Clinical trials: Acute Conditions, open to volunteers
Pain After Surgery, PSP
Intraoperative Bupivacaine Injection to Reduce Acute and Chronic Pain After TVT/TVT-O Surgery. Randomized Double-Blind Trial
This randomized, double-blind controlled trial will evaluate whether intraoperative injection of bupivacaine at the sling insertion site reduces postoperative pelvic and thigh pain in women undergoing TVT or TVT-O surgery for…
- Conditions
- Pain After Surgery, PSP, Chronic Pain Syndrome, Local Anesthesia Infiltration
- Trial name
- PAIN-TVT (NCT07429019)
- Testing
- Bupivacain (Postoperative)
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Amputation, Traumatic, Pain, Phantom
Feasibility of Using an App for Managing Phantom Limb Pain Associated with Combat Injury in Ukraine (PAMELA)
In Ukraine, since the beginning of the full-scale war on February 24, 2022, a large number of individuals have lost a limb(s). Many of these amputees cannot access appropriate care in terms of pain management and rehabilitation.
- Conditions
- Amputation, Traumatic, Pain, Phantom, Pain, Acute, Pain, Chronic
- Trial name
- PAMELA (NCT06604507)
- Testing
- non-pharmacological app
- Where
- 5 sites in Ukraine
- Volunteers
- 200 people
- Sponsor
- Winfried Meißner
Cognitive Dysfunction, Acquired Brain Injury
Fareon Open Label Device Clinical Trial
The purpose of this study is to assess the safety and feasibility of an at-home MMT treatment in patients with cognitive dysfunction related to acquired brain injury, Long COVID, traumatic brain injury, myalgic encephalomyelitis…
- Conditions
- Cognitive Dysfunction, Acquired Brain Injury, Traumatic Brain Injury
- Trial name
- NCT07600320
- Testing
- Fareon device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Activity-Related Knee Discomfort, Joint Discomfort
NT-II™ Collagen for Joint Discomfort and Function
The goal of this clinical trial is to learn whether a natural marine supplement called NT-II™ (Salmon Undenatured Type II Collagen) can help lower knee discomfort caused by physical activity in otherwise healthy adults.
- Conditions
- Activity-Related Knee Discomfort, Joint Discomfort, Functional Joint Pain, Functional Knee Pain
- Trial name
- NTII-JOINT (NCT07119645)
- Testing
- NT-II™ (240 mg), NT-II™ 480 mg, Glucosamine/Chondroitin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Hofseth Biocare ASA
Acute Coronary Syndromes, Coronary Arterial Disease (CAD)
Focused Orticumab Research for Treating Inflammation in Coronary Arteries
The goal of this clinical trial is to determine the clinical effect of orticumab treatment on inflammation in study participants with prior myocardial infarction who have elevated coronary inflammation based on CCTA.
- Conditions
- Acute Coronary Syndromes, Coronary Arterial Disease (CAD), Inflammation, Heart Disease
- Trial name
- FORTIFY (NCT06927739)
- Testing
- Orticumab
- Where
- 41 sites in United States, Czechia and 7 more
- Volunteers
- 240 people
- Sponsor
- Abcentra
Asthma Acute, Asthma Exacerbation
45th Multicenter Airway Research Collaboration
The study is a randomized controlled trial on the effect of emergency department initiation of Airsupra on acute asthma "recurrence" at 3 months and other related outcomes (acute asthma relapse, asthma control).
- Conditions
- Asthma Acute, Asthma Exacerbation, Asthma, Asthma Control Level
- Trial name
- MARC-45 (NCT07166939)
- Testing
- Airsupra
- Where
- United States
- Volunteers
- 1,860 people
- Sponsor
- Massachusetts General Hospital
AMI, STEMI
DAPAgliflozine to Attenuate Cardiac RemOdeling afTEr aCuTe myOcardial Infarction
Recent clinical trials have proven the cardiovascular benefits of new medications for patients with heart failure with reduced ejection fraction (HFrEF), especially sodium-glucose co-transporter 2 (SGLT2) inhibitors.
- Conditions
- AMI, STEMI, NSTEMI, Left Ventricular Dysfunction
- Trial name
- DAPAPROTECTOR (NCT05764057)
- Testing
- Dapagliflozin propanediol (FORXIGA™/FARXIGA™1)
- Where
- France
- Volunteers
- 450 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hematologic Malignancies
Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML
SLS009 (formerly GFH009) is a potent and highly selective CDK9 inhibitor. In this study the safety, tolerability, and antitumor activity of single agent SLS009 are assessed in two dose escalation groups (Group 1 in patients with…
- Trial name
- NCT04588922
- Testing
- SLS009, venetoclax, azacitidine
- Where
- 32 sites in United States, China
- Volunteers
- 160 people
- Sponsor
- Sellas Life Sciences Group
Acute Heart Failure (AHF), Cardiogenic Shock
Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients…
- Conditions
- Acute Heart Failure (AHF), Cardiogenic Shock, Heart Failure, Ketones
- Trial name
- KADHEF-2 (NCT07527156)
- Testing
- Ketone Monoester (KE)
- Where
- Czechia
- Volunteers
- 12 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Healthy Volunteers
Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers
Background: Opioid drugs are often prescribed for acute and chronic pain. But these drugs are addictive, and they lead to more than 14,000 overdose deaths in the United States each year.
- Trial name
- NCT07504601
- Testing
- (2R,6R)-Hydroxynorketamine
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Music Therapy
Effect of Music Therapy on Postoperative Health Outcomes
Patients underwent surgical procedure experiences acute postoperative pain, but less than half report adequate postoperative pain relief.
- Trial name
- MToPOHO (NCT04155528)
- Testing
- Music therapy
- Volunteers
- 60 people
- Sponsor
- Cairo University
Myocardial Infarction, ST Elevation Myocardial Infarction
Early Discharge Pathway Registry
Despite the year-on-year decrease, coronary artery disease (CAD) still remains one of the leading causes of mortality worldwide.
- Conditions
- Myocardial Infarction, ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction
- Trial name
- NCT06040528
- Where
- 2 sites in United Kingdom
- Volunteers
- 20,000 people
- Sponsor
- Queen Mary University of London
Opioid Consumption, Demographic Data
Single-level and Two-level Serratus Posterior Superior Intercostal Plan Block (SPSIPB)
Breast cancer is the most common malignancy in women; one of the mainstays of breast cancer treatment is surgery, and modified radical mastectomy is one of the standard treatments.
- Trial name
- NCT06751407
- Testing
- Single level SPSIPB, Two-level SPSIPB
- Volunteers
- 50 people
- Sponsor
- Ankara Etlik City Hospital
Acute Myeloid Leukemia, Relapsed/Refractory Acute Myeloid Leukemia
Salvage Haploidentical HSCT With DLI and Targeted Therapy for R/R AML
This is a prospective, single-center, observational study to evaluate the efficacy and safety of salvage haploidentical allogeneic hematopoietic stem cell transplantation (haplo-HSCT) combined with post-transplant relapse…
- Conditions
- Acute Myeloid Leukemia, Relapsed/Refractory Acute Myeloid Leukemia, AML, Relapsed/Refractory
- Trial name
- NCT07572695
- Testing
- Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (haplo-HSCT), Post-transplant Maintenance Therapy
- Volunteers
- 40 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Hypoxia, Normobaric Hypoxia
Effect of Acute Hypoxia on RIght VEntRicular Function in Healthy Adults.
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland.
- Conditions
- Hypoxia, Normobaric Hypoxia, Altitude Hypoxia, Right Heart Function
- Trial name
- RIVER-H (NCT07431567)
- Testing
- Normobaric Hypoxia
- Where
- 2 sites in Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mona Lichtblau
Hepatitis B, Chronic, Acute-On-Chronic Liver Failure
Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF
This study is to investigate investigate the safety and efficacy of Double plasma molecular adsorption system with sequential low-dose plasma exchange in treating hepatitis B virus-related acute-on-chronic liver failure.
- Trial name
- NCT04597164
- Testing
- Artificial liver support system
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Relapse/Refractory B-cell Acute Lymphoblastic Leukemia
Safety and Efficacy of CAR T Cell Therapy in Patients with R/r B-ALL
The goal of this clinical trial is to evaluate the safety and efficacy of CD19 CAR-T cells in pediatric patients of all genders, aged 2 to 18 years, with relapsing or refractory B cell acute lymphoblastic leukemia (r/r B-ALL).
- Trial name
- NCT06635330
- Testing
- anti-CD19 CAR T cell therapy
- Where
- Iran
- Volunteers
- 5 people
- Sponsor
- Kara Yakhteh Tajhiz Azma Company
Stretching, Control Condition
Hip Abduction and Adduction During Neurodynamic Stretching
Neurodynamic mobilization techniques are widely applied in rehabilitation and physiotherapy to enhance the mobility and function of peripheral nerves. Two main approaches are distinguished : Nerve tensioning and nerve flossing.
- Trial name
- HIPROT (NCT07350434)
- Testing
- Maximal neurodynamic flossing
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Burgundy
Fracture
Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department
The goal of this clinical trial is to learn if buprenorphine can treat pain in older adults who have broken bones. The main questions it aims to answer are: Is buprenorphine as effective as opioids to treat pain? Are there less…
- Trial name
- NCT07430345
- Testing
- Buprenorphine 0.15 MG, Hydromorphone 0.25 mg IV
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- The Cooper Health System
Mastectomy, Pain, Acute
Stellate Ganglion Block for Prevention of Post Mastectomy Depression
Complications after mastectomy include chronic pain and depression.
- Conditions
- Mastectomy, Pain, Acute, Pain, Chronic
- Trial name
- SGB (NCT06263907)
- Testing
- Stellate gangalion block
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Mansoura University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.