for 24 hours
- Where
- Australia
- Volunteers
- 11,096 people
- Sponsor
- The George Institute
Stroke Syndrome, Hemiplegia
Effects of Virtual Reality Based Rehabilitation in Acute Stroke Patients in an Inpatient Rehab Setting
To evaluate the effects of virtual reality-based rehabilitation (Neofect Glove) for newly diagnosed cognitively intact adult dominant hemisphere stroke patients with paresis of their hand in supplementation with conventional…
- Trial name
- NCT03039764
- Testing
- Rapael
- Where
- United States
- Sponsor
- Montefiore Medical Center
Stroke
Effect of SynPhNe Physio-neuro Platform on Hand Motor Function Rehabilitation of Acute and Subacute Stroke Patients
Stroke is a major cause of adult long term disability and the fourth leading cause of death and affects 1·8/1000 persons in Singapore.
- Trial name
- NCT05133232
- Testing
- SynPhNe physio-neuro platform
- Where
- Singapore
- Volunteers
- 51 people
- Sponsor
- National University Hospital, Singapore
Acute Ischemic Stroke AIS
The STem Cell-derived Extracellular Vesicle Therapy In Acute Ischemic Stroke (STEVIA)
This is a multicenter open-label, single-arm, dose escalation phase I clinical trial to evaluate the safety and tolerability of SNE-101 in patients with acute ischemic stroke
- Trial name
- STEVIA (NCT06995625)
- Testing
- SNE-101
- Where
- 3 sites in South Korea
- Volunteers
- 18 people
- Sponsor
- S&Ebio Co. Ltd.
Ischemic Stroke
The Safety and Efficacy of Cerebrolysin in Patients With Acute Ischemic Stroke
The study investigated the clinical efficacy and safety of a 10-day course of therapy with daily intravenous administration of 30mL Cerebrolysin based on a comparison with Placebo in patients with acute ischemic stroke.
- Trial name
- CASTA (NCT00868283)
- Testing
- Cerebrolysin, 0.9% Saline Solution
- Where
- 49 sites in China, Hong Kong and 1 more
- Volunteers
- 1,071 people
- Sponsor
- Ever Neuro Pharma GmbH
Cerebral Stroke
Treatment With AX200 for Acute Ischemic Stroke
The AXIS study is a randomized, double-blind, placebo-controlled, dose-escalating phase IIa trial to investigate treatment with AX200 (granulocyte-colony stimulating factor; G-CSF) for acute ischemic stroke.
- Trial name
- NCT00132470
- Testing
- AX200 (G-CSF)
- Where
- 2 sites in Germany
- Volunteers
- 42 people
- Sponsor
- Axaron Bioscience AG
Ischemic Stroke
Acute Effects of Thai Traditional Massage on Cerebrovascular Reactivity in Ischemic Stroke Patients
The investigators hypothesize that Acute Thai traditional massage will yield beneficial effects on cerebrovascular reactivity in ischemic stroke patients.
- Trial name
- NCT02270294
- Testing
- Thai traditional massage, No massage
- Where
- Thailand
- Volunteers
- 14 people
- Sponsor
- Chulalongkorn University
Platelet Aggregation Inhibitors
The Influence of CYP2C19 Polymorphism and Clinical Outcomes in Stroke Patients
Background: Clopidogrel, an antiplatelet prodrug, is widely used for prevention of the recurrent cardiovascular events. CYP2C19 is one of the crucial enzymes for the activation of clopidogrel.
- Trial name
- NCT02711410
- Testing
- Clopidogrel
- Volunteers
- 518 people
- Sponsor
- National Cerebral and Cardiovascular Center, Japan
Acute Ischemic Stroke
Intravenous rhPro-UK Before Stroke Thrombectomy in the Extended Time Window (BRIDGE-PUK EXTEND)
This randomized, double-blind, placebo-controlled phase III clinical trial aims to evaluate the efficacy and safety of intravenous recombinant human Prourokinase (rhPro-UK) in acute ischemic stroke patients with large vessel…
- Trial name
- NCT07389460
- Testing
- Intravenous rhPro-UK, Endovascular thrombectomy
- Where
- 10 sites in China
- Volunteers
- 820 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Acute Progressive Ischemic Stroke
Efficacy Argatroban in Ischemic Stroke With Early Deterioration (EASE)
Acute ischemic stroke (AIS) has the characteristics of high morbidity, high mortality, high disability rate and high recurrence rate. Progressive cerebral infarction (PIS) is a subtype of AIS, accounting for 10% - 40%.
- Trial name
- EASE (NCT04275180)
- Testing
- Argatroban
- Where
- 6 sites in China
- Volunteers
- 628 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke
Study on the Incremental Predictive Value of Early Resting-State EEG Phenotypes for Functional Prognosis and Risk Stratification in Acute Ischemic Stroke
This is a single-center, prospective, observational cohort study that plans to consecutively enroll 400 patients with acute ischemic stroke from July 2026 to July 2029.
- Trial name
- NCT07741669
- Where
- China
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing