Clinical trials: Acute Conditions
Relapse/Refractory B-cell Acute Lymphoblastic Leukemia
Safety and Efficacy of CAR T Cell Therapy in Patients with R/r B-ALL
The goal of this clinical trial is to evaluate the safety and efficacy of CD19 CAR-T cells in pediatric patients of all genders, aged 2 to 18 years, with relapsing or refractory B cell acute lymphoblastic leukemia (r/r B-ALL).
- Trial name
- NCT06635330
- Testing
- anti-CD19 CAR T cell therapy
- Where
- Iran
- Volunteers
- 5 people
- Sponsor
- Kara Yakhteh Tajhiz Azma Company
Congenital Metabolic Disorder, Acute Disease
Rapid Genetic Diagnosis Employing Next Generation Sequencing for Critical Illness in Infants and Children
Under the joint efforts of genetic and intensive expert, to establish the high-throughput whole exon sequencing(WES) and analysis all the possible pathogenic genes.
- Trial name
- NCT03175692
- Testing
- Whole Exome Sequencing
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Acute Myeloid Leukemia (AML), Acute Lymphocytic Leukemia (ALL)
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases
This is a treatment guideline for an unrelated umbilical cord blood transplant (UCBT) using a myeloablative preparative regimen for the treatment of hematological diseases, including, but not limited to acute leukemias.
- Conditions
- Acute Myeloid Leukemia (AML), Acute Lymphocytic Leukemia (ALL), Chronic Myelogenous Leukemia, Plasma Cell Leukemia
- Trial name
- NCT01962636
- Testing
- Fludarabine, Cyclophosphamide, Total Body Irradiation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Stretching, Control Condition
Hip Abduction and Adduction During Neurodynamic Stretching
Neurodynamic mobilization techniques are widely applied in rehabilitation and physiotherapy to enhance the mobility and function of peripheral nerves. Two main approaches are distinguished : Nerve tensioning and nerve flossing.
- Trial name
- HIPROT (NCT07350434)
- Testing
- Maximal neurodynamic flossing
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Burgundy
Post-COVID-19 Syndrome, Post-COVID Syndrome
Immunoadsorption Study Mainz in Adults With Post-COVID Syndrome
The aim of this study is to evaluate the efficiency and safety of immunoadsorption for the treatment of post-COVID syndrome (PCS).
- Conditions
- Post-COVID-19 Syndrome, Post-COVID Syndrome, Post COVID-19 Condition
- Trial name
- IAMPOCO (NCT05841498)
- Testing
- Immunoadsorption
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Medical Center Mainz
Rib Fractures, Pain Acute
Ultrasound Guided Serratus Anterior Plane Block in ED Patients With Rib Fractures
The goal of this clinical trial is to test the effectiveness of the Serratus Anterior Plane Block in patients with rib fractures.
- Conditions
- Rib Fractures, Pain Acute, Regional Anesthesia, Opioid Use
- Trial name
- NCT06299137
- Testing
- Serratus Anterior Plane Block, Ropivacaine injection
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rhode Island Hospital
Fracture
Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department
The goal of this clinical trial is to learn if buprenorphine can treat pain in older adults who have broken bones. The main questions it aims to answer are: Is buprenorphine as effective as opioids to treat pain? Are there less…
- Trial name
- NCT07430345
- Testing
- Buprenorphine 0.15 MG, Hydromorphone 0.25 mg IV
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- The Cooper Health System
Abdomen, Acute, Other Acute Pain
Low Dose Ketamine (LDK) Versus Morphine for Acute Pain Control in the Emergency Department
The purpose of this study is to compare the safety and effectiveness of intravenous low dose ketamine (LDK) to the industry standard of morphine (MOR) in regards to controlling acute pain in the emergency department.
- Conditions
- Abdomen, Acute, Other Acute Pain, Flank Pain, Back Pain
- Trial name
- NCT01538745
- Testing
- Ketamine, Morphine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Brooke Army Medical Center
Mastectomy, Pain, Acute
Stellate Ganglion Block for Prevention of Post Mastectomy Depression
Complications after mastectomy include chronic pain and depression.
- Conditions
- Mastectomy, Pain, Acute, Pain, Chronic
- Trial name
- SGB (NCT06263907)
- Testing
- Stellate gangalion block
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Mansoura University
Minimal Residual Disease, Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes
Daratumumab and Donor Lymphocyte Infusion in Treating Participants With Relapsed Acute Myeloid Leukemia After Stem Cell Transplant
This phase I/II trial studies the side effects and best dose of donor lymphocyte infusions when given together with daratumumab and to see how well they work in treating participants with acute myeloid leukemia that has come back…
- Conditions
- Minimal Residual Disease, Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes, Recurrent Adult Acute Myeloid Leukemia, Recurrent Childhood Acute Myeloid Leukemia
- Trial name
- NCT03537599
- Testing
- Daratumumab, Donor Lymphocyte Infusion, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Sumithira Vasu
Dyspepsia
High Resolution Gastric Mapping and Gastroduodenal Manometry
Dyspepsia is a common problem attributed to gastric sensorimotor dysfunctions ie, delayed, or less frequently rapid gastric emptying (GE), impaired gastric accommodation, and increased gastric sensation.
- Trial name
- NCT06941545
- Testing
- Alimetry, tVNS, Gastroduodenal Manometry
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
ST Elevation Myocardial Infarction
Long-term Clinical Outcomes of intraVascular Ultrasound-guided vs Angiography-guided Primary pErcutaneous Intervention in Patients With Acute ST Segment Elevated Myocardial Infarction
To examine the impact of IVUS guidance on clinical outcomes in the patient with Acute ST Segment Elevated Myocardial Infarction.
- Trial name
- LOVEinSTEMI (NCT04063345)
- Testing
- IVUS-guided PCI, Angiography-guided PCI
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Glucocorticoids, Overweight and Obesity
Acute Consequences of Glucocorticoid Secretion in Overweight and Obese Individuals During Maximum Calorie Intake
The investigator aim to understand whether food-induced glucocorticoids influence fat mass in overweight and obese people. In a randomized, cross-over study, 23 overweight and obese volunteers will receive a block and replace…
- Conditions
- Glucocorticoids, Overweight and Obesity, Overeating
- Trial name
- Gluco-Max (NCT06556277)
- Testing
- Metyrapone And Hydrocortisone
- Where
- Switzerland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Cirrhosis, Hepatic Encephalopathy
Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System
The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.
- Trial name
- NCT00424957
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Acute Coronary Syndromes, Heart Failure
Prospective Cohort of Acute Cardiology Referrals in an Ambulatory Day-Hospital Setting
Suspected acute or subacute cardiovascular diseases-including chest pain, dyspnea, and palpitations-are among the most common reasons for unscheduled emergency department visits and pre-hospital referrals.
- Conditions
- Acute Coronary Syndromes, Heart Failure, Pulmonary Embolism, Deep Vein Thrombosis, HTN-Hypertension
- Trial name
- CESAR (NCT07675434)
- Volunteers
- 25,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Rehabilitation
The Kinesio-taping for the Prevention of Painful Shoulder and for the Functional Recovery of Upper Limb After Stroke
This RCT aims to investigate the effectiveness of the early use of Kinesio-taping (KT) together with standard physiotherapy treatment, in the prevention of the shoulder pain of the hemiplegic upper limb following a cerebral…
- Trial name
- NCT05156164
- Testing
- Kinesio Tape Group, Control Group
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Pain Management
MCID and PASS for Acute Pain and Quality of Recovery After Orthopedic Surgery
This study seeks to define what constitutes an MCID and a PASS in patients undergoing a variety of elective major orthopedic surgery.
- Trial name
- NCT04811209
- Testing
- 1.Baseline Measurements Before Surgery, 2.Intraoperative Anesthetic Management, 3.Postoperative Analgesic Management
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University Health Network, Toronto
Post-COVID-19 Syndrome
Physiotherapy in Post COVID-19 Syndrome Patients
Patients who have undergone COVID-19 infection often have long-term sequelae. One of the most prevalent sequelae is pain. The main objective of this research is to investigate the efficacy of a cognitive behavioral…
- Trial name
- NCT05477199
- Testing
- Cognitive behavioral principles-based treatment program, Control intervention
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Universidad de Granada
Heart Failure, Dyspnea
Targeting Acute Congestion With Tolvaptan in Congestive Heart Failure
The primary objective of this study is to compare the effects of oral Tolvaptan vs. placebo as an adjunct to fixed dose IV furosemide on dyspnea relief in patients with acute decompensated heart failure The primary hypothesis is…
- Trial name
- TACTICS-HF (NCT01644331)
- Testing
- Tolvaptan
- Where
- 18 sites in United States
- Volunteers
- 257 people
- Sponsor
- Duke University
Amnesia
Transient Global Amnesia (TGA). Exploratory Study of the Default Mode Network During the Acute Phase
The transient global amnesia, in which the memory disorder is massive, transient and pure, offers a unique model for exploring episodic memory.
- Trial name
- ICTUS (NCT02010853)
- Testing
- IRMf
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.