Clinical trials: Acute Conditions
Pregnancy Complications, Obesity
Acute Exercise Effects in Obese Pregnancy
Obesity before and during pregnancy is associated with a higher risk for a number of obstetric and metabolic complications in women and their offspring.
- Conditions
- Pregnancy Complications, Obesity, Pre-Eclampsia, Gestational Diabetes
- Trial name
- NCT03750695
- Testing
- Resistance exercise, Aerobic Exercise, Rest
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Cardiac Surgery, Sternotomy
Pecto-Intercostal Fascial Plane Block Catheter Trial for Reduction of Sternal Pain
One of the most painful aspects of open heart surgery is the incision made through the skin and the sternum to access the heart (a "sternotomy").
- Conditions
- Cardiac Surgery, Sternotomy, Acute Pain
- Trial name
- NCT05054179
- Testing
- Ropivacaine 0.2% Injectable Solution Bolus, Normal Saline Infusion, Ropivacaine 0.2% Injectable Solution Infusion
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Acute Myeloid Leukemia, Chronic Myeloid Leukemia
A Dose Escalation Study of Intensity Modulated Total Marrow Irradiation (IMRT-TMI) Followed by Fludarabine as a Myeloablative Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Relapsed and Refractory Hematologic Malignancies
This is a phase I/II clinical trial to determine the maximum tolerated dose (MTD) of total marrow irradiation (TMI) followed by fludarabine in the context of a myeloablative conditioning regimen for allogeneic hematopoietic stem…
- Conditions
- Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Acute Lymphocytic Leukemia, Myelodysplastic Syndromes
- Trial name
- NCT05201183
- Testing
- Fludarabine + Total Marrow Irradiation
- Where
- United States
- Sponsor
- Naoyuki G. Saito, M.D., Ph.D.
AML, Adult, Minimal Residual Disease
A Study of Chidamide With AZA in MRD Positive AML After Transplant
acute myeloid leukemia (AML) is a malignant tumor of the hematopoietic system with high heterogeneity in cytogenetics and molecular biology.Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is still the primary…
- Trial name
- NCT06066905
- Testing
- chidamide and azacitidine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangdong Provincial People's Hospital
Cervical Pain
Effectiveness of Muscle Energy Technique (MET) Versus Stretching Exercises In Acute And Subacute Postural Neck Pain
This study will provide better evidence that which technique is more effective in acute and subacute postural neck pain. To find out the effectiveness of Muscle energy technique (MET) and stretching exercises in acute and…
- Trial name
- NCT06221566
- Testing
- Muscle Energy Technique, Stretching Exercises
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Dow University of Health Sciences
Pain, Acute
Methoxyflurane Analgesia for Paediatric Injuries
This is a randomised, double-blind, multicentre, placebo controlled study to evaluate the safety and efficacy of methoxyflurane (Penthrox®) for the treatment of acute pain in children and adolescents from 6 to less than 18 years…
- Trial name
- MAGPIE (NCT03215056)
- Testing
- Methoxyflurane, Normal saline
- Where
- 11 sites in Ireland, United Kingdom
- Volunteers
- 192 people
- Sponsor
- Medical Developments International Limited
Healthy (For Part A), Chronic Myeloid Leukemia (for Part B and C)
Safety and Anti-leukemic Activity of Vodobatinib (K0706) for Treatment of Ph+ CML Resistant/Intolerant to ≥3 Prior CML Therapies
Phase 1/2 study to determine safety, tolerability, pharmacokinetics, and anti-leukemic activity of Vodobatinib (K0706) in treatment-refractory/intolerant CML
- Trial name
- NCT02629692
- Testing
- Vodobatinib (K0706) capsules
- Where
- 35 sites in United States, Belgium and 8 more
- Volunteers
- 124 people
- Sponsor
- Sun Pharma Advanced Research Company Limited
Chronic Obstructive Pulmonary Disease
Residential Cleaning of Indoor Air to Protect COPD Patients
This study looks at whether air cleaning devices put in the bedroom and living room of your home could reduce the irritation of your lungs and body that is caused by indoor air pollution.
- Trial name
- CARE (NCT03750292)
- Testing
- HEPAirX air filter, control air filter
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Rochester
Stroke
Reduce Inefficiencies in Management of Spasticity
The purpose of this study is to evaluate the effectiveness of a spasticity screener and to determine if the spasticity screener results are useful to healthcare providers and impact clinical decision making
- Trial name
- ReIMage (NCT07639632)
- Testing
- Screener, Standard of care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity
Effect of High-intensity Intermittent Sprinting on Appetite Control on Obese Volunteers
Several studies have shown that high intensity intermittent sprints (HIIS) are more effective than moderate intensity continuous cycling (MICC) in reducing fat mass and improving insulin resistance in normal weight individuals.
- Trial name
- NCT01143363
- Testing
- resting - control, Moderate intensity exercise, High intensity intermittent training
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Long COVID
Evaluating the Neuromodulatory Effect of Ketamine in Long COVID-19
Plain Language Summary: This study is a clinical trial to see if ketamine can help treat symptoms of Long COVID, especially fatigue and problems with thinking clearly (often called "brain fog").
- Trial name
- NCT06821087
- Testing
- Ketamine only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas at Austin
Relapsed or Refractory Acute Myeloid Leukemia (AML)
A Study of HYML-122 and Cytarabine in Patients With FLT3 Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)
This is a single-arm, open, multicenter, phase 2 study to evaluate the efficacy, safety and pharmacokinetics of HYLM-122 in combination with cytarabine in Chinese subjects with FLT3 positive relapsed or refractory acute myeloid…
- Trial name
- NCT05241093
- Testing
- HYML-122; cytarabine
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Tarapeutics Science Inc.
Bipolar Disorders, Mood Disorders
A Study of the Effectiveness and Safety of Topiramate in the Treatment of Patients With Bipolar Disorder
The primary purpose of this study is to evaluate the effectiveness and safety of topiramate compared with placebo in the treatment of acute manic or mixed episodes in patients with Bipolar I Disorder.
- Conditions
- Bipolar Disorders, Mood Disorders, Affective Disorders, Psychotic
- Trial name
- NCT00240721
- Testing
- topiramate
- Volunteers
- 363 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Thermoregulation, Sleep Disturbance
Acute Sleep Deprivation on Whole-body Heat Exchange During Exercise-heat Stress in Young and Older Men
Sleep deprivation has long been thought to modulate thermoregulatory function. Seminal work on sleep deprivation and thermoregulation has demonstrated that sleep-deprived individuals experience greater elevations in core…
- Conditions
- Thermoregulation, Sleep Disturbance, Heat Exchange, Aging
- Trial name
- NCT05838014
- Testing
- Sleep deprivation, Normal sleep
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Pancreatitis, Acute
Resolution of Organ Injury in Acute Pancreatitis - RESORP
Acute pancreatitis (AP) is inflammation of the pancreas usually triggered by gallstones or drinking excessive alcohol. 80% of people who have an episode of AP will recover without complications.
- Trial name
- RESORP (NCT03342716)
- Where
- United Kingdom
- Volunteers
- 229 people
- Sponsor
- University of Edinburgh
Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia, Pediatric
CD123 Redirected T Cells for AML in Pediatric Subjects
Phase 1 open-label study to evaluate the safety of intravenously administered, lentivirally transduced T cells expressing anti-CD123 chimeric antigen receptors expressing tandem TCRζ and 4-1BB (TCRζ /4-1BB) costimulatory domains…
- Conditions
- Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia, Pediatric, Acute Myeloid Leukemia, Refractory
- Trial name
- NCT04678336
- Testing
- CART123 cells; cyclophosphamide; fludarabine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Pennsylvania
Intra Cerebral Hemorrhage, Hypertension
Proper Timing of Control of Hypertension and Outcome in Acute Spontaneous Intracerebral Hemorrhage.
The ideal management of blood pressure in BP after acute intracerebral haemorrhage is still debated and whether a higher intensive reduction of blood pressure after acute intracerebral haemorrhage may be better or not is still…
- Trial name
- NCT04167644
- Testing
- Modified Rankin Scale (mRS)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Mansoura University Hospital
Leukemia
R115777 in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of R115777 in treating patients who have refractory or…
- Trial name
- NCT00004009
- Testing
- tipifarnib
- Where
- 3 sites in United States
- Sponsor
- University of Maryland, Baltimore
Dyspnea, Heart Failure Acute
Evaluation of the Effectiveness of the CardioStory Device in Distinguishing Heart Failure From Other Causes in Patients Presenting With Dyspnea
The CARDIOSTORY.TN study is a prospective observational study at Sahloul University Hospital (Sousse, Tunisia) evaluating the CardioStory device for distinguishing heart failure (HF) from other causes of acute dyspnea.
- Trial name
- CARDIOSTORY (NCT07147699)
- Testing
- cardiostory
- Sponsor
- Hôpital Universitaire Sahloul
Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia
Phase 1 Study of CC-486 in Japanese Subjects With Hematological Neoplasms
To identify the maximum tolerated dose (MTD) of oral azacitidine on different treatment schedules in Japanese subjects with hematological neoplasms
- Conditions
- Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, Acute Myeloid Leukemia, Multiple Myeloma
- Trial name
- NCT01908387
- Testing
- Oral azacitidine
- Where
- 3 sites in Japan
- Volunteers
- 2 people
- Sponsor
- Celgene Corporation
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