Clinical trials: Acute Changes in Cognition
Cognitive Change, Well-Being, Psychological
Acute Effects of Physical Activity on Cognition and Well-being in University Students
Previous studies in young adults have shown that physical activity can generate positive emotions and improve attention, among other cognitive functions.
- Trial name
- ActClass4Brain (NCT06168526)
- Testing
- Acute physical activity
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitat Jaume I
Breast Cancer
Responsiveness to Acute Changes in Exercise and Relaxation (RACER) Trial
The purpose of this acute study is to compare the combined effects of aerobic exercise and relaxation training on fatigue and its related cognitive components, among breast cancer survivors.
- Trial name
- RACER (NCT03702712)
- Testing
- Aerobic Exercise and Relaxation, Aerobic Exercise Only, Relaxation Only
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Cognitive Performance, Well-Being
TETRA (Terrestrial Trunked Radio)
The purpose of this study is to investigate if electromagnetic radiation from TETRA handset can influence cognitive function and the well-being of healthy adults.
- Trial name
- NCT00395668
- Testing
- TETRA (at lowest carrier freq, std TDMA pulse at 17,6 Hz).
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Parkinson Disease
Low Frequency Subthalamic Nucleus Deep Brain Stimulation to Improve Verbal Fluency
Rationale: Parkinson's disease patients with deep brain stimulation electrodes represent a unique opportunity to study the influence of basal ganglia on neurocognitive function.
- Trial name
- NCT04383665
- Testing
- STN DBS 10Hz, STN DBS 130Hz, STN DBS off
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Southern California
Attention Deficit Hyperactivity Disorder, Stimulant Use
Acute Effects of Stimulant Medication in College Students With ADHD
The investigators will examine the acute effects of stimulant medication on executive functioning. The rationale for the proposed study is to examine the efficacy of stimulants for college students with ADHD and help prevent…
- Conditions
- Attention Deficit Hyperactivity Disorder, Stimulant Use, Working Memory, Change in Sustained Attention
- Trial name
- NCT03935646
- Testing
- Adderall IR 10mg
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Wyoming
Cognitive Change, Mood
The Effects of Resveratrol Supplementation on Inflammation and Cognitive Performance in Healthy Adults
Previous research has suggested that high levels of systemic inflammation can contribute to cognitive deficits and additional health problems; consumption of polyphenols have been shown to have an anti-inflammatory effect.
- Conditions
- Cognitive Change, Mood, Systemic Inflammation
- Trial name
- NCT04314739
- Testing
- Resveratrol
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Traumatic Brain Injury, Concussion, Brain
" Acute Brain Changes After Repetitive Headers in Soccer and the Effects of a Protective Device "
Soccer, the most popular sport in the world, exposes players to repeated head impacts and concussions, due to contact with another player or with the ground.
- Trial name
- Soccer-BRAIN (NCT04426188)
- Testing
- Heading series, Magnetic Resonance Imaging (MRI), Cognitive computerized assessment
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Postoperative Cognitive Dysfunction
Ketamine and Changes of the Short Portable Mental Status Questionnaire
Cognitive changes are related to aging, affecting the performance of older patients in the solution of problems and the execution of tasks.
- Trial name
- SPMSQ-E (NCT02049411)
- Testing
- Ketamine, physiological solution
- Where
- Mexico
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Aging, Protein Metabolism
Metabolite Changes Following Consumption Of Different Protein Drinks In Singapore Older Adults
The study aims to investigate the acute effects of different protein sources (i.e., casein, whey, soy) on metabolomic profiles (e.g., amino acids in the blood), along with other outcomes such as cognitive function, mood, and…
- Trial name
- NCT06956131
- Testing
- Casein Protein Isolate Drink, Whey Protein Isolate Drink, Soy Protein Isolate Drink
- Where
- Singapore
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Cognitive Change, Stress
Acute Effects of Mango Leaf Extract (Zynamite®) on Cognitive Function, Mood and Stress
This study aims to assess the effects of a single dose of Zynamite® on performance across a number of cognitive domains (attention, working memory, episodic memory, executive function), as well as during a period of cognitively…
- Trial name
- MLE-ZYN (NCT04299217)
- Testing
- Zynamite®
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Dementia, Mild Cognitive Impairment
Video Games to Track Cognitive Health
The purpose of this study is to assess cognitive function using a rapid, portable, computerized neurocognitive testing device in a wide variety of clinical settings.
- Conditions
- Dementia, Mild Cognitive Impairment, Cognitive Impairment, Cognitive Decline
- Trial name
- NCT03608722
- Testing
- SLUMS, MMSE, MoCA
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- BrainCheck, Inc.
Cognitive Change
Acute Effects of Moderate Intensity Aerobic Exercise on Cognitive Functions in Young Adult Males
60 healthy male university students will be included in this study. Physical fitness parameters, fluid intelligence, and physical activity level will be measured at baseline.
- Trial name
- NCT05905081
- Testing
- aerobic exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Izmir University of Economics
COVID-19, SARS-CoV-2 Infection
Physical and Cognitive Impairments in People Suffering From Long COVID
Of the 1,900,000 Canadians who have been infected by COVID-19, 8 to 15% will continue to experience COVID-19 related symptoms well after 12 weeks. The persistence of such symptoms is now defined as "long COVID" syndrome.
- Conditions
- COVID-19, SARS-CoV-2 Infection, Corona Virus Infection, Physical Disability
- Trial name
- NCT05216536
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Laval University
Depression
Changing Tactics? Optimizing ECT in Difficult-to-treat Depression
The goal of this randomized controlled trial is to address which treatment strategy (continue right unilateral (RUL) ECT or switch to bitemporal (BT) ECT speeds up recovery and has the least impact on memory function, in case of…
- Trial name
- ChaT (NCT05923801)
- Testing
- switch to BT electrode position, continue with RUL electrode position
- Where
- Belgium
- Volunteers
- 196 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cognitive Change, Mood Change
Cognitive Effects of Sage in Healthy Humans
Extracts of sage and polyphenols have separately been reported to interact with central nervous system (CNS) mechanisms relevant to cognitive performance but, to date, no trial has combined these interventions.
- Trial name
- NCT03695003
- Testing
- Cognivia
- Where
- United Kingdom
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Cognitive Change, Mood
Neurological, Inflammatory and Metabolic Effects of Acute Mushroom Intervention in Older Adults
This randomized crossover trial (RCT) investigates the acute effect (over a 6-hour period) of a meal containing varying serving sizes (doses) of freeze-dried oyster mushroom powder, on the cognitive behaviour and markers of…
- Conditions
- Cognitive Change, Mood, Metabolism, Inflammatory Response
- Trial name
- OYSACO (NCT05594329)
- Testing
- Instant noodle soup containing containing the equivalent of 2 servings (18.78g) of powdered Pleurotus oyster mushroom., Instant noodle soup containing containing the equivalent of 1 serving (9.39g) of powdered Pleurotus oyster mushroom., Instant noodle soup containing containing the equivalent of 0.5 serving (4.70g) of powdered Pleurotus oyster mushroom.
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Reading
Mood, Cognitive Change
The Effect of Acute Minocycline Administration on Emotional Processing and Cognition in Healthy Volunteers
There is growing interest in the possibility of producing more effective antidepressant treatments that target a wider range of pathways involved in depression, including anti-inflammatory and anti-glutamatergic systems.
- Trial name
- NCT03768557
- Testing
- Minocycline
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cognitive Change
Acute Dose-ranging Effects of Mango Leaf Extract (Zynamite® 15%) on Cognitive Function and Cerebral Blood Flow
Zynamite® is a novel mango (Mangifera indica) leaf extract standardized to contain polyphenol mangiferin.It has previously been shown to enhance brain oxygenation, physical performance and ergogenic parameters following…
- Trial name
- NCT05580146
- Testing
- Zynamite® 15% 150mg, Zynamite® 15% 300mg, Zynamite® 15% 600mg
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Cardiovascular System, Respiratory System
Acute Health Effects of High Temperature Exposure
This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of high temperature exposure and the underlying mechanisms.
- Conditions
- Cardiovascular System, Respiratory System, Cognitive Function
- Trial name
- NCT05575752
- Testing
- high temperature (32℃) group, moderate temperature (22℃) group
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fudan University