Clinical trials: Acute Cerebrovascular Accident
Acute CHF, Acute Stroke Syndromes
PREMIUM Registry: PRognostic HEModynamIc Profiling in the AcUtely Ill EMergency Department Patient
This multinational registry (3 USA, 2 European centers) will capture in the ED continuous non invasive hemodynamic monitoring (using Nexfin finger cuff technology) of patients presenting with acute heart failure, stroke syndromes…
- Conditions
- Acute CHF, Acute Stroke Syndromes, Systemic Infections
- Trial name
- PREMIUM (NCT01208077)
- Where
- 4 sites in United States, Italy and 1 more
- Volunteers
- 514 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Cerebral Hemorrhage
Decompressive Hemicraniectomy in Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage (ICH) remains a devastating disease with mortality rates up to 52% at 30 days. It is a major public health problem with an annual incidence of 10-30 per 100'000 population, accounting for 2…
- Trial name
- SWITCH (NCT02258919)
- Testing
- Decompressive craniectomy (DC) and best medical treatment, Best medical treatment
- Where
- 32 sites in Austria, Belgium and 6 more
- Volunteers
- 201 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Ischemic Stroke, Large Vessel Occlusion
Direct Angio Suite Acute Stroke Intervention With CT/DSA Hybrid Emergency Stroke Unit
This study investigates whether direct transfer to an emergency stroke unit equipped with NeuAngio-CT reduces time to endovascular reperfusion in patients with acute ischemic stroke and suspected intracranial large-vessel…
- Trial name
- NCT07670065
- Testing
- Direct Angio Suite Acute Stroke Intervention With CT/DSA Hybrid Emergency Stroke Unit, Conventional Thrombectomy
- Where
- China
- Volunteers
- 232 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Acute Ischemic
Immediate Angioplasty For Acute Ischemic Stroke With Severe Intracranial Atherosclerotic Stenosis
A multicenter, prospective, open-label, blinded endpoint, randomized controlled trial that aims to evaluate the effect of immediate angioplasty (with or without stenting) for acute ischemic stroke (AIS) with severe intracranial…
- Trial name
- MAGIC (NCT06437600)
- Testing
- Immediate angioplasty
- Where
- 2 sites in China
- Volunteers
- 412 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Stroke, Acute, Educational Problems
Off-script Diagnosis & Differential Diagnosis (D&D) Training and Residents' Stroke Knowledge
This study is a single-center, randomized, open-label, controlled, endpoint-blinded study to assess the effect of off-script diagnosis \& differential diagnosis (D\&D) training in improving the residents' knowledge of acute…
- Conditions
- Stroke, Acute, Educational Problems, Clinical Course
- Trial name
- CAST-AIS (NCT06941753)
- Testing
- Off-script diagnosis & differential diagnosis (D&D) training
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Cerebrovascular Occlusion, Collateral Blood Circulation
The Impact of NBP on the Collateral Circulation in ICA/M1 Occlusion
Stroke is the first leading cause of death in China, and is responsible for almost 22.4% of deaths. In approximately 80% of cases stroke is ischaemic, i.e.
- Conditions
- Cerebrovascular Occlusion, Collateral Blood Circulation, Anterior Cerebral Circulation Infarction
- Trial name
- INCIMO (NCT02594995)
- Testing
- NBP
- Where
- China
- Volunteers
- 311 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke
Effect of Speed-dependent Treadmill Training in Patients With Subacute Stroke
This study aimed to explore whether speed-dependent treadmill training is more effective at improving walking and balance performance than speed-stable treadmill training in patients with subacute stroke.
- Trial name
- NCT01328301
- Testing
- Experimental, Speed-stable treadmill training
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Acute Ischemic Stroke, Large Vessel Occlusion
Evaluation of the CONDA Stent Retriever in Acute Ischemic Stroke
The goal of this study is to evaluate the safety and performance of the CONDA stent retriever in patients with acute ischemic stroke due to large vessel occlusion, treated within 24 hours of symptom onset.
- Trial name
- ARTEMIS (NCT07174505)
- Testing
- Mechanical Thrombectomy using the CONDA Stent Retriever
- Where
- 2 sites in Hungary, Spain
- Volunteers
- 50 people
- Sponsor
- Anaconda Biomed S.L.
Basilar Artery Occlusion, Acute Cerebrovascular Accident
Intravenous Tenecteplase Plus EVT Versus EVT Alone on 4.5 to 24 Hours After Basilar Artery Occlusion
To assess the effect of intravenous tenecteplase plus endovascular thrombectomy (EVT) compared to EVT alone on 4.5 to 24 hours after stroke due to basilar artery occlusion.
- Conditions
- Basilar Artery Occlusion, Acute Cerebrovascular Accident, Stroke Due to Basilar Artery Occlusion
- Trial name
- NCT05701956
- Testing
- Tenecteplase, Endovascular thrombectomy
- Where
- China
- Volunteers
- 330 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Stroke, Acute, Ischemic Stroke, Acute
MyStroke for Stroke Survivors and Caregivers
The goal of this multicenter randomized trial is to evaluate the impact of a personalized video-based stroke education platform on patient-centered and health system-centered outcomes.
- Trial name
- NCT06442631
- Testing
- MyStroke
- Where
- 5 sites in United States
- Volunteers
- 690 people
- Sponsor
- University of Pennsylvania
Stroke
Association of Osmotic Drugs With Clinical Outcomes in Acute Large Hemispheric Infarction
Stroke remains the second leading cause of death worldwide, with 2%-8% of these being large hemispheric infarction (LHI) with an occupying effect and the worst prognosis.
- Trial name
- NCT05914272
- Testing
- Osmotic drugs
- Where
- 19 sites in China
- Volunteers
- 2,592 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Stroke
Non-immunogenic Staphylokinase in Reperfusion Therapy of Ischemic Stroke in Routine Clinical Practice
The study will collect data from aged 18 to 85 years with a diagnosis of acute stroke, who received thrombolytic treatment with a new agent, nonimmunogenic staphylokinase.
- Trial name
- REPIN (NCT05697575)
- Where
- Russia
- Volunteers
- 336 people
- Sponsor
- National Society for Neurosonology and Cerebral Circulation
Stroke, Acute, Cerebrovascular Disorders
The Norwegian Tenecteplase Stroke Trial 2
Background: Alteplase is the only approved acute drug treatment in ischemic stroke and aims at dissolving arterial clots causing cerebral ischemia. The overall benefit of alteplase is substantial.
- Conditions
- Stroke, Acute, Cerebrovascular Disorders, Ischemic Stroke
- Trial name
- NOR-TEST 2 (NCT03854500)
- Testing
- Tenecteplase, Alteplase
- Where
- Norway
- Volunteers
- 201 people
- Sponsor
- Haukeland University Hospital
Ischemic Stroke
A Pivotal Study Evaluating Safety and Effectiveness of Adaptative Tip Catheter in Patients With Acute Ischemic Stroke
The purpose of this study is to assess the safety and the effectiveness of the Adaptive Tip Catheter (ATC) used as a first line direct aspiration thrombectomy technique for patients suffering of an acute ischemic stroke.
- Trial name
- PHAST (NCT07367100)
- Testing
- Adaptive Tip Catheter
- Where
- 13 sites in Belgium, France and 2 more
- Volunteers
- 74 people
- Sponsor
- Neuravi Limited
Mechanical Thrombectomy, Acute Ischemic Stroke
High-Dose Atorvastatin for Vascular Wall Protection in Thrombectomy Patients
This project investigates the impact of statins on cerebral vascular wall damage after mechanical thrombectomy. The investigators will undertake a multi-center, prospective, parallel-controlled, open-label, superiority randomized…
- Trial name
- NCT05912686
- Testing
- Atorvastatin 80mg, Atorvastatin 20mg
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Zhongda Hospital
Middle Cerebral Artery Infarction, Anterior Cerebral Artery Infarction
Stem Cell Therapy For Acute Ischemic Stroke Patients
The purpose of this study is to determine whether patients with subacute ischemic stroke will benefit from infusion of patient's own bone marrow derived stem cells.
- Trial name
- InVeST (NCT02425670)
- Testing
- BMSCs
- Where
- 5 sites in India
- Volunteers
- 120 people
- Sponsor
- All India Institute of Medical Sciences
Ischemic Stroke
Implant for Augmentation of Cerebral Blood Flow Trial, Effectiveness and Safety in a 24 Hour Window
The primary objective of the study is to assess the safety and effectiveness of SPG stimulation with the ISS in patients with an acute ischemic stroke in the anterior circulation initiated within 24 hours from stroke onset.
- Trial name
- ImpACT-24B (NCT00826059)
- Testing
- Active Sphenopalatine Ganglion (SPG) Stimulation
- Where
- 73 sites in United States, Canada and 16 more
- Volunteers
- 1,078 people
- Sponsor
- BrainsGate
Stroke, Acute Ischemic
Posterior cerebraL ArTery Occlusion Study
For this retrospective study, the investigators will collect and analyze data of patients who presented with posterior artery occlusion and underwent mechanical thrombectomy (the type of endovascular stroke treatment) and…
- Trial name
- PLATO (NCT05291637)
- Where
- 22 sites in United States, Finland and 5 more
- Volunteers
- 1,282 people
- Sponsor
- Boston Medical Center
Stroke, Stroke, Acute
Earlier Mobilization Post Acute Thrombolysis
This is a phase III trial trying to determine whether 12-hour bed rest following IV thrombolysis therapy (i.e. tPA) for ischemic stroke is non-inferior to 24-hour bed rest by measure of outcomes on the modified Rankin Scale (mRS)…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- EMPATHY-I (NCT04153942)
- Testing
- Mobilization
- Sponsor
- Brian Silver
Sarcopenia, Stroke, Acute
Effects of Mobility Dose on Discharge Disposition in Critically Ill Stroke Patients
The primary aim of the study is to assess the mobility dose in neurocritical care patients with ischemic stroke or intracranial hemorrhage and its effects on discharge disposition and patient outcomes.
- Conditions
- Sarcopenia, Stroke, Acute, Muscle Weakness, Critical Illness
- Trial name
- NCT03347656
- Where
- 3 sites in United States, Germany
- Volunteers
- 164 people
- Sponsor
- Beth Israel Deaconess Medical Center
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