Clinical trials: Acute Conditions
Cognitive Dysfunction, Postoperative Delirium
Electroencephalographic Biomarker to Predict Acute Post-operatory Cognitive Dysfunction
Acute post-operatory cognitive dysfunction states are one of the most important complications in older patients after surgery. Two acute cognitive dysfunctions have been described: postoperative delirium (PD) and postoperative…
- Trial name
- NCT04214496
- Testing
- Sedline
- Where
- 2 sites in Chile
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Chile
Amnesia
Transient Global Amnesia (TGA). Exploratory Study of the Default Mode Network During the Acute Phase
The transient global amnesia, in which the memory disorder is massive, transient and pure, offers a unique model for exploring episodic memory.
- Trial name
- ICTUS (NCT02010853)
- Testing
- IRMf
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Chronic Kidney Diseases, Diabetes Mellitus, Type 2
Effect of Acute Fructose Load in Human
The metabolism of the monosaccharide fructose is less controlled than the metabolism of glucose, which will result in the metabolic product uric acid.
- Trial name
- NCT03157960
- Testing
- Blueberry drink, Blueberry and pizza, Soft beverage
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Cardiovascular Diseases, Acute MI
Impact of the Genetic Background as a Risk Factor for Atherosclerotic Cardiovascular Disease in the Brazilian Population
The main objective of this project is to evaluate the genomic information previously associated with cardiovascular diseases (CVD) and its importance as an independent risk predictor (expressed in Odds Ratio) when adjusted for…
- Conditions
- Cardiovascular Diseases, Acute MI, Stroke, Peripheral Arterial Disease
- Trial name
- CV-GENES (NCT05515653)
- Testing
- Exposure to genetics (polygenic)
- Where
- 41 sites in Brazil
- Volunteers
- 3,974 people, healthy volunteers welcome
- Sponsor
- Hospital Alemão Oswaldo Cruz
Cardiovascular Diseases, Coronary Artery Disease
Optimising Secondary Prevention and Quality of Life in Early Cardiac Rehabilitation
The primary aim of this research is to explore the adherence and drop-out from early cardiac rehabilitation (CR), to inform interventions to support patient's adherence to CR and facilitate maintenance.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Myocardial Infarction, Acute Coronary Syndrome
- Trial name
- OSPREY-CR (NCT04781699)
- Where
- 6 sites in United Kingdom
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Cardiovascular Diseases, Cognition
Acute Impact of Whey Protein-enriched Milk Fat Globule Membrane Supplementation on Postprandial Markers of Heart and Brain Health
In a single-blind, randomised, placebo-controlled crossover manner, this study aims to assess the impact of a high-fat mixed meal containing a whey protein (WP)-enriched milk fat globule membrane (MFGM) powdered ingredient on…
- Conditions
- Cardiovascular Diseases, Cognition, Overweight or Obesity, Postmenopausal Women
- Trial name
- NCT06953232
- Testing
- Whey protein-enriched milk fat globule membrane supplement, Whey protein-based supplement
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Sleep Deprivation, Sleep
The Effects of Acute Total Sleep Deprivation Versus Normal Sleep on Metabolism
The study proposes to investigate whether acute total deprivation affects metabolism as measured through blood and peripheral tissues.
- Trial name
- NCT01800253
- Testing
- Inhibitory task, Blood samples, Tissue samples
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Osteoarthritis, Rheumatoid Arthritis
A Phase 1 Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics of DW1809
Randomized, Open-label, Oral, Single-dose, two-Sequence, four-Period, crossover study
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Back Pain, Acute Upper Respiratory Tract Infection
- Trial name
- NCT05214677
- Testing
- DW1809, DW1809-1
- Where
- South Korea
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Malnutrition, Child, Wasting Disease
Cash Plus Interventions for Prevention of Acute Malnutrition in Children Under 5 and Their Mothers in Somalia
This trial studied different combinations of cash assistance to families that live in food insecure areas of Somalia and aimed to understand if this cash assistance provided reduced malnutrition of children and mothers.
- Conditions
- Malnutrition, Child, Wasting Disease, Stunting, Malnutrition
- Trial name
- NCT06642012
- Testing
- Cash only, Cash + Social Behavior Change Communication, Cash + top-up cash
- Where
- 2 sites in United States, Somalia
- Volunteers
- 3,384 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
COPD
The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR)
The investigators hypothesize that BFR exercise regimens result in a different acute cardiorespiratory response pattern compared to traditional exercise regimens.
- Trial name
- CaRe-BFR (NCT05163600)
- Testing
- BFR-CYC 50% peak / 50% AOP (exhaustive), BFR-CYC 3x2min, BFR Resistance 80% LOP
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Diarrhea
Early Administration of Lactose-free Milk in Children Presenting With Acute Diarrhea
The purpose of this study is to determine which nutritional regime is better for acute diarrhea in outcomes.
- Trial name
- NCT01269892
- Testing
- lactose-free milk, conventional milk
- Where
- Iran
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Acute Coronary Syndrome, Myocardial Infarction
Hepatocyte Growth Factor (HGF) Concentration in Myocardial Infarction
This is the continuation of previous study (registration number: NCT00844987) which revealed that hepatocyte growth factor (HGF) is a very early, good marker of myocardial injury and prognostic factor for post myocardial…
- Trial name
- NCT01233336
- Where
- Poland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Hypoxia, Brain
Supplementation of 500mg Trans-resveratrol Within Hypoxic and Normoxic Conditions, in Healthy Humans.
Objectives: Resveratrol, a non-flavonoid polyphenol, has been found to consistently modulate cerebral blood flow (CBF) following oral supplementation.
- Trial name
- NCT03100019
- Testing
- Resveratrol
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Interstitial Lung Disease, Chronic Thromboembolic Pulmonary Hypertension
129Xe MRI Cardiopulmonary
The goal of this NIH-sponsored study is to characterize three biomarkers derived from 129Xe gas exchange MRI and to understand how they change in response to interventions.
- Conditions
- Interstitial Lung Disease, Chronic Thromboembolic Pulmonary Hypertension, Acute Pulmonary Embolism, Anemia
- Trial name
- NCT06038630
- Testing
- Hyperpolarized Xe129, Oxygen Administration
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Bastiaan Driehuys
Low Back Pain
Study on the Sociopsychoemotional Mechanism of Dysfunction in Patients With Acute and Chronic Low Back Pain
Low back pain is defined as pain that extends from the 12th rib to the iliac bone, and its increasing incidence makes it one of the major causes of decreased productivity worldwide.
- Trial name
- NCT06684665
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Aging, Aphasia
Exercise Effects on Word Learning
The aging Veteran population will substantially increase over the next 10 years, as the 24.9% of Veterans who are currently between 55-64 years of age join the 38.5% who are already over age 65.
- Trial name
- NCT03370471
- Testing
- Retrieval Practice + Moderate Intensity Exercise, Retrieval Practice + Gentle Stretching, Study Only + Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Biological Availability, Healthy Participants
A Study on 2 Different Combination Tablets of Nirmatrelvir Plus Ritonavir to Compare Them With Marketed Paxlovid in Healthy Participants
Medicines that may have different names or be made in different ways but have the same effect on the body are called bioequivalent.
- Trial name
- NCT06397144
- Testing
- Paxlovid, Nirmatrelvir/ritonavir
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Trauma, Critical Illness
Mathematical Modeling of the Acute Inflammatory Response Following Injury
The purpose of this research study is to gather clinical and biologic information from severely injured patients to better understand and characterize the host response to injury and inflammation across several domains.
- Trial name
- NCT00250523
- Where
- United States
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Obesity
Effect of Acute Dietary Supplementation With Grape Seed Extract on Aortic Stiffness, Arterial Pressure, and Blood Vessel Dilation in Collegiate Obese Individuals at Rest
This study investigated if elevated BP and aortic stiffness characterized in obese individuals are attenuated following acute grape seed extract supplementation.
- Trial name
- NCT04389060
- Testing
- Grape seed extract
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- California Baptist University
HIV
Home Self-Testing for HIV to Increase HIV Testing Frequency in Men Who Have Sex With Men (The iTest Study)
The purpose of this study is to determine whether the availability of home self-testing for HIV will increase HIV testing frequency among men who have sex with men without negatively impacting their risk for HIV acquisition.
- Trial name
- NCT01161446
- Testing
- Home HIV self-testing with OraQuick ADVANCE® Rapid HIV-1/2 Antibody Test
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of Washington
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