Clinical trials: Acute Conditions
STEMI - ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
Non Culprit Functional Evaluation With 3D Angio QFR in STEMI PCI Procedure
Reliability of 3D angio QFR functional evaluation of all non culprit lesions >50% in STEMI patients during first acute procedure
- Conditions
- STEMI - ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention, Coronary Artery Disease
- Trial name
- NCT02998853
- Testing
- QFR measurement by dedicated workstation on xrays angio selected runs
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliera Sant'Anna e San Sebastiano
Acute Sciatica, Lumbar Disc Herniation
Chiropractic Spinal Manipulative Therapy for Acute Sciatica Secondary to Lumbar Disc Herniation
Comparisons of surgical and non-operative treatment of patients with acute sciatica secondary to lumbar intervertebral disc herniation (AS/LDH) have shown no appreciable difference in outcome.
- Trial name
- NCT01552486
- Testing
- Chiropractic Spinal Manipulative Therapy, Usual Care
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Vancouver General Hospital
Postoperative Pain, Adults
Safety and Efficacy Evaluation of S (+) - Ketamine in Adults
A multicenter, randomized, open-label, active controlled pragmatic clinical trial that evaluates the safety and efficacy of S (+) -ketamine for postoperative acute pain in adults in perioperative settings.
- Conditions
- Postoperative Pain, Adults, Anesthesia
- Trial name
- NCT04837170
- Testing
- Conventional therapy + S (+)-Ketamine, Conventional therapy
- Volunteers
- 12,000 people
- Sponsor
- Chinese PLA General Hospital
Pressure Ulcer, Skin Lesion
Prevention of Skin Damage in the Patient in Prone Position: Development of Education Interventions Based on a Training Needs Assessment Study.
This is study 1 of 3 - of the overall project: The ProneTection Quality Improvement Project. The three aims of this study, study 1 are: 1.
- Conditions
- Pressure Ulcer, Skin Lesion, Acute Respiratory Distress Syndrome
- Trial name
- NCT05238870
- Testing
- Interviews for the needs analysis. No intervention.
- Where
- 2 sites in Belgium
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Ghent
Back Pain
A Study to Evaluate the Safety and Tolerability of Arbaclofen Placarbil (XP19986) in Subjects With Acute Back Spasms
The purpose of the study is to evaluate safety and tolerability of arbaclofen placarbil sustained release tablets taken every 12 hours compared to placebo in subjects with acute back spasms in the lumbar region.
- Trial name
- NCT00817986
- Testing
- Arbaclofen placarbil, 20 mg, Arbaclofen placarbil, 30 mg, Arbaclofen placarbil, 40 mg
- Where
- 20 sites in United States
- Volunteers
- 161 people
- Sponsor
- XenoPort, Inc.
Long COVID
Stellate Ganglion Block for Long COVID Symptoms: A Randomized Controlled Trial
This single-center, randomized, controlled, single-blind clinical trial evaluates whether a stellate ganglion block (SGB) using bupivacaine can improve persistent symptoms in adults with long COVID.
- Trial name
- STAR-CO (NCT07374562)
- Testing
- Stellate Ganglion Block (Bupivacaine)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec
Copd, COPD Exacerbation
Change in Breathing Pattern on Non-invasive Ventilation of COPD Patients Under Home Mechanical Ventilation
Acute exacerbation of COPD (AECOPD) worsen prognosis and quality of life of COPD patients. Telemonitoring could be a useful tool for early identification of AECOPD. Parameters that have to be monitored are not well defined.
- Trial name
- NCT03018470
- Testing
- Analysis of data from NIV built-in software
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Rouen
Cardiovascular Diseases, Acute MI
Impact of the Genetic Background as a Risk Factor for Atherosclerotic Cardiovascular Disease in the Brazilian Population
The main objective of this project is to evaluate the genomic information previously associated with cardiovascular diseases (CVD) and its importance as an independent risk predictor (expressed in Odds Ratio) when adjusted for…
- Conditions
- Cardiovascular Diseases, Acute MI, Stroke, Peripheral Arterial Disease
- Trial name
- CV-GENES (NCT05515653)
- Testing
- Exposure to genetics (polygenic)
- Where
- 41 sites in Brazil
- Volunteers
- 3,974 people, healthy volunteers welcome
- Sponsor
- Hospital Alemão Oswaldo Cruz
Acute Promyelocytic Leukemia (APL)
Evaluate the Pharmacokinetics of Oral Arsenic Trioxide Solution Under Fasting and Fed Conditions, to Compare Intravenous Arsenic Trioxide, in Acute Promyelocytic Leukemia
Randomized, Open-Label Study to evaluate the Pharmacokinetics of Oral Arsenic Trioxide Solution (SDK001) under Fasting and Fed Conditions, to Compare to IV Arsenic Trioxide
- Trial name
- NCT06882031
- Testing
- Treatment A: Arsenic Trioxide (ATO) Intravenous, Treatment B: SDK001 (Arsenic Trioxide Oral solution) under faster state, Treatment C: SDK001 (Arsenic Trioxide Oral solution) under fed state
- Where
- Hong Kong
- Volunteers
- 12 people
- Sponsor
- SDK Therapeutics, Inc.
Hip Fractures
Effects of Music on Acute Postoperative Pain Intensity and Mobility After Fragility Hip Fracture
Music has been proven to be beneficial in postoperative care by reducing pain. The effects of music listening to reduce pain postoperatively are well studied among cases undergoing elective orthopaedic surgery.
- Trial name
- NCT06277102
- Testing
- music listening
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Hospital Authority, Hong Kong
STEMI, Acute Myocardial Infarction
Resistance STEMI Study
In acute myocardial infarction, early restoration of blood flow to the jeopardized myocardium is of paramount importance to limit infarct size and to improve long term outcome.
- Trial name
- NCT03439150
- Testing
- Absolute flow and resistance measurement
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Critical Care, Intensive Care, Fluid Accumulation
CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS
This study is enrolling adult patients who require a prolonged stay in the intensive care unit (ICU). These patients often receive large amounts of intravenous fluids, which can contain more salt (sodium and chloride) than the…
- Conditions
- Critical Care, Intensive Care, Fluid Accumulation, Fluid and Electrolyte Imbalance, Critical Illness
- Trial name
- CRUSADERS (NCT07189091)
- Testing
- Glucose 5% for fluid creep, NaCl 0.9% (normal saline) for fluid creep, PlasmaLyte as maintenance fluid
- Where
- 4 sites in Belgium
- Volunteers
- 640 people
- Sponsor
- University Hospital, Antwerp
Acute Myelogenous Leukemia, Chronic Myelomonocytic Leukemia
Study of DT388GMCSF Fusion Protein in Acute Myelogenous Leukemia (AML) and Chronic Myelomonocytic Leukemia (CMML)
DTGM belongs to a new generation of drugs designed to target leukemic cells. To achieve this, DTGM takes advantage of the ability of naturally-produced growth factor (GM, granulocyte-macrophage stimulating factor) to deliver a…
- Trial name
- NCT00074750
- Testing
- DTGM
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- M.D. Anderson Cancer Center
Post-acute Sequelae of SARS-CoV-2 Infection
Cognitive-Sensorimotor Function in Long-COVID
Growing evidence indicates that many people who have chronic post-acute sequelae of SARS-CoV-2 infection (PASC) will experience ongoing neurological and musculoskeletal impairment that can affect gait and balance.
- Trial name
- NCT06850350
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Esophageal and Gastric Varices
Comparison of Endoscopic Band Ligation Plus 24-hour Versus 72-hour Terlipressin Therapy
In the Western world, liver cirrhosis is a significant issue. Acute variceal bleeding (AVB) is a considerable complication of cirrhosis associated with high mortality.
- Trial name
- NCT05331768
- Testing
- banding ligation plus terlipressin infusion
- Where
- Mexico
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Acute Cardiogenic Shock
Transient Circulatory Support in Cardiogenic Shock
The purpose of this multicenter prospective study is to determine if the decision of transient circulatory support (TCS) in cardiogenic shock is relevant.
- Trial name
- ALLOASSIST (NCT03528291)
- Where
- France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Montpellier
Acute Leukemia
Monitoring the Diagnosis and Management of Acute Leukaemia In Pregnancy Study.
Acute leukaemia (AL) is an aggressive but potentially curable cancer that can affect women of childbearing age. When a pregnancy is complicated by a diagnosis of AL, clinicians face a complex dilemma: to balance risking the…
- Trial name
- LIPS (NCT04182074)
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Hull
Post Operative Pain, Acute
A Comparative Study Between Ultrasound Guided Thoracic Paravertebral Block VS Serrartus Anterior Muscle Block in VATS as Regard Their Effectiveness in Post-operative Analgesia
A comparative study between ultrasound guided thoracic paravertebral block VS ultrasound guided serrartus anterior muscle block in video-assisted thoracoscopic surgeries as regard their effectiveness in post-operative analgesia
- Trial name
- NCT05971368
- Testing
- thoracic paravertebal block, serratus anterior muscle block
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Acute Fracture Surgery, Alcohol Cessation Intervention
Alcohol Cessation Intervention in an Acute Surgical Setting
Hazardous alcohol intake is an independent risk factor for postoperative complications after major and minor operations, elective and emergency procedures for men and women.
- Conditions
- Acute Fracture Surgery, Alcohol Cessation Intervention, Postoperative Complications, Infection
- Trial name
- NCT00986791
- Testing
- GSP-A
- Where
- 3 sites in Denmark
- Volunteers
- 70 people
- Sponsor
- Bispebjerg Hospital
Chronic Myelomonocytic Leukemia, Myelodysplastic Syndrome With Isolated Del(5q)
WEE1 Inhibitor AZD1775 With or Without Cytarabine in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome
This randomized phase II trial studies how well WEE1 inhibitor AZD1775 with or without cytarabine works in treating patients with acute myeloid leukemia or myelodysplastic syndrome that has spread to other places in the body and…
- Conditions
- Chronic Myelomonocytic Leukemia, Myelodysplastic Syndrome With Isolated Del(5q), Myelodysplastic/Myeloproliferative Neoplasm, Previously Treated Myelodysplastic Syndrome
- Trial name
- NCT02666950
- Testing
- Cytarabine, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.