Clinical trials: Acute Cerebrovascular Disease
Ischemic Stroke
Methanesulfonic Acid Cinepazide Injection for Treatment of Acute Cerebral Infarction
Using placebo as control, The purpose of this study is to evaluate the efficacy and safety of methanesulfonic acid cinepazide injection to relieve disabled degree of acute cerebral infarction patients, and explore the best safe…
- Trial name
- NCT01851759
- Testing
- cinepazide
- Where
- China
- Volunteers
- 288 people
- Sponsor
- Xijing Hospital
Acute Ischemic Stroke Patients, Large Vessel Occlusion
A Comparison of Cyclic Manual Direct Aspiration Thrombectomy (Plunger Technique) vs. Static Manual Direct Aspiration Thrombectomy for Treatment of Acute Large Vessel Occlusion Stroke
This prospective, randomized controlled trial will compare two manual aspiration techniques for treating acute ischemic stroke due to large vessel occlusion: cyclic aspiration (Plunger technique) and static aspiration.
- Trial name
- Plunger (NCT07231380)
- Testing
- Plunger Technique, Static Manual Aspiration Thrombectomy
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
Stroke
Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke (DIAS-4)
The purpose of the study is to determine whether desmoteplase is effective and safe in the treatment of patients with acute ischaemic stroke when given within 3 to 9 hours from onset of stroke symptoms.
- Trial name
- NCT00856661
- Testing
- Desmoteplase
- Where
- 152 sites in United States, Belgium and 12 more
- Volunteers
- 270 people
- Sponsor
- H. Lundbeck A/S
Acute Ischemic Stroke AIS
The STem Cell-derived Extracellular Vesicle Therapy In Acute Ischemic Stroke (STEVIA)
This is a multicenter open-label, single-arm, dose escalation phase I clinical trial to evaluate the safety and tolerability of SNE-101 in patients with acute ischemic stroke
- Trial name
- STEVIA (NCT06995625)
- Testing
- SNE-101
- Where
- 3 sites in South Korea
- Volunteers
- 18 people
- Sponsor
- S&Ebio Co. Ltd.
Healthy, Stroke, Acute
Study of Cerebral Activation by fNIRS During Vibration-induced Illusion of Movement in Healthy and Stroke Participants.
The purpose of this study is to investigate the cerebral activation of healthy and stroke participants in 4 or 2 different conditions (repeated 2 times) of vibration-induced illusion of movement respectively, resulting in 8 or 4…
- Trial name
- VIBRANIRS (NCT06218563)
- Testing
- vibration-induced illusion of movement
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Cerebral Infarction, Brain Ischemia
Penumbral Based Novel Thrombolytic Therapy in Acute Ischemic Stroke
Rationale The only proven therapy for acute stroke is tPA within 4.5 hours of symptom onset. This is the standard of care for patients presenting to our hospital within that time frame.
- Conditions
- Cerebral Infarction, Brain Ischemia, Stroke
- Trial name
- TIAS (NCT02101606)
- Testing
- Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Acute Ischemic Stroke (AIS)
Study of the Safety and Neuroprotective Capacity of Scp776 in Acute Ischemic Stroke
A Randomized, Placebo-Controlled, Double-Blind, Multicenter Study of the Safety and Neuroprotective Capacity of Scp776 in Subjects Undergoing Endovascular Thrombectomy for Acute Ischemic Stroke
- Trial name
- ARPEGGIO (NCT05585606)
- Testing
- scp776 (1.9 mg/kg), scp776 (3.8 mg/kg), scp776 (4.8 mg/kg)
- Where
- 22 sites in United States
- Volunteers
- 120 people
- Sponsor
- Silver Creek Pharmaceuticals
Stroke, Acute, Apoplexy; Brain
Artificial Intelligence (AI) Support in Medical Emergency Calls
More than 12.000 patients suffer acute stroke in Norway every year, but less than half of them reach hospital within the current treatment window for thrombolysis.
- Conditions
- Stroke, Acute, Apoplexy; Brain, Emergencies, Communication, Multidisciplinary
- Trial name
- AISMEC (NCT04648449)
- Testing
- Artificial intelligence on emergency calls
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- Haukeland University Hospital
Resistance Training, Stroke
The Effect of Isokinetic Strengthening Training
Our participants will include 40 patients within one month of stroke, 43 patients who received total hip replacement or total knee replacement two to four weeks before.
- Conditions
- Resistance Training, Stroke, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- NCT02938416
- Testing
- Isokinetic strengthening exercise, Isotonic strengthening exercise, isometric strengthening exercise
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Taichung Veterans General Hospital
Acute Ischemic Stroke, Large Vessel Occlusion
EFfects of Y-6 SUblingual Tablets foR PaTients With AcUte Ischemic StRokE (FUTURE)
This study aims to evaluate the efficacy of Y-6 sublingual tablets in improving microcirculation dysfunction and reducing thrombo-inflammation in patients who had AIS caused by LVO and received reperfusion therapy.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Reperfusion
- Trial name
- NCT06138834
- Testing
- Low-dose Y-6 sublingual tablets, High-dose Y-6 sublingual tablets, Low-dose Cilostazol
- Volunteers
- 300 people
- Sponsor
- Beijing Tiantan Hospital
Arterial Ischemic Stroke
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke
Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also…
- Trial name
- DOP-MOBILIZE (NCT07232498)
- Testing
- Doppler-guided early mobilization
- Where
- 7 sites in Croatia, Portugal
- Volunteers
- 1,300 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Stroke, Acute, Ischemic Stroke, Acute
Endovascular Therapy for Large Core Patients With Uncertain Response to Thrombectomy
The purpose of this study is to assess the safety and efficacy of endovascular thrombectomy in both an early and extended time window in patients with large strokes due to large artery occlusion.
- Trial name
- OUTER LIMITS (NCT06961487)
- Testing
- EndovascularThrombectomy, Endovascular thrombectomy with any FDA-approved device
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Ischemic Stroke
SITS (Safe Implementation of Treatments in Stroke) Open Artery by Thrombectomy in Acute Occlusive Stroke Study
Ischemic stroke, i.e. irreversible damage of a part of the patient's brain, is caused by the formation of blood clot in the major vessel which gives blood supply to a certain part of the brain.
- Trial name
- SITS Open (NCT02326428)
- Testing
- Stent retriever endovascular device for thrombectomy, Intravenous thrombolysis by alteplase (Actilyse) (optional)
- Where
- Sweden
- Volunteers
- 341 people
- Sponsor
- Karolinska Institutet
Acute Brain Injury, Traumatic Brain Injury
Effect of Central Venous Catheterization on Brain Pressure in Acute Brain Injury Patients
Acute brain injury (ABI) is a serious condition that can cause a dangerous increase in pressure inside the skull (called intracranial pressure, or ICP), which can harm the brain.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracerebral Hemorrhage, Aneurysmal Subarachnoid Hemorrhage (aSAH)
- Trial name
- CVC-ICP (NCT07704528)
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
Administration of Celecoxib for Treatment of Intracerebral Hemorrhage : A Pilot Study
Primary: Change of volume of perihematomal edema as assessed by brain CT. Secondary: The change of ICH volume between the initial and the follow-up CT scans The neurological status at 90 day using E-GOS and mRS.
- Trial name
- ACE-ICH (NCT00526214)
- Testing
- celecoxib medication
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Stroke, Acute, Stroke
Functional Electrical Stimulation (FES) for Upper Extremity Recovery in Stroke
Stroke is the leading cause of activity limitation among older adults in the United States. NeuroMuscular Electrical Stimulation (NMES) can assist stroke survivors in regaining motor ability and decreasing activity limitation…
- Conditions
- Stroke, Acute, Stroke, Hemiparesis
- Trial name
- NCT00142792
- Testing
- NMES device with EMG-triggered and Cyclic capabilities
- Where
- 3 sites in United States
- Volunteers
- 122 people
- Sponsor
- MetroHealth Medical Center
Stroke, Stroke Acute
Individual vs Co-Treatment in Acute Stroke Rehabilitation and Evaluation
This is a single center, pragmatic, randomized trial comparing the effectiveness of two commonly used approaches (co-treatment and individual treatment) in acute care rehabilitation.
- Trial name
- ICARE (NCT07411534)
- Testing
- Co-treatment, Individual Treatment
- Where
- United States
- Volunteers
- 567 people
- Sponsor
- Vanderbilt University Medical Center
Acute Ischemic Stroke
Reperfuse Ischemic Vessels With Endovascular Recanalization Device in JAPAN (RIVER JAPAN)
The main objective of this study is to document that the thrombectomy catheter (Rev-01) is effective and safe when used for revascularization in subjects with acute ischemic stroke within 8 hours of symptom onset who are…
- Trial name
- NCT01895634
- Testing
- Rev-01
- Where
- Japan
- Volunteers
- 49 people
- Sponsor
- Johnson & Johnson K.K. Medical Company
Stroke, Acute
Robot Mediated Therapy-Upper Limb Outcomes in Stroke
This study aims to determine the clinical outcomes of stroke patients who are provided with adjunctive robot-mediated task specific therapy(RMTT) and robot-mediated impairment training (RMIT) as compared to those who are provided…
- Trial name
- NCT05805644
- Testing
- Robot mediated upper limb therapy
- Volunteers
- 96 people
- Sponsor
- Changi General Hospital
Acute Ischemic Stroke
Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke
Many patients with acute ischemic stroke are ineligible for currently available standard treatments (clot-busting medication, also known as intravenous thrombolytic or mechanical removal of a clot), and many are non-responders…
- Trial name
- TESSERACT 2 (NCT06440707)
- Testing
- High-definition Cathodal Transcranial Direct Current Stimulation (HD C-tDCS)
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
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