Clinical trials: Acute Coronary Disease
Sudden Cardiac Death, Acute Coronary Event
Finnish Genetic Study for Arrhythmic Events
Finnish Genetic Study for Arrhythmic Events (FinGesture is a prospective case-control study assessing the characteristics and genetic background of consecutive series of autopsy verified out-of-hospital victims of SCD vs.
- Trial name
- FinGesture (NCT02075866)
- Where
- Finland
- Volunteers
- 8,000 people
- Sponsor
- University of Oulu
ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
The EPIVER Randomized Controlled Trial
The trial aims to estimate the efficacy and safety of the intracoronary administration of adrenalin, verapamil, as well as their combination compared to standard treatment in patients with STEMI and refractory coronary no-reflow…
- Conditions
- ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention, No-Reflow Phenomenon
- Trial name
- EPIVER (NCT04573751)
- Testing
- Standard therapy, Epinephrine, Verapamil
- Where
- Russia
- Volunteers
- 104 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Stable Angina (SA), Unstable Angina (UA)
Breaking Fasts Ahead of Cardiac Caths
The goal of this clinical trial is to find out whether fasting is necessary before urgent inpatient cardiac catheterizations. For patients presenting with urgent heart-related pain or even mild heart attacks, researchers want to…
- Conditions
- Stable Angina (SA), Unstable Angina (UA), NSTEMI - Non-ST Segment Elevation MI
- Trial name
- BACON-RCT (NCT06996639)
- Testing
- Non-Fasting, Fasting
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of South Florida
Acute Myocardial Infarction
A Study of INO-1001, an Intravenous PARP (Poly [ADP Ribose] Polymerase) Inhibitor in Acute Heart Attack Patients Undergoing Primary Percutaneous Coronary Intervention
The primary purpose of this study is to assess the safety of INO-1001 in subjects who have experienced a heart attack and are to be treated with coronary angioplasty.
- Trial name
- NCT00271765
- Testing
- INO-1001
- Where
- 16 sites in United States, Israel
- Volunteers
- 40 people
- Sponsor
- Inotek Pharmaceuticals Corporation
STEMI - ST Elevation Myocardial Infarction
Thrombolysis in STEMI Patients Compared With pPCI on Recanalization Time in the Context of the COVID-19 Outbreak.
During the outbreak of COVID-19, for patients with acute ST-segment elevation myocardial infarction with unclear infection, the time of primary PCI is uncertain, and it is often expected to exceed 90 minutes or even 120 minutes.
- Trial name
- RESCUE-STEMI (NCT05354128)
- Testing
- Thrombolytic, percutaneous coronary stenting
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Ya-Wei Xu
Left Ventricular Remodeling, Plasma Multi-Omics
Prediction of LVAR and MACE in STEMI Though Plasma Multiomics Analysis
To identify plasma multi-omics biomarkers that predict left ventricular adverse remodeling (LVAR) and major adverse cardiovascular events (MACE) in patients with acute ST-segment elevation myocardial infarction, and to…
- Conditions
- Left Ventricular Remodeling, Plasma Multi-Omics, Acute ST-segment Elevation Myocardial Infarction, Immunomics
- Trial name
- NCT06885619
- Testing
- Diagnostic Test: echocardiography and blood collection
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
Acute Coronary Syndrome, STEMI
Chewing Ticagrelor Versus Prasugrel in ST-elevation Myocardial Infarction - A Platelet Reactivity Study
To examine the efficacy of chewing Ticagrelor versus Prasugrel in ST-elevation Myocardial Infarction (STEMI) patients on platelet reactivity.
- Trial name
- NCT03016611
- Testing
- Chewing Ticagrelor LD, Chewing Prasugrel LD
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Acute Coronary Syndrome, Recurrent Myocardial Infarction
Primary Prevention With Statin and Incidence of Recurrent MI and Cardiogenic Shock in Post-ACS Patients
This study aims to evaluate the effect of statin for primary prevention, towards lowering the incidence of recurrent myocardial infarction, cardiogenic shock and mortality in ACS patients.
- Conditions
- Acute Coronary Syndrome, Recurrent Myocardial Infarction, Cardiogenic Shock
- Trial name
- NCT03596944
- Testing
- Statin
- Where
- Indonesia
- Volunteers
- 145 people
- Sponsor
- Tarumanagara University
Acute Coronary Syndromes
Low-dose Interleukin-2 for the Reduction of Vascular Inflammation in Acute Coronary Syndromes - IVORY
Acute coronary syndromes (ACS) result from coronary plaque(s) disruption, which initiates a thrombotic process leading to partial or complete obstruction of the vessel lumen with subsequent myocardial ischaemia and necrosis.
- Trial name
- IVORY (NCT04241601)
- Testing
- Interleukin-2 [IL-2]
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Angina, Unstable, Cardiovascular Diseases
IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium.
The purpose of this study is to test the impact of pharmacological myocardial metabolic support, in the form of intravenous (IV) glucose, insulin and potassium (GIK), for the treatment of patients with threatened or established…
- Conditions
- Angina, Unstable, Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- IMMEDIATE (NCT00091507)
- Testing
- GIK
- Where
- 13 sites in United States
- Volunteers
- 911 people
- Sponsor
- Tufts Medical Center
Acute Heart Failure, Congestive Heart Failure
The Role of intraABDOminal Pressure and Point Of Care UltraSound to Guide Decongestive Therapy in Heart Failure
Systemic venous congestion is the primary therapeutic target of intravenous loop diuretics in patients admitted for acute heart failure (AHF).
- Conditions
- Acute Heart Failure, Congestive Heart Failure, Intraabdominal Hypertension, Cardio-Renal Syndrome
- Trial name
- ABDOPOCUS-HF (NCT07008365)
- Testing
- Furosemide 20 Milligrams
- Where
- 2 sites in Spain
- Volunteers
- 168 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Acute Coronary Syndrome, Myocardial Infarction
Telmisartan Versus Ramipril After Acute Coronary Syndrome
The purpose of this study is to compare the antinflammatory and endothelial progenitor cell (EPC) mobilizing effect of Ramipril and Telmisartan in patients presenting with acute coronary syndrome
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Disease
- Trial name
- TERACS (NCT00702936)
- Testing
- TELMISARTAN, RAMIPRIL
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Catholic University of the Sacred Heart
Acute Myocardial Infarction, Acute Myocardial Ischemia
Study of Dutogliptin in Combination With Filgrastim in Post-Myocardial Infarction
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Safety and Efficacy Study of Dutogliptin in Combination with Filgrastim in Early Recovery Post-Myocardial Infarction
- Conditions
- Acute Myocardial Infarction, Acute Myocardial Ischemia, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT03486080
- Testing
- Dutogliptin Tartrate, Filgrastim Injectable Product
- Where
- 12 sites in Austria, Belgium and 3 more
- Volunteers
- 49 people
- Sponsor
- Recardio, Inc.
Acute Myocardial Infarction, Congestive Heart Failure
Nicorandil Study to Reduce Cardiac Death After Percutaneous Coronary Intervention (PCI) in Hemodialysis Patients
Survival after invasive coronary revascularization is worse in patients with chronic kidney disease than in those without it. The investigators aimed to examine whether oral administration of nicorandil, a hybrid of nitrate and…
- Trial name
- NCT00848562
- Testing
- Nicorandil
- Where
- Japan
- Volunteers
- 129 people
- Sponsor
- Toujinkai Hospital
Acute Respiratory Distress Syndrome
Fluid Responsiveness Prediction During Prone Position
Predicting fluid responsiveness is primordial when caring for patients with circulatory shock as it allows correction of preload-dependent low cardiac output states, while preserving patients of the deleterious effects of…
- Trial name
- PROLOAD (NCT05898269)
- Testing
- Trendelenburg maneuver, End-expiratory occlusion test (EE OCC), End-expiratory and end-inspiratory occlusion test (EI OCC)
- Where
- 4 sites in France
- Volunteers
- 96 people
- Sponsor
- Hospices Civils de Lyon
Kidney Failure, Acute
Fenoldopam in Pediatric Cardiac Surgery
The purpose of this study is to determine whether fenoldopam infusion during cardiopulmonary bypass in young children with congenital heart disease is able to reduce indicators of acute kidney injury (biomarkers reduction…
- Trial name
- NCT00982527
- Testing
- Fenoldopam
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Acute Coronary Syndrome, Gender
Prospective Multicenter Registry of Gender, Diversity and Inclusion (GEDI) of Women With Acute Coronary Syndrome
Create a multicenter prospective registry that collects information from women affected by acute coronary syndrome (ACS). This registry aims to understand the diversity in the presentation of women with ACS.
- Conditions
- Acute Coronary Syndrome, Gender, Genetic Predisposition
- Trial name
- ACS GEDI (NCT06441942)
- Where
- 4 sites in Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Acute Coronary Syndrome
Coronary Flow Reserve in Patients With Bio-active Stent or Everolimus-eluting Stent Implanted in Acute Coronary Syndrome
The aim of the trial is to assess coronary artery reactivity using adenosine-induced coronary flow reserve (CFR) by transthoracic echocardiography in patients with Bio-active stent (BAS) and Everolimus-eluting stent (EES) distal…
- Trial name
- BASE-CFR (NCT01080872)
- Testing
- CFR
- Where
- 2 sites in Finland
- Volunteers
- 40 people
- Sponsor
- The Hospital District of Satakunta
Elective Cardiac Surgery
Pleiades Safety and Feasibility Study
The "Pleiades" study is a non randomised, prospective, single center clinical trial that aims to evaluate the safety and the procedural feasibility of an innovative flow assist device (Pleioflow-RF) in adult patients undergoing…
- Trial name
- NCT05662501
- Testing
- Pleioflow-RF
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Pleioflow
Valvular Heart Disease
Impact of Perioperative Shedding of the Endothelial Glycocalyx on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery.
Endothelial glycocalyx, the luminal structure of healthy vasculature, plays critical roles in regulation of inflammatory responses, vascular permeability, blood coagulation.
- Trial name
- NCT03197051
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Yonsei University
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