Clinical trials: Acute Copd Exacerbation
COPD Acute Exacerbation
Change in Sleep Breathing During Hospital Admission for COPD Exacerbation
hronic obstructive pulmonary disease (COPD) is a common lung disease that can worsen suddenly, leading to hospital admission. During these exacerbations, breathing becomes unstable and recovery is difficult to predict.
- Trial name
- CHABLIS (NCT07361744)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Asten Sante
COPD Exacerbation Acute
Combination Antibiotic Therapy Compared to Monotherapy in the Treatment of Acute COPD
The investigators hypothesized that the empirical use of fluoroquinolones together with beta-lactam antibiotics will change their therapeutic success in patients with acute exacerbations of COPD compared to that in patients in…
- Trial name
- COPD (NCT04879030)
- Testing
- Beta-Lactams, Fluoroquinolone
- Where
- Vietnam
- Volunteers
- 170 people
- Sponsor
- Haiphong University of Medicine and Pharmacy
COPD
EMG in COPD - Factor Analysis
Acute exacerbations of COPD contribute to significant morbidity and mortality in the United Kingdom (UK). The ability to assess response to treatment during exacerbations that require hospitalisation would allow clinicians to…
- Trial name
- EMGCOPD (NCT02721199)
- Testing
- Neural Respiratory Drive Automated EMGpara assessment
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease Exacerbation
Muscle Oxygenation in Chronic Obstructive Pulmonary Disease
The aim of our study is to examine the Peripheral Muscle Oxygenations at rest and in motion on the 2nd day of hospitalized patients and before discharge in Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease and to…
- Conditions
- Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease Exacerbation, Muscle Oxygenation
- Trial name
- NCT05808621
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Bandırma Onyedi Eylül University
Chronic Obstructive Pulmonary Disease
Effects of Traditional Chinese Medicine on Outcomes in Patients With AECOPD Risk Window
This study aims to objectively evaluate the clinical efficacy and safety of Traditional Chinese Medicine in the treatment of AECOPD Risk Window, providing a basis for the formulation of TCM treatment plan with AECOPD.
- Trial name
- NCT04851093
- Testing
- TCM granule plus conventional drug
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Henan University of Traditional Chinese Medicine
COPD Exacerbation Acute
CRP, Procalcitonin and Pro-BNP as Diagnostic and Prognostic Markers in AECOPD
Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) are one of the chief causes for admission to Emergency Department. AECOPD is a significant cause for mortality and morbidity worldwide.
- Trial name
- AECOPD (NCT06514599)
- Where
- Turkey (Türkiye)
- Volunteers
- 196 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Acute Decompensated Heart Failure, COPD Exacerbation
Use of ΔIVC for Early Diagnosis of AHF in AECOPD
Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis.
- Trial name
- NCT05327374
- Testing
- calculation of the inferior vena cava collapsibility index
- Where
- 3 sites in Tunisia
- Volunteers
- 401 people
- Sponsor
- University of Monastir
Chronic Obstructive Pulmonary Disease
BACE Trial Substudy 1 - PROactive Substudy
A first sub-analysis of the BACE trial will address physical activity levels in a subgroup of the intervention study with portable validated activity monitors.
- Trial name
- PROactive (NCT02205242)
- Testing
- Azithromycin, Dynaport®
- Where
- 6 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- Wim Janssens
Chronic Obstructive Pulmonary Disease
Short Antibiotic Treatment Versus Duration Guided by Markers of Inflammation in the Treatment of AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in the world. In a recent study, we showed that administration of levofloxacin is superior to placebo in the treatment of decompensation of COPD; it…
- Trial name
- AECOPD (NCT02067780)
- Testing
- Levofloxacin 500mg
- Where
- Tunisia
- Volunteers
- 310 people
- Sponsor
- University of Monastir
COPD Exacerbation
Effect of High Flow Nasal During Exercise in COPD Patients
Early pulmonary rehabilitation is recommended after an episode of severe exacerbation of chronic obstructive pulmonary disease (COPD). However, its implementation is challenging particularly as regard exercise training.
- Trial name
- AiRehab (NCT03058081)
- Testing
- High Flow nasal cannula
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Groupe Hospitalier du Havre
Chronic Obstructive Pulmonary Disease
Tiotropium In Early Chronic Obstructive Pulmonary Disease Patients in China
Chronic obstructive pulmonary disease (COPD) is one of the commonest respiratory diseases. During the early stage of COPD, patients only have mild respiratory symptoms or signs which may lead to under-diagnosis of the disease.
- Trial name
- Tie-COPD (NCT01455129)
- Testing
- Tiotropium
- Where
- 25 sites in China
- Volunteers
- 841 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
COPD Exacerbation, COPD
Borg Score Outcomes in Respiratory Compromised Acute Exacerbating Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Treatment Via Vibrating Mesh Nebuliser Versus Jet Nebuliser in the Emergency Department
The purpose of this study is to compare clinical outcomes in patients with acute COPD treated with a vibrating mesh nebuliser (VMN) versus a current standard jet nebuliser (JN), in the Emergency Department (ED).
- Trial name
- BRAVE (NCT04181073)
- Testing
- Jet Nebuliser, Vibrating Mesh Nebuliser
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- NHS Greater Clyde and Glasgow
Copd Exacerbation Acute, Readmission
Identification of Patients Admitted With COPD Exacerbations and Predicting Readmission Risk Using Machine Learning
Patients with Chronic Obstructive Pulmonary Disease (COPD) who are admitted to hospital are at high risk of readmission. While therapies have improved and there are evidence-based guidelines to reduce readmissions, there are…
- Conditions
- Copd Exacerbation Acute, Readmission, Machine Learning, Natural Language Processing
- Trial name
- NCT04192175
- Where
- Canada
- Volunteers
- 65,000 people
- Sponsor
- University Health Network, Toronto
Pulmonary Disease, Chronic Obstructive
Task-specific Training for Patients With Acute Exacerbation of COPD
Patients with Chronic Obstructive Pulmonary Disease (COPD) experience a progressive deterioration in their quality of life. Task-specific training is a type of approach focused on chronic patients that allows the acquisition of…
- Trial name
- COPD (NCT06224075)
- Testing
- Task-specific training, Usual care
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Universidad de Granada
Bronchiectasis Adult, Bronchiectasis With Acute Exacerbation
Exploring How Viral Infections Affect People With Chronic Lung Disease
Many people with chronic lung disease have disease flare-ups. It was previously believed that these were mainly caused by bacteria but recent evidence suggests that viruses could be an important trigger.
- Conditions
- Bronchiectasis Adult, Bronchiectasis With Acute Exacerbation, COPD (Chronic Obstructive Pulmonary Disease), Respiratory Infection Virus
- Trial name
- PRIVILEGE (NCT06625944)
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Imperial College London
Angina, Acute Bronchiolitis
Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care
Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France…
- Conditions
- Angina, Acute Bronchiolitis, Acute Bronchitis, COPD Exacerbation (AECOPD)
- Trial name
- GRASP (NCT07359287)
- Testing
- Antibiotic prescribing according to guidelines
- Where
- France
- Volunteers
- 4,500 people
- Sponsor
- University Hospital, Caen
Chronic Obstructive Pulmonary Disease (COPD), Decompensated COPD With (Acute) Exacerbation
Breathing-swallowing Interaction in Chronic Obstructive Pulmonary Disease Patients - Impact of Non Invasive Ventilation
In the investigators' knowledge there are no data about the impact of non invasive mechanical ventilation on the breathing-swallowing interaction.
- Trial name
- NCT01518075
- Testing
- Spontaneous Breathing, Non Invasive Mechanical Ventilation
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
COPD, Muscle Weakness
Feasibility of Strength Training in Patients Hospitalized Due to COPD
To examine the feasibility of progressive unilateral knee-extension strength training using ankle weight cuffs in patients hospitalized due to acute exacerbation in COPD
- Trial name
- NCT01981200
- Testing
- Resistance training in AECOPD
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Frederikssunds Hospital, Denmark
COPD, Emphysema or COPD
Steroid Resistance During COPD Exacerbations With Respiratory Failure
Chronic obstructive pulmonary disease (COPD) is a lung disease caused by cigarette smoke that affects millions of people. In the United States, COPD is the 3rd leading cause of death making it one of our most important public…
- Conditions
- COPD, Emphysema or COPD, COPD Exacerbation, COPD Exacerbation Acute
- Trial name
- NCT03680495
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Colorado, Denver
Chronic Obstructive Pulmonary Disease
PPSV23 Pneumococcal Vaccine in Chronic Obstructive Pulmonary Disease (COPD)
Streptococcus pneumoniae is the most common causes of community-acquired pneumonia and exacerbations in chronic obstructive pulmonary disease (COPD) patients, which are associated with morbidity, mortality, and higher health-care…
- Trial name
- NCT01381367
- Testing
- PPSV23 pneumococcal vaccine (Pneumovax®), Normal Saline
- Where
- Taiwan
- Volunteers
- 38 people
- Sponsor
- Far Eastern Memorial Hospital